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| 1 | Recent advances in energy storage mechanism of aqueous zinc-ion batteries显示文摘Aqueous rechargeable zinc-ion batteries(ZIBs)have recently attracted increasing research interest due to their unparalleled safety,fantastic cost competitiveness and promising capacity advantages compared with the commercial lithium ion batteries.However,the disputed energy storage mechanism has been a confusing issue restraining the development of ZIBs.Although a lot of efforts have been dedicated to the exploration in battery chemistry,a comprehensive review that focuses on summarizing the energy storage mechanisms of ZIBs is needed.Herein,the energy storage mechanisms of aqueous rechargeable ZIBs are systematically reviewed in detail and summarized as four types,which are traditional Zn^(2+)insertion chemistry,dual ions co-insertion,chemical conversion reaction and coordination reaction of Zn^(2+)with organic cathodes.Furthermore,the promising exploration directions and rational prospects are also proposed in this review. | Duo Chen Mengjie Lu Dong Cai Hang Yang Wei Han | 2021 | Journal of Energy Chemistry2021，30，3： | 12 |
| 2 | 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1显示文摘 | Huirong Yang Jia Wang Mengjie Liu Xizi Chen Min Huang Dan Tan Meng-Qiu Dong Catherine C. L, Wong Jiawei Wang Yanhui Xu Hong-Wei Wang | 2016 | Protein & Cell2016，7，12： | 7 |
| 3 | Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats显示文摘Male Wistar 7-day-old rats were injected with 40 mg/kg ketamine intraperitoneally, followed by three additional injections of 20 mg/kg ketamine each upon restoration of the righting reflex. Neonatal rats injected with equivalent volumes of saline served as controls. Hippocampal samples were collected at 1, 7 or 14 days following administration. Electron microscopy showed that neuronal structure changed noticeably following ketamine treatment. Specifically, microtubular structure became irregular and disorganized. Quantitative real time-PCR revealed that phosphorylated tau mRNA was upregulated after ketamine. Western blot analysis demonstrated that phosphorylated tau levels at serine 396 initially decreased at 1 day after ketamine injection, and then gradually returned to control values. At 14 days after injection, levels of phosphorylated tau were higher in the ketamine group than in the control group. Tau protein phosphorylated at serine 404 significantly increased after ketamine injection, and then gradually decreased with time. However, the levels of tau protein at serine 404 were significantly greater in the ketamine group than in the control group until 14 days. The present results indicate that ketamine induces an increase of phosphorylated tau mRNA and excessive phosphorylation of tau protein at serine 404, causing disruption of microtubules in the neonatal rat hippocampus and potentially resulting in damage to hippocampal neurons. | Haiyan Jin Zhiyong Hu Mengjie Dong Yidong Wu Zhirui Zhu Lili Xu | 2013 | Neural Regeneration Research2013，8，17： | 5 |
| 4 | Artificial intelligence in gastric cancer:applications and challenges显示文摘Gastric cancer(GC)is one of the most common malignant tumors with high mortality.Accurate diagnosis and treatment decisions for GC rely heavily on human experts’careful judgments on medical images.However,the improvement of the accuracy is hindered by imaging conditions,limited experience,objective criteria,and inter-observer discrepancies.Recently,the developments of machine learning,especially deep-learning algorithms,have been facilitating computers to extract more information from data automatically.Researchers are exploring the far-reaching applications of artificial intelligence(AI)in various clinical practices,including GC.Herein,we aim to provide a broad framework to summarize current research on AI in GC.In the screening of GC,AI can identify precancerous diseases and assist in early cancer detection with endoscopic examination and pathological confirmation.In the diagnosis of GC,AI can support tumor-node-metastasis(TNM)staging and subtype classification.For treatment decisions,AI can help with surgical margin determination and prognosis prediction.Meanwhile,current approaches are challenged by data scarcity and poor interpretability.To tackle these problems,more regulated data,unified processing procedures,and advanced algorithms are urgently needed to build more accurate and robust AI models for GC. | Runnan Cao Lei Tang Mengjie Fang Lianzhen Zhong Siwen Wang Lixin Gong Jiazheng Li Di Dong Jie Tian | 2022 | Gastroenterology Report2022，10，1： | 3 |
