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| 1 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 2 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 3 | Natural purification effects in the river in consideration with domestic wastewater pollutant discharge reduction effects显示文摘The first social experiment program in Japan to reduce domestic wastewater pollutant discharge by 'soft interventions' in households has been conducted in the Yamato-gawa River drainage area since 2005.The Yamato-gawa River has been listed as one of the worst water quality rivers in Japan because of the larger annual average BOD.'Hard interventions' including deployment of wastewater treatment facilities and artificial installation of natural purification facilities in the river has been conducted in these years to improve river water quality.At the first Yamato-gawa River social experiment program (YR-SEP) in March 2005,BOD at the monitoring point near the river mouth decreased about 6% during the Program.Natural purification effect along the river was evaluated in this article with one-dimensional water quality model for the six river sections.Larger biological oxygen consumption rate,k b ,was estimated in the sections with artificially installed natural purification facilities.The effect of 'soft interventions' in households in the YR-SEP was estimated as 25% BOD decrease in the nearest monitoring point to the river mouth,when all the households participate in the Program and BOD discharge reduction rate with 'soft interventions' in households was 40%. | Yoshiaki Tsuzuki Masato Fujii Yasuo Mochihara Kouki Matsuda Minoru Yoneda | 2010 | Journal of Environmental Sciences2010，22，6： | 5 |
| 4 | Genome-wide scan revealed that polymorphisms in the PNPLA3 , SAMM50 , and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan显示文摘 | Takuya Kitamoto Aya Kitamoto Masato Yoneda Hideyuki Hyogo Hidenori Ochi Takahiro Nakamura Hajime Teranishi Seiho Mizusawa Takato Ueno Kazuaki Chayama Atsushi Nakajima Kazuwa Nakao Akihiro Sekine Kikuko Hotta | 2013 | Human Genetics2013，，7： | 5 |
| 5 | Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst显示文摘The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver. | Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda Kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 6 | Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis显示文摘AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis. | Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 7 | Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease显示文摘AIM:To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease(NAFLD)patients.METHODS:A total of 1048 patients with liver-biopsyconfirmed NAFLD were enrolled from nine hepatology centers in Japan(stage 0,216;stage 1,334;stage 2,270;stage 3,190;stage 4,38).The weight and height of the patients were measured using a calibrated scale after requesting the patients to remove their shoes and any heavy clothing.Venous blood samples were obtained in the morning after the patients had fasted overnight for 12 h.Laboratory evaluation was performed in all patients.Statistical analysis was conducted using SPSS version 12.0.Continuous variables were expressed as mean±SD.RESULTS:The optimal cutoff value of platelet count,serum albumin,and aminotransferase/alanine aminotransferase ratio(AAR)was set at<15.3 104/μL,<4.0g/dL,and>0.9,respectively,by the receiver operating characteristic curve.These three variables were combined in an unweighted sum(platelet count=1 point,serum albumin=1 point,AAR=1 point)to form an easily calculated composite score for predicting cirrhosis in NAFLD patients,called the PLALA(platelet,albumin,AAR)score.The diagnosis of PLALA≥2 had sufficient accuracy for detecting liver cirrhosis in NAFLD patients.CONCLUSION:The PLALA score may be an ideal scoring system for detecting cirrhosis in NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use. | Takaomi Kessoku Yuji Ogawa Masato Yoneda Kento Imajo Yoshio Sumida Yuichiro Eguchi Hideki Fujii Hideyuki Hyogo Masafumi Ono Yasuaki Suzuki Takumi Kawaguchi Kazuaki Chayama Saiyu Tanaka Kazuma Fujimoto Keizo Anzai Toshiji Saibara Michio Sata Yoshito Itoh Atsushi Nakajima Takeshi Okanoue Japan Study Group of NAFLD(JSG-NAFLD) | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 8 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 9 | Emerging drugs for non-alcoholic steatohepatitis显示文摘 | Wataru Tomeno Masato Yoneda Kento Imajo Yuji Ogawa Takaomi Kessoku Satoru Saito Yuichiro Eguchi Atsushi Nakajima | 2013 | Expert Opinion on Emerging Drugs2013，，3： | 2 |
| 10 | Epidemiology and Management of Drug-induced Liver Injury: Importance of the Updated RUCAM显示文摘Drug-induced liver injury(DILI)is a major cause of acute liver injury,liver failure,and liver transplantation worldwide.In recent years,immune checkpoint inhibitors have become widely used.This has led to an increase in DILI,for which pathophysiology and management methods differ significantly from the past.As the number of cases of acute liver injury and liver transplantation due to DILI is expected to increase,information about a DILI is becoming more valuable.DILI is classified into two types according to its etiology:intrinsic DILI,in which the drug or its metabolites cause liver damage that is dose-dependent and predictable;and idiosyncratic DILI,in which liver damage is also dose-independent but unpredictable.In addition,depending on the course of the disease,chronic DILI or drug-induced autoimmune hepatitis may be present.The number of DILI cases caused by antimicrobial agents is decreasing,whereas that caused by drugs for malignant tumors and health foods is increasing.The Roussel Uclaf Causality Assessment Method is widely used to assess causality in DILI.Liver injury is a type of immune-related adverse event.The pattern of hepatic injury in immune-related adverse events is mostly hepatocellular,but mixed type and bile stasis have also been reported.Sclerosing cholangitis caused by immune checkpoint inhibitors has also been reported as a unique type of injury.Treatment mainly comprises withdrawal of immune checkpoint inhibitors and steroid administration;however,mycophenolate mofetil may be considered if the disease is refractory to steroids. | Takashi Kobayashi Michihiro Iwaki Asako Nogami Masato Yoneda | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 1 |
