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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Shape-free finite element method:The plane hybrid stress-function (HS-F) element method for anisotropic materials显示文摘The sensitivity problem to mesh distortion and the low accuracy problem of the stress solutions are two inherent difficulties in the finite element method.By applying the fundamental analytical solutions (in global Cartesian coordinates) to the Airy stress function of the anisotropic materials,8-and 12-node plane quadrilateral hybrid stress-function (HS-F) elements are successfully developed based on the principle of the minimum complementary energy.Numerical results show that the present new elements exhibit much better and more robust performance in both displacement and stress solutions than those obtained from other models.They can still perform very well even when the element shapes degenerate into a triangle and a concave quadrangle.It is also demonstrated that the proposed construction procedure is an effective way for developing shape-free finite element models which can completely overcome the sensitivity problem to mesh distortion and can produce highly accurate stress solutions. | CEN Song FU XiangRong ZHOU GuoHua ZHOU MingJue LI ChenFeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 7 |
| 3 | Application of the quadrilateral area coordinate method:a new element for laminated composite plate bending problems显示文摘最近,一些新四边的有限元素被四边的区域坐标(QAC ) 方法成功地开发。与用 isoparametric 坐标的那些传统的模型相比,这些新模型对网孔失真不太敏感。在这篇论文,一新基于排水量, 4 节点 20-DOF (5-DOF 每节点) 四边的弯曲元素基于一阶砍为任意的把压成薄片的合成盘子的分析的变丑理论被介绍。它的弯曲部分基于元素 AC-MQ4,高效的 Mindlin-Reissner 板元素由 QAC 方法提出了的最近开发和概括一致条件方法;并且它的在里面飞机排水量地被双线性的形状功能在 isoparametric 坐标插入内推。而且,混合 processing 以后过程,被作者第一建议,再被采用改进压力答案,为特别横向砍压力。产生元素,作为 AC-MQ4-LC 表示了,在所有线性静态、动态的数字例子展出优秀性能。它再证明 QAC 方法,概括一致条件方法,和混合 processing 以后过程是为开发简单、有效、可靠的有限元素模型的有效工具。 | Song Cen Xiangrong Fu Yuqiu Long Hongguang Li Zhenhan Yao | 2007 | Acta Mechanica Sinica2007，23，5： | 6 |
| 4 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 5 | Malaria Surveillance of Entry People During the COVID-19 Epidemic—Guangdong Province,China,October 2020–May 2021显示文摘Summary What is already known about this topic?Malaria control was affected by the coronavirus disease 2019(COVID-19)pandemic.This study conducted active case finding for key flights and key populations to determine malaria transmission.What is added by this report?Surveillance for malaria was conducted for entry personnel coming from areas affected by malaria.It is estimated that at least 100,000 tests were conducted in Guangdong Province. | De Wu Zhuohui Deng Rongxin Lin Qiang Mao Wenchen Lu Caiwen Ruan Yongzhen Cen Ning Xiao Tie Song | 2021 | China CDC weekly2021，3，38： | 2 |
| 6 | Circ_0049447 acts as a tumor suppressor in gastric cancer through reducing proliferation, migration, invasion, and epithelial-mesenchymal transition显示文摘Background:Although increasing abnormal expression of circular RNAs(circRNAs)has been revealed in various cancers,there were a small number of studies about circRNAs in gastric cancer(GC).Here,we explored the expression and function of a novel circRNA,circ_0049447,in GC.Methods:A total of 80 GC tissues and non-tumorous tissues were collected from the First Affiliated Hospital of China Medical University.And all cells were cultured with 10%fetal bovine serum and incubated at 37°C and 5%CO2.The expression of circ_0049447 was quantified by real-time polymerase chain reaction.The biological function of circ_0049447 on proliferation,migration,invasion,and epithelial-mesenchymal transition(EMT)was evaluated by cell counting kit-8(CCK-8),colony formation assay,transwell migration and invasion assay,and Western blotting.Luciferase report assay was used to verify the direct binding between circ_0049447 and predicted microRNA(miRNA).Furthermore,a xenograft mouse model was