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| 1 | Comparative study of the net exchange of CO_(2) in 3 types of vegetation ecosystems on the Qinghai-Tibetan Plateau显示文摘Using the eddy covariance method,from 1 July2003 to 30 June 2004, we conducted the observation andanalysis of ecosystem CO2 flux in 3 types of alpine meadowvegetation (Kobresia humilis, Potentilla fruticosa shrub andKobresia tibetica swamp meadows) on the Qinghai-TibetanPlateau. The results show that the Kobresia humilis meadow,the shrub meadow and the swamp meadow’s highest CO2uptake rates are 16.78, 10.42 and 16.57 μmol·m?2·s?1respectively, while their highest CO2 release rates are 8.22,7.73 and 18.67 μmol·m?2·s?1 respectively. The Kobresiahumilis meadow and shrub meadow’s annual atmosphericuptakes are 282 g CO2/m2 and 53 g CO2/m2, respectively,while swamp meadow’s annual atmospheric release is 478 gCO2/m2. This proves that the Kobresia humilis meadow andthe shrub meadow on the Qinghai-Tibetan Plateau haverelatively low potential for CO2 uptake and release comparedto C4 grasslands, a number of lowland grasslands, andforests. Moreover, swamp meadow has relatively high releasepotential. This, in turn, reveals clear differences in carbonsource/sink between different types of vegetation in theQinghai-Tibetan Plateau alpine meadow ecosystem. Thesedifferences are mainly brought by differences in thevegetations’ photosynthetic capacity and soil respiration. | ZHAO Liang LI Yingnian ZHAO Xinquan XU Shixiao TANG Yanhong YU Guirui GU Song DU Mingyuan WANG Qinxue | 2005 | Chinese Science Bulletin2005，50，16： | 34 |
| 2 | Effect of multidisciplinary team treatment on outcomes of patients with gastrointestinal malignancy显示文摘AIM: To evaluate the effect of multidisciplinary team (MDT) treatment modality on outcomes of patients with gastrointestinal malignancy in China. METHODS: Data about patients with gastric and colorectal cancer treated in our center during the past 10 years were collected and divided into two parts. Part 1 consisted of the data collected from 516 consecutive complicated cases discussed at MDT meetings in Peking University School of Oncology (PKUSO) from December 2005 to July 2009. Part 2 consisted of the data collected from 263 consecutive cases of resect-able locally advanced rectal cancer from January 2001 to January 2005. These 263 patients were divided into neoadjuvant therapy (NT) group and control group. Patients in NT group received MDT treatment, namely neoadjuvant therapy + surgery + postoperative adjuvant therapy. Patients in control group underwent direct surgery + postoperative adjuvant therapy. The outcomes in two groups were compared. RESULTS: The treatment strategy was altered after discussed at MDT meeting in 76.81% of gastric cancer patients and in 58.33% of colorectal cancer patients before operation. The sphincter-preservation and local control of tumor were better in NT group than in control group. The 5-year overall survival rate was also higher in NT group than in control group (77.23% vs 69.75%, P = 0.049). CONCLUSION: MDT treatment modality can significantly improve the outcomes of patients with gastrointestinal malignancy in China. | Chang-Zheng Du Jie Li Yong Cai Ying-Shi Sun Wei-Cheng Xue Jin Gu | 2011 | World Journal of Gastroenterology2011，17，15： | 31 |
| 3 | value of contrast-enhanced ultrasound in the differential diagnosis of gallbladder lesion显示文摘AIM To describe contrast-enhanced ultrasound(CEUS) features and evaluate differential diagnosis value of CEUS and conventional ultrasound for patients with benign and malignant gallbladder lesions. METHODS This study included 105 gallbladder lesions. Before surgical resection and pathological examination, conventional ultrasound and CEUS were performed to examine for lesions. Then, all the lesions were diagnosed as(1) benign,(2) probably benign,(3) probably malignant or(4) malignant using both conventional ultrasound and CEUS. The CEUS features of these gallbladder lesions were analyzed and diagnostic efficiency between conventional ultrasound and CEUS was compared.RESULTS There were total 17 cases of gallbladder cancer and 88 cases of benign lesion. Some gallbladder lesions had typical characteristics on CEUS(e.g., gallbladder adenomyomatosis had typical characteristics of small nonenhanced areas on CEUS). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CEUS were 94.1%, 95.5%, 80.0%, 98.8%and 95.2%, respectively. These were significantly higher than conventional ultrasound(82.4%, 89.8%, 60.9%, 96.3% and 88.6%, respectively). CEUS had an accuracy of 100% for gallbladder sludge and CEUS helped in differential diagnosis among gallbladder polyps, gallbladder adenoma and gallbladder cancer.CONCLUSION CEUS may provide more useful information and improve the diagnosis efficiency for the diagnosis of gallbladder lesions than conventional ultrasound. | Hui-Ping Zhang Min Bai Ji-Ying Gu Ying-Qian He Xiao-Hui Qiao Lian-Fang Du | 2018 | World Journal of Gastroenterology2018，24，6： | 27 |
| 4 | Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/Cas9 system显示文摘 | Jia Li Bai-bing Zhang Yong-gang Ren Shan-ye Gu Yuan-hang Xiang Cheng Huang Jiu-lin Du | 2015 | Cell Research2015，25，5： | 22 |
| 5 | Response of yield,quality,water and nitrogen use efficiency of tomato to different levels of water and nitrogen under drip irrigation in Northwestern China显示文摘The objective of this study was to investigate the effects of applying different amounts of water and nitrogen on yield, fruit quality, water use efficiency(WUE), irrigation water use efficiency(IWUE) and nitrogen use efficiency(NUE) of drip-irrigated greenhouse tomatoes in northwestern China. The plants were irrigated every seven days at various proportions of 20-cm pan evaporation(E_p). The experiment consisted of three irrigation levels(I1, 50% E_p; I2, 75% E_p; and I3, 100% E_p) and three N application levels(N1, 150 kg N ha^(–1); N2, 250 kg N ha^(–1); and N3, 350 kg N ha^(–1)). Tomato yield increased with the amount of applied irrigation water in I2 and then decreased in I3. WUE and IWUE were the highest in I1. WUE was 16.5% lower in I2 than that in I1, but yield was 26.6% higher in I2 than that in I1. Tomato yield, WUE, and IWUE were significantly higher in N2 than that in N1 and N3. NUE decreased with increasing N levels but NUE increased with increase the amount of water applied. Increasing both water and N levels increased the foliar net photosynthetic rate. I1 and I2 treatments significantly increased the contents of total soluble solids(TSS), vitamin C(VC), lycopene, soluble sugars(SS), and organic acids(OA) and the sugar:acid ratio in the fruit and decreased the nitrate content. TSS, VC, lycopene, and SS contents were the highest in N2. The harvest index(HI) was the highest in I2N2. I2N2 provided the optimal combination of tomato yield, fruit quality, and WUE. The irrigation and fertilisation regime of 75% E_p and 250 kg N ha^(–1) was the best strategy of water and N management for the production of drip-irrigated greenhouse tomato. | DU Ya-dan CAO Hong-xia LIU Shi-quan GU Xiao-bo CAO Yu-xin | 2017 | Journal of Integrative Agriculture2017，16，5： | 23 |
| 6 | Plasma miR-216a as a potential marker of pancreatic injury in a rat model of acute pancreatitis显示文摘AIM:To study the potential value and specificity of plasma miR-216a as a marker for pancreatic injury.METHODS:Two rat models were applied in this article:L-arginine-induced acute pancreatitis was used as one model to explore the potential value of plasma miR-216a for detection of pancreatic injury;nonlethal sepsis induced in rats by single puncture cecal ligation and puncture(CLP)was used as the other model to evaluate the specificity of plasma miR-216a compared with twocommonly used markers(amylase and lipase)for acute pancreatitis.Plasmas were sampled from rats at indicated time points and total RNA was isolated.Real-Time Quantitative reverse transcriptase-polymerase chain reaction was used to quantify miR-216a in plasmas.RESULTS:In the acute pancreatitis model,among five time points at which plasmas were sampled,miR-216a concentrations were significantly elevated 24 h after arginine administration and remained significantly increased until 48 h after operation(compared with 0 h time point,P<0.01,Kruskal-Wallis Test).In the CLP model,plasma amylase and lipase,two