| 5 | Simultaneously improving strength and ductility through laminate structure design in Mg–8.0Gd–3.0Y-0.5Zr alloys显示文摘The laminate structure was applied to improve the mechanical properties of Mg-8.0 Gd-3.0 Y-0.5 Zr alloys.Two types of laminate structures only with different distribution positions of fine grains were produced by friction-stir processing.Results show that the trilayer structure sample exhibits an excellent strengthductility synergy compared to the homogenous structure and bilayer structure.The enhanced mechanical properties are resulted from the hetero-deformation induced(HDI)stress strengthening and strain hardening which would be enhanced by increasing the quantity of interface.These observations suggest a crucial role of the number of interfaces in designing the laminate structure. | Jing Li Mengjie Zhao Li Jin Fenghua Wang Shuai Dong Jie Dong | 2021 | Journal of Materials Science & Technology2021，，12： | 2 |
| 6 | CT radiomics can help screen the coronavirus disease2019(COVID-19): a preliminary study显示文摘The coronavirus disease 2019(COVID-19) is raging across the world.The radiomics,which explores huge amounts of features from medical image for disease diagnosis,may help the screen of the COVID-19.In this study,we aim to develop a radiomic signature to screen COVID-19 from CT images.We retrospectively collect 75 pneumonia patients from Beijing Youan Hospital,including 46 patients with COVID-19 and 29 other types of pneumonias.These patients are divided into training set(n = 50) and test set(n = 25) at random.We segment the lung lesions from the CT images,and extract 77 radiomic features from the lesions.Then unsupervised consensus clustering and multiple cross-validation are utilized to select the key features that are associated with the COVID-19.In the experiments,while twenty-three radiomic features are found to be highly associated with COVID-19,four key features are screened and used as the inputs of support vector machine to build the radiomic signature.We use area under the receiver operating characteristic curve(AUC) and calibration curve to assess the performance of our model.It yields AUCs of 0.862 and 0.826 in the training set and the test set respectively.We also perform the stratified analysis and find that its predictive ability is not affected by gender,age,chronic disease and degree of severity.In conclusion,we investigate the value of radiomics in screening COVID-19,and the experimental results suggest the radiomic signature could be a potential tool for diagnosis of COVID-19. | Mengjie FANG Bingxi HE Li LI Di DONG Xin YANG Cong LI Lingwei MENG Lianzhen ZHONG Hailin LI Hongjun LI Jie TIAN | 2020 | Science China(Information Sciences)2020，63，7： | 2 |
| 7 | Morbidity Analysis of the Notifiable Infectious Diseases in China,2018显示文摘Introduction Notifiable infectious disease surveillance is important for understanding the trends in morbidity for certain diseases,especially detection of acute infectious disease outbreaks and changing epidemiology.A web-based reporting system was deployed in January 2004,which has improved data collection and speed tremendously.This report provides an updated analysis for reports published in 2013 and 2015.Methods Data from the National Notifiable Disease Reporting System(NNDRS)was used.The NNRDS shows data from 39 notifiable diseases split into three categories(A,B,and C)based on severity and importance.A descriptive analysis was conducted to analyze the morbidity of notifiable diseases in China.Results In 2018,the morbidity of national notifiable diseases was 559.41 per 100,000 population,an increase of 12.88% compared with the average of 2015–2017.The proportion of laboratory confirmed cases was 36.22%,which decreased 4.03% compared with the average of that in the recent three years.Diseases transmitted by direct contact/fecal–oral transmission accounted for the largest proportion,49.37% of the total reported cases,followed by the respiratory transmitted diseases,blood-borne/sexually transmitted diseases,and the zoonotic and vectorborne diseases with a proportion of 25.18%,24.60%,and 0.85%,respectively.Pathogenic descriptive analysis showed that the viral-infected cases accounted for 73.78% of the totals,followed by the bacterialinfected and parasitic diseases.Conclusion The national morbidity of notifiable infectious diseases showed increases in 2018,mostly due to higher morbidity of category C diseases,such as HFMD,infectious diarrhea,and influenza,and these diseases need to be further prioritized in disease control and prevention efforts.Laboratory confirmed cases remain low and need to be improved to improve data quality. | Shuaibing Dong Xiang Ren Cuihong Zhang Mengjie Geng Yuliang Zhu Lusha Shi Lijie Zhang Zhongjie Li Liping Wang | 2019 | China CDC weekly2019，1，4： | 2 |
