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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Investigating the dynamics of wetland landscape pattern in Beijing from 1984 to 2008显示文摘北京沼泽地的风景模式由于自然、人工的元素经历了一个重要变化。由遥感和 GIS 技术支持了,用在北京的从 1984~2008 的多时间的 TM 图象,这份报纸包括补丁区域通过选择典型索引分析了沼泽地风景模式的动态特征,补丁一般水准区域,分数维的尺寸索引,差异,优势,传染索引和每种沼泽地类型的空间矩心是计算的。最后,纸探索了进化模式和沼泽地风景模式的开车因素。结果如下被获得:全部的沼泽地区域在时期期间增加了 19841996,然后从 1996 ~ 2004 衰退。在 1994 的沼泽地区域说明了仅仅那中的 47.37% 个在 2004。人工的沼泽地区域的比例比自然沼泽地的大。水库沼泽地的比例是 33.50% ~ 53.73% 并且有最大的平均区域。有最少的平均区域的池溏和稻地沼泽地类型说明了 16.46% ~ 45.09% 全部的沼泽地区域。自然的河沼泽地的驱动力主要是自然元素;它的分数维的尺寸索引比其它大。沼泽地风景的香农差异索引在 2004 在 1992 ~ 1.34 从 1.11 增加了,显示每种沼泽地类型的比例之间的差别减少了,每种沼泽地类型的区域是均匀地分布式的。传染索引从 65.59 ~ 58.41 下沉了,显示连接降级了。Miyun 水库有最大的区域,它的区域变化在矩心的地点上有大影响。沼泽地资源从自然、人工的因素的联合效果逐渐地堕落了。在时期期间 20062008,增加的降水和干旱条件被减轻。政府实现了积极政策的系列节省水资源,并且沼泽地区域增加了。 | ZHANG Yiran GONG Zhaoning GONG Huili ZHAO Wenji | 2011 | Journal of Geographical Sciences2011，21，5： | 16 |
| 3 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 4 | Spatial-temporal Characteristics of Land Subsidence Corresponding to Dynamic Groundwater Funnel in Beijing Municipality,China显示文摘Due to long-term over-exploitation of groundwater in Beijing Municipality,regional groundwater funnels have formed and land subsidence has been induced.By combining a groundwater monitoring network,GPS monitor-ing network data,radar satellite SAR data,GIS and other new technologies,a coupled process model based on the dy-namic variation of groundwater and the deformation response of land subsidence has been established.The dynamic variation of groundwater funnels and the land subsidence response process were analyzed systematically in Beijing.Study results indicate that current groundwater funnel areas are distributed mainly in the southwest of Shunyi District,the northeast of Chaoyang District and the northwest of Tongzhou District,with an average decline rate of groundwa-ter level of 2.66 m/yr and a maximum of 3.82 m/yr in the center of the funnels.Seasonal and interannual differences exist in the response model of land subsidence to groundwater funnels with uneven spatial and temporal distribution,where the maximum land subsidence rate was about-41.08 mm/yr and the area with a subsidence rate greater than 30 mm/yr was about 1637.29 km2.Although a consistency was revealed to exist between a groundwater funnel and the spatial distribution characteristics of the corresponding land subsidence funnel,this consistency was not perfect.The results showed that the response model of land subsidence to the dynamic variation of groundwater was more revealing when combining conventional technologies with InSAR,GIS,GPS,providing a new strategy for environmental and hydrogeological research and a scientific basis for regional land subsidence control. | CHEN Beibei GONG Huili LI Xiaojuan LEI Kunchao ZHANG Youquan LI Jiwei GU Zhaoqin DANG Yanan | 2011 | Chinese Geographical Science2011，21，6： | 13 |
| 5 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 6 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 7 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
| 8 | Prevalent intrinsic emission from nonaromatic amino acids and poly(amino acids)显示文摘Nonaromatic amino acids are generally believed to be nonemissive, owing to their lack of apparently remarkable conjugation within individual molecules. Here we report the intrinsic visible emission of nonaromatic amino acids and poly(amino acids) in concentrated solutions and solid powders. This unique and widespread luminescent characteristic can be well rationalized by the clustering-triggered emission(CTE) mechanism, namely the clustering of nonconventional chromophores(i.e. amino, carbonyl,and hydroxyl) and subsequent electron cloud overlap with simultaneous conformation rigidification. Such CTE mechanism is further supported by the single crystal structure analysis, from which 3 D through space electronic communications are uncovered.Besides prompt fluorescence, room temperature phosphorescence(RTP) is also detected from the solids. Moreover, persistent RTP is observed in the powders of exampled poly(amino acids) of ε-poly-L-lysine(.-PLL) after ceasing UV irradiation. These results not only illustrate the feasibility of employing the building blocks of nonaromatic amino acids in the exploration of new luminescent biomolecules, but also provide significant implications for the emissions of peptides and proteins at aggregated or crystalline states. Meanwhile, they may also shed lights on further understanding of autofluorescence from biological systems. | Xiaohong Chen Weijian Luo Huili Ma Qian Peng Wang Zhang Yuan Yongming Zhang | 2018 | Science China Chemistry2018，61，3： | 8 |
