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| 1 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 2 | Luminescent metal nanoclusters for biomedical applications显示文摘Luminescent metal nanoclusters (NCs) have recently emerged as a novel class of luminescent nanomaterials and hold significant potential in biomedicine owing to their ultrasmall (<2nm) size,excellent photostability,and good biocompatibility.The recent rapid advances in the synthesis and functionalization of luminescent metal NCs have enabled scientists to develop colorful nanomaterials and nanodevices for a wide range of biomedical applications.In this review,we summarize the characteristics and advantages of luminescence from metal NCs,and highlight their applications in biomedicine.We focus on the research in biomedical detection,bio-imaging,drug delivery,and therapy,especially for the advances in the last five years.Luminescent metal NCs display a series of unique superiorities in biomedical applications,and the recent achievements have brought a lot of benefits to the diagnosis and treatment of clinical diseases,especially for tumors and cancers.Finally,we put forward the main challenges that currently still hinder the basic science studies and the practical development of luminescent metal NCs in biomedical applications.Overall,we expect that luminescent metal NCs will play a much more important role in future biomedicine and clinical applications. | Yu Su Tiantian Xue Yuxin Liu Jinxia Qi Rongchao Jin Zhenkun Lin | 2019 | Nano Research2019，12，6： | 6 |
| 3 | A double crosslinking MXene/cellulose nanofiber layered film for improving mechanical properties and stable electromagnetic interference shielding performance显示文摘With the discovery of the two-dimensional(2D) MXene, it shows a great application potential in the field of electromagnetic interference(EMI) shielding, but the mechanical brittleness and easy oxidation of MXene limit its wide application. For this reason, a double crosslinking strategy is provided to solve the above problems in a nacre-like “brick-mortar” layered MXene/cellulose nanofiber(MXene/CNF) film.Typically, the film was firstly suffered by dopamine modification, then was further reinforced by secondary Ca^(2+)bridging, so as to obtain excellent mechanical properties and antioxidative EMI shielding performance. Comparing with the single crosslinking, the double crosslinking strategy reveals a higher efficiency in improving the mechanical property. The mechanical strength and toughness of the double crosslinking MXene/CNF film can increase to 142.2 MPa and 9.48 MJ/m^(3), respectively. More importantly, while achieving good mechanical properties, the MXene composite film still holds a very stable EMI shielding performance of more than 44.6 dB when suffering from the oxidation treatment of hightemperature annealing, showing excellent anti-oxidation ability and environment tolerance. Therefore,this work provides a universal but effective double crosslinking strategy to solve the mechanical brittleness and easy oxidation of MXene-based composites, thus showing a huge potential in flexible EMI shielding applications. | Shilu Luo Tiantian Xiang Jingwen Dong Fengmei Su Youxin Ji Chuntai Liu Yuezhan Feng | 2022 | Journal of Materials Science & Technology2022，，34： | 4 |
| 4 | Accurate assessment of antibiotic susceptibility and screening resistant strains of a bacterial population by linear gradient plate显示文摘The dynamics of a bacterial population exposed to theminimum inhibitory concentration (MIC) of an antibiotic is an important issue in pharmacological research.Therefore,a novel antibiotic susceptibility test is urgently needed that can both precisely determine the MIC and accurately select antibiotic-resistant strains from clinical bacterial populations.For this purpose,we developed a method based on Fick's laws of diffusion using agar plates containing a linear gradient of antibiotic.The gradient plate contained two layers.The bottom layer consisted of 15 mL agar containing the appropriate concentration of enrofloxacin and allowed to harden in the form of a wedge with the plate slanted such that the entire bottom was just covered.The upper layer consisted of 15 mL plain nutrient agar added with the plate held in the horizontal position.After allowing vertical diffusion of the drug from the bottom agar layer for 12 h,the enrofloxacin concentration was diluted in proportion to the ratio of the agar layer thicknesses.The uniform linear concentration gradient was verified by measuring the enrofloxacin concentration on the agar surface.When heavy bacterial suspensions