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| 1 | Surveillance of Mycoplasma pneumoniae infection among children in Beijing from 2007 to 2012显示文摘 | Zhao Hanqing Li Shaoli Cao Ling Yuan Yi Xue Guanhua Feng Yanling Yan Chao Wang Liqiong Fan Zhaoyang Sun Hongmei | 2014 | Chinese Medical Journal2014，，7： | 61 |
| 2 | Selection and development of representative simple sequence repeat primers and multiplex SSR sets for high throughput automated genotyping in maize显示文摘In the current study, 1900 maize simple sequence repeat (SSR) primers published in MaizeGDB were screened utilizing reference literature, 15 representative Chinese maize inbred lines and 15 Chinese maize hybrids from national regional testing. In total, 500 highly polymorphic primers were identified and used to construct a genetic map. 100 evenly distributed primers, 10 primers per chromosome, were further selected as a set of universal SSR core primers, recommended as preferred primers for general studies. These core primers were then redesigned and used to construct a high throughput multiplex PCR system based on a five-color fluorescence capillary detection system. We report here that two sets of ten-plex PCR combinations have been constructed, each consisting of 10 primers, with one primer per chromosome. | WANG FengGe ZHAO JiuRan DAI JingRui YI HongMei KUANG Meng SUN YanMei YU XinYan GUO JingLun WANG Lu | 2007 | Chinese Science Bulletin2007，52，2： | 35 |
| 3 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 6 | Preparation and characterization of microcapsule containing epoxy resin and its self-healing performance of anticorrosion covering material显示文摘Microencapsulated healing agents that possess adequate strength,long shelf-life,and excellent bonding to the host material are required for self-healing materials. The in situ encapsulation method is demonstrated over an order of magnitude size reduction for the preparation of urea-formaldehyde(UF) capsules filled with a healing agent,a mixture epoxy resin of the epoxy 711 and E-51. Capsules with diameters as small as about 100 μm are achieved under the agitation rate of 800 r min-1. The capsules possess a uniform UF shell wall(4 μm average thickness) . By using the analysis of scanning electronic microscope(SEM) ,thermal analysis(TG-DTA) and FTIR,the characteristics of the microcapsules were investigated respectively. Successful self-healing has been demonstrated for anticorrosion covering materials with microcapsules. | LIAO LePing ZHANG Wei XIN Yi WANG HongMei ZHAO Yang LI WuJun | 2011 | Chinese Science Bulletin2011，56，4： | 8 |
| 7 | Transdermal permeation of Zanthoxylum bungeanum essential oil on TCM components with different lipophilicity显示文摘Objective:To investigate the percutaneous penetration enhancement effect of essential oil from Zanthoxylum bungeanum Maxim.(Z.bungeanum oil)on active components in externally-applied traditional Chinese medicines.Methods:Five model drugs,geniposide,puerarin,ferulic acid,tetramethylpyrazine,and osthole,were chosen based on their lipophilicity and tested using in vitro transdermal permeation studies consisting of Franz diffusion cells and full thickness rat abdominal skin.Scanning electron microscopy was employed to observe the morphological changes of rat skin tissue after treatment with Z.bungeanum oil.The molecular interactions between the oil and the polar head groups in stratum corneum(SC)lipids were monitored using molecular dynamic simulation,and the SC/vehicle partition coefficients and saturation solubilities of the selected model drugs treated with and without the oil were also determined to ascertain its mechanisms of action.Results:As oil concentration increased,the log ERflow trended toward a negative linear relationship with the lipophilicity of drugs.After treatment with Z.bungeanum oil,a mild lifting up and wrinkle on the SC surface were observed,and appeared to become more pronounced as oil concentration increased.There was no significant difference between the control and the Z.bungeanum oil at different concentrations in terms of saturation solubility of GP,while saturation solubilities of the 4 other drugs gradually increased as oil concentration increased.The oxygen-containing constituents in Z.bungeanum oil,such as terpinen-4-ol and 1,8-cineole,which accounted for 57.95%of total oil,could form stable hydrogen bonds with the polar head group of ceramide 3.Conclusion:Z.bungeanum oil facilitated transdermal permeation of drugs with different lipophilicity,including the extremely hydrophilic and lipophilic drugs,whereas it exhibited greater enhancement activity for strongly hydrophilic drugs.The mechanisms of transdermal permeation enhancement by the oil could be explained with SC/vehicle partition coefficient,saturation solubility,and the interactions with SC lipids. | Yi Lan Jingyan Wang Shuwang He Shuying Li Peng Tan Hongmei Lin Qing Wu | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 6 |
