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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 3 | 西藏色季拉山林线冷杉种群结构与动态显示文摘急尖长苞冷杉(Abies georgei var.smithii)是西藏东南部地区高山林线森林群落的主要建群树种,主要分布在色季拉山海拔3600~4400m区域,并成为阴坡高山林线的优势树种。通过对色季拉山林线群落交错区域的定位调查,分析了急尖长苞冷杉的个体生长、种群结构与动态以及林线特征。分析结果表明:(1)西藏色季拉山海拔4320m处为森林郁闭上限,该区域存在两种类型的高山林线,阳坡为渐变型林线,林线树种为方枝柏(Sabina saltuaria);阴坡为急变型林线,林线树种为急尖长苞冷杉。阳坡与阴坡林线分布海拔上限分别为4570m和4390m,阳坡高于阴坡180m;阳坡与阴坡林线群落交错区垂直宽度分别为250m和70m,阳坡比阴坡宽180m。(2)阴坡海拔3700~3800m属急尖长苞冷杉分布的最适范围,种群径级结构表现为典型的反'J'型,种群密度约380株/hm2;种群年龄结构表现为'金字塔'型,属于扩展型种群。(3)静态生命表和种群存活曲线反映了急尖长苞冷杉种群在形成初期的20a和生长发育的60~160a分别经历了强烈的环境筛选和竞争自疏,以及后期与环境变化相关的死亡波动,200a左右为急尖长苞冷杉的生理寿命,种群后期基本稳定,400a左右为极限寿命。 | 任青山 杨小林 崔国发 王景升 黄瑜 WEI Xiao hua LI Qinglin | 2007 | 生态学报2007，27，7： | 70 |
| 4 | Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells显示文摘AIM:To investigate the roles and mechanism of signal transducer and activator of transcription 3 (STAT3) in invasion of human colon cancer cells by RNA interference. METHODS: Small interfering RNA (siRNA) targeting Signal transducer and activator of transcription 3 (STAT3) was transfected into HT29 colon cancer cells. STAT3 protein level and DNA-binding activity of STAT3 was evaluated by western blotting and electrophoretic mobility shift assay (EMSA), respectively. We studied the anchorage-independent growth using colony formation in soft agar, and invasion using the boyden chamber model, anoikis using DNA fragmentation assay and terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL), respectively. Western blot assay was used to observe the protein expression of Bcl-xL and survivin in colon cancer HT29 cells. RESULTS: RNA interference (RNAi) mediated by siRNA leads to suppression of STAT3 expression in colon cancer cell lines. Suppression of STAT3 expression by siRNA could inhibit anchorage-independent growth, and invasion ability, and induces anoikis in the colon cancer cell line HT29. It has been shown that knockdown of STAT3 expression by siRNA results in a reduction in expression of Bcl-xL and survivin in HT29 cells. CONCLUSION: These results suggest that STAT3 siRNA can inhibit the invasion ability of colon cancer cells through inducing anoikis, which antiapoptotic genes survivin and Bcl-xL contribute to regulation of anoikis.These studies indicate STAT3 siRNA could be a useful therapeutic tool for the treatment of colon cancer. | Yu Fan You-Li Zhang Ying Wu Wei Zhang Yin-Huan Wang Zhao-Ming Cheng Hua Li | 2008 | World Journal of Gastroenterology2008，14，3： | 51 |
| 5 | Association factors of target organ damage: analysis of 17 682 elderly hypertensive patients in China显示文摘背景高血压的目标机关损坏(狐)在在亚洲的高血压的狐上的老高血压的 patients.The 研究是为死亡或残疾的主要原因,特别在中国老高血压的病人,很这研究的 limited.The 目的是在这是的更旧的中国高血压的 inpatients.Methods 评估狐的流行和关联词因素回顾的调查和数据从 19 | CUI Hua WANG Fan FAN Li HU Yi-xin HU Guo-liang LIU Lin HONG Chang-ming | 2011 | Chinese Medical Journal2011，，22： | 60 |
| 6 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 7 | Spatial pattern of impervious surfaces and their impacts on land surface temperature in Beijing,China显示文摘陆地表面温度( LST )被城市的 surfacestructures 重重地影响,是在检验的城市的环境 analysis.This 学习的一个重要参数 effectimpervious 表面()空间模式在北京穿上 LST , China.A 分类 andregression 树模型(大车)被收养估计作为用二个季节与 QuickBird.LST 相结合的 Landsat imagesfrom 的一个连续变量从 Landsat 题目的 Mapper ( TM )图象被检索检验在之间的关系并且 | XIAO Rong-bo OUYANG Zhi-yun ZHENG Hua LI Wei-feng SCHIENKE Erich W WANG Xiao-ke | 2007 | Journal of Environmental Sciences2007，19，2： | 47 |
