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| 1 | Dynamic characteristics of an intestine capsule robot with variable diameter显示文摘This paper proposes an intestine capsule robot with variable diameter. It is driven by external rotating magnetic field and has the function of automatic radial clearance compensation. An external magnetic field generating device and a capsule robot with variable diameter are developed. Radial dynamic balance equation and kinematics equation of the capsule robot traveling inside flexible elasto-wall environment are established, and dynamic characteristics of the capsule robot inside flexible elasto-wall pipe and rigid wall pipe environments are analyzed and compared. Simulations and experiment results show that its dynamic characteristics in both pipes are almost the same. Under the action of radial clearance compensation, fluid dynamic pressure around outer surface of the capsule robot and its propulsion, as well as its adaptability to diameter change range, are significantly improved. Its propulsion and moving speed are controlled by adjusting rotating angular speed of the rotating magnetic field. This innovative capsule robot with radial clearance compensation has a promising prospect for inside intricate gastrointestinal (GI) tract in non-invasive therapy applications. | ZHANG YongShun JIANG ShengYuan ZHANG XueWen YU HongHai WANG DianLong GUO DongMing | 2010 | Chinese Science Bulletin2010，55，17： | 11 |
| 2 | Outline of Uranium Resources Characteristics and Metallogenetic Regularity in China显示文摘Uranium,as one of twenty-six kinds of important minerals in China,is strategic resource and energy mineral,which has been thoroughly investigated in the project of National Potential Evaluation of Uranium Resource.During the implementation of this project,the authors summarized the metallogenic regularity of uranium resource in China systematically,through the researches of geological characteristics of uranium resource,uranium deposits type(genetic and prediction type),temporal and spatial distribution,and metallogenic series.Based on the investigation of present situation and progress in uranium exploration,this paper proposes the uranium deposits in China should be divided into 4 classes,9 types,21 subtypes in genetic,and 50 types in prediction;suggests to divide China into 29 uranium metallogenic belts and 20 uranium prospective area,and constructs 20uranium-polymetallic metallogenic series,through summarizing temporal and spatial distribution characteristics and metallogenic regularity of uranium deposits in China.The above research is beneficial to the comprehensive understanding of regional uranium metallogenic regularity,and will direct the uranium exploration in the future. | CAI Yuqi ZHANG Jindai LI Ziying GUO Qingyin SONG Jiye FAN Honghai LIU Wusheng QI Fucheng ZHANG Minglin | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 11 |
| 3 | Nutritional compositions of various potato noodles:Comparative analysis显示文摘In this study,three kinds of noodles,wheat,Shepody potato and Atlantic potato noodles,were produced with blended powder consisting of wheat flour and certain amounts of various potato flours.In order to investigate the effects of potato flour on the nutritional characteristics of noodles,the nutrient compositions of four types of noodles were analyzed:fresh noodle,dried noodle,fresh noodle after boiling,and dried noodle after boiling.Results showed that the contents of protein,crude fiber,total ash,reducing sugar,vitamin B1,vitamin B2,vitamin B3,vitamin C,most mineral elements,dietary fiber,and amino acids in potato noodles were higher than those in wheat noodles.Furthermore,drying and boiling could decrease the contents of vitamin B1,vitamin B3,and mineral elements in noodles,but the nutrient contents in potato noodles remained higher than those in wheat noodles.The comprehensive nutritional values of noodles were evaluated using the index of nutritional quality,the results showed that the nutritional value of Shepody potato noodles was the highest,followed by that of Atlantic potato noodles and then wheat noodles. | Xu Fen Hu Honghai Dai Xiaofeng Liu Qiannan Huang Yanjie Zhang Hong | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 9 |
