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| 1 | Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model显示文摘人的间充质的干细胞(hMSCs ) 装家到肿瘤地点并且禁止肿瘤细胞的生长。很少对内在的分子的机制被知道连接 hMSCs 到肿瘤房间的指向的抑制。在这研究,我们从 hMSCs 用一个动物移植模型,一个合作文化系统和调节媒介在二根人的 hepatoma 房间线(H7402 和 HepG2 ) 上调查了 hMSCs 的效果。当 SCID 老鼠与 H7402 细胞和 Z3 hMSCs 的一个相等的数字被注射时,动物移植研究证明肿瘤形成的潜伏的时间被延长并且肿瘤尺寸更小。当 co 有教养时与 Z3 房间, H7402 细胞增殖减少了,增加的 apoptosis,和 Bcl-2 的表示, c-Myc,原子抗原(PCNA ) 和 survivin 低是的增殖的房间调整了。在有调节媒介的处理源于 Z3 hMSC 文化以后, H4702 房间出现了减少的形成殖民地的能力和减少的增长。Immunoblot 分析证明 beta-catenin, Bcl-2, c-Myc, PCNA 和 survivin 表示是在 H7402 和 HepG2 房间调整的 down。总起来说,我们的调查结果证明 hMSCs 禁止 H7402 和 HepG2 人的肝癌症房间线的恶意的显型,它包括增长,形成殖民地的能力和 oncogene 表示试管内和体内。而且,我们的研究提供表明小径的 Wnt 可以在调停 hMSC 的指向和肿瘤房间抑制有一个角色的证据。 | Ling Qiao Zhili Xu Tiejun Zhao Zhigang Zhao Mingxia Shi Robert C Zhao Lihong Ye Xiaodong Zhang | 2008 | Cell Research2008，18，4： | 68 |
| 2 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 3 | NK cell-based immunotherapy for malignant diseases显示文摘生来的杀手(NK ) 房间对癌症在主人免疫起关键作用。在反应,癌症开发机制逃离 NK 房间攻击或导致有缺点的 NK 房间。当前的 NK 基于房间的癌症免疫疗法试图用几条途径克服 NK 房间麻痹。一条途径使用扩展 allogeneic NK 房间,它没被象自体同源的 NK 房间一样的自我 histocompatibility 抗原禁止,为采纳细胞的免疫疗法。另一条采纳转移途径使用稳定的 allogeneic NK 房间线,它为质量控制和大规模生产是更实际的。第三条途径是新鲜 NK 房间或 NK 房间线的基因修正高度表示 cytokines, Fc 受体或妄想的肿瘤抗原受体。治疗学的 NK 细胞能从各种各样的来源被导出,包括细胞,干细胞或甚至导致的 pluripotent 干细胞( iPSCs ),和许多激发器能被用于的外设或绳索血在实验室或好生产实践( GMP )的大规模生产设备包括可溶的生长因素,使不能调动的分子或抗体,和另外的细胞的使活跃之物。到在临床的试用的癌症的对待几类型的 NK 房间治疗的一张表这里被考察。基于 NK 的免疫疗法的几条不同途径例如织物特定的 NK 房间,漂亮面向受体的 NK 房间和化学上对待的 NK 房间,被讨论。一些新技术或策略到由非侵略的成像的监视器 NK 房间治疗,预定 NK 房间治疗由的效率在 vivo 实验并且在临床的试用评估 NK 房间治疗途径也被介绍。 | Min Cheng Yongyan Chen Weihua Xiao Rui Sun Zhigang Tian | 2013 | Cellular & Molecular Immunology2013，10，3： | 61 |
| 4 | NK cell receptor imbalance and NK cell dysfunction in HBV nfection and hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 当前由于手术后的复发和转移是癌症死亡和普通差预后的恶意的第三个领先的原因。在长期的肝炎 B 之间有重要关联病毒(HBV ) 感染和 hepatocarcinogenesis。作为对病毒的感染和肿瘤的宿主防卫的第一根线,生来的杀手( NK )细胞表示很多有免疫力的识别受体( NK 受体( NKR ))在 hepatocytes ,肝正弦曲线 endothelial 细胞,星形的细胞和 Kupffer 细胞上认出 ligands ,它维持在有免疫力的反应和 NK 细胞的有免疫力的忍耐之间的平衡。不幸地,百分比和肝 NK 房间的绝对数字在 HCC 的发展和前进期间显著地减少。NK 房间受体和肝 NK 房间的机能障碍的反常表示贡献长期的 HBV 感染和 HCC 的前进并且显著地为肝癌症与差的预后被联系。在这评论,我们在 HCC 在反肿瘤免疫者回答集中于 NK 房间受体的角色,特别地 HBV 相关的 HCC。我们明确地讨论肿瘤房间怎么从 NK 房间躲避攻击并且 NKR 的新兴的理解怎么可以为 HCC 帮助新奇治疗的发展。小说单音 -- 并且指向 NK 房间 receptor-ligand 系统的治疗学的策略可以潜在地导致的联合在 HCC 的成功、有效的免疫疗法。 | Cheng Sun Haoyu Sun Cai Zhang Zhigang Tian | 2015 | Cellular & Molecular Immunology2015，12，3： | 55 |
| 5 | Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health. | Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei | 2020 | National Science Review2020，7，6： | 54 |
| 6 | Functional exhaustion of antiviral lymphocytes in COVID-19 patients显示文摘In December 2019,a novel coronavirus was first reported in Wuhan,China.1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and is responsible for coronavirus disease 2019(COVID-19).Up to 28 February 2020,79,394 cases have been confirmed according to China’s National Health Commission.Outside China,the virus has spread rapidly to over 36 countries and territories. | Yuanhong Xuand Zhigang Tian Meijuan Zheng Yong Gao Gang Wang Guobin Song Siyu Liu Dandan Sun Yuanhong Xu Zhigang Tian | 2020 | Cellular & Molecular Immunology2020，17，5： | 54 |
| 7 | Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction显示文摘证据建议 exosomes 能转移在房间之间的基因材料。然而,他们在肝炎 B 的角色病毒(HBV ) 感染遗体不清楚。这里,我们报导在长期的肝炎 B (CHB ) 病人的 sera 在场的 exosomes 包含了两 HBV nucleic 酸和 HBV 蛋白质,并且以一种活跃方式把 HBV 转移了到 hepatocytes。尤其是, HBV nucleic 酸在生来的杀手(NK ) 被检测从在到 HBV 积极的 exosomes 的暴露以后的 CHB 病人和健康施主的房间。通过即时荧光显微镜学和流动 cytometry, 1,1-dioctadecyl-3,3,3,3, -tetramethylindodicarbocyanine, 4-chlorobenzenesulfnate 盐() 标记的 exosomes 被观察与 NK 房间交往并且被 NK 房间收起,它被转变生长因素提高 -- 治疗。而且, HBV 积极的 exosomes 损害了 NK 房间功能,包括干扰素(IFN )- 生产, cytolytic 活动, NK 房间增长和幸存,以及房间到的应答 poly (我: C ) 刺激。HBV 感染压制了模式识别受体的表示,特别 retinoic 酸可诱导的基因我(RIG-I ) 在 NK 房间上,导致原子因素 B (NF-B ) 和 p38 阻抑激活 mitogen 的蛋白质 kinase 小径。我们的结果在 CHB 感染期间在 HBV 传播和 NK 房间机能障碍加亮 exosomes 的一个以前未得到欣赏的角色。 | Yinli Yang Qiuju Han Zhaohua Hou Cai Zhang Zhigang Tian Jian Zhang | 2017 | Cellular & Molecular Immunology2017，14，5： | 47 |