| 8 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 9 | Neurons secrete miR-132.containing exosomes to regulate brain vascular integrity显示文摘脉管的完整帮助维持大脑微型环境动态平衡,它为中央神经系统的正常开发和函数是批评的。神经房间能调整大脑,这被知道脉管的正直。由于包含的神经与血管的相互作用的高复杂性,不管多么大脑的神经规定理解脉管的正直仍然是原始的。用未经触动的 zebrafish 幼虫和有教养的啮齿类动物大脑房间,我们发现神经原转移 miR-132,一高度保存了并且充实神经原的 microRNA,经由到 endothelial 房间(EC ) 到的 secreting exosomes 维持大脑脉管的正直。后面的 translocation 到通过 exosome 成为主观的 EC, miR-132 调整脉管的 endothelial cadherin (VE-cadherin ) 的表示,重要 adherens 连接蛋白质,由直接指向真核细胞的延伸因素 2 kinase (eef2k ) 。neuronal miR-132 表示或 exosome 分泌物的混乱,或脉管的 eef2k 的 overexpression 损害 VE-cadherin 表示和大脑脉管的正直。我们的学习显示 miR-132 作为调停的一个细胞间的信号扮演大脑的神经规定脉管的完整并且建议 neuronal exosome 是为神经与血管的通讯的一条新奇大街。 | Bing Xu Yu Zhang Xu-Fei Du Jia Li Hua-Xing Zi Ji-Wen Bu Yong Yan Hua Han Jiu-Lin Du | 2017 | Cell Research2017，27，7： | 46 |
| 10 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 11 | Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015显示文摘Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required. | SONG Peng Kun MAN Qing Qing LI Hong PANG Shao Jie JIA Shan Shan LI Yu Qian HE Li ZHAO Wen Hua ZHANG Jian | 2019 | Biomedical and Environmental Sciences2019，32，8： | 45 |
| 12 | Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus显示文摘Since December 2019,an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China.As of 8 pm,31 January 2020,more than 20 pediatric cases have been reported in China.Of these cases,ten patients were identified in Zhejiang Province,with an age of onset ranging from 112 days to 17 years.Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCo V (the 4th edition) and current status of clinical practice in Zhejiang Province,recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health,the National Children's Regional Medical Center,Children's Hospital,Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. | Zhi-Min Chen Jun-Fen Fu Qiang Shu Ying-Hu Chen Chun-Zhen Hua Fu-Bang Li Ru Lin Lan-Fang Tang Tian-Lin Wang Wei Wang Ying-Shuo Wang Wei-Ze Xu Zi-Hao Yang Sheng Ye Tian-Ming Yuan Chen-Mei Zhang Yuan-Yuan Zhang | 2020 | World Journal of Pediatrics2020，16，3： | 45 |
| 13 | Small sphincterotomy combined with endoscopic papillary large balloon dilation vs sphincterotomy alone for removal of common bile duct stones显示文摘AIM:To evaluate the efficacy and safety of endoscopic papillary large diameter balloon dilation(EPLBD)following limited endoscopic sphincterotomy(EST)and EST alone for removal of large common bile duct(CBD)stones.METHODS:We retrospectively compared EST+EPLBD(group A,n=64)with EST alone(group B,n=89)for the treatment of large or multiple bile duct stones.The success rate of stone clearance,procedure-related complications and incidents,frequency of mechanical lithotripsy use,and recurrent stones were recorded.RESULTS:There was no statistically significant difference between the two groups regarding periampullary diverticula(35.9%vs 34.8%,P>0.05),pre-cut sphincterotomy(6.3%vs 6.7%,P>0.05),size(12.1±2.0mm vs 12.9±2.6 mm,P>0.05)and number(2.2±1.9vs 2.4±2.1,P>0.05)of stones or the diameters of CBD(15.1±3.3 mm vs 15.4±3.6 mm,P>0.05).The rates of overall stone removal and stone removal in the first session were not significantly different between the two groups[62/64(96.9%)vs 84/89(94.4%),P>0.05;and 58/64(90.6%)vs 79/89(88.8%),P>0.05,respectively].The rates of post-endoscopic retrograde cholangiopancreatography pancreatitis and hyperamylasemia were not significantly different between the two groups[3/64(4.7%)vs 4/89(4.5%),P>0.05;7/64(10.9%)vs 9/89(10.1%),P>0.05,respectively].There were no cases of perforation,acute cholangitis,or cholecystitis in the two groups.The rate of bleeding and the recurrence of CBD stones were significantly lower in group A than in group B[1/64(1.6%)vs 5/89(5.6%),P<0.05;1/64(1.6%)vs 6/89(6.7%),P<0.05,respectively].CONCLUSION:EST+EPLBD is an effective and safe endoscopic approach for removing large or multiple CBD stones. | Shi-Bin Guo Hua Meng Zhi-Jun Duan Chun-Yan Li | 2014 | World Journal of Gastroenterology2014，20，47： | 43 |