commonly used biomarkers for acute pancreatitis,were significantly elevated 24 h after operation(compared with 0 h time point,P<0.01 and 0.05 respectively,Pairwise Bonferroni corrected ttests),while miR-216a remained undetectable among four tested time points.CONCLUSION:Our article showed for the first time that plasma miR-216a might serve as a candidate marker of pancreatic injury with novel specificity. | Xiang-Yu Kong,Yi-Qi Du,Lei Li,Xiao-Hua Man,Yan-Fang Gong,Li-Ning Xiao,Yong-Zhi Zheng,Shang-Xin Deng,Jun-Jun Gu,Zhao-Shen Li,Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shang-hai 200433,China Jian-Qiang Liu,Department of Gastroenterology,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,Fujian Province,China Guo-Kun Wang,Jia-Qi Zhu,Department of Cardiology,Changhai Hospital,Second Military Medical University,Shang-hai 200433,China | 2010 | World Journal of Gastroenterology2010，16，36： | 19 |
| 7 | Sedimentary geochemistry of the Cambrian-Ordovician cherts: Implication on archipelagic ocean of North Qilian orogenic belt显示文摘The Caledonian North Qilian orogenic belt lies between the North China plate and the Qaidam mi-croplates, and resulted from the collision among the Qaidam microplate, mid-Qilian block and the North China plate. The orogen initiated from the rifting of the Late Proterozoic Rodinia, and then it experi-enced stages of Cambrian rift basin and Ordovician archipelagic oceanic basin, and foreland basin during Silurian to Early-Middle Devonian. The average ratios of Al/(Al+Fe+Mn), Al/(Al+Fe), δ Ce, Lan/Ybn and Lan/Cen from cherts of Cambrian Heicigou Formation are 0.797, 0.627, 1.114, 0.994 and 1.034 re-spectively. In the NAS standardized REE distribution pattern, the cherts from Xiangqianshan is slightly HREE enriched, and the cherts from Ganluci and Shiqingdong are plane. All of these features indicated that Cambrian cherts of the Heicigou Formation originated from a continental margin rift background. On the contrary, the average ratios of Al/(Al+Fe+Mn), Al/(Al+Fe), δ Ce, Lan/Ybn, Lan/Cen of the Ordovician chert from Dakecha, Cuijiadun, Shihuigou, Laohushan, Heicigou, Maomaoshan, Bianmagou, Da-chadaban, Baiquanmen, Jiugequan and Angzanggou, are respectively 0.72, 0.58, 0.99, 1.09 and 0.96 respectively. Their NAS standardized REE distribution patterns of most Ordovician cherts are plane mode or slightly HREE enriched. The REE distribution pattern of few samples of cherts are slightly LREE enriched. Characteristics of sedimentary geochemistry and tectonic evolution demonstrated that the Cambrian-Ordovician cherts, associated with rift, oceanic, island arc and back-arc volcanic rocks, was not formed in a typical abyssal oceanic basin or mid-oceanic ridge. On the contrary, they formed in a deepwater basin of continental margin or a archipelagic ocean tectonic setting. Several Early Paleo-zoic ophiolite belts in North Qilian and adjacent periphery Qaidam microplate imply that an archipelagic ocean during Ordovician existed in the east of Pro-Tethys. | DU YuanSheng1,2, ZHU Jie1, GU SongZhu1, 2, XU YaJun1 & YANG JiangHai1 1 Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 2 Key Laboratory of Biogeology and Environment Geology of Education Ministry, Wuhan 430074, China | 2007 | Science China Earth Sciences2007，50，11： | 17 |
| 8 | Design,modeling,and control of morphing aircraft:A review显示文摘A morphing aircraft can adapt its configuration to suit different types of tasks,which is also an important requirement of Unmanned Aerial Vehicles(UAV).The successful development of an unmanned morphing aircraft involves three steps that determine its ability and intelligent:configuration design,dynamic modeling and flight control.This study conducts a comprehensive survey of morphing aircraft.First,the methods to design the configuration of a morphing aircraft are presented and analyzed.Then,the nonlinear dynamic characteristics and aerodynamic interference caused by a morphing wing are described.Subsequently,the dynamic modeling and flight control methods for solving the flight control problems are summarized with respect to these features.Finally,the general as well as special challenges ahead of the development of intelligent morphing aircraft are discussed.The findings can provide a theoretical and technical reference for designing future morphing aircraft or morphing-wing UAVs. | Lingling CHU Qi LI Feng GU Xintian DU Yuqing HE Yangchen DENG | 2022 | Chinese Journal of Aeronautics2022，35，5： | 16 |
