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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 3 | Simulated Sensitivity of Ozone Generation to Precursors in Beijing during a High O_(3) Episode显示文摘This study uses the WRF-Chem model combined with the empirical kinetic modeling method(EKMA curve)to study the compound pollution event in Beijing that happened in 13−23 May 2017.Sensitivity tests are conducted to analyze ozone sensitivity to its precursors,and to develop emission reduction measures.The results suggest that the model can accurately simulate the compound pollution process of photochemistry and haze.When VOCs and NOx were reduced by the same proportion,the effect of O_(3)reduction at peak time was more obvious,and the effect during daytime was more significant than at night.The degree of change in ozone was peak time>daytime average.When reducing or increasing the ratio of precursors by 25%at the same time,the effect of reducing 25%VOCs on the average ozone concentration reduction was most significant.The degree of change in ozone decreased with increasing altitude,the location of the ozone maximum change shifted westward,and its range narrowed.As the altitude increases,the VOCs-limited zone decreases,VOCs sensitivity decreases,NOx sensitivity increases.The controlled area changed from near-surface VOCs-limited to high-altitude NOx-limited.Upon examining the EKMA curve,we have found that suburban and urban are sensitive to VOCs.The sensitivity tests indicate that when VOCs in suburban are reduced about 60%,the O_(3)-1h concentration could reach the standard,and when VOCs of the urban decreased by about 50%,the O_(3)-1h concentration could reach the standard.Thus,these findings could provide references for the control of compound air pollution in Beijing. | Meng CUI Xingqin AN Li XING Guohui LI Guiqian TANG Jianjun HE Xin LONG Shuman ZHAO | 2021 | Advances in Atmospheric Sciences2021，38，7： | 7 |
| 4 | High detectivity photodetectors based on perovskite nanowires with suppressed surface defects显示文摘Solution-processable,single-crystalline perovskite nanowires are ideal candidates for developing low-cost photodetectors,but their detectivities are limited due to a high level of unintentional defects.Through the surfaceinitiated solution-growth method,we fabricated high-quality,single-crystalline,defects-suppressed MAPbI_(3) nanowires,which possess atomically smooth side surfaces with a surface roughness of 0.27 nm,corresponding to a carrier lifetime of 112.9 ns.By forming ohmic MAPbI_(3)∕Au contacts through the dry contact method,highperformance metal–semiconductor–metal photodetectors have been demonstrated with a record large linear dynamic range of 157 dB along with a record high detectivity of 1.2×10^(14) Jones at an illumination power density of 5.5 nW∕cm^(2).Such superior photodetector performance metrics are attributed to,first,the defects-suppressed property of the as-grown MAPbI_(3) nanowires,which leads to a quite low noise current in the dark,and second,the ohmic contact between MAPbI_(3) and Au interfaces,which gives rise to an improved responsivity compared with the Schottky contact counterpart.The realized high-performance MAPbI_(3) nanowire photodetector advances the development of low-cost photodetectors and has potential applications in weak-signal photodetection. | GUOHUI LI RUI GAO YUE HAN AIPING ZHAI YUCHENG LIU YUE TIAN BINING TIAN YUYING HAO SHENGZHONG LIU YUCHENG WU YANXIA CUI | 2020 | Photonics Research2020，8，12： | 4 |
| 5 | DNA repair gene XRCC1 polymorphisms and susceptibility to childhood acute lymphoblastic leukemia: a meta-analysis显示文摘Objective: To estimate the relationship between genetic polymorphisms of X-ray repair cross- complementing group 1 (XRCC1) and the susceptibility to childhood acute lymphoblastic leukemia (ALL). Methods: Relevant case-control studies were enrolled in the meta-analysis. We applied Rev Man 4.2 software to pool raw data and test studies' heterogeneity and to calculate the incorporated odds ratio (OR) and 95% confidence interval (95% CI). Results: Our data showed that the OR for the Gln allele of the Arg399Gln polymorphism, compared with the Arg allele, was 1.35 (95% CI, 1.16-1.57; P<0.0001) for childhood ALL patients. Similarly, the homozygous genotype Gln/Gln and heterozygous genotype Arg/Gln both significantly increased the risk of childhood ALL compared with the wild genotype Arg/Arg (OR =1.58; 95% CI, 1.13-2.21; P=0.008; OR =1.51; 95% CI, 1.21-1.87; P=0.0002). The dominant model of Arg399Gln was associated with childhood ALL risk (OR =1.54; 95% CI, 1.25-1.89; P<0.0001). The ethnic subgroup analysis demonstrated that the Gln allele in all five ethnic groups was prone to be a risk factor for childhood ALL just with different degrees of correlation while Arg194Trp SNP showed a protective or risk factor or irrelevant thing in different races. Conclusions: XRCC1 399 polymorphism may increase the risk of childhood ALL. Different ethnic groups with some gene polymorphism have different disease risks. | Juan Du Cong Lu Guohui Cui Yan Chen Jing He | 2013 | Chinese Journal of Cancer Research2013，25，4： | 4 |