| 8 | Renewable Energy Transmission by HVDC Across the Continent:System Challenges and Opportunities显示文摘Rapid development of renewable energy in China is driving a major shift in the characteristics and control requirements of the electricity grid.Since the best renewable energy resources are far away from load centers in the east and southeast,transmission over long distances is required.Over 20 high-voltage DC(HVDC)transmission lines,with a combined capacity exceeding 150 GW,are in operation or are currently under construction.This rapid expansion of new generation and transmission capacities based on power electronics starts to change the characteristics of the grid,especially in areas where they concentrate,creating new stability problems and operational challenges.New system theories and technologies are required to support the development and operation of a future grid that relies more and more on power electronics.This paper highlights the characteristics of power electronics as used in renewable energy generation and HVDC transmission systems,discusses the impacts of these power-electronics-based assets on grid stability and operational requirements,and identifies opportunities for the development of both new system theories and system technologies to support a national energy policy that emphasizes the use of clean energy. | Jian Sun Mingjie Li Zhigang Zhang Tao Xu Jingbo He Haijiao Wang Guanghui Li | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 43 |
| 9 | THEORY OF DIELECTRIC ELASTOMERS显示文摘In response to a stimulus,a soft material deforms,and the deformation provides a function.We call such a material a soft active material (SAM).This review focuses on one class of soft active materials: dielectric elastomers.When a membrane of a dielectric elastomer is subject to a voltage through its thickness,the membrane reduces thickness and expands area,possibly straining over 100%.The dielectric elastomers are being developed as transducers for broad applications,including soft robots,adaptive optics,Braille displays,and electric generators.This paper reviews the theory of dielectric elastomers,developed within continuum mechanics and thermodynamics,and motivated by molecular pictures and empirical observations.The the-ory couples large deformation and electric potential,and describes nonlinear and nonequilibrium behavior,such as electromechanical instability and viscoelasticity.The theory enables the finite element method to simulate transducers of realistic configurations,predicts the efficiency of elec-tromechanical energy conversion,and suggests alternative routes to achieve giant voltage-induced deformation.It is hoped that the theory will aid in the creation of materials and devices. | Zhigang Suo (School of Engineering and Applied Sciences,Kavli Institute for Nanobio Science and Technology,Harvard University,Cambridge,MA 02138,USA) | 2010 | Acta Mechanica Solida Sinica2010，23，6： | 37 |
| 10 | Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway显示文摘Puerarin,a major isoflavonoid derived from the Chinese medical herb radix puerariae(Gegen),has been reported to inhibit neuronal apoptosis and play an anti-inflammatory role in focal cerebra ischemia model rats.Recent findings regarding stroke pathophysiology have recognized that anti-inflammation is an important target for the treatment of ischemic stroke.The cholinergic anti-inflammatory pathway is a highly robust neural-immune mechanism for inflammation control This study was to investigate whether activating the cholinergic anti-inflammatory pathway can be involved in the mechanism of inhibiting the inflammatory response during puerarin-induced cerebra ischemia/reperfusion in rats.Results showed that puerarin pretreatment(intravenous injection)reduced the ischemic infarct