| 8 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 9 | Design and experiment of visual navigated UGV for orchard based on Hough matrix and RANSAC显示文摘The objective of this study was to develop a visual navigation system capable of navigating an unmanned ground vehicle(UGV)travelling between tree rows in the outdoor orchard.Thus far,while most research has developed algorithms that deal with ground structures in the orchard,this study focused on the background of canopy plus sky to eliminate the interference factors such as inconsistent lighting,shadows,and color similarities in features.Aiming at the problem that the traditional Hough transform and the least square method are difficult to be applied under outdoor conditions,an algorithm combining Hough matrix and random sample consensus(RANSAC)was proposed to extract the navigation path.In the image segmentation stage,this study used an H-component that was adopted to extract the target path of the canopy plus sky.Then,after denoising and smoothing the image by morphological operation,line scanning was used to determine the midpoint of the target path.For navigation path extraction,this study extracted the feature points through Hough matrix to eliminate the redundant points,and RANSAC was used to reduce the impact of the noise points caused by different canopy shapes and fit the navigation path.The path acquisition experiment proved that the accuracy of Hough matrix and RANSAC method was 90.36%-96.81%and the time consumption of the program was within 0.55 s under different sunlight intensities.This method was superior to the traditional Hough transform in real-time and accuracy,and had higher accuracy,slightly worse real-time compared with the least square method.Furthermore,the OPENMV was used to capture the ground information of the orchard.The experiment proved that the recognition rate of OPENMV for identifying turning information was 100%,and the program running time was 0.17-0.19 s.Field experiments showed that the UGV could autonomously navigate the rows with a maximum lateral error of 0.118 m and realize the automatic turning of the UGV.The algorithm satisfied the practical operation requirements of autonomous vehicles in the orchard.So the UGV has the potential to guide multipurpose agricultural vehicles in outdoor orchards in the future. | Mingkuan Zhou Junfang Xia Fang Yang Kan Zheng Mengjie Hu Dong Li Shuai Zhang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，6： | 1 |
| 10 | Explicating the Role of Metal Centers in Porphyrin-Based MOFs of PCN-222(M) for Electrochemical Reduction of CO_(2)显示文摘The porphyrin-based MOFs formed by combining Zrclusters and porphyrin carboxylic acids with clear M-Nactive centers show unique advantages in electrocatalytic reduction of CO(CORR). However, its conductivity is still the bottleneck that limits its catalytic activity due to the electrical insulation of the Zr cluster. Therefore, the porphyrin-based MOFs of PCN-222(M)(M = Mn, Co, Ni, Zn) with explicit M-Ncoordination were combined with the highly conductive material carbon nanotube(CNT) for discussing the influence of metal centers on the CORR performance based on theoretical calculations and experimental observations. The results show that the PCN-222(Mn)/CNT, PCN-222(Co)/CNT, and PCN-222(Zn)/CNT all exhibit high selectivity to CO(FECO > 80%) in the range of-0.60 to-0.70 V vs. RHE. The FECOmax of PCN-222(Mn)/CNT(-0.60 V vs. RHE), PCN-222(Co)/CNT(-0.65 V vs. RHE), and PCN-222(Zn)/CNT(-0.70 V vs.RHE) are 88.5%, 89.3% and 92.5%, respectively. The high catalytic activity of PCN-222(Mn)/CNT and PCN-222(Co)/CNT comes from the excellent electron mobility of their porphyrin rings and their low ΔG*COOH(0.87 and 0.58 eV). It reveals that the strength of backbonding π of the transition metal and its influence on the electron mobility in the porphyrin ring can affect its CORR activity. | Mengjie Liu Mengting Peng Baoxia Dong Yunlei Teng Ligang Feng Qiang Xu | 2022 | Chinese Journal of Structural Chemistry2022，41，7： | 1 |
| 11 | Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms显示文摘 | Demin Cai Junjian Wang Yimin Jia Haoyu Liu Mengjie Yuan Haibo Dong Ruqian Zhao | 2016 | BBA - Molecular and Cell Biology of Lipids2016，，： | 1 |
