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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage显示文摘AIM:To evaluate whether desferrioxamine decreases ischemia and perfusion injury aggravated by cold storage(CS)in a rat liver perfusion model. METHODS:Isolated rat livers were kept in CS in University of Wisconsin Solution for 20 h at 4℃,then exposed to 25 min of warm ischemia(WI)at 37℃ followed by 2 h of warm perfusion(WP)at 37℃with oxygenated(95%oxygen and 5%carbon dioxide) Krebs-Henseleit buffer.Desferrioxamine(DFO),an iron chelator,was added at different stages of storage,ischemia and perfusion:in CS only,in WI only,in WP only, in WI and perfusion,or in all stages.Effluent samples were collected after CS and after WI.Perfusate samples and bile were collected every 30 min(0,0.5,1,1.5 and 2 h)during liver perfusion.Cellular injury was assessed by the determination of lactate dehydrogenase(LDH) and aspartate aminotransferase(AST)in the effluent and perfusate samples.Total iron was analysed in the perfusate samples.After WP,the liver was collected for the determination of liver swelling(wet to dry ratio) and liver morphological examination(hematoxylin and eosin staining). RESULTS:Increased CS time caused increased liver dysfunction during WP.After 2 h of WP,liver injury was indicated by increased release of AST(0.5 h CS:9.4± 2.2 U/g liver vs 20 h CS:45.9±10.8 U/g liver,P<0.05) and LDH(0.5 h CS:59±14 U/g liver vs 20 h CS:297 ±71 U/g liver,P<0.05).There was an associated increase in iron release into the perfusate(0.5 h CS:0.11 ±0.03μmoL/g liver vs 20 h CS:0.58±0.10μmoL/g liver,P<0.05)and reduction in bile flow(0.5 h CS: 194±12μL/g vs 20 h CS:71±8μL/g liver,P<0.05). When DFO was added during WI and WP following 20 h of CS,release of iron into the perfusate was de- creased(DFO absent 0.58±0.10μmoL/g liver vs DFO present 0.31±0.06μmoL/g liver,P<0.05),and liver function substantially improved with decreased release of AST(DFO absent 45.9±10.8 U/g liver vs DFO present 8.1±0.9 U/g liver,P<0.05)and LDH(DFO absent 297±71 U/g liver vs DFO present 56±7 U/g liver,P<0.05),and increased bile flow(DFO absent 71±8μL/g liver vs DFO present 237±36μL/g liver, P<0.05).DFO was also shown to improve liver morphology after WP.Cellular injury(the release of LDH and AST)was significantly reduced with the addition of DFO in CS medium but to a lesser extent compared to the addition of DFO in WP or WI and perfusion.There was no effect on liver swelling or bile flow when DFO was only added to the CS medium. CONCLUSION:DFO added during WI and perfusion decreased liver perfusion injury aggravated by extended CS. | Peter G Arthur Xian-Wa Niu Wen-Hua Huang Bastiaan DeBoer Ching Tat Lai Enrico Rossi John Joseph Gary P Jeffrey | 2013 | World Journal of Gastroenterology2013，19，5： | 2 |
| 3 | Role of MCP-1 in cardiovascular disease: Molecular mechanisms and clinical implications 显示文摘 | Niu J Kolattukudy P E | 2009 | Clin Sci (Lond)2009，117，3： | 1 |
| 4 | Suppression of frizzled-2-mediated wnt/Ca2 + signaling significantly attenuates intracellular calcium accumulation in vitro and in a rat model of traumatic brain injury显示文摘 | Niu LJ Xu RX Zhang P | | 0，，： | 1 |
| 5 | Model of turbine optimal initial pressure under off-design operation based on SVR and GA显示文摘 | NIU P ZHANG W | 2012 | Neurocomputing2012，78，： | 1 |
| 6 | Nitrogen vacancy-promoted photocatalytic activity of graphitic carbon nitride显示文摘 | Niu P Liu G Cheng H M | 2012 | The Journal of Physical Chemistry C2012，116，11： | 1 |
| 7 | Role of Rel/NF-kappa B tran- scription factors in apoptosis of human hepatocellular carcinoma cells 显示文摘 | CHIAO P J NA R NIU J | 2002 | Cancer2002，95，8： | 1 |
| 8 | Contraction-related stimuli reg- ulate GLUT4 traffic in C2C 12-GLUT4myc skeletal muscle cells显示文摘 | Niu W Bilan P J Ishikura S | 2010 | Am J Physiol Endocrinol Metab2010，298，5： | 1 |
| 9 | Distrib-uted detection in a large wireless sensor network显示文摘 | NIU Ruixin VARSHNEY P K CHENG Qi | 2006 | Information Fusion2006，7，4： | 1 |
| 10 | Design and optimization of runner and gating systems for the die casting of thin-walled magnes- ium telecommunication parts through numerical simulation 显示文摘 | Hu B H Tong K K Niu X P | 2000 | Journal ofMaterials Processing Technology2000，105，： | 1 |
| 11 | Increasing the visible light absorption of graphitic carbon nitride(melon)photocatalysts by homogeneous self-modification with nitrogen vacancies显示文摘 | Niu P Yin L C Yang Y Q Liu G Cheng H M | 2014 | Advanced Materials2014，26，47： | 1 |
| 12 | Graphene-based non-noble-metal Co/N/C catalyst for oxygen reduction reaction in alkaline solution显示文摘 | Niu K X Yang B P Cui J F | 2013 | J Power Sources2013，243，6： | 1 |
| 13 | A simple hydrophobicity - based ap- proach to predict the toxicity of unknown organic micropollutant mix- tures in marine water显示文摘 | Lin ZF Zhong P Niu XJ | 2005 | Marine Pollution Bulletin2005，50，： | 1 |
| 14 | Simulation and analysis for a permanent contactor with and without current-feedback system显示文摘 | CHEN D LIU Y JI L NIU C P | | 0，，08： | 1 |
| 15 | Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential显示文摘 | Jiao L Y Ouyang S Y Liang M F Niu F F Shaw N Wu W Ding W Jin C Peng Y Zhu Y P Zhang F S Wang T Li C Zuo X B Luan C H Li D X Liu Z J | 2013 | J Virol2013，87，12： | 1 |
| 16 | A feature-based ro- bust digital image watermarking scheme using band let transform显示文摘 | Niu P P Wang X Y Jin H B Lu M Y | 2011 | Optics & Laser Technology2011，43，3： | 1 |
| 17 | How do rat cortical cells cultured with aluminum die:necrosis or apoptosis?显示文摘 | Zhang QL Boscolo P Niu PY | 2008 | Int J Immunopathol Pharmacol2008，21，1： | 1 |
| 18 | Radioactive logging interpretation in CCSD-Main Hole显示文摘 | Pan H P Niu Y X Wang W X | 2007 | Journal of China University of Geosciences2007，，： | 1 |
| 19 | Construction and application of an electronic spatiotemporal expression profile and gene ontology analysis platform based on the EST database of the silkworm,Bombyx mori显示文摘 | Gan L P Zhang W Y Niu Y S | | 0，，： | 1 |
| 20 | Neural network ensemble modeling for nosiheptide fermentation process based on partial least squares regression显示文摘 | Niu D P Wang F L Zhang L L | 2011 | Chemometrics and Intelligent Laboratory Systems2011，105，1： | 1 |
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