volume,improved neurological deficit after cerebra ischemia/reperfusion and decreased the levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin brain tissue.Pretreatment with puerarin(intravenous injection)attenuated the inflammatory response in rats,which was accompanied by janus-activated kinase 2(JAK2)and signal transducers and activators of transcription 3(STAT3)activation and nuclear factor kappa B(NF-κB)inhibition.These observations were inhibited by the alpha7 nicotinic acetylcholine recepto(α7nAchR)antagonistα-bungarotoxin(α-BGT).In addition,puerarin pretreatment increased the expression ofα7nAchR mRNA in ischemic cerebral tissue.These data demonstrate that puerarin pretreatment strongly protects the brain against cerebral ischemia/reperfusion injury and inhibits the inflammatory response.Our results also indicated that the anti-inflammatory effect of puerarin may partly be mediated through the activation of the cholinergic anti-inflammatory pathway. | Xiaojie Liu Zhigang Mei Jingping Qian Yongbao Zeng Mingzhi Wang | 2013 | Neural Regeneration Research2013，8，34： | 39 |
| 11 | FH 17 cells in human recurrent pregnancy loss and ~re-eclampsia显示文摘 | Binqing Fu | 2014 | Cellular & Molecular Immunology2014，11，6： | 36 |
| 12 | Preliminary results pertaining to coseismic displacement and preseismic strain accumulation of the Lushan M_S7.0 earthquake,as reflected by GPS surveying显示文摘This paper presents the coseismic displacement and preseismic deformation fields of the Lushan MS7.0 earthquake that occurred on April 20,2013.The results are based on GPS observations along the Longmenshan fault and within its vicinity.The coseismic displacement and preseismic GPS results indicate that in the strain release of this earthquake,the thrust rupture is dominant and the laevorotation movement is secondary.Furthermore,we infer that any possible the rupture does not reach the earth’s surface,and the seismogenic fault is most likely one fault to the east of the Guanxian-Anxian fault.Some detailed results are obtainable.(1)The southern segment of the Longmenshan fault is locked preceding the Lushan earthquake.After the Wenchuan earthquake,the strain accumulation rate in the southeast direction accelerates in the epicenter of the Lushan earthquake,and the angle between the principal compressional strain and the seismogenic fault indicates that a sinistral deformation background in the direction of the seismogenic fault precedes the Lushan earthquake.Therefore,it is evident that the Wenchuan MS8.0 earthquake accelerated the pregnancy of the Lushan earthquake.(2)The coseismic displacements reflected by GPS data are mainly located in a region that is 230 km(NW direction)×100 km(SW direction),and coseismic displacements larger than 10 mm lie predominantly in a100-km region(NW direction).(3)On a large scale,the coseismic displacement shows thrust characteristics,but the associated values are remarkably small in the near field(within 70 km)of the earthquake fault.Meanwhile,the thrust movement in this70-km region does not correspond with the attenuation characteristics of the strain release,indicating that the rupture of this earthquake does not reach the earth’s surface.(4)The laevorotation movements are remarkable in the 50-km region,which is located in the hanging wall that is close to the earthquake fault,and the corresponding values in this case correlate with the attenuation characteristics of the strain release. | WU YanQiang JIANG ZaiSen WANG Min CHE Shi LIAO Hua LI Qiang LI Peng YANG YongLin XIANG HePing SHAO ZhiGang WANG WuXing WEI WenXin LIU XiaoXia | 2013 | Chinese Science Bulletin2013，58，28： | 33 |
| 13 | Liver natural killer cells: subsets and roles in liver immunity显示文摘肝代表常常由于它的唯一的地点和血供应暴露于许多导出勇气的抗原的一个前线免疫者机关。与在天生的豁免的一个占优势的角色,肝与各种各样的天生的有免疫力的房间,在天赋之中,杀手(NK ) 房间在主人辩护并且在维持有免疫力的平衡起重要作用被充实。肝的 NK 房间首先被描述为 ‘坑 cells’在在 1970 年代的老鼠肝。在老鼠和人的肝的 NK 房间的最近的研究显示出那二个不同 NK 房间子集,肝居民 NK 房间和常规 NK (cNK ) 房间,在这个机关是在场的。这里,我们在不同种类考察肝 NK 细胞子集,重游老鼠与在老鼠和人的肝的居民 NK 细胞有关的肝的坑细胞和加亮的最近的进步,并且也在肝免疫讨论 NK 细胞的双角色。 | Hui Peng Eddie Wisse Zhigang Tian | 2016 | Cellular & Molecular Immunology2016，13，3： | 34 |