| 12 | The microgravity enhanced polymer-mediated siRNA gene silence by improving cellular uptake显示文摘Microgravity(MG)effect is a weightlessness phenomenon caused by the distance from the ground or low gravity of other planets outside the earth's atmosphere.The various effects of MG have been corroborated in human and animal studies and modeled in cell-based analogs.However,the impact of MG on siRNA performance remains to be elucidated,which is crucial for aerospace medicine.In this study,we prepared nucleic acid nanomicelles(EAASc/siRNA)by using tri-block copolymer of PEG45-PAMA40-P(C7A36-DBA37)(EAASc)and siRNA and explored its working mechanism under simulated microgravity(SMG)condition generated by a random positioning machine(RPM).The binding ability of EAASc to siRNA and silence activity were firstly confirmed in normal gravity(NG)environment.Evaluation of PLK1 mRNA expression revealed that gene inhibition efficiencies were increased by 28.7%(HepG2)and 28.9%(A549)under SMG condition,compared with those under NG condition.In addition,mechanism exploration indicated that morphology and migration capability of cancer cells were significantly changed,the internalization of EAASc/siRNA by cells was magnified when the cells were incubated with RPM.No significant difference was observed regarding the expression profiles of genes involved in RNA interference(RNAi)pathway,including Ago2,Dicer,TRBP,and so on.Taken together,siRNA activity was elevated under SMG condition owning to increased cellular internalization.This study,for the first time to our knowledge,provides valuable theory for development and application of siRNA therapeutic in space in the future. | Tongren Yang Chanchan Yu Changrong Wang Chunhui Li Mengjie Zhang Xiaofan Luo Yuhua Weng Anjie Dong Xiaoqiong Li Yulin Deng Yuanyu Huang | 2020 | Biophysics Reports2020，6，6： | 1 |
| 13 | Experimental models for cancer brain metastasis显示文摘Brain metastases are a leading cause of cancer-related mortality.However,progress in their treatment has been limited over the past decade,due to an incomplete understanding of the underlying biological mechanisms.Employing accurate in vitro and in vivo models to recapitulate the complexities of brain metastasis offers the most promising approach to unravel the intricate cellular and physiological processes involved.Here,we present a comprehensive review of the currently accessible models for studying brain metastasis.We introduce a diverse array of in vitro and in vivo models,including cultured cells using the Transwell system,organoids,microfluidic models,syngeneic models,xenograft models,and genetically engineered models.We have also provided a concise summary of the merits and limitations inherent to each model while identifying the optimal contexts for their effective utilization.This review serves as a comprehensive resource,aiding researchers in making well-informed decisions regarding model selection that align with specific research questions. | Zihao Liu Shanshan Dong Mengjie Liu Yuqiang Liu Zhiming Ye Jianhao Zeng Maojin Yao | 2024 | Cancer Pathogenesis and Therapy2024，2，1： | 0 |
| 14 | Mono-dispersed Ag nanoparticles decorated graphitic carbon nitride:An excellent lubricating additive as PPESK composite film显示文摘Studies show that two dimensional(2D)nanomaterial and its hybrid have a great promise in tribology for the special laminar microstructure.However,the majority of performed investigations about 2D graphitic carbon nitride(g-C_(3)N_(4))nanosheets are most focused on energy storage,catalysis,adsorption,rarely tribology.In the present study,g-C_(3)N_(4) supporting mono-dispersed Ag nanoparticle hybrid(g-C_(3)N_(4)/Ag)is prepared,and its microstructure and chemical composition are determined.More specifically,the tribological performance as the lubricating additive of poly phthalazinone ether sulfone ketone(PPESK)composite is investigated using the ball-on-disc friction tester.Moreover,the corresponding enhancement mechanism is well proposed based on the experimental analysis and theoretical simulation.Obtained results show that Ag nanoparticles with a size of about 10-20 nm are homogeneously anchored on g-C_(3)N_(4) nanosheets,favoring for good compatibility between g-C_(3)N_(4)/Ag and PPESK.It is found that when 0.3 wt%of g-C_(3)N_(4)/Ag is added to PPESK,the friction coefficient and wear rate of PPESK decrease by 68.9%and 97.1%,respectively.These reductions are mainly attributed to the synergistic self-lubricating effect of Ag nanoparticles and g-C_(3)N_(4) nanosheet,the formation of transfer film,as well as the limited effect of g-C_(3)N_(4)/Ag on the shear deformation of PPESK composite film.Furthermore,it is found that the proposed g-C_(3)N_(4)/Ag-PPESK composite still keeps reasonable friction-reducing and wear-resistant properties under heavy loads and high rotating speeds.The present study demonstrates that the proposed g-C_(3)N_(4)/Ag hybrid is an excellent lubricating additive for polymer composites. | Beibei CHEN Mengjie ZHANG Kan ZHANG Zhe DONG Jiaye LI Gai ZHAO | 2022 | Friction2022，10，5： | 0 |