| 4 | Effects of cotton field management practices on soil CO2 emission and C balance in an arid region of Northwest China显示文摘Changes in both soil organic C storage and soil respiration in farmland ecosystems may affect atmospheric CO2 concentration and global C cycle. The objective of this field experiment was to study the effects of three crop field management practices on soil CO2 emission and C balance in a cotton field in an arid region of Northwest China. The three management practices were irrigation methods(drip and flood), stubble managements(stubble-incorporated and stubble-removed) and fertilizer amendments(no fertilizer(CK), chicken manure(OM), inorganic N, P and K fertilizer(NPK), and inorganic fertilizer plus chicken manure(NPK+OM)). The results showed that within the C pool range, soil CO2 emission during the whole growing season was higher in the drip irrigation treatment than in the corresponding flood irrigation treatment, while soil organic C concentration was larger in the flood irrigation treatment than in the corresponding drip irrigation treatment. Furthermore, soil CO2 emission and organic C concentration were all higher in the stubble-incorporated treatment than in the corresponding stubble-removed treatment, and larger in the NPK+OM treatment than in the other three fertilizer amendments within the C pool range. The combination of flood irrigation, stubble incorporation and application of either NPK+OM or OM increased soil organic C concentration in the 0-60 cm soil depth. Calculation of net ecosystem productivity(NEP) under different management practices indicated that the combination of drip irrigation, stubble incorporation and NPK+OM increased the size of the C pool most, followed by the combination of drip irrigation, stubble incorporation and NPK. In conclusion, management practices have significant impacts on soil CO2 emission, organic C concentration and C balance in cotton fields. Consequently, appropriate management practices, such as the combination of drip irrigation, stubble incorporation, and either NPK+OM or NPK could increase soil C storage in cotton fields of Northwest China. | QianBing ZHANG Ling YANG ZhenZhu XU YaLi ZHANG HongHai LUO Jin WANG WangFeng ZHANG | 2014 | Journal of Arid Land2014，6，4： | 8 |
| 5 | Elevated Neurosteroids in the Lateral Thalamus Relieve Neuropathic Pain in Rats with Spared Nerve Injury显示文摘Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of c-aminobutyric acid A receptors(GABA_ARs), which play a vital role in pain modulation in the lateral thalamus, a main gate where somatosensory information enters the cerebral cortex. Using high-performance liquid chromatography/tandem mass spectrometry,we found increased levels of neurosteroids(pregnenolone,progesterone, deoxycorticosterone, allopregnanolone, and tetrahydrodeoxycorticosterone) in the chronic stage of neuropathic pain(28 days after spared nerve injury) in rats.The expression of the translocator protein TSPO, the upstream steroidogenesis rate-limiting enzyme, increased at the same time. In vivo stereotaxic microinjection of neurosteroids or the TSPO activator AC-5216 into the lateral thalamus(AP-3.0 mm, ML ±3.0 mm, DV 6.0 mm)alleviated the mechanical allodynia in neuropathic pain,while the TSPO inhibitor PK 11195 exacerbated it. The analgesic effects of AC-5216 and neurosteroids were significantly attenuated by the GABA_AR antagonist bicuculline. These results suggested that elevated neurosteroids in the lateral thalamus play a protective role in the chronic stage of neuropathic pain. | Meng Zhang Jia Liu Meng-Meng Zhou Honghai Wu Yanning Hou Yun-Feng Li Yuxin Yin Lemin Zheng Feng-Yu Liu Ming Yi You Wan | 2016 | Neuroscience Bulletin2016，32，4： | 6 |
