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| 1 | Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats显示文摘Male Wistar 7-day-old rats were injected with 40 mg/kg ketamine intraperitoneally, followed by three additional injections of 20 mg/kg ketamine each upon restoration of the righting reflex. Neonatal rats injected with equivalent volumes of saline served as controls. Hippocampal samples were collected at 1, 7 or 14 days following administration. Electron microscopy showed that neuronal structure changed noticeably following ketamine treatment. Specifically, microtubular structure became irregular and disorganized. Quantitative real time-PCR revealed that phosphorylated tau mRNA was upregulated after ketamine. Western blot analysis demonstrated that phosphorylated tau levels at serine 396 initially decreased at 1 day after ketamine injection, and then gradually returned to control values. At 14 days after injection, levels of phosphorylated tau were higher in the ketamine group than in the control group. Tau protein phosphorylated at serine 404 significantly increased after ketamine injection, and then gradually decreased with time. However, the levels of tau protein at serine 404 were significantly greater in the ketamine group than in the control group until 14 days. The present results indicate that ketamine induces an increase of phosphorylated tau mRNA and excessive phosphorylation of tau protein at serine 404, causing disruption of microtubules in the neonatal rat hippocampus and potentially resulting in damage to hippocampal neurons. | Haiyan Jin Zhiyong Hu Mengjie Dong Yidong Wu Zhirui Zhu Lili Xu | 2013 | Neural Regeneration Research2013，8，17： | 5 |
| 2 | Involvement of long non-coding RNAs in the progression of esophageal cancer显示文摘Esophageal cancer(EC)is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide.Therefore,exploring the pathogenesis of ECand searching for new targeted therapies are the current research hotspot for EC treatment.Long non-coding RNAs(lncRNAs)are endogenous RNAs with more than 200 nucleotides,but without proteincoding function.In recent years,lncRNAs have gradually become the focuses in the field of non-coding RNA.Some lncRNAs have been proved to be closely related to the pathogenesis of EC.Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation,apoptosis,and metastasis by inhibiting or promoting target gene expression.LncRNAs can also regulate the progression of EC through epithelial-mesenchymal transformation(EMT),which is closely related to the occurrence,development,and prognosis of EC.In this article,we review and discuss the involvement of lncRNAs in the progression of EC. | Wenhua Xue Yuanyuan Zheng Zhibo Shen Lifeng Li Zhirui Fan Wenbin Wang Zijia Zhu Yunkai Zhai Jie Zhao Quancheng Kan | 2021 | Cancer Communications2021，41，5： | 4 |
| 3 | Air quality for metals and sulfur in Shanghai, China, determined with moss bags显示文摘 | Tong Cao Min Wang Li An Yinghao Yu Yuxia Lou Shuiliang Guo Benrong Zuo Yan Liu Jiming Wu Yang Cao Zhirui Zhu | 2008 | Environmental Pollution2008，，： | 1 |
| 4 | Spatial and temporal changes of heavy metal concentrations in mosses and its indication to the environments in the past 40 years in the city of Shanghai, China显示文摘 | Tong Cao Li An Min Wang Yuxia Lou Yinghao Yu Jiming Wu Zhirui Zhu Yangkung Qing Janice Glime | 2008 | Atmospheric Environment2008，，21： | 1 |
| 5 | Global characterization of neutral saccharides in crude and processed Radix Rehmanniae by hydrophilic interaction liquid chromatography tandem electrospray ionization time-of-flight mass spectrometry显示文摘 | Zhirui Liu Ziyang Lou Xuan Ding Xiang Li Yunpeng Qi Zhenyu Zhu Yifeng Chai | 2013 | Food Chemistry2013，，3： | 1 |
| 6 | Global characterization of neutral saccharides in crude and processed Radix Rehmanniae by hydrophilic interaction liquid chromatography tandem electrospray ionization time-of-flight mass spectrometry显示文摘 | Zhirui Liu Ziyang Lou Xuan Ding Xiang Li Yunpeng Qi Zhenyu Zhu Yifeng Chai | 2013 | Food Chemistry2013，，3： | 1 |
