|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Uplift of the Longmen Shan range and the Wenchuan earthquake显示文摘 | Zhiqin Xu Shaocheng Ji Haibing Li Liwei Hou Xiaofang Fu Zhihui Cai | 2008 | Episodes2008，31，3： | 106 |
| 2 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 3 | Identification and mapping of genes for improving yield from Chinese common wild rice (O.rufipogon Griff.) using advanced backcross QTL analysis显示文摘To identify useful genes from wild rice which have been lost or weakened in cultivated rice has become more and more important for modern breeding strategy. In this study, a BC4 population derived from 94W1, an accession of common wild rice (Oryza rufipogon Griff.) from Dongxiang in Jiangxi Province of China, as the donor, and a high-yielding Indica cultivar (O. sativa L.), 'Guichao 2', as the recipient, was used to identify quantitative trait loci (QTL) associated with yield and its components. Based on the analysis for the genotype of BC4F1 population with 87 SSR markers distributed throughout the genome and investigation of the plant height, yield and yield components of BC4F2, a total of 52 QTLs, were detected. Of 7 QTLs associated with grain yield per plant, 2 QTLs on chromosome 2 and chromosome 11 for grain yield, explaining 16% and 11% of the phenotypic variance respectively, were identified. The alleles from Dongxiang common wild rice in those two loci could increase the yield of 'Guichao 2' by | Dejun Li Chuanqing Sun Yongcai Fu Cheng Li Zuofeng Zhu Liang Chen Hongwei Cai Xiangkun Wang | 2002 | Chinese Science Bulletin2002，47，18： | 39 |
| 4 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 5 | Relationship between tumor necrosis factor-α and liver fibrosis显示文摘RelationshipbetweentumornecrosisfactorαandliverfibrosisWANGXin,CHENYueXiang,XUCaiFu,ZHAOGuoNing,HUANGYuXinandWANGQinLiD... | WANG Xin, CHEN Yue Xiang, XU Cai Fu, ZHAO Guo Ning, HUANG Yu Xin and WANG Qin Li Department of Gastroenterology, Tangdu Hospital, The Fourth Military Medical University, Xi′an 710038, Shaanxi Province, China | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 6 | Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis显示文摘Background:Psoriasis is a chronic inflammatory skin disease,affecting about 0.6%of the Chinese population.Many patients are not well controlled by conventional treatments,thus there is need for new treatment regimens.In this study,we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque psoriasis.Methods:This study was a 52-week,multicentre,randomized,double-blind,placebo-controlled,parallel-group,Phase 3 trial.A sub-population of study participants(≥18 years)of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab,or placebo.The co-primary endpoints were psoriasis area severity index(PASI)75 and Investigator’s Global Assessment(IGA)0/1 at Week 12.Results:A total of 441 Chinese patients were enrolled in this study.Co-primary outcomes were achieved;300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75(97.7%and 87.2%vs.3.7%,respectively;P<0.001),and IGA 0/1(82.3%and 69.7%vs.2.7%;P<0.001)at Week 12.Treatment efficacy was maintained until Week 52.There was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week period.Conclusion:Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis. | Lin Cai Jian-Zhong Zhang Xu Yao Jun Gu Quan-Zhong Liu Min Zheng Shi-Fa Zhang Jin-Hua Xu Cheng-Xin Li Hao Cheng Qing Guo Wei-Li Pan Shen-Qiu Li Ruo-Yu Li Zai-Pei Guo Zhi-Qi Song Shan-Shan Li Xiu-Qin Dong Linda Wang Rong Fu Pascaline Regnault Pascal Charef Ratal Mazur Manmath Patekar | 2020 | Chinese Medical Journal2020，，22： | 21 |