| 8 | Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action显示文摘The present study was conducted to verify the influence of luteolin on apoptosis of Eca109 cells and to further investigate the possible mechanisms underlying its effect on apoptosis.The cells were exposed to different concentrations of luteolin(0,40,80,120,160,200,240M)for 24,48,and 72 h respectively.The influence of luteolin on proliferation of Eca109 cells was detected using MTT assay.Eca109 cells were then treated with luteolin(0,40,160,240M)for 24 h.The effect of luteolin on cell cycle progression and apoptosis was assayed by using flow cytometry(FCM).Expression of caspase9 and caspase3 mRNA and protein was analyzed by real-time PCR and Western blot respectively.The results showed that luteolin could inhibit the proliferation of Eca109 cells at all concentrations in a time-dependent manner and the relative inhibition rate showed an inverted U-shaped association with the concentration of luteolin.Further,the cell cycle was arrested in the S phase following treatment with luteolin.Apoptosis analysis indicated that luteolin could induce the apoptosis of Eca109 cells across the three concentration groups,which exhibited a trend of first promotional and then inhibitory with the increases in luteolin concentration.The effect of luteolin on the mRNA and protein expression of caspase 9 and caspase3 first manifested as promotion,then inhibition.Therefore,luteolin may serve a role in promoting cell apoptosis by inducing Eca109 cell apoptosis that involves the expression of caspase3,caspase9 mRNA and protein.This study provides theoretical basis for further study and clinical application of luteolin.The specific mechanism has not yet been clarified and the other activation pathways inducing apoptosis need to be further studied. | Shaokang Wang Lingmeng Fu Yi Wu Hongmei Xiao Jing Wang Guiju Sun | 2019 | Food Science and Human Wellness2019，8，2： | 6 |
| 9 | A flutter-effect-based triboelectric nanogenerator for breeze energy collection from arbitrary directions and self-powered wind speed sensor显示文摘Triboelectric nanogenerators(TENGs)have been developed rapidly into an efficient wind energy collection equipment.Reducing the frictionwear and energy loss in breeze energy collection is a research direction worthy of attention.Herein,a flutter-effect-based triboelectricnanogen erator(FE-TENG)is designed to collect the breeze energy at low wind speed from arbitrary directions.Distinguishing from previouswind-driven TENGs,the wind-driven part of this device is separated from the TENG units,which not only avoids the wear of friction layerscaused by direct wind contact but also reduces the energy loss,therefore,relatively stable electric outputs are obtained with Voc-281 V,Isc-13.4μA,Qsc-143 nC,and output power-4 mW at the wind speed of 4.5 m/s,respectively.In addition,a real-time wind speed monitoringsystem based on LabVIEW software with high sen sitivity and fast response to wind is achieved relying on the excellent linear relation shipbetween wind speed and electrical output signal.Furthermore,it has been successfully applied as power sources for portable electronics,about 170 commercial light-emitting devices(LEDs)are lighted and a digital watch is successfully driven at the wind speed of 2.9 m/s.This worknot only provides a new structure and idea for the future collection of clean and sustainable breeze energy from arbitrary directions but also hasgreat potential in the field of self-powered systems. | Jie Hu Xianjie Pu Hongmei Yang Qixuan Zeng Qian Tang Dazhi Zhang Chenguo Hu Yi Xi | 2019 | Nano Research2019，12，12： | 6 |