| 6 | Passivation of degradation path enables high performance perovskite nanoplatelet lasers with high operational stability显示文摘MAPbI_(3)perovskite has attracted widespread interests for developing low-cost near infrared semiconductor gain media.However,it faces the instability issue under operation conditions,which remains a critical challenge.It is found that the instability of the MAPbI_(3)nanoplatelet laser comes from the thermal-induced degradation progressing from the surface defects towards neighboring regions.By using PbI_(2) passivation,the defect-initiated degradation is significantly suppressed and the nanoplatelet degrades in a layer-by-layer way,enabling the MAPbI_(3)laser to sustain for 4500 s(2.7×10^(7) pulses),which is nearly three times longer than that of the nanoplatelet laser without passivation.Meanwhile,the PbI_(2) passivated MAPbI_(3)nanoplatelet laser with the nanoplatelet cavity displays a maximum quality factor up to∼7800,the highest reported for all MAPbI_(3)nanoplatelet cavities.Furthermore,a high stability MAPbI_(3)nanoplatelet laser that can last for 8500 s(5.1×10^(7) pulses)is demonstrated based on a dual passivation strategy,by retarding the defect-initiated degradation and surface-initiated degradation simultaneously.This work provides in-depth insights for understanding the operating degradation of perovskite lasers,and the dual passivation strategy paves the way for developing high stability near infrared semiconductor laser media. | GUOHUI LI HUIHUI PI YANFU WEI BOLIN ZHOU YA GAO RONG WEN YUYING HAO HAN ZHANG BENG S.ONG YANXIA CUI | 2022 | Photonics Research2022，10，6： | 2 |
| 7 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 8 | PtSerpin from the swimming crab Portunus trituberculatus , a putative regulator of prophenoloxidase activation with antibacterial activity显示文摘 | Yuan Liu Guohui Shi Zhaoxia Cui Danli Luo Chengwen Song Xihong Li Min Hui Yingdong Li | 2014 | Fish and Shellfish Immunology2014，，： | 1 |
| 9 | Direct analysis of trans-resveratrol in red wine by high performance liquid chromatography with ehemiluminescent detection显示文摘 | Jian Zhou Hua Cui Guohui Wan | 2004 | Food Chemistry2004，88，： | 1 |
| 10 | A deep Q-learning network based active object detection model with a novel training algorithm for service robots显示文摘This paper focuses on the problem of active object detection(AOD).AOD is important for service robots to complete tasks in the family environment,and leads robots to approach the target ob ject by taking appropriate moving actions.Most of the current AOD methods are based on reinforcement learning with low training efficiency and testing accuracy.Therefore,an AOD model based on a deep Q-learning network(DQN)with a novel training algorithm is proposed in this paper.The DQN model is designed to fit the Q-values of various actions,and includes state space,feature extraction,and a multilayer perceptron.In contrast to existing research,a novel training algorithm based on memory is designed for the proposed DQN model to improve training efficiency and testing accuracy.In addition,a method of generating the end state is presented to judge when to stop the AOD task during the training process.Sufficient comparison experiments and ablation studies are performed based on an AOD dataset,proving that the presented method has better performance than the comparable methods and that the proposed training algorithm is more effective than the raw training algorithm. | Shaopeng LIU Guohui TIAN Yongcheng CUI Xuyang SHAO | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，11： | 1 |
| 11 | Bioassay-directed purification of an acidic phospholipase A 2 from Agkistrodon halys pallas venom显示文摘 | Yuwei Wang Guohui Cui Ming Zhao Jian Yang Chao Wang Roger W. Giese Shiqi Peng | 2008 | Toxicon2008，，7： | 1 |
| 12 | Determination of quinolones residues in prawn using high-performance liquid chromatography with Ce (Ⅳ)-Ru ( bpy ) 3 2 + -HNO3 chemiluminescence detection 显示文摘 | WAN Guohui CUI Hua PAN Yilan | 2006 | J Chromatogr B2006，，： | 1 |
| 13 | PtSerpin from the swimming crab Portunus trituberculatus , a putative regulator of prophenoloxidase activation with antibacterial activity显示文摘 | Yuan Liu Guohui Shi Zhaoxia Cui Danli Luo Chengwen Song Xihong Li Min Hui Yingdong Li | 2014 | Fish and Shellfish Immunology2014，，： | 1 |
| 14 | The effect of complexation of Cu(II)with P6A peptide and its analogs on their thrombolytic activities显示文摘 | Mei Yang Guohui Cui Ming Zhao | 2008 | International Journal of Pharmaceutics2008，362，： | 1 |
| 15 | Direct analysis of trans-resveratrol in red wine by high performance liquid chromatography with chemiluminescent detection显示文摘 | Jian Zhou Hua Cui Guohui Wan | 2004 | Food Chemistry2004，88，4： | 1 |
| 16 | Ultrasound enhanced gradient elution of super heavy oil from weathered soils using TX100/SBDS mixed salt micellar solutions显示文摘 | Guodong Ji Cui Zhou Guohui Zhou | 2010 | Ultrasonics - Sonochemistry2010，，2： | 1 |
