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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | 2D Layered Double Hydroxide Nanosheets and Their Derivatives Toward E cient Oxygen Evolution Reaction显示文摘Layered double hydroxides(LDHs)have attracted tremendous research interest in widely spreading applications.Most notably,transition-metal-bearing LDHs are expected to serve as highly active electrocatalysts for oxygen evolution reaction(OER)due to their layered structure combined with versatile com-positions.Furthermore,reducing the thickness of platelet LDH crystals to nanometer or even molecular scale via cleavage or delamination provides an important clue to enhance the activity.In this review,recent progresses on rational design of LDH nanosheets are reviewed,including direct synthesis via traditional coprecipitation,homogeneous precipitation,and newly developed topochemical oxidation as well as chemical exfoliation of parent LDH crystals.In addition,diverse strategies are introduced to modulate their electrochemical activity by tuning the composition of host metal cations and intercalated counter-anions,and incorporating dopants,cavi-ties,and single atoms.In particular,hybridizing LDHs with conductive components or in situ growing them on conductive substrates to produce freestanding electrodes can further enhance their intrinsic catalytic activity.A brief discussion on future research directions and prospects is also summarized. | Xueyi Lu Hairong Xue Hao Gong Mingjun Bai Daiming Tang Renzhi Ma Takayoshi Sasaki | 2020 | Nano-Micro Letters2020，12，7： | 8 |
| 3 | Are small RNAs a big help to plants?显示文摘The discovery of RNA interference(RNAi) has augmented our knowledge of gene regulation and presents a fascinating technology that has a great potential for application in genetic analysis,disease therapy,plant protection,and many other areas.In this review,we will focus on the biological functions of RNAi and its application in agriculture with a brief introduction to the history of its discovery and molecular mechanism. | MAO YingBo,XUE XueYi & CHEN XiaoYa National Key Laboratory of Plant Molecular Genetics,Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China | 2009 | Science China(Life Sciences)2009，52，3： | 7 |
| 4 | Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery:SMILE and FS-LASIK显示文摘Background:To investigate the impact of the ablation ratio on 5-year postoperative posterior corneal stability in myopic eyes after small incision lenticule extraction(SMILE)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)surgery.Methods:A prospective,nonrandomized,cohort study:80 eyes of 43 patients underwent SMILE surgery and 63 eyes of 32 patients underwent FS-LASIK surgery at the EYE&ENT Hospital,Fudan University.Ablation ratio was defined as lenticule thickness(SMILE cases)or ablation depth(FS-LASIK cases)divided by central corneal thickness(CCT).Posterior corneal elevation changes were recorded as posterior central elevation(PCE),posterior corneal surface at thinnest point(PTE)and posterior corneal mean elevation(PME).Patients were followed up at 6-month and 5-year interval to investigate the impact of the ablation ratio on posterior corneal elevation after SMILE and FSLASIK surgery.Results:PCE dropped at the 6-month follow-up for both SMILE(decreased by−1.11±2.93μm,P<0.05)and FSLASIK groups(decreased by−0.46±3.72μm,P<0.05).PTE also dropped in SMILE(reduced by−2.04±3.02μm,P<0.05)and FS-LASIK group(reduced by−1.28±4.21μm,P<0.05)at the 6-month follow-up.Stable PCE(elevation change:SMILE−0.28±4.03μm;FS-LASIK 0.79±4.13μm,P>0.05)and PTE(elevation change:SMILE−0.08±4.28μm;FS-LASIK 1.42±3.85μm,P>0.05)for both groups were recorded at the 5-year follow-up compared to the 6-month visit.Ablation ratio was strongly correlated with 5-year postoperative PCE(β=2.68±1.05,P<0.01)and PTE(β=2.35±1.17,P<0.05).Cut-off value for 5-year postoperative raised PCE and PTE was 27.3 and 27.1%,respectively.Conclusions:Ablation ratio was strongly correlated with postoperative posterior corneal elevation in a 5-year follow-up in both SMILE and FS-LASIK groups.PCE and PTE underwent slight backward displacement 6-month postoperatively and remain stable at the 5-year follow-up.Threshold of the ablation ratio for resisting forward displacement of posterior corneal surface was 27.3 and 27.1%for SMILE and FS-LASIK groups,respectively. | Meiyan Li Danjuan Yang Yu Zhao Weiming Yang Jianmin Shang Xueyi Zhou Peijun Yao Dong Yang Xue Lin Xingtao Zhou | 2020 | Eye and Vision2020，7，1： | 1 |