| 9 | Field test of HTS receivers on CDMA demonstration cluster in China显示文摘This paper presents the field test of our first demonstration cluster with five base stations (BTS) on code division multiple access (CDMA) wireless communication in China, while each BTS was installed with a high temperature superconductor (HTS) receiver. The HTS receivers have the same centre frequency of 830 MHz, a bandwidth of 13 MHz, and a noise figure (NF) of 0.9 dB. After the conventional receivers in the BTSs were replaced by the HTS receivers, a consequent drive test was carried out. A 2.35 dB decrease of the mean mobile transmit power was observed in the demonstration cluster. | WEI Bin GUO XuBo PIAO YunLong JIN ShiChao ZHANG XiaoPing GAO LongMa PENG HuiLi YIN ZheSheng CAO BiSong | 2009 | Chinese Science Bulletin2009，54，4： | 7 |
| 10 | Anti-corruption, government subsidies, and investment efficiency显示文摘The problem of corruption in socio-economic development has long been a focus of academics and practitioners. To address this concern in China, the 18th National Congress of the Communist Party of China instituted a new anti-corruption policy. In this paper, we examine the impact of this recently enacted anti-corruption policy on the investment efficiency of subsidized enter- prises from the perspective of government subsidies. We conclude that govern- ment subsidies have a significant positive impact on the overinvestment behavior of enterprises and that the anti-corruption work done by the govern- ment has effectively restrained the excessive investment behavior of government-subsidized enterprises. Further, we find that the anti-corruption policy is more effective in restricting overinvestment in subsidized stateowned enterprises than in non-state-owned enterprises. We examine the impact of the anti-corruption policy on excessive investment caused by government subsidies and enrich the body of research related to investment efficiency.We also provide empirical support for further research on the anti-corruption policy at the macro-market and micro-enterprise levels. The findings highlight the need to establish new cooperation between governmentand enterprises, to rationalize the distribution of administrative resources, and to promote the sustained and healthy development of the national economy. | Huili Zhang Ran An Qinlin Zhong | 2019 | China Journal of Accounting Research2019，，1： | 7 |
| 11 | Does media governance restrict corporate overinvestment behavior? Evidence from Chinese listed firms显示文摘Using China's A-share listed firms from 2007 to 2011, this paper empirically tests how media governance affects firms' levels of overinvestment and whether external supervision and informal institutional mechanisms reduce these levels.We find that media governance and overinvestment are significantly negatively related. When firms are located in a district with a stronger media governance environment their levels of overinvestment are lower, indicating that media governance significantly restricts overinvestment behavior. When internal corporate governance efficiency is low, the negative relationship between the media environment and overinvestment behavior is significantly enhanced,indicating that when internal governance or formal systems have reduced efficacy, an important complementary role is played by external supervision and the informal institutional environment. After considering endogeneity and different measures of overinvestment and other related variables, the conclusions remain unchanged. | Huili Zhang Zengrui Su | 2015 | China Journal of Accounting Research2015，，1： | 6 |
| 12 | Effects of the Fhb1 gene on Fusarium head blight resistance and agronomic traits of winter wheat显示文摘The gene Fhb1 has been used in many countries to improve wheat Fusarium head blight(FHB) resistance. To make better use of this gene in the Yellow-Huai River Valleys Winter Wheat Zone(YHWZ), the most important wheat-producing region of China, it is desirable to elucidate its effects on FHB resistance and agronomic traits in different genetic backgrounds. Based on a diagnostic marker for Fhb1, six BC2 populations were developed by crossing dwarf-male-sterile(DMS)-Zhoumai 16 to three Fhb1 donors(Ningmai 9, Ningmai 13, and Jianyang 84) and backcrossing to Zhoumai 16 and Zhoumai16’s derivative cultivars(Lunxuan 136 and Lunxuan 13) using marker-assisted backcross