| 17 | Response of spikelet water status to high temperature and its relationship with heat tolerance in rice显示文摘In rice, high-temperature stress(HT) during flowering results in decreased grain yield via a reduction in spikelet fertility;however, the effect of plant water status on spikelet fertility under HT remains unknown. To investigate the relationship between spikelet water status and spikelet fertility under HT, two experiments were performed under temperature-controlled conditions using four genotypes with varying tolerance to HT. Rice plants were exposed to HT for seven consecutive days during the flowering stage under three soil water treatments(soil water potential 0, -20, and -40 kPa), as well as under hydroponic conditions in a separate experiment. HT significantly decreased spikelet fertility, pollen fertility, and anther dehiscence under each of the three water treatments. HT significantly increased the spikelet transpiration rate, and this change was accompanied by a significant decrease in the internal temperature of the spikelets. HT decreased pollen grain diameter in heat-sensitive genotypes. HT had varying effects on the water potential of panicles and anthers but increased anther soluble-sugar concentration. Different aquaporin genes showed different expression profiles under HT, and the expression levels of PIPs for plasma membrane intrinsic proteins and TIPs for tonoplast intrinsic proteins increased in anthers but decreased in glumes.Correlation analyses showed that anther dehiscence and pollen(spikelet) fertility were tightly associated with anther water status, and the expression levels of almost all anther aquaporin genes were significantly correlated with anther dehiscence under HT. In summary, an increased spikelet transpiration rate and decreased internal spikelet temperature were associated with alleviation of the effects of HT in rice genotypes with varying degrees of heat tolerance, and the response of spikelet water status to HT, involving increased total expression of aquaporins and soluble sugar content, thereby improved pollen fertility,anther dehiscence, and spikelet fertility, especially in heat-resistant genotypes. The heat-resistant genotypes N22 and SY63 may adopt different approaches to reduce heat damage. | Wencheng Wang Kehui Cui Qiuqian Hu Chao Wu Guohui Li Jianliang Huang Shaobing Peng | 2021 | The Crop Journal2021，9，6： | 1 |
| 18 | SI of Interaction energy prediction of organic molecules using Deep Tensor Neural Network显示文摘The support informations of DTNN architecture and prediction results of six testing cases in K-fold are listed here. | Yuan Qi Hong Ren Hong Li Dinglin Zhang Hongqiang Cui Junben Weng Guohui Li Guiyan Wang Yan Li | 2021 | Chinese Journal of Chemical Physics2021，34，1： | 0 |
| 19 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 20 | A Task-Oriented Hybrid Cloud Architecture with Deep Cognition Mechanism for Intelligent Space显示文摘Intelligent Space(IS)is widely regarded as a promising paradigm for improving quality of life through using service task processing.As the field matures,various state-of-the-art IS architectures have been proposed.Most of the IS architectures designed for service robots face the problems of fixedfunction modules and low scalability when performing service tasks.To this end,we propose a hybrid cloud service robot architecture based on a Service-Oriented Architecture(SOA).Specifically,we first use the distributed deployment of functional modules to solve the problem of high computing resource occupancy.Then,the Socket communication interface layer is designed to improve the calling efficiency of the function module.Next,the private cloud service knowledge base and the dataset for the home environment are used to improve the robustness and success rate of the robot when performing tasks.Finally,we design and deploy an interactive system based on Browser/Server(B/S)architecture,which aims to display the status of the robot in real-time as well as to expand and call the robot service.This system is integrated into the private cloud framework,which provides a feasible solution for improving the quality of life.Besides,it also fully reveals how to actively discover and provide the robot service mechanism of service tasks in the right way.The results of extensive experiments show that our cloud system provides sufficient prior knowledge that can assist the robot in completing service tasks.It is an efficient way to transmit data and reduce the computational burden on the robot.By using our cloud detection module,the robot system can save approximately 25% of the averageCPUusage and reduce the average detection time by 0.1 s compared to the locally deployed system,demonstrating the reliability and practicality of our proposed architecture. | Yongcheng Cui Guohui Tian Xiaochun Cheng | 2023 | Computers, Materials & Continua2023，76，8： | 0 |
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