| 14 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 15 | Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma显示文摘MicroRNAs 是否定地在 post-transcriptional 水平调制基因表示的短规章的 RNA,并且深深地涉及癌症的几种类型的致病。调查特定的 miRNAs 和他们的目标基因是否参予喉的癌的分子的致病, oligonucleotide microarrays 被用来与正常纸巾相比在喉的癌纸巾估计 microRNAs 和 mRNAs 的微分表示侧面。oncogenic miRNA, microRNA-21 (miR-21 ) ,被发现是在喉的癌纸巾的 upregulated。由特定的 antisense oligonucleotides 的 miR-21 击倒而 miR-21 的 overexpression 提高了细胞的生长活动,由殖民地形成试金检测了,禁止了 HEp-2 细胞的增长潜力。miR-21 抑制引起的房间数字减小由于 G1-S 阶段转变的控制的损失,而不是 apoptosis 的显著增加。随后, miR-21 的新目标基因, BTG2,被发现是在喉的癌纸巾的 downregulated。BTG2 被知道充当一个平底锅房间周期管理者和肿瘤 suppressor。这些调查结果显示 miR-21 的那异常表情可以由维持 BTG2 的底层贡献喉的癌的恶意的显型。oncogenic miR-21 和它的目标基因的鉴定, BTG2,为癌症诊断和治疗在喉的癌是潜在地珍贵的。 | Min Liu Haidong Wu Tao Liu Yixuan Li Fang Wang Haiying Wan Xin Li Hua Tang | 2009 | Cell Research2009，19，7： | 40 |
| 16 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 17 | The edaravone and 3-n-butylphthalide ring-opening derivative lob effectively attenuates cerebral ischemia injury in rats显示文摘目的: 复合 10b 是 edaravone 和 3-n-butylphthalide (NBP ) 的戒指洞衍生物的一个混合分子。这研究的目的是在焦点的服的局部缺血以后在老鼠在大脑损坏上检验复合 10b 的效果。 | Kai HUA Xiao SHENG Ting-ting LI Lin-na WANG Yi-hua ZHANG Zhang-jian HUANG Hui JI | 2015 | Acta Pharmacologica Sinica2015，36，8： | 35 |
| 18 | The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022显示文摘Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3). | Hua Zhao Wenling Wang Li Zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong Changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，38： | 35 |
| 19 | Microstructures and Mechanical Properties of Fe-Mn-(Al, Si) TRIP/TWIP Steels显示文摘The mechanical properties and microstructure of two low carbon high manganese steels with 23.8% (No.1) and 33% (No.2) (mass percent) of manganese were investigated. The results showed that No.1 steel possesses high strength and high plasticity, and No.2 steel has a relatively high strength and extraordinary plasticity. The No.1 steel exhibits both TRIP (transformation induced plasticity) and TWIP (twin induced plasticity) effects during the deformation; while only TWIP effect appeared under the same deformation condition for No.2 steel. The comparison between the microstructures and mechanical properties of two steels was made, and the strengthening mechanisms were also analyzed. | DING Hua TANG Zheng-You LI Wei WANG Mei SONG Dan | 2006 | Journal of Iron and Steel Research(International)2006，13，6： | 31 |
| 20 | Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells显示文摘这研究检验了 shikonin 导致的发信号的事件在 Bcr/Abl-positive 导致 apoptosis 的正式就职长期的骨髓内产生的白血病(电流型逻辑) 房间(例如, K562, LAMA84 ) 。有 shikonin 的 K562 细胞的处理(例如, 0.5 M )导致了反应的氧种类( ROS )的快速的产生伴随的 apoptosis 的深刻正式就职,打击 c-Jun-N-terminal kinase ( JNK )和 p38 的激活, mitochondrial 蛋白质细胞色素 c 和 Smac/DIABLO 的显著版本, PARP 的 caspase-9 和-3,和劈开的激活。完全 ROS 清除堵住了所有上述事件(即, apoptosis 的 JNK 和 p38 phosphorylation,细胞色素 c 和 Smac/DIABLO 版本, caspase 和 PARP 劈开,以及正式就职) 后面的 shikonin 处理。JNK 的抑制并且 JNK1 击倒显著地稀释的细胞色素 c 版本, caspase 劈开和 apoptosis,但是没影响调停 shikonin 的 ROS 生产。另外, caspase 激活的抑制完全堵住了导致 shikonin 的 apoptosis,但是有点没修改调停 shikonin 的细胞色素 c 版本或 ROS 产生。总的来说,这些调查结果证明导致 shikonin 的氧化损害在 apoptotic 发信号在一个近似的点操作串联,并且随后激活,并且导致 apoptosis 压力相关的 JNK 小径,扳机 mitochondrial 机能障碍,细胞色素 c 版本,和 caspase 激活。我们的数据也建议 shikonin 可以是为电流型逻辑的处理的一个有希望的代理人,, ROS 的一个发电机。 | Xin Mao Chun Rong Yu Wen Hua Li Wen Xin Li | 2008 | Cell Research2008，18，8： | 31 |
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