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| 1 | Study on the Application of UHVDC Hierarchical Connection Mode to Multi-infeed HVDC System显示文摘随着我国特高压交直流技术的广泛应用,多馈入直流集中落入受端负荷中心将是未来我国电网发展所面临的重要问题。为从电网结构上有效解决多馈入直流系统的问题,提出一种特高压直流分层接入交流电网的方式。研究分层接入方式直流多馈入短路比计算方法的适用性,从理论上对比特高压直流不同接入方式下多馈入直流电网的系统特性,证明特高压直流分层接入方式有助于提高多馈入直流系统的电压支撑能力,引导潮流在1000kV与500kV层级间合理分布。结合国家电网规划,仿真验证了特高压直流分层接入方式的优势。 | LIU Zhenya QIN Xiaohui ZHAO Liang ZHAO Qingbo | 2013 | 中国电机工程学报2013，33，10： | 80 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 4 | Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results. | OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei | 2008 | 空间科学学报2008，28，5： | 24 |
| 5 | The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia显示文摘The programmed cell death-1(PD-1)/PD-ligand 1(PD-L1)pathway is critical for normal pregnancy by promoting regulatory T(Treg)cell development and inhibiting the Th17 response.However,the relationship between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance in pre-eclampsia(PE)is an enigma.In this study,decreased PD-1 and PD-L1 expression and a Treg/Th17 imbalance were observed at the maternal-fetal interface in PE.The regulatory effects of the PD-1/PD-L1 pathway on the Treg and Th17 cell quantities were determined in vitro by targeting T-cell proliferation,differentiation and transdifferentiation.First,decreased PD-1 expression might contribute to a higher Th17 cell frequency by promoting proliferation in PE.Second,the percentages of Treg but not Th17 cells differentiated from peripheral naive CD4+T cells were increased by PD-L1 Fc administration.This effect was accompanied by decreased PI3K/AKT/m-TOR and increased PTEN mRNA expression and was completely reversed by PD-1 blockade.Finally,the percentage of IL-17-producing Treg cells increased and was positively associated with the Th17 cell frequency in PE.Increased RORγt and IL-17 but not Foxp3 and IL-10 mRNA expression by Treg cells was observed with PD-1 blockade.Similar findings occurred when Treg cells were exposed to IL-6/IL-23/IL-1βand were reversed by PD-L1 Fc.Taken together,our findings indicate that the PD-1/PD-L1 pathway contributes to the Treg/Th17 imbalance via‘one-two punch’approaches:(i)promoting Th17 cell proliferation,(ii)inhibiting Treg cell differentiation and(iii)enhancing Treg cell plasticity into Th17 cells in PE.The therapeutic value of PD-L1 Fc for PE treatment will be explored in the future. | Yonghong Zhang Zhaozhao Liu Mei Tian Xiaohui Hu Liling Wang Jinlu Ji Aihua Liao | 2018 | Cellular & Molecular Immunology2018，15，7： | 21 |
| 6 | Review of the characteristics and graded utilisation of coal gasification slag显示文摘The characteristics of the energy structure of rich coal,less oil and less gas,coupling with a high external dependence on oil and natural gas and the emphasis on the efficient and clean utilisation of coal,have brought opportunities for coal chemical industry.However,with the large-scale popularisation of coal gasification technology,the production and resulting storage of coal gasification slag continue to increase,which not only result in serious environmental pollution and a waste of terrestrial resources,but also seriously affect the sustainable development of coal chemical enterprises.Hence,the treatment of coal gasification slag is extremely important.In this paper,the production,composition,morphology,particle size structure and water holding characteristics of coal gasification slag are introduced,and the methods of carbon ash separation of gasification slag,both domestically and abroad,are summarised.In addition,the paper also summarises the research progress on gasification slag in building materials,ecological restoration,residual carbon utilisation and other high-value utilisation,and ultimately puts forward the idea of the comprehensive utilisation of gasification slag.For large-scale consumption to solve the environmental problems of enterprises and achieve high-value utilisation to increase the economic benefits of enterprises,it is urgent to zealously design a reasonable and comprehensive utilisation technologies with simple operational processes,strong adaptability and economic benefits. | Xiaodong Liu Zhengwei Jin Yunhuan Jing Panpan Fan Zhili Qi Weiren Bao Jiancheng Wang Xiaohui Yan Peng Lv Lianping Dong | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 21 |
| 7 | Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China显示文摘Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary site.Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site.Results: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis. | Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping Liu Shulian Wang Jing Jin Lin Gui Yan Sun | 2019 | Chinese Journal of Cancer Research2019，31，1： | 19 |