| 5 | Cotton plants expressing CYP6AE14 double-stranded RNA show enhanced resistance to bollworms 显示文摘 | Mao Yingbo Tao Xiaoyuan Xue Xueyi | 2011 | Transgenic Research2011，20，3： | 1 |
| 6 | Cysteine protease enhances plant-mediated bollworm RNA inter- ference 显示文摘 | Mao Yingbo Xue Xueyi Tao Xiaoyuan | 2013 | Plant Mol Biol2013，83，12： | 1 |
| 7 | Spatially-controlled porous nanoflake arrays derived from MOFs:An efficiently long-life oxygen electrode显示文摘The urge nt expectati on of the n ext-ge neratio n en ergy storage devices for electric vehicles has drive n researchers'atte ntion to the lithium-oxyge n(Li-O2)batteries due to the satisfied specific energy density.Herein,spatially-controlled CO3O4 nanoflake arrays with three-dimensional networked morphology are adopted as flexible and self-sta nding oxyge n cathodes in L1-O2 batteries.The spin el-phase CO3O4 nano flakes were con verted from two dimensi on metal-orga nic frameworks with abundant available cha nnels and large specific surface area.The open-structure nano flake arrays possess sufficie nt Li2O2/cathode contact interface,great bifunctional catalytic performa nee and adequate Li2O2 accommodation,leading to the enhanced electrochemical performance of the L1-O2 batteries.As expected,the binder-free porous CO3O4/CT cathode delivers a high capacity of 6,509 mAh·g^-1(200 mA·g^-1)and enhanced stability over 100 cycles(limited by 1,000 mAh·g^-1).In additi on,pouch-type Li-O2 batteries were successfully desig ned and cycled with CO3O4/CT cathode as oxyge n electrodes,dem on strating its potential application for flexible electronics and wearable energy storage devices. | Hao Gong Tao Wang Hairong Xue Xueyi Lu Wei Xia Li Song Songtao Zhang Jianping HeRenzhi Ma | 2019 | Nano Research2019，12，10： | 1 |
| 8 | Synthesis of Ethylbenzene by Alkylation of Benzene with Diethyl Carbonate over Parent MCM- 22 and Hydrothermally Treated MCM-22 显示文摘 | Li Yongxin Xue Bing He Xueyi | 2009 | J Mol Catal A : Chem2009，301，12： | 1 |
| 9 | Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery:SMILE and FS-LASIK显示文摘Background:To investigate the impact of the ablation ratio on 5-year postoperative posterior corneal stability in myopic eyes after small incision lenticule extraction(SMILE)and femtosecond laser-assisted in situ keratomileusis(FS-LASIK)surgery.Methods:A prospective,nonrandomized,cohort study:80 eyes of 43 patients underwent SMILE surgery and 63 eyes of 32 patients underwent FS-LASIK surgery at the EYE&ENT Hospital,Fudan University.Ablation ratio Was defined as lenticule thickness(SMILE cases)or ablation depth(FS-LASIK cases)divided by central corneal thickness(CCT).Posterior corneal elevation changes were recorded as posterior central elevation(PCE),posterior corneal surface at thinnest point(PTE)and posterior corneal mean elevation(PME).Patients were followed up at 6-month and 5-year intervals to investigate the impact of the ablation ratio on posterior corneal elevation after SMILE and FS-LASIK surgery.Results:PCE dropped at the 6-month follow-up for both SMILE(decreased by-1.11±2.93μm,P<0.05)and FSLASIK groups(decreased by-0.46±3.72μm,P<0.05).PTE also dropped in SMILE(reduced by-2.04±3.02μm,P<0.05)and FS-LASIK group(reduced by-1.28±4.21μm,P<0.05)at the 6-month follow-up.Stable PCE(elevation change:SMILE-0.28±4.03μm;FS-LASIK 0.79±4.13μm,P>0.05)and PTE(elevation change:SMILE-0.08±4.28μm;FS-LASIK 1.42±3.85μm,P>0.05)for both groups were recorded at the 5-year follow-up compared to the 6-month visit.Ablation ratio was strongly correlated with 5-year postoperative PCE(β=2.68±1.05,P<0.01)and PTE(β=2.35±1.17,P<0.05).Cut-off value raised for 5-year postoperative PCE and PTE was 27.3%and 27.1%,respectively.Conclusions:Ablation ratio was strongly correlated with postoperative posterior corneal elevation in a 5-year follow-up in both SMILE and FS-LASIK groups.PCE and PTE underwent slight backward displacement 6 months postoperatively and remain stable at the 5-year follow-up.Threshold of the ablation ratio for resisting forward displacement of posterior corneal surface Was 27.3%and 27.1%for SMILE and FS-LASIK groups,respectively. | Meiyan Li Danjuan Yang Yu Zhao Weiming Yang Jianmin Shang Xueyi Zhou Peijun Yao Dong Yang Xue Lin Xingtao Zhou | 2023 | Eye and Vision2023，9，1： | 0 |
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