breeding. The progenies were assessed for FHB resistance and major agronomic traits.The Fhb1 alleles were identified using the gene-specific molecular marker. The plants with the Fhb1-resistant genotype(Fhb1-R) in these populations showed significantly fewer infected spikelets than those with the Fhb1-susceptible genotype(Fhb1-S). When Lunxuan 136 was used as the recurrent parent, Fhb1-R plants showed significantly fewer infected spikelets per spike than Fhb1-R plants produced using Lunxuan 13 as the recurrent parent, indicating that the genetic backgrounds of Fhb1 influence the expression of FHB resistance. Fhb1-R plants from the DMS-Zhoumai 16/Ningmai 9//Zhoumai 16/3/Lunxuan 136 population showed the highest FHB resistance among the six populations and a significantly higher level of FHB resistance than the moderately susceptible control Huaimai 20. No significant phenotypic differences between Fhb1-R and Fhb1-S plants were observed for the eight agronomic traits investigated. These results suggest that it is feasible to improve FHB resistance of winter wheat withoutreducing yield potential by introgressing Fhb1 resistance allele into FHB-susceptible cultivars in the YHWZ. | Teng Li Hongjun Zhang Yiwen Huang Zhenqi Su Yun Deng Hongwei Liu Chunyan Mai Guangjun Yu Huili Li Liqiang Yu Tongquan Zhu Li Yang Hongjie Li Yang Zhou | 2019 | The Crop Journal2019，7，6： | 6 |
| 13 | N_2O and NH_3 emissions from a bioreactor landfill operated under limited aerobic degradation conditions显示文摘The combination of leachate recirculation and aeration to landfill may be an efficient way for in-situ nitrogen removal.However,nitrogenous substances contained in the landfill layer are concomitantly transformed into N2O and NH3,leading to increased emissions into the atmosphere.In the present study,the emissions of N2O and NH3 were measured under conditions of fresh or partially stabilized refuse with or without leachate recirculation or intermittent aeration.The results showed that the largest N2O emission(12.4 mg-N/L of the column) was observed in the aerated column loaded with partially stabilized refuse and recycled with the leachate of low C/N ratio;while less than 0.33 mg-N/L of the column was produced in the other columns.N2O production was positively correlated with the prolonged aerobic time and negatively related with the C/N ratio in the recycled leachate.NH3 volatilization increased with enhanced gas flow and concentration of free ammonia in the leachate,and the highest cumulative volatilization quantity was 1.7 mg-N/L of the column. | Pinjing He Na Yang Huili Gu Hua Zhang Liming Shao | 2011 | Journal of Environmental Sciences2011，23，6： | 5 |
| 14 | Effects of soaking process on arsenic and other mineral elements in brown rice显示文摘One of the main food crops in the world,rice can accumulate high levels of arsenic from flooded paddy soils,which seriously threatens human health.Soaking,a common processing method for brown rice products,especially for brown rice noodles,was investigated in this study.Japonica rice(Dao Hua Xiang No.2)and Indica rice(Ye Xiang You No.3)were selected for studying the effects of soaking on arsenic concentrations,species,and distributions.Results revealed that soaking can efficiently remove arsenic in these two rice varieties,and the main part of removal is endosperm with the maximal rate of about 40%.Inorganic arsenic(I-As)(about 85%)is the main species of arsenic reduction.Meanwhile,the variations of four other elements(i.e.,Mg,Ca,Zn,and Fe)were analyzed.Collectively,the findings of this study indicate that soaking can efficiently remove arsenic in brown rice under controlled soaking conditions,which thereby reduces the arsenic intake for brown rice customers. | Fan Zhang Fengying Gu Huili Yan Zhenyan He Bolun Wang Hao Liu Tingting Yang Feng Wang | 2020 | Food Science and Human Wellness2020，9，2： | 5 |