were spread on the agar surface and incubated for more than 12 h,only resistant cells were able to form colonies beyond the boundary of confluent growth of susceptible cells.In this way,the true MIC of enrofloxacin was determined.The MICs obtained using this linear gradient plate were consistent with those obtained using conventional antibiotic susceptibility tests.Discrete colonies were then spread onto a gradient plate with higher antibiotic concentrations;the boundary line increased significantly,and gene mutations conferring resistance were identified.This new method enables the rapid identification of resistant strains in the bacterial population.Use of the linear gradient plate can easily identify the precise MIC and reveal the dynamic differentiation of bacteria near the MIC.This method allows the study of genetic and physiological characteristics of individual strains,and may be useful for early warning of antibiotic resistance that may occur after use of certain antimicrobial agents,and guide clinical treatment. | LIU YuQing LI JingRan DU JiaFa HU Ming BAI Hua QI Jing GAO Chao WEI TianTian SU Hong JIN JianLing GAO PeiJi | 2011 | Science China(Life Sciences)2011，54，10： | 4 |
| 5 | Influences of Sense of Place on Farming Households' Relocation Willingness in Areas Threatened by Geological Disasters:Evidence from China显示文摘Scholars from environmental psychology,geography, disaster science, and sociology have recently focused attention on evacuation and relocation behaviors and influencing factors in hazard-threatened areas. However, existing studies are mainly focused on developed countries and the influence of individual characteristics,household characteristics, and the perception of risk of urban households on evacuation and relocation behaviors.Few studies examine developing countries and the influence of farmers' sense of place in geological hazardthreatened areas. Using statistics of farming households in an area threatened by landslides, this is a pilot study to explore the relationship of sense of place to the relocation willingness of farming households while controlling for other variables. The results show that:(1) Households with higher scores of place identity and place dependence are less willing to relocate, whereas place attachment has no significant relationship to household relocation willingness;(2) Risk perception dimensions, including probability,threat, and controllability have a significant relationship to household relocation willingness, while worry and fear of the unknown have no significant relationship;(3) Household characteristics, including income, whether a household has experienced economic loss from landslides, and social support are significantly correlated with household relocation willingness, while gender, age, experience, distance to hazard sites, size of household, children, older people, and housing material are not. The results for information and education are not robust. This study contributes to the current literature by improving the understanding of the relationship of sense of place to the relocation willingness of farming households in villages threatened by geological disasters in rural China. | Dingde Xu Li Peng Shaoquan Liu Chunjiang Su Xuxi Wang Tiantian Chen | 2017 | International Journal of Disaster Risk Science2017，8，1： | 2 |
| 6 | Quantification of SARS-CoV-2 antigen levels in the blood of patients with COVID-19显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused the global outbreak of coronavirus disease 2019(COVID-19).By far,more than 35 million people had been infected by SARS-CoV-2,resulting in more than 1 million deaths globally.It is well recognized that SARSCoV-2 preferentially attacks pulmonary epithelial cells,leading to acute respiratory distress syndrome(ARDS). | Bin Su Jiming Yin Xingguang Lin Tiantian Zhang Xiao Yao Ying Xu Yao Lu Wenzhi Wang Kun Liu Jie Zhang Liangzhi Xie Ronghua Jin Yingmei Feng | 2021 | Science China(Life Sciences)2021，64，7： | 2 |
| 7 | Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis显示文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear. | Tiantian Wang Lin Yang Zejun Liang Lin Wang Feijing Su Xiangxiu Wang Xuanhe You Chengqi He | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 8 | zhongguo ge quyu change chengjie nengli de pingjia (Evaluation on the Regional Carrying Capacity of Industries in China)显示文摘 | Su Hua Hu Tiantian Huang Linbao | | 0，，05： | 1 |
| 9 | Semantic Similarity-based Grading of Student Programs显示文摘 | Wang Tiantian Su Xiaohong Wang Yuying | 2007 | Information and Software Technology2007，49，2： | 1 |