| 6 | Seasonal variations of dimethylsulfide (DMS) and dim-ethylsulfoniopropionate (DMSP) in the sea-surface microlayer and subsurface water of Jiaozhou Bay and its adjacent area显示文摘The distributions of DMS and its precursor dimethylsulfoniopropionate, in both dissolved (DMSPd) and particulate fractions (DMSPp) were determined in the sea-surface microlayer and correspond-ing subsurface water of the Jiaozhou Bay, China and its adjacent area in May and August 2006. The concentrations of all these components showed a clear seasonal variation, with higher concen-trations occurring in summer. This can be mainly attributed to the higher phytoplankton biomass observed in summer. Simultaneously, the enrichment extents of DMSPd and DMSPp in the mi-crolayer also exhibited seasonal changes, with higher values in spring and lower ones in summer. Higher water temperature and stronger radiant intensity in summer can enhance their solubility and photochemical reaction in the microlayer water, reducing their enrichment factors (the ratio of concentration in the microlayer to that in the corresponding subsurface water). A statistically significant relationship was found between the microlayer and subsurface water concentrations of DMS, DMSP and chlorophyll a, demonstrating that the biogenic materials in the microlayer come primarily from the underlying water. Moreover, our data show that the concentrations of DMSPp and DMS were significantly correlated with the levels of chlorophyll a, indicating that phytoplank-ton biomass might play an important role in controlling the distributions of biogenic sulfurs in the study area. The ratios of DMS/chlorophyll a and DMSPp/chlorophyll a varied little from spring to summer, suggesting that there was no obvious change in the proportion of DMSP producers in the phytoplankton community. The mean sea-to-air flux of DMS from the study area was estimated to be 5.70 μmol/(m2·d), which highlights the effects of human impacts on DMS emission. | ZHANG Honghai YANG Guipeng LIU Chunying LI Chenxuan | 2009 | Acta Oceanologica Sinica2009，28，2： | 6 |
| 7 | Relationship between plant canopy characteristics and photosynthetic productivity in diverse cultivars of cotton(Gossypium hirsutum L.)显示文摘Genotype and plant type affect photosynthetic production by changing the canopy structure in crops.To analyze the mechanism of action of heterosis and plant type on canopy structure in cotton(Gossypium hirsutum L.),we had selected two cotton hybrids(Shiza 2,Xinluzao 43) and two conventional varieties(Xinluzao 13,Xinluzao 33) with different plant types in this experiment.We studied canopy characteristics and their correlation with photosynthesis in populations of different genotypes and plant types during yield formation in Xinjiang,China.Canopy characteristics including leaf area index(LAI),mean foliage tilt angle(MTA),canopy openness(DIFN),and chlorophyll relative content(SPAD).The results showed that LAI and SPAD peak values were higher and their peak values arrived later,and the adjustment capacity of MTA during the flowering and boll-forming stages was stronger in Xinluzao 43,with the normal-leaf,pagoda plant type,than these values in other varieties.DIFN of Xinluzao 43 remained between0.09 and 0.12 during the flowering and boll-forming stages,but was lower than that in the other varieties during the boll-opening stage.Thus,these characteristics of Xinluzao 43 were helpful for optimizing the light environment and maximizing light interception,thereby increasing photosynthetic capability.The photosynthetic rate and photosynthetic area were thus affected by cotton genotype as changes in the adjustment range of MTA,increases in peak values of LAI and SPAD,and extension of the functional stage of leaves.Available photosynthetic area and canopy light environment were affected by cotton plant type as changes in MTA and DIFN.Heterosis expression and plant type development were coordinated during different growth stages,the key to optimizing the canopy structure and further increasing yield. | Guoyi Feng Honghai Luo Yali Zhang Ling Gou Yandi Yao Yongzeng Lin Wangfeng Zhang | 2016 | The Crop Journal2016，4，6： | 6 |