| 8 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 9 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 10 | An Adaptive Tag Anti-Collision Protocol in RFID Wireless Systems显示文摘A novel anti-collision algorithm in RFID wireless network is proposed.As it is put forward on the basis of collision tree(CT)and improved collision tree(lCT) anti-collision protocols,we call it adaptive collision tree protocol(ACT).The main novelty of this paper is that the AD strategy is introduced and used in ACT to decrease collisions and improve the tag system throughput.AD strategy means that query strings will divide into two or four branches adaptively according to the label quantity.This scheme can decrease both depth of query and collision timeslots,and avoid producing too much idle timeslots at the same time.Both theoretical analysis and simulation results indicate that the novel proposed anticollision protocol ACT outperforms the previous CT and ICT protocols in term of time complexity,system throughput,and communication complexity. | LIU Xiaohui QIAN Zhihong ZHAO Yanhang GUO Yuqi | 2014 | China Communications2014，11，7： | 16 |
| 11 | Giant photonic spin Hall effect in momentum space in a structured metamaterial with spatially varying birefringence显示文摘The photonic spin Hall effect(SHE)in the reflection and refraction at an interface is very weak because of the weak spin-orbit interaction.Here,we report the observation of a giant photonic SHE in a dielectric-based metamaterial.The metamaterial is structured to create a coordinate-dependent,geometric Pancharatnam–Berry phase that results in an SHE with a spin-dependent splitting in momentum space.It is unlike the SHE that occurs in real space in the reflection and refraction at an interface,which results from the momentum-dependent gradient of the geometric Rytov–Vladimirskii–Berry phase.We theorize a unified description of the photonic SHE based on the two types of geometric phase gradient,and we experimentally measure the giant spin-dependent shift of the beam centroid produced by the metamaterial at a visible wavelength.Our results suggest that the structured metamaterial offers a potential method of manipulating spin-polarized photons and the orbital angular momentum of light and thus enables applications in spin-controlled nanophotonics. | Xiaohui Ling Xinxing Zhou Xunong Yi Weixing Shu Yachao Liu Shizhen Chen Hailu Luo Shuangchun Wen Dianyuan Fan | 2015 | Light(Science & Applications)2015，4，1： | 15 |
| 12 | Fluidization of non-spherical particles:Sphericity,Zingg factor and other fluidization parameters显示文摘A comparison of sphericity and Zingg factor for particle morphology and description of fluidized-bed dynamics are presented.It is found that Zingg factor Fz = LH/B2(where L,H and B are,respectively,the length,breadth and height of a particle) well describes the effect of particle morphology.Experimental results show that non-spherical particles give poor fluidizing quality as compared to spherical particles in terms of pressure drop,Umf,etc.With the same volume-equivalent diameter,non-spherical particles have lower Umf and fluidizing coefficient δ.Some smooth curves have been obtained between the parameters δ,Umf and Fz.The quality of fluidization could be evaluated by fluidizing coefficient,which has been correlated to the Zingg factor and minimum fluidizing velocity in this paper. | Baiqian Liu Xiaohui Zhang Ligang Wang Hui Hong | 2008 | Particuology2008，6，2： | 14 |
| 13 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 14 | IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome显示文摘Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome(pSS),but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear.Here,we first found negative correlations between IL-10^(+)regulatory B(Breg)cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome(ESS).Moreover,we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice.In culture,IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation.By using an adoptive transfer approach and two-photon live imaging,we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining cervical lymph nodes of RAG-2−/−mice transferred with IL-10-deficient B cells during ESS development compared with those of RAG-2−/−mice transferred with wild-type B cells.In ESS mice,CD19^(+)CD1d^(hi)CD5^(+)Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation.Consistently,CD19^(+)CD24^(+)CD38^(hi) Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the suppression of autologous Tfh cell expansion.Furthermore,the adoptive transfer of IL-10-producing Breg cells markedly suppressed the Tfh cell response and ameliorated ESS progression in ESS mice.Together,these findings demonstrate a critical role for IL-10-producing Breg cells in restraining the effector Tfh cell response during pSS development. | Xiang Lin Xiaohui Wang Fan Xiao Kongyang Ma Lixiong Liu Xiaoqi Wang Dong Xu Fei Wang Xiaofei Shi Dongzhou Liu Yan Zhao Liwei Lu | 2019 | Cellular & Molecular Immunology2019，16，12： | 13 |
