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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Mechanisms of hepatocellular carcinoma progression显示文摘Hepatocellular carcinoma(HCC) is the most common primary malignancy of the liver. It is the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In the United States, there has been only minimal improvement in the prognosis for HCC patients over the past 15 years. Details of the molecular mechanisms and other mechanisms of HCC progression remain unclear. Consequently, there is an urgent need for better understanding of these mechanisms. HCC is often diagnosed at advanced stages, and most patients will therefore need systemic therapy, with sorafenib being the most common at the present time. However, sorafenib therapy only minimally enhances patient survival. This review provides a summary of some of the known mechanisms that either cause HCC or contribute to its progression. Included in this review are the roles of viral hepatitis, non-viral hepatitis, chronic alcohol intake, genetic predisposition and congenital abnormalities, toxic exposures, and autoimmune diseases of the liver. Well-established molecular mechanisms of HCC progression such as epithelial-mesenchymal transition, tumor-stromal interactions and the tumor microenvironment, cancer stem cells, and senescence bypass are also discussed. Additionally, we discuss the roles of circulating tumor cells,immunomodulation, and neural regulation as potential new mechanisms of HCC progression. A better understanding of these mechanisms could have implications for the development of novel and more effective therapeutic and prognostic strategies, which are critically needed. | Olorunseun O Ogunwobi Trisheena Harricharran Jeannette Huaman Anna Galuza Oluwatoyin Odumuwagun Yin Tan Grace X Ma Minhhuyen T Nguyen | 2019 | World Journal of Gastroenterology2019，25，19： | 21 |
| 3 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 4 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 5 | Measurements of γ/γ' Lattice Misfit and γ' Volume Fraction for a Ru-containing Nickel-based Single Crystal Superalloy显示文摘A conventional X-ray diffractometer has been used to determine the γ/γ lattice misfit and γ volume fraction for a Ru-containing nickel-based single crystal superalloy at room temperature.The rocking curve was used to characterize the distribution of subgrains.The diffraction peaks obtained by ω-2θ scan were used to determine the γ/γ lattice misfit and γ volume fraction.A three peaks fitting model was proposed.The peak fitting results are in good agreement with the model.The X-ray diffraction results indicate that the nickel-based single crystal superalloy was not a perfect monocrystalline material,which is comprised of many subgrains;and each subgrain also consists of large numbers of mosaic structures.In addition,two anomalous reflection phenomena were found during the experiment and discussed with respect to their occurrence and impact on the measurement.The experimental results show that the γ/γ lattice misfit and γ volume fraction will be various at the different regions of its dendritic microstructure.The average γ/γ lattice misfit and γ volume fraction of the experimental alloy are approximately-0.2% and 70%,respectively.Furthermore,the γ volume fraction calculated by atom microprobe(AP) data is also basically consistent with the experimental results. | X.P. Tan J.L. Liu X P Song T. Jin X.F. Sun Z.Q. Hu | 2011 | Journal of Materials Science & Technology2011，27，10： | 3 |
| 6 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 7 | Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease显示文摘 | Tan W C Xiang X Qiu D | 2003 | Am J Med2003，115，4： | 2 |
| 8 | Keap1-Nrf2-ARE和p53/p21信号通路在对乙酰氨基酚引起肝损伤后肝再生中的作用显示文摘对乙酰氨基酚(acetaminophen,APAP)过量使用是引起肝损伤的主要原因。代偿性肝再生是药物性肝损伤的关键因素。但是APAP引起的肝损伤后肝再生的分子机制尚不清楚。本文旨在讨论Keapl—Nrf2-ARE和p53/p21信号通路在APAP引起肝损伤后肝再生中的作用。研究人员通过给予小鼠400mg/kg的APAP体内注射后发现,小鼠在12h内表现出巨大的肝毒性,而肝脏功能的恢复却要在24h之后。 | Fan X Chen P Tan H 牛强 | 2014 | 中华损伤与修复杂志(电子版)2014，9，5： | 2 |
| 9 | Robust nonlinear coordinated generator excitation and SVC control for power systems 显示文摘 | WANG Y Y TAN Y L GUO G X | 2000 | Electrical Power and Energy Systems2000，22，： | 2 |
| 10 | Variations of bacterioplankton community composition during Microcystis spp. blooms in a shallow eutrophic lake显示文摘 | Xing P Kong FX Cao HS Zhang M Tan X | 2007 | 中国生物学文摘2007，21，8： | 2 |
| 11 | Damping analysis of beams covered with multiple PCLD patches显示文摘 | Zheng H Tan X M Cai C | 2006 | International Journal of Mechanical Sciences2006，48，12： | 1 |
| 12 | Influence of environmental factors on reductive bioprecipitation of uranium by sulfate reducing bacteria 显示文摘 | Yi Z J Tan K X Tan A L | 2007 | International Biodeterioration and Biodegradation2007，60，4： | 1 |
| 13 | Melatonin in Chinese medicinal herbs显示文摘 | Chen G Huo Y Tan D X Liang Z Zhang W Zhang Y | 2003 | Life Sci2003，73，1： | 1 |
| 14 | Damping analysis of beams covered with multiple PCLD patches显示文摘 | Zheng H Tan X M Cai C | 2006 | International Journal of Mechanical Sciences2006，48，： | 1 |
| 15 | Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma:Identification of potential tumor markers显示文摘 | TAN Y X ZHOU H | 2005 | Proteomics2005，5，4： | 1 |
| 16 | A Novel Strategy to Fabricate γ-Fe2O3-MWCNTs Hybrids with Selectively Ferromagnetic or Superparamagnetic Properties 显示文摘 | Fan X B Tan F Y Zhang G L | 2007 | Mater Sci & Eng A2007，45，： | 1 |
| 17 | Hidden semi-Markov model for anomaly detection显示文摘 | Tan X B Xi H S | 2008 | Applied Mathematics and Computation2008，205，2： | 1 |
| 18 | Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome显示文摘 | Tan R Xu X Ogg GS | 1999 | Blood1999，93，5： | 1 |
| 19 | Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population显示文摘 | Miao X Xing D Tan W | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，11： | 1 |
| 20 | Preparation and characterization of polyaniline/nano-Fe304 composites via a novel Pickering emulsion route 显示文摘 | Xiao Q Tan X Ji L | 2007 | Synthetic Metals2007，157，： | 1 |
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