| 9 | Electroacupuncture activates enteric glial cells and protects the gut barrier in hemorrhaged rats显示文摘AIM:To investigate whether electroacupuncture ST36 activates enteric glial cells,and alleviates gut inflammation and barrier dysfunction following hemorrhagic shock.METHODS:Sprague-Dawley rats were subjected to approximately 45% total blood loss and randomly divided into seven groups:(1) sham:cannulation,but no hemorrhage;(2) subjected to hemorrhagic shock(HS);(3) electroacupuncture(EA) ST36 after hemorrhage;(4) vagotomy(VGX)/EA:VGX before hemorrhage,then EA ST36;(5) VGX:VGX before hemorrhage;(6) a-bungarotoxin(BGT)/EA:intraperitoneal injection of a-BGT before hemorrhage,then EA ST36; and(7) a-BGT group:a-BGT injection before hemorrhage.Morphological changes in enteric glial cells(EGCs) were observed by immunofluorescence,and glial fibrillary acidic protein(GFAP; a protein marker of enteric glial activation) was evaluated using reverse transcriptase polymerase chain reaction and western blot analysis.Intestinal cytokine levels,gut permeability to 4-k Da fluorescein isothiocyanate(FITC)-dextran,and the expression and distribution of tight junction protein zona occludens(ZO)-1 were also determined.RESULTS:EGCs were distorted following hemorrhage and showed morphological abnormalities.EA ST36 attenuated the morphological changes in EGCs at 6 h,as compared with the VGX,a-BGT and HS groups.EA ST36 increased GFAP expression to a greater degree than in the other groups.EA ST36 decreased intestinal permeability to FITC-dextran(760.5 ± 96.43 ng/m L vs 2466.7 ± 131.60 ng/m L,P < 0.05) and preserved ZO-1 protein expression and localization at 6 h afterhemorrhage compared with the HS group.However,abdominal VGX and a-BGT treatment weakened or eliminated the effects of EA ST36.EA ST36 reduced tumor necrosis factor-a levels in intestinal homogenates after blood loss,while vagotomy or intraperitoneal injection of a-BGT before EA ST36 abolished its antiinflammatory effects.CONCLUSION:EA ST36 attenuates hemorrhageinduced intestinal inflammatory insult,and protects the intestinal barrier integrity,partly via activation of EGCs. | Sen Hu Zeng-Kai Zhao Rui Liu Hai-Bin Wang Chun-Yu Gu Hong-Min Luo Huan Wang Ming-Hua Du Yi Lv Xian Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 15 |
| 10 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 11 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 12 | A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling显示文摘Extracellular matrix(ECM)deposition following reactive oxygen species(ROS)overproduction has a key role in diabetic nephropathy(DN),thus,antioxidant therapy is considered as a promising strategy for treating DN.Here,we investigated the therapeutic effects of AB38b,a novel syntheticα,β-unsaturated ketone compound,on the oxidative stress(OS)and ECM accumulation in type 2 diabetes mice,and tried to clarify the mechanisms underlying the effects in high glucose(HG,30 mM)-treated mouse glomerular mesangial cells(GMCs).Type 2 diabetes model was established in mice with high-fat diet feeding combined with streptozocin intraperitoneal administration.The diabetic mice were then treated with AB38b(10,20,40 mg·kg^?1·d^?1,ig)or a positive control drug resveratrol(40 mg·kg^?1·d^?1,ig)for 8 weeks.We showed that administration of AB38b or resveratrol prevented the increases in malondialdehyde level,lactate dehydrogenase release,and laminin and type IV collagen deposition in the diabetic kidney.Simultaneously,AB38b or resveratrol markedly lowered the level of Keap1,accompanied by evident activation of Nrf2 signaling in the diabetic kidney.The underlying mechanisms of antioxidant effect of AB38b were explored in HG-treated mouse GMCs.AB38b(2.5?10μM)or resveratrol(10μM)significantly alleviated OS and ECM accumulation in HG-treated GMCs.Furthermore,AB38b or resveratrol treatment effectively activated Nrf2 signaling by inhibiting Keap1 expression without affecting the interaction between Keap1 and Nrf2.Besides,AB38b treatment effectively suppressed the ubiquitination of Nrf2.Taken together,this study demonstrates that AB38b ameliorates experimental DN through antioxidation and modulation of Keap1/Nrf2 signaling pathway. | Lei Du Lei Wang Bo Wang Jin Wang Meng Hao Yi-bing Chen Xi-zhi Li Yuan Li Yan-fei Jiang Cheng-cheng Li Hao Yang Xiao-ke Gu Xiao-xing Yin Qian Lu | 2020 | Acta Pharmacologica Sinica2020，41，3： | 13 |