| 7 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 8 | Construction of habitat suitability models(HSMs) for benthic macroinvertebrate and their applications to instream environmental flows:A case study in Xiangxi River of Three Gorges Reservior region,China显示文摘Based on a long-term ecological monitoring, the present study chose the most dominant benthic macroinvertebrate (Baetis spp.) as tar- get organisms in Xiangxi River, built the habitat suitability models (HSMs) for water depth, current velocity and substrate, respectively, which is the first aquatic organisms model for habitat suitability in the Chinese Mainland with a long-term consecutive in situ measurement. In order to protect the biointegrity and function of the river ecosystem, the theory system of instream environmental flow should be cat- egorized into three hierarchies, namely minimum required instream flow (hydrological level), minimum instream environmental flow (bio- species level), and optimum instream environmental flow (ecosystem level). These three hierarchies of instream environmental flow models were then constructed with the hydrological and weighted usable area (WUA) method. The results show that the minimum required instream flow of Xiangxi River calculated by the Tennant method (10% of the mean annual flow) was 0.615 m3 s 1; the minimum instream environmental flow accounted for 19.22% of the mean annual flow (namely 1.182 m3 s 1), which was the damaged river channel flow in the dry season; and 42.91% of the mean annual flow (namely 2.639 m3 s 1) should be viewed as the optimum instream environmental flow in order to protect the health of the river ecosystem, maintain the instream biodiversity, and reduce the impact of small hydropower stations nearby the Xiangxi River. We recommend that the hydrological and biological methods can help establish better instream environmental flow models and design best management practices for use in the small hydropower station project. | Fengqing Li Qinghua Cai Xiaocheng Fu Jiankang Liu | 2009 | Progress in Natural Science:Materials International2009，19，3： | 18 |
| 9 | Surgical strategy for presacral tumors: analysis of 33 cases显示文摘背景 Presacral 肿瘤是位于因为在那里的 presacral 或 retrorectal space.Although 是在有恶意的 presacral 肿瘤的病人的预后的实质的改进,知道的空间的高度很少发生的肿瘤,更新的外科的策略的发展是可能的进一步改进这篇文章的 tumors.The 目的是在 33 种情况中报导我们的经验,并且考察外科的策略,病理学的特征和复杂并发症的预防的恶意的 presacral 的 oncologic 结果复发在外科以后在 18 个月内发生在 teratoma 的一种情况中,由 trans 骶的切除治好;本地复发和肺转移手术后地在 6 个月内在 angiosarcoma 的一种情况中同时发生了,病人一个月以后死于大多数 presacral 肿瘤的主要治疗是的呼吸 failure.Conclusions 外科的途径的外科的 resection.Selection 为 presacral tumors.The 地点的完全的切除术是很重要的,肿瘤,皮的条件和软纸巾和病人的尺寸和怪癖是体型都是限定词 factors. | LI Guo-dong CHEN Kai FU Dong MA Xiao-jun SUN Meng-xiong SUN Wei CAI Zheng-dong | 2011 | Chinese Medical Journal2011，，23： | 16 |
| 10 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 11 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 12 | Exogenous application of a low concentration of melatonin enhances salt tolerance in rapeseed(Brassica napus L.) seedlings显示文摘Melatonin is a naturally occurring compound in plants. Here, we tested the effect of exogenous melatonin on rapeseed(Brassica napus L.) grown under salt stress. Application of 30 μmol L^(–1) melatonin alleviated salt-induced growth inhibition, and the shoot fresh weight, the shoot dry weight, the root fresh weight, and the root dry weight of seedlings treated with exogenous melatonin increased by 128.2, 142.9, 122.2, and 124.2%, respectively, compared to those under salt stress. In addition, several physiological parameters were evaluated. The activities of antioxidant enzymes including peroxidase(POD), catalase(CAT) and ascorbate peroxidase(APX) were enhanced by 16.5, 19.3, and 14.2% compared to their activities in plants without exogenous melatonin application under salt stress, while the H_2O_2 content was