| 10 | The neuroprotective effect of walnut-derived peptides against glutamate-induced damage in PC12 cells: mechanism and bioavailability显示文摘In our previous study, defatted walnut meal hydrolysate(DWMH) could attenuate D-galactose-induced acute memory deficits in vivo, and six potent active peptides including WSREEQ, WSREEQE, WSREEQEREE, ADIYTE, ADIYTEEAG and ADIYTEEAGR were identified. The aim of this study was to investigate the possible mechanism underlying their neuroprotective effects on glutamate-induced apoptosis in PC12 cells and their digestive stability. Results showed that all these peptides could attenuate the reduction of cell viability caused by glutamate in PC12 cells, especially WSREEQEREE and ADIYTEEAGR. The addition of Arg residue in WSREEQEREE and ADIYTEEAGR might be the potential reason for their stronger protective effects. Additionally, these two peptides possibly protected PC12 cells against glutamate-induced apoptosis via activating intracellular antioxidant defence(superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px)) through Kelch-like ECH-associated protein 1(Keap1) inhibition, inhibiting ROS production, Ca;influx and mitochondrial membrane potential(MMP) collapse as well as regulating the expression of apoptosis-related proteins(Bax and Bcl-2). This might be due to the presence of Trp, Tyr and Arg in these two peptides. However, encapsulation of WSREEQEREE and ADIYTEEAGR should be considered based on their digestive sensibility during in vitro gastrointestinal digestion. | Shuguang Wang Lin Zheng Tiantian Zhao Qi Zhang Guowan Su Mouming Zhao | 2022 | Food Science and Human Wellness2022，11，4： | 1 |
| 11 | Ability-training-oriented automated assessment in introductory programming course显示文摘 | Tiantian Wang Xiaohong Su Peijun Ma Yuying Wang Kuanquan Wang | 2011 | Computers & Education2011，1，56： | 1 |
| 12 | Ability-training-oriented automated assessment in introductory programming course显示文摘 | Tiantian Wang Xiaohong Su Peijun Ma | 2011 | Computers & Education2011，1，56： | 1 |
| 13 | Ability-training-oriented automated assessment in introductory programming course显示文摘 | Tiantian Wang Xiaohong Su Peijun Ma Yuying Wang Kuanquan Wang | 2010 | Computers & Education2010，，1： | 1 |
| 14 | Semantic similarity-based grading of student programs显示文摘 | Wang Tiantian Su Xiaohong Wang Yuying | 2007 | Information and Software Technology2007，49，2： | 1 |
| 15 | Detection of semantically similar code显示文摘 | Tiantian WANG Kechao WANG Xiaohong SU Peijun MA | 2014 | Frontiers of Computer Science2014，8，6： | 1 |
| 16 | Hyperbranched poly(ether amine)(hPEA)as novel backbone for amphiphilic one-component type-Ⅱ polymeric photoinitiators显示文摘To make photoinitiators(PI) to be polymeric and water-soluble is an effective approach to develop the high efficient photoinitiator systems with low-migration, low-toxic and environment-friend. We developed a series of novel amphiphilic hyperbranched polymeric photoinitiators(hPEA-TXs, and hPEABPs) by introducing thioxanthone(TX) or benzophenone(BP) moieties into the periphery of the hyperbranched poly(ether amine)(hPEA) comprised of the hydrophilic poly(ethylene oxide)(PEO) short chain and coinitiator amine moieties in the backbone. Compared with their water-soluble low-molecular weight analogues, the resulting hyperbranched polymeric photoinitiators hPEA101-TX, hPEA211-TX,hPEA101-BP and hPEA211-BP could be dissolved very well not only in many organic systems including acrylate monomers, but also in water with high solubility of 10 wt%. The photopolymerization kinetics of water-soluble monomer acrylamide(AM) and three hydrophobic multifunctional acrylate monomers initiated by these hyperbranched photoinitiators were investigated in detail by photo-differential scanning calorimetric(photo-DSC). Both hPEA-TXs and hPEA-BPs can initiate photopolymerization of AM as efficiently as their low-molecular weight analogues MGA-TX and MGA-BP, respectively. The final double bond conversion(DBC) of oil-soluble monomer hexanediol diacrylate(HDDA) photoinitiated by these hyperbranched photoinitiators can reach as high as 99%. Especially for photopolymerization of multifunctional monomers initiated by these hyperbranched polymeric photoinitiators, the final DBC of trimethylolpropane triacrylate(TMPTA) and pentaerythritol tetraacrylate(PETTA) can reach 80% and60%, respectively, which is much higher than that of low-molecular weight photoinitiators. | Tiantian Li Zhilong Su Hongjie Xu Xuesong Jiang Xiaodong Ma Jie Yin | 2018 | Chinese Chemical Letters2018，29，3： | 1 |
| 17 | Semantic Similarity-based Grading of Student Programs 显示文摘 | Wang Tiantian Su Xiaohong Wang Yuying | 2007 | Info- rmation and Software Technology2007，49，2： | 1 |