| 15 | Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells显示文摘它被报导了那氧化低密度的脂蛋白(Ox-LDL ) 能增加 adipophilin 的表示。然而,详细机制充分没被理解。这研究的目的是在 adipophilin 表示和细胞内部的类脂化合物微滴累积上调查 Ox-LDL 的机制。一个鼠标像巨噬细胞的房间线, RAW264.7,全部被使用,并且 Ox-LDL 以一种剂量依赖者方式导致了 adipophilin 表示,这被发现。而且, Ox-LDL 导致了 peroxisome 激活 proliferator 的受体 --(PPAR ) 表示和 PPAR 特定的禁止者 T0070907 没废除 Ox-LDL-induced adipophilin 表示,而是特定的收缩筋 GW1929。而且, Ox-LDL 导致了 ERK1/2 的 phosphorylation,并且由 PD98059 的 ERK1/2-specific 抑制压制了 Ox-LDL-induced PPAR 和 adipophilin 表示。结果显示出那 ERK1/2 或 PPAR 特定的抑制减少了细胞内部的类脂化合物微滴的数量。同时, PPAR 特定的收缩筋增加了细胞内部的类脂化合物微滴。这些结果建议 Ox-LDL-induced 经由 ERK1/2 激活在 adipophilin 水平增加是在 RAW264.7 房间导致细胞内部的类脂化合物微滴的更大的数量的机制之一,它显示 adipophilin 涉及动脉粥样硬化患者前进。 | Qingnan Liu Zhibing Dai Zhiqiang Liu Xiaohui Liu Chaoke Tang Zuo Wang Guanghui Yi Lushan Liu Zhisheng Jiang Yongzong Yang Zhonghua Yuan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 13 |
| 16 | Rupture directivity of the August 3rd, 2014 Ludian earthquake(Yunan, China)显示文摘An M6.5 earthquake occurred on August 3rd, 2014 in Ludian of Yunnan Province in China, causing severe casualty and economic loss. Local broadband waveform inversion with the CAP method demonstrates that the earthquake is a strike-slip event, with the strike along 70° and 160° for the two nodal planes respectively. However, the geological structure in the epicentral region is complicated with abundant active faults, and it is challenging to identify the seismogenic fault with the focal plane solutions due to nodal-plane ambiguity. We resolved the rupture directivity by measuring the difference between centroid location and hypocenter of the Ludian earthquake with the time shift from CAP inversion, and found that the nodal plane with the strike of 160° is the ruptured fault plane. Moreover, the rupture is found to propagate from northwest to southeast. | HE XiaoHui NI SiDao LIU Jie | 2015 | Science China Earth Sciences2015，58，5： | 12 |
| 17 | CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy显示文摘CRISPR/Cas9 is a versatile genome-editing tool which is widely used for modifying the genome of both prokaryotic and eukaryotic organisms for basic research and applications. An increasing number of reports have demonstrated that CRISPR/Cas9-mediated genome editing is a powerful technology for gene therapy. Here, we review the recent advances in CRISPR/Cas9-mediated gene therapy in animal models via different strategies and discuss the challenges as well as future prospects. | Xiaohui Zhang Liren Wang Mingyao Liu Dali Li | 2017 | Science China(Life Sciences)2017，60，5： | 12 |
| 18 | Influence of refined hierarchical martensitic microstructures on yield strength and impact toughness of ultra-high strength stainless steel显示文摘The hierarchical martensitic features in ultra-high strength stainless steel(UHSSS),including the prior austenite grains,martensite packets,blocks and laths with the descending size,were refined to various extents by employing different thermomechanical processes and then carefully characterized.Their relation to yield strength and impact toughness was analyzed.We conclude that the refinement of martensitic structures could lead to the significant increase of yield strength,which follows the Hall-Petch relation with the effect grain size defined by high angle boundaries(HABs).Impact toughness of UHSSS depends on the frequency and capability for retained austenite(RA)grains at both HABs and martensite lath boundaries to trap the propagating cracks via strain-induced transformation,in which the film-like RA grains at lath boundaries appear to make the greater contribution. | Haiwen Luo Xiaohui Wang Zhenbao Liu Zhiyong Yang | 2020 | Journal of Materials Science & Technology2020，47，16： | 12 |
| 19 | rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study显示文摘Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ever.Here,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated information.Accelerated by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at http://gffzz188fe103f8f1460asvwnk9of9c5cb6ovk.ffgz.tsg.suse.edu.cn/xiaolei-lab/r MVP. | Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li Xiaolei Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 20 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
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