| 10 | Recent progresses in H2-PEMFC at DICP显示文摘Proton exchange membrane fuel cell(PEMFC) as a power supply device has attracted wide attention in China and abroad for its advantages of high energy density, energy conversion efficiency and zero pollution.With the vigorous support of China's national policy, research institutes and enterprises have carried out extensive and pragmatic work on the basic materials, key components, stacks, auxiliary systems of PEMFCs, as well as the hydrogen station construction in order to realize the wide application of hydrogen energy.PEMFC System and Engineering Research Center of DICP is one of the earliest players in the H2-PEMFCs field.Advances have been achieved in the fields of low-platinum contained catalysts,PEMs, high-efficiency MEAs, low-cost metal bipolar plates, low-temperature and impurity air environment adaptability, stacks and systems.This paper introduces recent progresses of H2-PEMFCs at DICP in key materials, components, stacks, systems and the applications.The engineering status of proton exchange membrane water electrolysis(PEMWE) and the alkaline anion exchange membrane fuel cells(AEMFCs)are also summarized. | Feng Xie Zhigang Shao Ming Hou Hongmei Yu Wei Song Shucheng Sun Li Zhou Baolian Yi | 2019 | Journal of Energy Chemistry2019，28，9： | 4 |
| 11 | How Are Secondary Vocational Schools in China Measuring up to Government Benchmarks?显示文摘Drawing on a survey of 106 secondary vocational schools and 7309 students in two provinces of China,this descriptive paper assesses whether vocational schooling is measuring up to government benchmarks for quality and whether poor students are able to access quality schools.We find that secondary vocational schoob have met government benchmarks for teacher qualification and training,student opportunities for practical training and adequate facilities.Furthermore,poor students access schoob of similar quality to non-poor students,even though 34 percent of poor students do not receive financial aid.We conclude that recent policies are successfully ensuring secondary vocational school quality and equity of access to school quality between poor and non-poor students.However,financial aid policies should be re-examined,such that poor students receive sufficient coverage.Moreover,given that input-based measures only proxy school quality,the government should consider holding schoob accountable for outcomes such as student learning. | Hongmei Yi Linxiu Zhang Chengfang Liu James Chu Prashant Loyalka May Maani Jianguo Wei | 2013 | China & World Economy2013，21，3： | 4 |
| 12 | Solution evaporation processed high quality perovskite films显示文摘Organic-inorganic hybrid perovskite solar cells(PSCs), due to their high power conversion efficiency(PCE) and low cost, have been considered as one of the most promising photovoltaic devices. Welldistributed large-grain perovskite crystals play an important role for light adsorption and charge transfer.While, high quality perovskite crystals closely relate to the preparation method. Generally, the preparation of perovskite films requires a nitrogen atmosphere and toxic anti-solvents, which hinder their practical applications. Here, we reported a novel and simple solution evaporation process followed with a methylammonium iodide(MAI) solution immersion to prepare high quality perovskite films. Porous lead iodide(PbI_2) films were firstly formed by evaporation of PbI_2 precursor solution. The obtained porous PbI_2 films were completely transformed into well-distributed large-grain perovskite films after a quick MAI solution immersion. As a result, the corresponding PCE was enhanced by 30% compared to that prepared with a regular sequential deposition. This solution evaporation method provides a convenient and practical way for preparing high-quality perovskite films. | Aqiang Liu Kang Liu Huimin Zhou Hongmei Li Xiaoqing Qiu Yang Yi Min Liu | 2018 | Science Bulletin2018，63，23： | 3 |
| 13 | Thermodynamic characterization of two novel spin-crossover complexes显示文摘Two novel FeII spin crossover complexes [Fe(L1)3](BF4)25H2O (1) and [Fe(L2)3](BF4)2·2H2O (2) with 4-NHR-1,2,4-triazole (R = isopropyl, L1; cyclohexyl, L2) were synthesized. 1 and 2 remain white at room temperature, whereas they turn purple at liquid temperature. Variable temperature optical detection and magnetic susceptibilities measurement show that the spin-crossover phenomenon for 1 was observed between 120 K and 170 K. The hysteresis loop is about 10 K. The Tc temperature of 2 is 190 K, but no thermal hysteresis loop was found. The molar thermodynamic functions and the microscopic parameters were obtained from the theoretical analysis in terms of the domain model, two level Ising model and regular solution model, respectively. | DING Bin, WANG Hongmei, YI Long, CHENG Peng, LI Licun, ZHAI Yuping, LIAO Daizheng, YAN Shiping & JIANG Zonghui Department of Chemistry, Nankai University, Tianjin 300071, China Correspondence should be addressed to Cheng Peng or Liao Daizheng (e-mail: pcheng@nankai.edu.cn) | 2003 | Chinese Science Bulletin2003，48，22： | 3 |