| 15 | Holographic insulator/superconductor phase transitions with excited states显示文摘We construct a family of solutions of the holographic insulator/superconductor phase transitions with the excited states in the AdS soliton background by using both the numerical and analytical methods. The interesting point is that the improved SturmLiouville method can not only analytically investigate the properties of the phase transition with the excited states, but also the distributions of the condensed fields in the vicinity of the critical point. We observe that, regardless of the type of the holographic model, the excited state has a higher critical chemical potential than the corresponding ground state, and the difference of the dimensionless critical chemical potential between the consecutive states is around 2.4, which is different from the finding of the metal/superconductor phase transition in the Ad S black hole background. Furthermore, near the critical point, we find that the phase transition of the systems is of the second order and a linear relationship exists between the charge density and chemical potential for all the excited states in both s-wave and p-wave insulator/superconductor models. | Liang OuYang Dong Wang XiongYing Qiao MengJie Wang QiYuan Pan JiLiang Jing | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，4： | 0 |
| 16 | Immigration,transformation,and emission control of sulfur and nitrogen during gasification of MSW:Fundamental and engineering review显示文摘This paper proposes a comprehensive summary and analysis of an important issue during municipal solid waste(MSW)gasification-sulfur and nitrogen pollution.It provides an overview of the fundamentals of MSW and the basic aspects of nitrogen and sulfur elements.Their characteristics of immigration,transformation and distribution during gasification with control solutions in realized or potential engineering are also concluded.The analysis indicates that the complete scenario of the occurrence form of sulfur and nitrogen elements in MSW is difficult to obtain,owing to the diverse sources and complicated compositions.However,with the assistance of advanced characterization and quantification methods(XPS,XRD,TG-FTIR,et al.),the common sulfur-and nitrogen-containing compounds in both organic and inorganic states can be detected.Adjustment of gasification conditions can regulate the transformation of these elements for emission control.The multiple pollutants including H_(2)S,SO_(x),COS,NH_(3),HCN and NO_(x)cannot be eliminated by one-step treatment but a combination of adsorption and catalytic treatments may realize the control goal.This research aims to benefit meeting emission standards during MSW gasification and to provide a reference for other processes such as incineration,pyrolysis and other feedstocks like biomass and refuse derived fuel(RDF). | Shuchao Cheng Xueyu Ding Xinxin Dong Mengjie Zhang Xinqi Tian Yang Liu Yaji Huang Baosheng Jin | 2023 | Carbon Resources Conversion2023，6，3： | 0 |
| 17 | Enhanced Hydrogen Embrittlement Resistance via Cr Segregation in Nanocrystalline Fe-Cr Alloys显示文摘Hydrogen is a clean fuel with numerous sources,yet the hydrogen industry is plagued by hydrogen embrittlement(HE)issues during the storage,transportation,and usage of hydrogen gas.HE can compromise material performance during service,leading to significant safety hazards and economic losses.In the current work,the influence of element Cr on the HE resistance of nanocrystalline Fe-Cr alloys under different hydrogen concentrations and strain rates was evaluated.With hybrid Monte Carlo(MC)and molecular dynamics(MD)simulations,it was found that Cr atoms were segregated at grain boundaries(GB)and inhibited the GB decohesion.Correspondingly,Cr segregation improved the strength and plasticity of the nanocrystalline Fe-Cr alloys,especially the HE resistance.Moreover,the Cr segregation reduced the diffusion coefficient of hydrogen and inhibited hydrogen-induced cracking.This work provided new insight into the development of iron-based alloys with high HE resistance in the future. | Linshuo Dong Feiyang Wang Hong-Hui Wu Mengjie Gao Penghui Bai Shuize Wang Guilin Wu Junheng Gao Xiaoye Zhou Xinping Mao | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，12： | 0 |
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