| 18 | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization显示文摘Matrix vesicles(MVs)have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle characteristics and abundant calcium and phosphorus content.However,the role of MVs in the progression of osteoporosis is poorly understood.Here,we report that annexin A5,an important component of the matrix vesicle membrane,plays a vital role in bone matrix homeostasis in the deterioration of osteoporosis.We first identified annexin A5 from adherent MVs but not dissociative MVs of osteoblasts and found that it could be sharply decreased in the bone matrix during the occurrence of osteoporosis based on ovariectomized mice.We then confirmed its potential in mediating the mineralization of the precursor osteoblast lineage via its initial binding with collagen type I to achieve MV adhesion and the subsequent activation of cellular autophagy.Finally,we proved its protective role in resisting bone loss by applying it to osteoporotic mice.Taken together,these data revealed the importance of annexin A5,originating from adherent MVs of osteoblasts,in bone matrix remodeling of osteoporosis and provided a new strategy for the treatment and intervention of bone loss. | Guanyue Su Demao Zhang Tiantian Li Tong Pei Jie Yang Shasha Tu Sijun Liu Jie Ren Yaojia Zhang Mengmeng Duan Xinrui Yang Yang Shen Chenchen Zhou Jing Xie Xiaoheng Liu | 2023 | Bone Research2023，11，4： | 0 |
| 19 | An Empirical Study of Code Clone Clustering Based on Clone Evolution显示文摘There are lots of code clones appearing in software,which are similar code fragments with each other. In the past decades,researchers have proposed some state-of-the-art methods to detect clones. The code clones have showing some relationship with the evolution of software. In order to explore relationships between clones and their evolution,we propose a framework to cluster clones with a Fuzzy C-means clustering method.Firstly,we detect all the clones using Ni Cad,and build the clone genealogies for multiple versions software.Secondly,we extract some metrics to describe the clones and their evolution. Finally,we cluster all clone's vectors,which are generated with the different metrics for different proposes. Experimental results on six open source software packages have shown the relationships among the clone life,the number of change times,the clone pattern and et al. can help developers to understand clones. | Fanlong Zhang Xiaohong Su Wen Zhao Tiantian Wang | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，2： | 0 |
| 20 | Molecular characterization and expression of HSP70, HSF and HSBP genes in Octopus vulgaris during thermal stress显示文摘Temperature is an important environmental factor that affects the growth and survival of Octopus vulgaris, the common octopus. To understand the protective mechanism that O. vulgaris exhibits under heat stress, we used rapid amplification of c DNA ends(RACE) to obtain full-length sequences of three heat stress response related genes:(1) the heat shock protein 70(OvHSP70),(2) the heat shock transcription factor(OvHSF), and(3) the heat shock factor-binding protein(OvHSBP) of O. vulgaris. The OvHSP70, OvHSF, and OvHSBP proteins contained2 222 bp, 2 264 bp, 841 bp that encoded for 635, 458 and 90 amino acids, respectively. The results of multiple sequence alignment showed that the amino acid sequences of OvHSP70 were highly conserved with respect to other species. Similarly, the DNA binding domain, the trimerization domain of OvHSF, and the coiled coil region of OvHSBP also had highly conserved regions. The real-time polymerase chain reaction(PCR) results indicated that OvHSP70 was temperature-dependent and time-dependent, showing a positive response to heat stress. On exposure to 28°C and to 30°C, the m RNA expression levels of OvHSF and OvHSBP were higher than those in the control group at 24°C. The m RNA expression of OvHSBP significantly increased with heat treatment at 26°C, while the m RNA expression of OvHSF decreased. The experimental results indicated that the expression of OvHSP70,OvHSF and OvHSBP were all sensitive to heat stress, which suggests that these three genes may play an important role for O. vulgaris in responding to environmental stress. Thus, this study sets a theoretical foundation for further in-depth studies on the molecular protective mechanisms of the heat response in O. vulgaris. | HONG Jingni MAO Yong NIU Sufang SUN Tiantian SU Yongquan | 2015 | Acta Oceanologica Sinica2015，34，8： | 0 |
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