used to validate the function of circ_0049447 in vivo.Results:We demonstrated that circ_0049447 was downregulated in GC(P<0.001).The area under the receiver operating characteristic curve reached 0.838,while sensitivity was 82.3%and specificity was 77.2%.CCK-8 and colony formation assay showed that overexpression of circ_0049447 could inhibit the proliferation(P<0.05).Transwell migration and invasion assay showed upregulated circ_0049447 could impede migration in GC cells(P<0.05).In addition,overexpression of circ_0049447 could impede GC cell EMT.Upregulation of miR-324-5p in GC specimens and direct binding between miR-324-5p with circ_0049447 proven by luciferase reporter assay indicated that circ_0049447 may inhibit GC by sponging certain miRNA.Conclusion:Circ_0049447 acts as a tumor suppressor in GC through reducing proliferation,migration,invasion,and EMT,and it is a promising biomarker for diagnosis. | Kai-Wen Tang Zhe-Xu Guo Zhong-Hua Wu Cen Zhou Jie Sun Xin Wang Yong-Xi Song Zhen-Ning Wang | 2021 | Chinese Medical Journal2021，，11： | 2 |
| 7 | Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504显示文摘 | Wenwei Hu Chang S. Chan Rui Wu Cen Zhang Yvonne Sun Jun S. Song Laura H. Tang Arnold J. Levine Zhaohui Feng | 2010 | Molecular Cell2010，，： | 1 |
| 8 | MicroRNA-375 targets the 3-phosphoinositide-dependent protein kinase?1gene in pancreatic carcinoma显示文摘 | Shi-Duo Song Jian Zhou Jin Zhou Hua Zhao Jian-Nong Cen De-Chun Li | 2013 | Oncology Letters2013，，4： | 1 |
| 9 | Application of the quadrilateral area coordinate method: A new element for Mindlin-Reissner plate 显示文摘 | Cen Song Long Yuqiu Yao Zhenhan Chiew Singping | 2006 | International Journal for Numerical Methods in Engineering2006，66，1： | 1 |
| 10 | A new hybrid-enhanced displacement-based element for the analysis of laminated composite plates 显示文摘 | Cen Song Long Yuqiu Yao Zhenhan | 2002 | Computers & Structures2002，80，910： | 1 |
| 11 | End-to-end differentiation of congestion and wireless losses显示文摘 | Cen Song Cosman P C Voelker G M | 2003 | IEEE Transaction on Networking2003，11，5： | 1 |
| 12 | The analytical trial function method (ATFM) for finite element analysis of plane crack/notch problems显示文摘 | FU Xiang-rong CEN Song LONG Yu-qiu JIANG Xiu-gen JU Jin-san | 2008 | Key Engineering Matemals2008，，： | 1 |
| 13 | Analytical trial function method for de- velopment of new 8-node plane element based on variational principle containing Airy stress function显示文摘 | FU Xiang-rong CEN Song LI C F CHEN Xiao-ming | 2010 | Engineering Computations2010，27，4： | 1 |
| 14 | Development of eight-node quadrilateral membrane elements using the area coordinates method 显示文摘 | SOh Ai-Kah Long Yuqiu Cen Song | 2000 | Computational Mechanics2000，25，： | 1 |
| 15 | 8- and 12-node plane hybrid stress-function ele- ments immune to severely distorted mesh containing elements with concave shapes显示文摘 | CEN Song FU Xiang-rong ZHOU Ming-jue | 2011 | Com- puter Methods in Applied Mechanics and Engineering2011，200，2932： | 1 |
| 16 | A 4-node hybrid stress-function (HS-F) plane element with drilling degrees of freedom less sensitive to severe mesh distortions 显示文摘 | CEN Song ZHOU Ming-jue FU Xiang-rong | 2011 | Com- puters & Structures2011，89，55： | 1 |
| 17 | MieroRNA-375 is downregulated in pancreatic cancer and inhibits cell proliferation in vitro 显示文摘 | Zhou J Song S Cen J et M | 2012 | Oncol Res2012，20，56： | 1 |
| 18 | End -to -end differentiation of congestion and wireless losses显示文摘 | Song Cen Cosman Pamela C Voelker Geoffrey M | 2003 | ACM/ IEEE transaction on networking2003，11，5： | 1 |
| 19 | End-to-end differentiation of congestion and wireless losses显示文摘 | Song Cen Pamela C Cosman Geoffrey M Voelker | 2003 | IEEE/ACM Transactions on Networking2003，11，5： | 1 |
| 20 | 利用四边形面积坐标法构建的4结点膜单元的几何非线性分析显示文摘 | Yu Du and Song Cen | 2008 | 钢结构2008，，12： | 1 |
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