| 14 | The immunologic and hematopoietic profiles of mesenchymal stem cells derived from different sections of human umbilical cord显示文摘间充质的干细胞(MSC ) 广泛地在 allogeneic 干细胞移植被使用了。我们比较了 immunologic, MSC 的造血的特征源于整个人的脐的绳索(UC ) ,以及从 UC 的不同的节,包括羊膜的膜(AM ) ,沃顿的果冻(WJ ) ,和脐的容器(紫外) 。房间显型被流动 cytometry 检验。淋巴细胞转变测试和混合淋巴细胞反应被执行评估从 UC 导出的 MSC 的免疫调节的活动。cytokines 的 mRNA 表示被即时聚合酶链反应检测。造血的功能被文化 co MSC 学习, CD34 + 房间从绳索血孤立。我们的结果显示出包括 UC 与这四不同的节分开的那 MSC, WJ,紫外,并且 AM 有类似的生物特征。所有 MSC 有多系区别能力并且能区分进造骨细胞, adipocytes,和 chondrocytes。MSC 也以一种剂量依赖者方式禁止了 allogeneic T 房间的增长。cytokines 的相对 mRNA 表示被检验,并且结果显示出比 MSC 的有的更高的 interleukin-6 (IL6 ) , IL11,干细胞因素,和 FLT3 表示从 UC 的特定的节导出的那 UCMSC。当 co 有教养时, CD34 + 房间有高繁殖效率, MSC 源于 UC, UCMSC 在之中是最有效的喂层的不同的节。我们的学习证明 MSC 能与支持特征的类似的 immunomodulation 和造血作用从整个 UC 或 UC 的特定的节被孤立。 | Man Xu Bin Zhan Yuanlin Liu Jin Zhang Hongxia Sheng Rui Shi Li Liao Na Liu Jiangwei Hu Jun Wang Hongmei Ning Ting Liu Yi Zhang Hu Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 3 |
| 15 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 16 | Microstructure, mechanical properties and tribological behavior of tribofilm generated from natural serpentine mineral powders as lubricant additive显示文摘 | Helong Yu Yi Xu Peijing Shi Hongmei Wang Min Wei Keke Zhao Binshi Xu | 2013 | Wear (-)2013，，1： | 2 |
| 17 | Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study:principal components analysis vs.partial least squares显示文摘With recent advances in biotechnology, genome-wide association study(GWAS) has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression(LR) based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk of inflating type I error and reducing power. Dimension reduction-based techniques, such as principal component-based logistic regression(PC-LR), partial least squares-based logistic regression(PLS-LR), have recently gained much attention in the analysis of high dimensional genomic data. However, the perfor?mance of these methods is still not clear, especially in GWAS. We conducted simulations and real data application to compare the type I error and power of PC-LR, PLS-LR and LR applicable to GWAS within a defined single nucleotide polymorphism(SNP) set region. We found that PC-LR and PLS can reasonably control type I error under null hypothesis.On contrast, LR, which is corrected by Bonferroni method, was more conserved in all simulation settings. In particular, we found that PC-LR and PLS-LR had comparable power and they both outperformed LR, especially when the causal SNP was in high linkage disequilibrium with genotyped ones and with a small effective size in simulation. Based on SNP set analysis, we applied all three methods to analyze non-small cell lung cancer GWAS data. | Honggang Yi Hongmei Wo Yang Zhao Ruyang Zhang Junchen Dai Guangfu Jin Hongxia Ma Tangchun Wu Zhibin Hu Dongxin Lin Hongbing Shen Feng Chen | 2015 | The Journal of Biomedical Research2015，29，4： | 2 |
| 18 | The amplified fluorescence quenching of heteroatomic conjugated polymers based on the “molecular wire”effects显示文摘Tremendous interest has been evoked in the utility of the fluorescent conjugated polymers towards the creation of ultra-sensitive systems based on the molecular wire effects which can amplify the transduction events. Here, a series of new polymers pyridine substitute poly (phen- ylene ethynylene)s are synthesized by Sonogashira-Hagihara coupling reaction. The impact of structure modification on the physical properties and spectral characteristics of poly-mers has been investigated. The quenching studies are car-ried out and exhibit that recognition site (pyridyle group) highly influences the quenching efficiency. The results show that polymer PI with pyridyl group entrapped in the conju-gated backbone has the specific and sensitive response to Pd(Ⅱ). The fluorescence quenching of PⅠby Pd(Ⅱ) is about 65 times greater than that of model monomer. | HUANG Hongmei WANG Kemin XIAO Yi ZHAI Qiuge AN Delie HUANG Shasheng LI Du | 2003 | Chinese Science Bulletin2003，48，18： | 2 |
| 19 | Downregulation of Beclin1 and Impairment of Autophagy in a Small Population of Colorectal Cancer显示文摘 | Zhihong Chen Yanchun Li Chi Zhang Hongmei Yi Chang Wu Junpu Wang Yuwu Liu Jieqiong Tan Jifang Wen | 2013 | Digestive Diseases and Sciences2013，，10： | 2 |
| 20 | Ulinastatin reduces urinary sepsis?related inflammation by upregulatingIL?10 and downregulating TNF?α levels显示文摘 | Xian Chen Yi Wang Hongmei Luo Zhigang Luo Lisha Liu Wujun Xu Tao Zhang Ning Yang Xiangyang Long Neng Zhu Huang Xie Jun Liu | 2013 | Molecular Medicine Reports2013，，1： | 2 |
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