| 15 | Ultrasound-guided microwave ablation for symptomatic adenomyosis:More areas of concern for more uniform and promising outcomes显示文摘Adenomyosis is a common gynecological disease in reproductive women,which causes serious dysmenorrhea,menorrhagia,anemia,and infertility,and has a serious impact on the physical and mental health of women.Considering that the efficacy of the traditional medication and surgical treatment is not ideal,an increasing number of patients are searching for more effective and less invasive therapies.Ultrasound(US)-guided microwave ablation(MWA)has emerged as a new effective and minimally invasive alternative treatment for symptomatic adenomyosis,and it is widely being used in clinical settings.Several studies have proven that it is an efficient and safe treatment modality for symptomatic adenomyosis,but a significant variance in clinical outcomes reported in previous studies was also observed.Herein,we have analyzed the potential causes of this problem from the aspects of the diagnosis of adenomyosis,symptom evaluation before ablation,steps of USguided ablation treatment,and outcome evaluation after ablation.Simultaneously,the clinical problems existing in the ablation treatment of adenomyosis are discussed,and the directions of future research are pointed out. | Huili Zhang Songyuan Yu Huixiong Xu | 2022 | Journal of Interventional Medicine2022，5，3： | 4 |
| 16 | Single-cell RNA sequencing of meiocytes and microspores reveals the involvement of the Rf4 gene in redox homeostasis of CMS-C maize显示文摘Normal microsporogenesis is determined by both nuclear and mitochondrial genes. In maize C-type cytoplasmic male sterility, it is unclear how the development of meiocytes and microspores is affected by the mitochondrial sterility gene and the nuclear restorer gene. In this study, we sequenced the transcriptomes of single meiocytes(tetrad stage) and early mononucleate microspores from sterile and restorer lines. The numbers of expressed genes varied in individual cells and fewer than half of the expressed genes were common to the same cell types. Four comparisons revealed 3379 differentially expressed genes(DEGs), with 277 putatively associated with mitochondria, 226 encoding transcription factors,and 467 possibly targeted by RF4. KEGG analysis indicated that the DEGs in the two lines at the tetrad stage were involved predominantly in carbon metabolism and in amino acid biosynthesis and metabolism, whereas the DEGs during the transition from the tetrad stage to the early mononucleate stage were associated mostly with regulation of protein metabolism, fatty acid metabolism, and anatomical structure morphogenesis. Thus, meiocyte and microspore development was affected by the surrounding cells and the restorer gene, and the restorer gene helped restore the redox homeostasis of microspores and the normal cellular reconstruction during the transition. | Huaisheng Zhang Huili Yang Desheng Hu Bing Li Yanan Lin Wen Yao Zhanyong Guo Haochuan Li Dong Ding Zhanhui Zhang Yanmin Hu Yadong Xue Jihua Tang | 2021 | The Crop Journal2021，9，6： | 4 |
| 17 | Silk materials for medical, electronic and optical applications显示文摘Silk derived from the silkworm Bombyx mori is among the most important fibrous protein biomaterials due to large-scale production from natural sources, excellent biocompatibility, unique mechanical properties and controllable degradation. Silk fibroin can be processed into a variety of formats to match different applications, such as tissue engineering, drug delivery or as the passive substrate of a bio-device. Advances in fabrication technologies provide new possibilities for the combination of silk fibroin with other nanomaterials to functionalize silk fibroin for specialized purposes, including sensing, cell visualization,resistance to ultraviolet light and provision of antibacterial properties. As the requirement for wearable and intelligent devices has become increasingly important over recent years, silk fibroin has been utilized as the active element in electronic and optical instruments. This review summarizes these recent advances in the innovative applications of silk fibroin. | FAN SuNa ZHANG Yi HUANG XiangYu GENG LiHong SHAO HuiLi HU XueChao ZHANG YaoPeng | 2019 | Science China(Technological Sciences)2019，62，6： | 4 |
| 18 | A screening assay for thyroid hormone signaling disruption based on thyroid hormone-response gene expression analysis in the frog Pelophylax nigromaculatus显示文摘Amphibian metamorphosis provides a wonderful model to study the thyroid hormone(TH)signaling disrupting activity of environmental chemicals, with Xenopus laevis as the most commonly used species. This study aimed to establish a rapid and sensitive screening assay based on TH-response gene expression analysis using Pelophylax nigromaculatus, a native frog species distributed widely in East Asia, especially in China. To achieve this, five candidate TH-response genes that were sensitive to T3 induction were chosen as molecular markers, and T3 induction was determined as 0.2 nmol/L T3 exposure for 48 hr. The developed assay can detect the agonistic activity of T3 with a lowest observed effective concentration of 0.001 nmol/L and EC50 