| 13 | Characterizing CO_2 fluxes for growing and non-growing seasons in a shrub ecosystem on the Qinghai-Tibet Plateau显示文摘To assess carbon budget for shrub ecosystems on the Qinghai-Tibet Plateau, CO2flux was measured with an open-path eddy covariance system for an alpine shrub ecosystem during growing and non-growing seasons. CO2 flux dynamics was distinct between the two seasons. During the growing season from May to September, the ecosystem exhibited net CO2uptake from 08:00 to 19:00 (Beijing Standard Time), but net CO2 emission from 19:00 to 08:00.Maximum CO2 uptake appeared around 12:00 with values of 0.71, 1.19, 1.46 and 0.67 g CO2m-2 h-1 for June, July, August and September, respectively. Diurnal fluctuation of CO2 flux showed higher correlation with photosynthetic photon flux density than temperature. The maximum net CO2 influx occurred in August with a value of 247 g CO2 m-2. The total CO2 uptake by the ecosystem was up to 583 g CO2 m-2 for the growing season. During the non-growing season from January to April and from October to December, CO2 flux showed small fluctuation with the largest net CO2 efflux of 0.30 g CO2 m-2 h-1 in April. The diurnal CO2 flux was close to zero during most time of the day, but showed a small net CO2 efflux from 11:00 to 18:00. Diurnal CO2 flux, is significantly correlated to diurnal temperature in the non-growing season. The maximum monthly net CO2 efflux appeared in April, with a value of 105 g CO2 m-2. The total net CO2 efflux for the whole non-growing season was 356 g CO2 m-2. | XU Shixiao, ZHAO Xinquan, FU Yuling, ZHAO Liang, LI Yingnian, CAO Guangmin, GU Song, WANG Qinxue & DU Mingyuan Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100136, China National Institute for Environmental Studies, Tsukuba 305-8569, Japan National Institute for Agro-Environmental Science, Tsukuba 305-8604, Japan | 2005 | Science China Earth Sciences2005，48，z1： | 12 |
| 14 | Epigenetic Modifications of mRNA and DNA in Plants显示文摘Advances in the detection and mapping of messenger RNA(mRNA)N^6-methyladenosine(m 6A)and 5-methylcytosine(m 5C),and DNA N^6-methyldeoxyadenosine(6mA)redefined our understanding of these modifications as additional tiers of epigenetic regulation.In plants,the most prevalent internal mRNA modifications,m^6A and m^5C,play crucial and dynamic roles in many processes,including embryo development,stem cell fate determination,trichome branching,leaf morphogenesis,floral transition,stress responses,fruit ripening,and root development.The newly identified and widespread epigenetic marker 6mA DNA methylation is associated with gene expression,plant development,and stress responses.Here,we review the latest research progress on mRNA and DNA epigenetic modifications,including the detection,dynamics,distribution,functions,regulatory proteins,and evolution,with a focus on m^6A,m^5C,and 6mA.We also provide some perspectives on future research of the newly identified and unknown epigenetic modifications of mRNA and DNA in plants. | Zhe Liang Adeel Riaz Sadaruddin Chachar Yike Ding Hai Du Xiaofeng Gu | 2020 | Molecular Plant2020，13，1： | 12 |