| 8 | Let-7b-5p regulates proliferation and apoptosis in multiple myeloma by targeting IGF1R显示文摘多重骨髓瘤(公里) 全球是从 hematological 恶意的死亡的最普通的原因,并且最近的研究表明了 let-7b-5p 能在 tumorigenesis 起一个禁止的作用。然而,在公里的 let-7b-5p 的角色仍然保持不清楚。这研究的目的是阐明 let-7b-5p 在公里由充当肿瘤 suppressor 的分子的机制。这里,量的即时聚合酶链反应结果证明 let-7b-5p 的表示显著地在公里纸巾和公里房间线(RPMI-8226 和 U266 房间) 被减少。而且, let-7b-5p 的在表示上显著地压制了 RPMI-8226 房间增长并且导致了 S/G2 房间周期拘捕和 apoptosis。酶记者试金结果证明(IGF1R ) 像胰岛素的生长因素受体 1 被 let-7b-5p 否定地在 post-transcriptional 水平调整。在 RPMI-8226 房间的 IGF1R 的 mRNA 和蛋白质层次由 let-7b-5p 是下面调整的。而且, let-7b-5p 禁止者改变的房间显型能被 IGF1R silencing (si-IGF1R ) 救。一起拿,我们的结果证明 let-7b-5p 在公里作为肿瘤 suppressor 工作,建议那 let-7b-5p 可以是为公里的一个潜在的治疗学的目标。 | Honghai Xu Cong Liu Yuelin Zhang Xiong Guo Zongzhi Liu Zhenqun Luo Yanhai Chang Shizhang Liu Zhengming Sun Xiaoqing Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 9 | Experimental studies on dimethylsulfide (DMS) and dimethylsulfoniopropionate (DMSP) production by four marine microalgae显示文摘The production of dimethylsulfide (DMS) and dimethylsulfoniopropionate (DMSP) by marine microalgae was investigated to elucidate more on the role of marine phytoplankton in ocean-atmosphere interactions in the global biogeochemical sulfur cycle.Axenic laboratory cultures of four marine microalgae–Isochrysis galbana 8701,Pavlova viridis,Platymonas sp.and Chlorella were tested for DMSP production and conversion into DMS.Among these four microalgae,Isochrysis galbana 8701 and Pavlova viridis are two species of Haptophyta,while Chlorella and Platymonas sp.belong to Chlorophyta.The results demonstrate that the four algae can produce various amounts of DMS(P),and their DMS(P) production was species specific.With similar cell size,more DMS was released by Haptophyta than that by Chlorophyta.DMS and dissolved DMSP (DMSPd) concentrations in algal cultures varied significantly during their life cycles.The highest release of DMS appeared in the senescent period for all the four algae.Variations in DMSP concentrations were in strong compliance with variations in algal cell densities during the growing period.A highly significant correlation was observed between the DMS and DMSPd concentrations in algal cultures,and there was a time lag for the variation trend of the DMS concentrations as compared with that of the DMSPd.The consistency of variation patterns of DMS and DMSPd implies that the DMSPd produced by phytoplankton cells has a marked effect on the production of DMS.In the present study,the authors’ results specify the significant contribution of the marine phytoplankton to DMS(P) production and the importance of biological control of DMS concentrations in oceanic water. | LI Chengxuan YANG Guipeng PAN Jinfen ZHANG Honghai | 2010 | Acta Oceanologica Sinica2010，29，4： | 4 |
| 10 | Temporal variations of dimethylsulfide and dimethylsulfoniopropionate in the southern Yellow Sea in spring and autumn显示文摘Temporal distributions of dimethylsulfide(DMS) and dimethylsulfoniopropionate(DMSP) were studied in the southern Yellow Sea(SYS) during April and September 2010. The mean concentrations(range) of DMS, dissolved and particulate DMSP(DMSPd and DMSPp) in the surface waters in spring are 1.69(0.48–4.92), 3.18(0.68–6.75)and 15.81(2.82–52.33) nmol/L, respectively, and those in autumn are 2.80(1.33–5.10), 5.45(2.19–11.30) and 30.63(6.24–137.87) nmol/L. On the whole, the distributions of DMS and DMSP in spring are completely different from those in autumn. In the central part of the SYS, the concentrations of DMS and DMSP in spring are obviously higher than those in autumn, but the opposite situation is found on the south of 34°N, which can be attributed to the differences in nutrients and phytoplankton biomass and composition between spring and autumn. Besides,the seasonal variations of water column stability and the Changjiang diluted water also have significant impact on the distributions of DMS and DMSP in spring and autumn on the south of 34°N. DMS and DMSPp concentrations coincide well with chlorophyll a(Chl a) levels in the spring cruise, suggesting that phytoplankton biomass may play an important role in controlling the distributions of DMS and DMSPp in the study area. Annual DMS emission rates range from 0.015 to 0.033 Tg/a(calculated by S), respectively, using the equations of Liss and Merlivat(1986) and Wanninkhof(1992). This result implies a significant relative contribution of the SYS to the global oceanic DMS fluxes. | YANG Jian YANG Guipeng ZHANG Honghai ZHANG Shenghui | 2016 | Acta Oceanologica Sinica2016，35，2： | 3 |