| 7 | Global characterization of neutral saccharides in crude and processed Radix Rehmanniae by hydrophilic interaction liquid chromatography tandem electrospray ionization time-of-flight mass spectrometry显示文摘 | Zhirui Liu Ziyang Lou Xuan Ding Xiang Li Yunpeng Qi Zhenyu Zhu Yifeng Chai | 2013 | Food Chemistry2013，，3： | 1 |
| 8 | Recommendation about the perioperative prevention of infection to healthcare workers and the anesthesia management of children with SARS-CoV-2 infection显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread widely and persistently over 100 countries.New challenges have occurred in the perioperative management of airway and anesthesia in children diagnosed with SARS-CoV-2 infection.According to current publications and to our own experiences in anesthesia management for cases with SARS-CoV-2 suspected,we reviewed concerns about the perioperative prevention of SARS-CoV-2 to medical staff and the anesthesia strategy to the patient. | Jinjin Huang Yaoqin Hu Jiangmei Wang Dongpi Wang Zhirui Zhu Zhiyong Hu Ziying Jin Hongfei Lin Wenfang Huang Weiqing Shen Yilei Jiang Miaofeng Hu Jingzhen Wu Yaojun Suo Qiang Shu | 2020 | World Journal of Pediatric Surgery2020，3，1： | 0 |
| 9 | An in-situ spectroscopy investigation of alkali metal interaction mechanism with the imide functional group显示文摘Organic anode materials have attracted considerable interest owing to their high tunability by adopting various active functional groups.However,the interaction mechanisms between the alkali metals and the active functional groups in host materials have been rarely studied systematically.Here,a widely used organic semiconductor of perylene-3,4,9,10-tetracarboxylic diimide(PTCDI)was selected as a model system to investigate how alkali metals interact with imide functional groups and induce changes in chemical and electronic structures of PTCDI.The interaction at the alkali/PTCDI interface was probed by in-situ X-ray photoelectron spectroscopy(XPS),ultraviolet photoelectron spectroscopy(UPS),synchrotron-based near edge X-ray absorption fine structure(NEXAFS),and corroborated by density functional theory(DFT)calculations.Our results indicate that the alkali metal replaces the hydrogen atoms in the imide group and interact with the imide nitrogen of PTCDI.Electron transfer induced gap states and downward band-bending like effects are identified on the alkali-deposited PTCDI surface.It was found that Na shows a stronger electron transfer effect than Li.Such a model study of alkali insertion/intercalation in PTCDI gives insights for the exploration of the potential host materials for alkali storage applications. | Xu Lian Zhirui Ma Zhonghan Zhang Jinlin Yang Shuo Sun Chengding Gu Yuan Liu Honghe Ding Jun Hu Xu Cao Junfa Zhu Shuzhou Li Wei Chen | 2020 | Nano Research2020，13，12： | 0 |
| 10 | Rapid and fine tailoring longitudinal surface plasmon resonances of gold nanorods by end-selective oxidation显示文摘Facile achievement of gold nanorods(AuNRs) with controllable longitudinal surface plasmon resonance(LSPR) is of great importance for their applications in various fields.The LSPR of AuNRs is sensitive to their aspect ratio,which is still hard to be precisely tuned by direct synthesis.In this work,we report a simple approach for end-selective etching of AuNRs by a rapid oxidation process with Au(Ⅲ) in cetyltrimethylammonium bromide(CTAB) solution at a mild temperature.The LSPR wavelength and the length of AuNRs blue shifted linearly as a function of the amount of Au(Ⅲ),while the diameter of Au NRs remained nearly constant.The oxidative rate is tempe rature dependent,and the oxidative process for a desired LSPR can be accomplished within 15 min at 60℃.Further investigations indicated that Br determine the occurrence of the oxidation between AuNRs and Au(Ⅲ),and a small amount of surfactant chain(CTA+) is crucial for stabilizing AuNRs.This method presents a quick but robust strategy for acquiring AuNRs with an arbitrary intermediate LSPR wavelength using the same starting AuNRs,and can be a powerful tool for subsequent applications. | Wenhan Li Zhirui Guo Qiuyuan Tai Yawen Li Yefei Zhu Tingting Bai | 2020 | Chinese Chemical Letters2020，31，9： | 0 |
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