| 15 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 16 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 17 | Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice显示文摘Mecobalamin,a form of vitamin B12 containing a central metal element(cobalt),is one of the most important mediators of nervous system function.In the clinic,it is often used to accelerate recovery of peripheral nerves,but its molecular mechanism remains unclear.In the present study,we performed sciatic nerve crush injury in mice,followed by daily intraperitoneal administration of mecobalamin(65 μg/kg or 130 μg/kg) or saline(negative control).Walking track analysis,histomorphological examination,and quantitative real-time PCR showed that mecobalamin significantly improved functional recovery of the sciatic nerve,thickened the myelin sheath in myelinated nerve fibers,and increased the cross-sectional area of target muscle cells.Furthermore,mecobalamin upregulated m RNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury,and of neurotrophic factors(nerve growth factor,brain-derived nerve growth factor and ciliary neurotrophic factor) in the L4–6 dorsal root ganglia.Our findings indicate that the molecular mechanism underlying the therapeutic effect of mecobalamin after sciatic nerve injury involves the upregulation of multiple neurotrophic factor genes. | Lin Gan Minquan Qian Keqin Shi Gang Chen Yanglin Gu Wei Du Guoxing Zhu | 2014 | Neural Regeneration Research2014，9，22： | 11 |
| 18 | Classification and regionalization of the forming environment of windblown sand disasters along the Tarim Desert Highway显示文摘Through the systematic field survey and observations, the factor quantification as well as setting the criteria, the sand disaster-forming environment along the Tarim Desert Highway can be divided into four grades by the classification and regionalization based on fuzzy mathematics. The length of the regions with significant sand disaster accounted for 37.1% of the total highway length. Particularly, the area along the Tarim Desert Highway, based on the sand disaster-forming environment classification as well as the difference in the five basic landform units along the highway, combined with the difference of wind regime, can be divided into five regions, in which the length of the regions suffering severe sand damage occupied 64.3% of the total highway length. In addition, the index of disaster formation grade along the highway decreased from north to south, showing a repeated spatial pattern in small length scales. | LEI JiaQiang LI ShengYu FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo LIU Shang DU WenYi YAN ZengHui WANG YongChang | 2008 | Chinese Science Bulletin2008，53，S2： | 11 |
| 19 | Iron-doped nickel disulfide nanoarray: A highly efficient and stable electrocatalyst for water splitting显示文摘特别地为阳极的氧进化反应(OER ) ,发展中的有效切开水的 electrocatalysts 是在精力变换技术的重要挑战。在这研究,我们经由它的 nickel-iron-layered 的 sulfidation 在 Ti 网孔(Fe 0.1-NiS2 NA/Ti ) 上报导做铁的镍二硫化物 nanoarray 的发展两倍氢氧化物先锋(NiFe-LDH NA/Ti ) 。作为三维的 OER 阳极, Fe 0.1-NiS2 NA/Ti 在 1.0 M KOH 展出显著活动和稳定性,与完成 100 mAlecular 解吸附作用的 231 mV 的低过电位的要求。温度的功能在 36 和 44 点显示出解吸附作用山峰的试验性地测量的微分工作功能? | Na Yang Chun Tang Kunyang Wang Gu Du Abdullah M. Asiri Xuping Sun | 2016 | Nano Research2016，9，11： | 11 |
| 20 | Silurian Seismites in Hanxia,Yumen,North Qilian Mountains,and Their Tectonic Significance显示文摘The Caledonian orogenic belt of the North Qilian Mountains is anintensely active structure belt. In the process of the Late Caledonian syn-orogeny, the North Qilian-Hexi Corridor area was situated on the tectonic background of a syn-orogenic basin. In response to the orogenic process of the North Qilian Mountains, typical earthquake event deposits-seismites of the Silurian were widely distributed around Hanxia of Yumen City, the Liyuan River of Sunan County and Biandukou of Minle County. In the Hanxia area, where seismites are typically developed, clastic deposits of tidal-flat facies are the background deposits of the Hanxia Formation. The earthquake event deposits are characterized by sandy mudstone veins, synsedimentary microfractures, micro-corrugated laminations and earthquake breccias, which in turn constitute complex seismites, featuring seismic corrugation, shattering and liquefied sandy mudstone veins, auto clastic breccias and intraclastic parabreccias. The seismites and tidal flat deposits formed typical sequences of earthquake event deposits. | DU Yuansheng, GONG Shuyun, HAN Xin, WANG Jiasheng, GU Songzhuand LIN Wenjiao Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, Hubei | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 11 |
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