at around 0.118–1.229 nmol/L, exhibiting comparable or higher sensitivity than previously reported assays. We further validated the efficiency of the developed assay by detecting the TH signaling disrupting activity of tetrabromobisphenol A(TBBPA), a known TH signaling disruptor. In accordance with previous reports, we found a weak TH agonistic activity for TBBPA in the absence of T3,whereas a TH antagonistic activity was found for TBBPA at higher concentrations in the presence of T3, showing that the P. nigromaculatus assay is effective for detecting TH signaling disrupting activity. Importantly, we observed non-monotonic dose-dependent disrupting activity of TBBPA in the presence of T3, which is difficult to detect with in vitro reporter gene assays. Overall, the developed P. nigromaculatus assay can be used to screen TH signaling disrupting activity of environmental chemicals with high sensitivity. | Yinfeng Zhang Yuanyuan Li Zhanfen Qin Huili Wang Jianzhong Li | 2015 | Journal of Environmental Sciences2015，27，8： | 4 |
| 19 | Photocatalytic Activity of Lanthanum and Sulfur Co-doped TiO_2 Photocatalyst under Visible Light显示文摘A novel lanthanum and sulfur co-doped TiO 2 photocatalyst was synthesized by precipitation-dipping method,and characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM)and UV-Vis diffuse reflectance spectroscopy.Compared with the S-doped TiO 2 ,La-doped TiO 2 and the standard Degussa P25 photocatalysts,the lanthanum and sulfur co-doped TiO 2 photocatalyst(the molar percentage of La is 3.0%)calcined at 450℃for 2 h showed the strongest absorption for visible light and highest activities for degradation of reactive blue 19 dye in aqueous solution under visible light(λ>400 nm)irradiation.It was also discovered that the co-doping of lanthanum and sulfur hindered the aggregation and growth of TiO 2 particles, and the doping of lanthanum reduced slightly the phase transition temperature of TiO 2 from anatase to rutile. | XIA Huili ZHUANG Huisheng XIAO Dongchang ZHANG Tao | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 4 |
| 20 | Seasonal patterns in water uptake for Medicago sativa grown along an elevation gradient with shallow groundwater table in Yanchi county of Ningxia,Northwest China显示文摘Lucerne(Medicago sativa L.) is a deep-rooted perennial leguminous forage with high evapo-transpiration rate exceeding the annual precipitation in semi-arid areas of Northwest China.Groundwater might be the potential water sources of lucerne in the area with shallow groundwater table.In this study,stable isotopic compositions of oxygen and hydrogen(δ18O and δD) of different water sources and xylem sap were analyzed to determine the seasonal(April,June,July and August) and topographic(three slope positions) variations in water sources for lucerne growing in Ningxia eastern semi-arid area adjacent to Mu Us Desert characterized by shallow groundwater table.Iso Source software was used to calculate the probable contribution of different water sources to the total plant water uptake.Stomatal conductance,stem water potential,carbon isotope discrimination(?^(13)C) of whole plant were also determined for evaluating the water status of lucerne growing at different slope positions.The results showed that soil water content increased as the elevation decreased.Oxygen compositions of soil water in the 0–40 cm profile fluctuated considerably.Soil water δ^(18)O values in deep profile(>3.5 m) were similar to those in groundwater,implying the recharge of groundwater to this soil layer.Highest water utilization rate from deep soil profile(below 350 cm) was recorded for lucerne grown at the slope position 1(groundwater table depth of 3.5–3.9 m) in April,June and July.The lucernes at slope position 2(groundwater table depth of 5.8–6.4 m) and slope position 3(groundwater table depth 7.1–8.3 m) mostly used water from deep soil layers(below 350 cm) during dry period,and turned to use water from superficial soil layer in wet period.Higher yield,?^(13)C value of whole plant and stomatal conductance were observed for lucerne grown at the slope position 1 than those at other slope positions.These results indicated that groundwater is a significant water source for transpiration of lucerne grown in Ningxia semi-arid area with shallow groundwater table where lucerne grassland is suggested to be established so as to obtain better yield performance. | ZHU Lin ZHANG Huili GAO Xue QI Yashu XU Xing | 2016 | Journal of Arid Land2016，8，6： | 4 |
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