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| 1 | Oral esomeprazole vs injectable omeprazole for the prevention of hemorrhage after endoscopic submucosal dissection显示文摘AIM To evaluate the effectiveness of oral esomeprazole(EPZ) vs injectable omeprazole(OPZ) therapy to prevent hemorrhage after endoscopic submucosal dissection(ESD).METHODS A case-control study was conducted using a quasirandomized analysis with propensity score matching. A total of 258 patients were enrolled in this study. Patients were treated with either oral EPZ or injectable OPZ. The endpoint was the incidence of hemorrhage after ESD.RESULTS Data of 71 subjects treated with oral EPZ and 172 subjects treated with injectable OPZ were analyzed. Analysis of 65 matched samples revealed no difference in the incidence of hemorrhage after ESD between the oral EPZ and injectable OPZ groups(OR = 0.89, 95%CI:0.35-2.27, P ≥ 0.99).CONCLUSION We conclude that oral EPZ therapy is a useful alternative to injectable PPI therapy for the prevention of hemorrhage after ESD. | Takashi Uchiyama Takuma Higurashi Hitoshi Kuriyama Yoshinobu Kondo Yasuo Hata Atsushi Nakajima | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，10： | 8 |
| 2 | characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases显示文摘AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP. | Yusuke Sekino Masahiko Inamori Eiji Yamada Hidenori Ohkubo Eiji Sakai Takuma Higurashi Hiroshi Iida Kunihiro Hosono Hiroki Endo Takashi Nonaka Hirokazu Takahashi Tomoko Koide Yasunobu Abe Eiji Gotoh Shigeru Koyano Yoshiyuki Kuroiwa Shin Maeda Atsushi Nakajima | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Visual distraction alone for the improvement of colonoscopy-related pain and satisfaction显示文摘AIM: To evaluate the effect of a relaxing visual distraction alone on patient pain, anxiety, and satisfaction during colonoscopy.METHODS: This study was designed as an endoscopistblinded randomized controlled trial with 60 consecutively enrolled patients who underwent elective colonoscopy at Yokohama City University Hospital, Japan. Patients were randomly assigned to two groups: group 1 watched a silent movie using a head-mounted display, while group 2 only wore the display. All of the colonoscopies were performed without sedation. We examined pain, anxiety, and the satisfaction of patients before and after the procedure using questionnaires that included the Visual Analog Scale. Patients were also asked whether they would be willing to use the same method for a repeat procedure.RESULTS: A total of 60 patients were allocated to two groups. Two patients assigned to group 1 and one patient assigned to group 2 were excluded after the randomization. Twenty-eight patients in group 1 and 29 patients in group 2 were entered into the final analysis. The groups were similar in terms of gender, age, history of prior colonoscopy, and pre-procedural anxiety score. The two groups were comparable in terms of the cecal insertion rate, the time to reach the cecum, the time needed for the total procedure, and vital signs. The median anxiety score during the colonoscopy didnot differ significantly between the two groups(median scores, 20 vs 24). The median pain score during the procedure was lower in group 1, but the difference was not significant(median scores, 24.5 vs 42). The patients in group 1 reported significantly higher median post-procedural satisfaction levels, compared with the patients in group 2(median scores, 89 vs 72, P = 0.04). Nearly three-quarters of the patients in group 1 wished to use the same method for repeat procedures, and the difference in rates between the two groups was statistically significant(75.0% vs 48.3%, P = 0.04). Patients with greater levels of anxiety before the procedure tended to feel a painful sensation. Among patients with a pre-procedural