| 11 | Earle's balanced salts solution and rapamycin differentially regulate the Bacillus Calmette-Guerin-induced maturation of human dendritic cells显示文摘Autophagy 被显示了提高杆菌 Calmette-Gu 的功效吗? | Yan Min Wenxi Xu Dan Liu Hongbo Shen Ying Xu Shulin Zhang Lu Zhang Honghai Wang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 12 | Hydrochemical characteristics and water quality evaluation of shallow groundwater in Suxian mining area,Huaibei coalfield,China显示文摘The aim of this study is to evaluate the hydrogeochemical characteristics and water environmental quality of shallow groundwater in the Suxian mining area of Huaibei coalfield,China.The natural formation process of shallow groundwater in Suxian is explored using Piper trilinear charts and Gibbs diagrams,and by examining the ratios between the major ions.United States Salinity Laboratory(USSL)charts,Wilcox diagrams,and the water quality index(WQI)are further employed to quantify the differences in water quality.The results reveal that the main hydrochemical facies of groundwater are HC03-Ca,and that silicate dissolution is the main factor controlling the ion content in shallow groundwater.The USSL charts and Wilcox diagrams show that most of the water samples would be acceptable for use in irrigation systems.The WQI results for each water sample are compared and analyzed,and the quality of groundwater samples around collapse ponds is found to be relatively poor. | Hao Yu Herong Gui Honghai Zhao Meichen Wang Jun Li Hongxia Fang Yaqi Jiang Yaru Zhang | 2020 | International Journal of Coal Science & Technology2020，7，4： | 3 |
| 13 | Decolourization of the azo dye Orange G in aqueous solution via a heterogeneous Fenton-like reaction catalysed by goethite显示文摘 | Honghai Wu Xiaowen Dou Dayi Deng Yufeng Guan Liguo Zhang Guangping He | 2012 | Environmental Technology2012，，14： | 2 |
| 14 | Experimental study on high viscosity fluid micro-droplet jetting system显示文摘 | XiaYun Shu HongHai Zhang HuaYong Liu Dan Xie JunFeng Xiao | 2010 | Science in China Series E: Technological Sciences2010，，1： | 2 |
| 15 | Characteristics of spatial magnetic torque of an intestine capsule micro robot with a variable diameter显示文摘A drive and control method is put forward for a variable diameter capsule micro robot to screw forward in intestine using magnetic coupling between an inner actuator inside the robot and the rotational magnetic field generated by a rotating outer actuator. The structures of the outer and inner actuators are magnet cylinders with multiple magnetic poles in tegular shape alternating with dissimilar radial magnetization. An universal mathematical model of magnetic torque at eccentric state is established based on the equivalent magnetic charge method, and the characteristics of magnetic torque with respect to structural parameters of actuators are theoretically studied. Experiments show that the driving method features advantages such as powerful magnetic torque, high safety, reliability, etc. The driving ability of the variable diameter capsule micro robot is greatly improved by its automatic radial clearance compensation. The magnetic drive system has a promising prospect of medical applications in intestine. | ZHANG YongShun YUE Ming GUO DongMing WANG DianLong YU HongHai JIANG ShengYuan ZHANG XueWen | 2009 | Science China(Technological Sciences)2009，52，7： | 2 |
| 16 | OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING显示文摘Stimulator of interferon genes(STING)is an adaptor protein that is critical for effective innate antiviral and antitumor immunity.The activity of STING is heavily regulated by protein ubiquitination,which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases.Here,we report that the deubiquitinase OTUD5 interacts with STING,cleaves its K48-linked polyubiquitin chains,and promotes its stability.Consistently,knockout of OTUD5 resulted in faster turnover of STING and subsequently impaired type I IFN signaling following cytosolic DNA stimulation.More importantly,Lyz2-Cre Otud5^(fl/Y) mice and CD11-Cre Otud5^(fl/Y) mice showed more susceptibility to herpes simplex virus type 1(HSV-1)infection and faster development of melanomas than their corresponding control littermates,indicating that OTUD5 is indispensable for STING-mediated antiviral and antitumor immunity.Our data suggest that OTUD5 is a novel checkpoint in the cGAS-STING cytosolic DNA sensing pathway. | Yunyun Guo Fei Jiang Lingli Kong Haifeng Wu Honghai Zhang Xiaorong Chen Jian Zhao Baoshan Cai Yanqi Li Chunhong Ma Fan Yi Lei Zhang Bingyu Liu Yi Zheng Lingqiang