| 14 | Ambient volatile organic compounds pollution in China显示文摘Owing to rapid economic and industrial development,China has been suffering from degraded air quality and visibility. Volatile organic compounds(VOCs)are important precursors to the formation of ground-level ozone and hence photochemical smog. Some VOCs adversely affect human health. Therefore,VOCs have recently elicited public concern and given new impetus to scientific interest. China is now implementing a series of polices to control VOCs pollution. The key to formulating policy is understanding the ambient VOCs pollution status. This paper mainly analyzes the species,levels,sources,and spatial distributions of VOCs in ambient air. The results show that the concentrations of ambient VOCs in China are much higher than those of developed countries such as the United States and Japan,especial benzene,which exceeds available standards. At the same time,the ozone formation potential(OFP)and secondary organic aerosol formation potential(SOAFP)of various VOCs are calculated. Aromatics and alkenes have much higher OFPs,while aromatics have higher SOAFP. The OFPs of ambient VOCs in the cities of Beijing,Guangzhou and Changchun are very high,and the SOAFP of ambient VOCs in the cities of Hangzhou,Guangzhou and Changchun are higher. | Xinmin Zhang Zhigang Xue Hong Li Li Yan Yuan Yang Yi Wang Jingchun Duan Lei Li Fahe Chai Miaomiao Cheng Weiqi Zhang | 2017 | Journal of Environmental Sciences2017，29，5： | 34 |
| 15 | Development of a Haploid-Inducer Mediated Genome Editing System for Accelerating Maize Breeding显示文摘Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of them still fall short for rapid generation of pure elite lines with integrated favorable traits. Here, we report the development of a Haploid-Inducer Mediated Genome Editing (IMGE) approach, which utilizes a maize haploid inducer line carrying a CRISPR/Cas9 cassette targeting for a desired agronomic trait to pollinate an elite maize in bred line and to generate genome-edited haploids in the elite maize background. Homozygous pure DH lines with the desired trait improvement could be generated within two generations, thus bypassing the lengthy procedure of repeated crossing and backcrossing used in conventional breeding for integrating a desirable trait into elite commercial backgrounds. | Baobao Wang Lei Zhu Binbin Zhao Yongping Zhao Yurong Xie Zhigang Zheng Yaoyao Li Juan Sun Haiyang Wang | 2019 | Molecular Plant2019，12，4： | 32 |
| 16 | Plankton community composition in the Three Gorges Reservoir Region revealed by PCR-DGGE and its relationships with environmental factors显示文摘To explore the relationships between community composition and the environment in a reservoir ecosystem, plankton communities from the Three Gorges Reservoir Region were studied by PCR-denaturing gradient gel electrophoresis fingerprinting. Bacterial and eukaryotic operational taxonomic units (OTUs), generated by DGGE analysis of the PCR-amplified 16S and 18S rRNA genes, were used as surrogates for the dominant 'biodiversity units'. OTU composition among the sites was heterogeneous; 46.7% of the total bacterial OTUs (45) and 64.1% of the eukaryotic OTUs (39) were identified in less than half of the sampling sites. Unweighted pair group method with arithmetic averages (UPGMA) clustering of the OTUs suggested that the plankton communities in the Xiangxi Rive sites were not always significantly different from those from the Yangtze River sites, despite clear differences in their environmental characterizations. Canonical correspondence analysis (CCA) was applied to further investigate the relationships between OTU composition and the environmental factors. The first two CCA ordination axes suggested that the bacterial community composition was primarily correlated with the variables of NO3--N, dissolved oxygen (DO), and SiO32--Si, whereas, the eukaryotic community was mainly correlated with the concentrations of DO, PO43--P, and SiO32--Si. | YAN Qingyun YU Yuhe FENG Weisong YU Zhigang CHEN Hongtao | 2008 | Journal of Environmental Sciences2008，20，6： | 27 |