anxiety score of 50 or higher, the anxiety score during the procedure was significantly lower in the group that received the visual distraction(median scores, 20 vs 68, P = 0.05); the pain score during the colonoscopy was also lower(median scores, 23 vs 57, P = 0.04). No adverse effects arising from the visual distraction were recognized.CONCLUSION: Visual distraction alone improves satisfaction in patients undergoing colonoscopy and decreases anxiety and pain during the procedure among patients with a high pre-procedural anxiety score. | Shotaro Umezawa Takuma Higurashi Shiori Uchiyama Eiji Sakai Hidenori Ohkubo Hiroki Endo Takashi Nonaka Atsushi Nakajima | 2015 | World Journal of Gastroenterology2015，21，15： | 3 |
| 4 | Development of a two channel aerosol retrieval algorithm on global scale using NOAA /AVHRR显示文摘 | Higurashi A N T | 1999 | Atmos Sci1999，56，7： | 1 |
| 5 | A possible correlation between satellite-derived cloud and aerosol micro- physical parameters显示文摘 | Nakajima T Higurashi A Kawamoto K | 2001 | Geophys Res Lett2001，28，： | 1 |
| 6 | Livebirth prevalence and follow-up of malformation syndromes in 27,472 newborns显示文摘 | Higurashi M Oda M Iijima K | 1990 | Brain Dev1990，12，： | 1 |
| 7 | Livebirths prevalence and fol- low - up of malfor - mation syndromes in 27,472 newborns 显示文摘 | Higurashi M Oda M Iijima K | 1990 | Brain Dev1990，12，： | 1 |
| 8 | A carotenoid-bindingprotein(CBP)plays a crucial role in cocoon pigmentation of silk-worm(Bombyx mori)larvae显示文摘 | Tabunoki H Higurashi S Ninagi O | 2004 | Febs Lett2004，567，23： | 1 |
| 9 | Monolithically integrated optical displacement sensor based on triangulation and optical beam deflection显示文摘 | Eiji Higurashi Renshi Sawada Takahiro Ito | 1999 | Applied Optics1999，38，920： | 1 |
| 10 | Both the Fab and Fc domains of IgG are essential for ROS emission from TNF-a-primed neutrophils by IVIG 显示文摘 | Higurashi S Machino Y Suzuki E | 2012 | Biochem Biophys Res Commun2012，417，2： | 1 |
| 11 | Correction of Atmosphere Effect on ADEOS/OCTS Ocean Color Data:Algorithm Description and Evaluation of Its Performance显示文摘 | Fukushima H Higurashi A Mitomi Y | 1998 | Journal of Oceanography1998，54，： | 1 |
| 12 | Chemically dimefized intravenous imrnunoglobulin has potent ameliorating activity in a mouse immune thrombocytopenic purpura model 显示文摘 | Machino Y Suzuki E Higurashi S | 2012 | Biochem Biophys Res Commun2012，418，4： | 1 |
| 13 | Elevated chromosome aberration frequency after X-ray exposure of cultured fibeoblasts derived from patients with porokeratosis显示文摘 | Higurashi M Ariizumi-Shibusawa C | | Cancer0，，： | 1 |
| 14 | Plasma cell myeloma of the skull base:report of two cases显示文摘 | Saburou Yagishita Kazuhiko Fujitsu | 2004 | Brain Tumor Pathology2004，21，： | 1 |
| 15 | A stress analysis of pipe flange connections 显示文摘 | Sawa T Higurashi N Akagawa H | 1991 | Journal of Pressure Vessel Technology ASME1991，113，： | 1 |
| 16 | A carotenoid-binding protein (CBP) plays a crucial role in cocoon pigmentation of silkworm (Bombyx mori) larvae显示文摘 | TABUNOKI H HIGURASHI S NINAGI O | 2004 | FEBS Letters2004，567，： | 1 |
| 17 | A carotenoid-binding protein (CBP) plays a crucial role in cocoon pigmentation of silkworm ( Bombyx mori ) larvae 显示文摘 | Tabunoki H Higurashi S Ninagi O | 2004 | FEBS Lett2004，567，23： | 1 |
| 18 | Specificity of the J-protein Sisl in the propagation of 3 yeast prions 显示文摘 | Higurashi T Hines JK Sahi C | 2008 | Proc Nail Acad Sci USA2008，105，16： | 1 |
| 19 | Monolithically integrated optical displacement sensor based on triangulation and optical beam deflection显示文摘 | | 1999 | Applied Optics1999，38，9： | 1 |
| 20 | Development of a two channel aerosol retrieval algorithm on global scale using NOAA AVHRR显示文摘 | Higurashi A Nakajima T | 1999 | J Atmos Sci1999，56，： | 1 |
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