Zhang Chengjiang Gao | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 17 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 18 | Ultra-deep adsorptive removal of thiophenic sulfur compounds from FCC gasoline over the specific active sites of CeHY zeolite显示文摘Adsorption desulfurization performance of Na Y,HY and Ce HY zeolites is evaluated in a miniature fixedbed flow by model gasoline containing with thiophene,tetrahydrothiophene,2-methylthiophene,benzothiophene or mixed sulfur compounds.The structural properties of adsorbents are characterized by XRD,N2-adsorption and XPS techniques.Adsorption desulfurization mechanisms of these sulfur compounds over the specific active sites of adsorbents as a major focus of this work,have been systematically investigated by using in situ FT-IR spectroscopy with single and double probing molecules.Desulfurization experimental results show that the Ce HY adsorbent exhibits superior adsorption sulfur capacity at breakthrough point of zero sulfur for ultra-deep removal of each thiophenic sulfur compound,especially in the capture of aromatic 2-methylthiophene(about ca.28.6 mgS/gadsorbent).The results of in situ FT-IR with single probing molecule demonstrate an important finding that high oligomerization ability of thiophene or 2-methylthiophene on the CeHY can promote the breakthrough adsorption sulfur capacity,mainly resulting from the synergy between Br?nsted acid sites and Ce(III)hydroxylated species active sites located in the supercages of Ce HY.Meanwhile,the result of in situ FT-IR with double probing molecules further reveals the essence of oligomerization reactions of thiophene and 2-methylthiophene molecules on those specific active sites.By contrast,the oligomerization reaction of benzothiophene molecules on the active sites of Ce HY cannot occur due to the restriction of cavity size of supercages,but they can be adsorbed on the Br?nsted acid sites via protonation,and on Ce(III)hydroxylated species and extra-framework aluminum hydroxyls species via direct'S-M'bonding interaction.As to the tetrahydrothiophene,adsorption mechanism is similar to that of benzothiophene,except in the absence of protonation.The paper can provide a new design idea of specific adsorption active sites in excellent desulfurization adsorbents for elevating higher quality of FCC gasoline in the future. | Yun Zu Chang Zhang Yucai Qin Xiaotong Zhang Li Zhang Honghai Liu Xionghou Gao Lijuan Song | 2019 | Journal of Energy Chemistry2019，28，12： | 2 |
| 19 | Equilibrium, kinetics and thermodynamic studies for sorption of chlorobenzenes on CTMAB modified bentonite and kaolinite显示文摘 | Yuehong Shu Laisheng Li Qiuyun Zhang Honghai Wu | 2009 | Journal of Hazardous Materials2009，，1： | 2 |
| 20 | Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration显示文摘Inflammatory responses of nucleus pulposus(NP)can induce imbalanced anabolism and catabolism of extracellular matrix,and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc(IVD)degeneration.Herein,we constructed a siSTING delivery hydrogel of aldehyde hyaluronic acid(HA-CHO)and poly(amidoamine)PAMAM/siRNA complex to intervene the abnormal STING signal for IVD degeneration treatment,where the formation of dynamic Schiff base bonds in the system(siSTING@HPgel)was able to overcome the shortcomings such as low cellular uptake,short half-life,and rapid degradation of siRNA-based strategy.PAMAM not only formed complexes with siRNA to promote siRNA transfection,but also served as dynamic crosslinker to construct hydrogel,and the injectable and self-healing hydrogel efficiently and steadily silenced STING expression in NP cells.Finally,the siSTING@HPgel significantly eased IVD inflammation and slowed IVD degeneration by prolonging STING knockdown in puncture-induced IVD degeneration rat model,revealing that STING pathway was a therapeutic target for IVD degeneration and such novel hydrogel had great potential for being applied to many other diseases for gene delivery. | Jiaxin Chen Haifeng Zhu Yutao Zhu Chenchen Zhao Shengyu Wang Yixin Zheng Ziang Xie Yang Jin Honghai Song Linjun Yang Jin Zhang Jiayong Dai Zhijun Hu Huaiyu Wang | 2022 | Bioactive Materials2022，7，3： | 2 |
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