decreased by 11.2% by exogenous melatonin. Furthermore, melatonin treatment promoted solute accumulation by increasing the contents of proline(26.8%), soluble sugars(15.1%) and proteins(58.8%). The results also suggested that higher concentrations(>50 μmol L^(–1)) of melatonin could attenuate or even prevent the beneficial effects on seedling development. In conclusion, application of a low concentration of exogenous melatonin to rapeseed plants under salt stress can improve the H_2O_2-scavenging capacity by enhancing the activities of antioxidant enzymes such as POD, CAT and APX, and can also alleviate osmotic stress by promoting the accumulation of osmoregulatory substances such as soluble proteins, proline, and water soluble glucan. Ultimately, exogenous melatonin facilitates root development and improves the biomass of rapeseed seedlings grown under salt stress, thereby effectively alleviating the damage of salt stress in rapeseed seedlings. | ZENG Liu CAI Jun-song LI Jing-jing LU Guang-yuan LI Chun-sheng FU Gui-ping ZHANG Xue-kun MA Hai-qing LIU Qing-yun ZOU Xi-ling CHENG Yong | 2018 | Journal of Integrative Agriculture2018，17，2： | 11 |
| 13 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 14 | Hepatic artery complications after orthotopic liver transplantation: interventional treatment or retransplantation?显示文摘背景为在 orthotopic 肝移植(OLT ) 以后的肝的动脉复杂并发症的主要治疗学的治疗包括 thrombolysis,经皮的 transluminal angioplasty, stent 放置,和肝移植。在 OLT 以后的肝的动脉复杂并发症的预后与类型有关不仅,程度,并且预定而且仔细与选择联系了并且治疗学的方法预定。然而,没有关于这些复杂并发症的治疗的意见的一致。这研究的目的是在 25 个病人的临床的数据与肝的动脉血栓(帽子) 和肝的动脉狭窄诊断了的 OLT.Methods 以后为肝的动脉复杂并发症决定最佳的治疗() 在 2003 年 10 月和 2007 年 3 月之间回顾地被考察。治疗包括了包含 thrombolysis,经皮的 transluminal angioplasty 和 stent 放置的肝移植和干预。在有帽子的五个病人之中的结果, 3 与 thrombolysis 被对待。一个人恢复了,一个人在 thrombolysis 以后死了,因为周期性的帽子,另一一个在移植以后死于多器官失败。留下 2 个病人经历了成功的移植并且在那以后幸存。在介绍与的 12 个病人之中手术后地在 1 个月以内有, 2 个病人由于不可逆的肝失败和另外一个经历了移植 10 个病人与干预被对待。肝功能没能在 3 个病人改善,因为 ischemic 胆管炎,移植在 stent 放置以后在 4 个病人被执行。在经历肝移植的 6 个病人之中,二分别地死于 intracranial 出血和感染。介绍与的八个病人手术后地在 1 个月以后有, 5 个病人与 interventional 管理被对待并且在 stent 以后恢复了放置。在另外一个之中, 3 个病人介绍了与, 2 病人的肝功能是稳定的,一个病人由于 ischemic 胆汁管 lesion.Conclusions 收到了迟了的肝移植个性化的治疗学的政体应该在在 OLT 以后对待肝的动脉复杂并发症被采用根据手术后的时期,打字并且 ischemic 胆汁管损害是否存在。肝移植是为有肝的动脉血栓的病人的最好的治疗。Interventional 治疗没有不可逆的肝失败,近来有或胆汁管局部缺血是适当的,而移植被推荐为早。 | YANG Yang LI Hua FU Bin-sheng ZHANG Qi ZHANG Ying-cai LU Ming-qiang CAI Chang-jie XU Chi WANG Gen-shu YI Shu-hong ZHANG Jian ZHANG Jun-feng YI Hui-min JIANG Nan JIANG Hua ZHU Kang-shun JIANG Zai-bo SHAN Hong CHEN Gui-hua | 2008 | Chinese Medical Journal2008，，20： | 9 |
| 15 | Electrochemical aptasensor for the detection of vascular endothelial growth factor(VEGF) based on DNA-templated Ag/Pt bimetallic nanoclusters显示文摘In this paper, the DNA-templated Ag/Pt bimetallic nanoclusters were successfully synthesized using an optimized synthetic scheme. The obtained DNA-Ag/Pt NCs have an ultrasmall particle size and excellent distribution. The DNA-Ag/Pt NCs show intrinsic peroxidase-mimicking activity and can effectively catalyze the H_2O_2-mediated oxidation of a substrate, 3,30,5,50-tetramethylbenzidine(TMB), to produce a blue colored product. Based on this specific property, we employed the aptamer of VEGF to design a label-free electrochemical biosensor for VEGF detection. Under the optimized experimental conditions, a linear range from 6.0 pmol/L to 20 pmol/L was obtained with a detection limit of 4.6 pmol/L. The proposed biosensor demonstrated its high specificity for VEGF and could directly detect the VEGF concentration in human serum samples of breast cancer patients with satisfactory results. This novel electrochemical aptasensor was simple and convenient to use and was cost-effective and label-free in design, and would hold potential applications in medical diagnosis and treatment. | Xian-Ming Fu Zhi-Jing Liu Shu-Xian Cai Yan-Ping Zhao Dong-Zhi Wu Chun-Yan Li Jing-Hua Chen | 2016 | Chinese Chemical Letters2016，27，6： | 9 |