| 17 | Investigation of Surface Integrity on TC17 Titanium Alloy Treated by Square-spot Laser Shock Peening显示文摘Laser shock peening(LSP) is an innovative surface treatment method,which has been shown to greatly improve the fatigue life of many metallic components.This work investigates surface integrity of TC17 titanium alloy treated by LSP with innovative square laser spot.Nd:glass laser with duration of 30 ns and spot size of 4 mm×4 mm is applied.The surface morphology and surface residual stress of the TC17 titanium alloy,treated with varying peening parameters such as laser power density and overlapping ratio,have been studied in detail.The results show that laser pulse energy greatly influences surface morphology and surface residual stress around single-spot treated areas,and compressive residual stresses are saturated as laser pulse energy is over 55 J.There are significantly different surface morphologies and residual stress distributions at the overlapped areas with different overlapping ratios.A relative smooth surface is produced with uniform compressive residual stress distribution at an overlapping ratio of 8 %.The experiment of residual stress relaxation is implemented by measuring residual stress at the center of four overlapped spots and by four point bending fatigue test at the frequency of 105 Hz.The compressive residual stresses induced by LSP are found to relax quite slowly under cyclic fatigue loading. | CAO Ziwen XU Haiying ZOU Shikun CHE Zhigang | 2012 | Chinese Journal of Aeronautics2012，25，4： | 27 |
| 18 | Exosomes: new molecular targets of diseases显示文摘细胞外的泡(EV ) 包括 apoptotic 身体, microvesicles 和 exosomes,并且他们象 diseased 状态一样在正常在 cell-to-cell 通讯作为关键管理者表演。EV 包含自然货物分子,例如 miRNA, mRNA 和蛋白质,并且通过循环把这些功能的货物转移到附近的房间或更多的远房间。这些机能上地活跃的分子然后影响不同发信号的串联。传送到接受者房间的消息依赖于 EV 的作文,它由父母房间和 EV 生物的续生说是坚定的。因为他们象在循环, biocompatibility,低 immunogenicity 和毒性的增加的稳定性那样的性质, EV 为治疗学作为吸引人的交货系统引起了注意。这评论在为治疗学的目的使用 exosomes 在治疗和潜在的优点和挑战集中于 exosomes 的功能的使用。 | Saheli SAMANTA Sheeja RAJASINGH Nicholas DROSOS Zhigang ZHOU Buddhadeb DAWN Johnson RAJASINGH | 2018 | Acta Pharmacologica Sinica2018，39，4： | 27 |
| 19 | Deformation mechanism and excavation process of large span intersection within deep soft rock roadway显示文摘The FLAC3D software was used to simulate and analyze numerically the displacement, stress and plastic zone distribu-tion characteristics of a large span intersection in a deep soft rock roadway after the surrounding rock was excavated. Our simula-tion results show that there are two kinds of dominating factors affecting roadway stability at points of intersection, one is the angle between horizontal stress and axial direction of the roadway and the other are the angles at the points of intersection. These results are based on a study we carried out as follows: first, we analyzed the failure mechanism of a large span intersection and then we built a mechanical model of a rock pillar at one of the points of intersection. At the end of this analysis, we obtained the failure characteristics of the critical parts on the large span intersection. Given these failure characteristics, we proposed a new supporting method, i.e., a Double-Bolt Control Technology (DBCT). By way of numerical simulation, DBCT can effectively control the deformation of the surrounding rock at the points of intersection in roadways. | LI Guofeng, HE Manchao, ZHANG Guofeng, TAO Zhigang Institute of Geotechnical Engineering, China University of Mining & Technology, Beijing 100083, China | 2010 | Mining Science and Technology2010，20，1： | 24 |
| 20 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
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