| 11 | Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)显示文摘 | Noritoshi Kobayashi Takuma Higurashi Hiroshi Iida Hironori Mawatari Hiroki Endo Yuichi Nozaki Ayako Tomimoto Kyoko Yoneda Tomoyuki Akiyama Koji Fujita Hirokazu Takahashi Masato Yoneda Masahiko Inamori Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Satoru | 2008 | Journal of Hepato-Biliary-Pancreatic Surgery2008，，5： | 1 |
| 12 | Emerging drugs for non-alcoholic steatohepatitis显示文摘 | Wataru Tomeno Masato Yoneda Kento Imajo Yuji Ogawa Takaomi Kessoku Satoru Saito Yuichiro Eguchi Atsushi Nakajima | 2013 | Expert Opinion on Emerging Drugs2013，，3： | 1 |
| 13 | Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort显示文摘BACKGROUND Non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver biopsy.Quantitative multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected T1(cT1)],as well as elastography techniques[vibration-controlled transient elastography(VCTE)liver stiffness measure],magnetic resonance elastography(MRE)and 2D Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver biopsy.AIM To evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH patients.METHODS From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan®,VCTE,MRE and 2DSWE.Patients were subsequently biopsied,and samples were scored by three independent pathologists.The diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard diagnoses.Concordance between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa statistics.RESULTS N=145 patients with mean age of 60(SD:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the analysis.For identifying patients with NASH,MR liver fat and cT1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(cT1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffness measure(AUC:0.94)and 2D-SWE(AUC:0.94).For assessment of steatosis≥1,MR liver fat was the best performing non-invasive test(AUC:0.92),compared to controlled attenuated parameter(AUC:0.75).Assessment of the agreement between pathologists showed that concordance was best for steatosis(a=0.58),moderate for ballooning(a=0.40)and fibrosis(a=0.40),and worst for lobular inflammation(a=0.11).CONCLUSION Quantitative mpMRI is an effective alternative to liver biopsy for diagnosing NASH and non-alcoholic fatty liver,and thus may offer clinical utility in patient management. | Kento Imajo Louise Tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima | 2021 | World Journal of Gastroenterology2021，27，7： | 1 |
| 14 | Genome-wide scan revealed that polymorphisms in the PNPLA3 , SAMM50 , and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan显示文摘 | Takuya Kitamoto Aya Kitamoto Masato Yoneda Hideyuki Hyogo Hidenori Ochi Takahiro Nakamura Hajime Teranishi Seiho Mizusawa Takato Ueno Kazuaki Chayama Atsushi Nakajima Kazuwa Nakao Akihiro Sekine Kikuko Hotta | 2013 | Human Genetics2013，，7： | 1 |
| 15 | Variations in the FTO gene are associated with severe obesity in the Japanese显示文摘 | Kikuko Hotta Yoshio Nakata Tomoaki Matsuo Seika Kamohara Kazuaki Kotani Ryoya Komatsu Naoto Itoh Ikuo Mineo Jun Wada Hiroaki Masuzaki Masato Yoneda Atsushi Nakajima Shigeru Miyazaki Katsuto Tokunaga Manabu Kawamoto Tohru Funahashi Kazuyuki Hamaguchi Kenta | 2008 | Journal of Human Genetics2008，，6： | 1 |
| 16 | Acute Appendicitis Associated with Peutz-Jeghers-Type Hamartoma of the Appendix显示文摘 | Hiroshi Iida Masahiko Inamori Yusuke Sekino Hiroki Endo Tomoyuki Akiyama Koji Fujita Hirokazu Takahashi Masato Yoneda Noritoshi Kobayashi Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Satoru Saito Hisashi Oshiro Yasushi Rino Atsushi Nakajma | 2008 | Digestive Diseases and Sciences2008，，10： | 1 |
| 17 | Differentiating sclerosing cholangitis caused by autoimmune pancreatitis and primary sclerosing cholangitis according to endoscopic duodenal papillary features显示文摘 | Kensuke Kubota Shingo Kato Tomoyuki Akiyama Masato Yoneda Koji Fujita Masami Ogawa Masahiko Inamori Noritoshi Kobayashi Satoru Saito Yukio Kakuta Hisashi Ohshiro Atsushi Nakajima | 2008 | Gastrointestinal Endoscopy2008，，6： | 1 |
| 18 | Serum Ferritin Is a Clinical Biomarker in Japanese Patients with Nonalcoholic Steatohepatitis (NASH) Independent of HFE Gene Mutation显示文摘 | Masato Yoneda Yuichi Nozaki Hiroki Endo Hironori Mawatari Hiroshi Iida Koji Fujita Kyoko Yoneda Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Noritoshi Kobayashi Kensuke Kubota Satoru Saito Shiro Maeyama Kikuko Hotta Atsushi Nakajima | 2010 | Digestive Diseases and Sciences2010，，3： | 1 |
| 19 | Type IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage显示文摘 | Masato Yoneda Hironori Mawatari Koji Fujita Kyoko Yonemitsu Shingo Kato Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Yuichi Nozaki Yasunobu Abe Kensuke Kubota Satoru Saito Tomoyuki Iwasaki Yasuo Terauchi Shinji Togo Shiro Maeyama Atsushi Nakajim | 2007 | Journal of Gastroenterology2007，，5： | 1 |
| 20 | High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH显示文摘 | Masato Yoneda Hironori Mawatari Koji Fujita Hiroshi Iida Kyoko Yonemitsu Shingo Kato Hirokazu Takahashi Hiroyuki Kirikoshi Masahiko Inamori Yuichi Nozaki Yasunobu Abe Kensuke Kubota Satoru Saito Tomoyuki Iwasaki Yasuo Terauchi Shinji Togo Shiro Maeyama At | 2007 | Journal of Gastroenterology2007，，7： | 1 |
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