| 16 | XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells显示文摘Autophagy 被激活响应滋养的饥饿维持细胞的精力动态平衡。然而, autophagy 固执地没被激活,它糟糕在机械学的水平被理解。这里,我们报导 FoxO1 的那周转涉及夫酸安饥饿引起的动态 autophagic 过程。X-box-binding protein-1u (XBP-1u ) 由招募在 FoxO1 降级有一个关键角色 FoxO1 到 20S proteasome。另外,由 Ser61 和 Ser176 上的细胞外的调整蛋白质 kinases1/2 (ERK1/2 ) 的 XBP-1u 的 phosphorylation 被发现在夫酸安饥饿之上为在 XBP-1u 和 FoxO1 之间的增加的相互作用批评。而且,引起 FoxO1 的持续水平和 autophagy 的坚持的激活的 XBP-1u 击倒,在房间生存能力导致重要减少。最后,在 XBP-1u 之间的反的关联和 FoxO1 表示同意很好,表示侧面在许多人的癌症纸巾观察了。因此,我们的调查结果连接到 XBP-1u-induced FoxO1 的 autophagy 的动态过程降级。 | Ying Zhao Xue Li Mu-Yan Cai Ke Ma Jing Yang Jingyi Zhou Wan Fu Fu-Zheng Wei Lina Wang Dan Xie Wei-Guo Zhu | 2013 | Cell Research2013，23，4： | 8 |
| 17 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 18 | Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial显示文摘Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney disease.Objective:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan potassium.Design,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical trial.Primary glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 mg.Main outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of treatment.Results:A total of 735 participants were enrolled.The percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg group.Compared with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein level.Compared with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine protein.With a superiority threshold of 15%,neither was statistically significant.eGFR,serum creatinine and serum albumin from the baseline did not change statistically significant.The average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any group.Conclusion:SYKFT decreased the proteinuria and improved the TCM syndrome scores of primary glomerulonephritis patients,with no change in the rate of decrease in the eGFR.SYKFT plus losartan potassium therapy decreased proteinuria more than losartan potassium therapy alone.Trial registration number:NCT02063100 on ClinicalTrials.gov. | Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua Wang Rong Wang Nian-song Wang Xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song Jian Chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen | 2021 | Journal of Integrative Medicine2021，19，2： | 8 |
| 19 | Early liver retransplantation versus late liver retransplantation: analysis of a single-center experience显示文摘背景 Orthotopic 肝移植(re-OLT ) 是为肝接枝的不可逆的失败的唯一的有效治疗。早、迟了的接枝失败让路给应该独立被讨论的二个不同临床的条件。这研究被设计比较早、迟了的 re-OLT 因为有差的接枝的病人在我们的中心在主要移植以后工作并且在 re-OLT.Methods 总结我们的临床的经验在我们到2007年2月的从2004年1月的中心的 31 re-OLTs 的临床的数据回顾地被分析,近来与 17 个盒子与早 re-OLT 和第二个组的 14 个盒子由第一个组组成胆汁的道复杂并发症是的 re-OLT.Results 为早 re-OLT (57.1%)的主要指示并且迟了另外的普通指示是在在迟了的 re-OLT 的主要疾病的早 re-OLT 和复发的脉管的复杂并发症。没有重要差别关于在操作,冷局部缺血时间,起作用的持续时间,和 perioperative 死亡期间流血的体积在这些组之间被发现;除了结束阶段肝疾病的模型(吞没) 分数。结果在迟了的 re-OLT 为在早 re-OLT 和 9 个病人的 7 个病人是致命的。二死亡由于在早 re-OLT 的严重败血相关的疾病由于有 3 死亡的多重机关失败,并且 4 死亡在迟了的 re-OLT 由于 hepatocellular 癌(HCC ) 的复发由于有 3 死亡的严重败血相关的疾病。分别地,在 re-OLT 以后的和 2 年的保险统计的幸存率为在早 re-OLT 的病人是 55.2% 和 36.9% ,并且 65.1% 和 52% 分别地,为在迟了的 re-OLT 的病人。没有重要差别关于在二 groups.Conclusions 之间的幸存率被发现类似的临床的结果能在早、迟了的 re-OLT 被完成。预定的合适的指示和最佳的操作,足够的外科手术前的准备,富有经验的外科的过程,和有效 perioperative 反感染策略在 re-OLT 以后贡献病人的全面幸存率的改进。 | CHEN Gui-hua FU Bin-sheng YANG Yang CAI Chang-jie LU Min-qiang LI Hua WANG Gen-shu YI Shu-hong XU Chi ZHANG Jun-feng ZHANG Tong WANG Guo-ying | 2008 | Chinese Medical Journal2008，，20： | 7 |
| 20 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021，31，8： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员