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| 1 | Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma显示文摘AIM: To assess the clinical features and prognosis of 151 patients with extrahepatic metastases from primary hepatocellular carcinoma (HCC), and describe the treatment strategy for such patients. METHODS: After the diagnosis of HCC, all 995 consecutive HCC patients were followed up at regular intervals and 151 (15.2%) patients were found to have extrahepatic metastases at the initial diagnosis of primary HCC or developed such tumors during the follow-up period. We assessed their clinical features, prognosis, and treatment strategies. RESULTS: The most frequent site of extrahepatic metastases was the lungs (47%), followed by lymph nodes (45%), bones (37%), and adrenal glands (12%). The cumulative survival rates after the initial diagnosis of extrahepatic metastases at 6, 12, 24, and 36 mo were 44.1%, 21.7%, 14.2%, 7.1%, respectively. The median survival time was 4.9 mo (range, 0-37 mo). Fourteen patients (11%) died of extrahepatic HCC, others died of primary HCC or liver failure. CONCLUSION: The prognosis of HCC patients with extrahepatic metastases is poor. With regard to the cause of death, many patients would die of intrahepatic HCC and few of extrahepatic metastases. Although most of HCC patients with extrahepatic metastases should undergo treatment for the primary HCC mainly, treatment of extrahepatic metastases in selected HCC patients who have good hepatic reserve, intrahepatictumor stage (T0-T2), and are free of portal venous invasion may improve survival. | Kiminori Uka Hiroshi Aikata Shintaro Takaki Hiroo Shirakawa Soo Cheol Jeong Keitaro Yamashina Akira Hiramatsu Hideaki Kodama Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，3： | 44 |
| 2 | Earthworm fibrinolytic enzyme:anti-tumor activity on human hepatoma cells in vitro and in vivo显示文摘背景蚯蚓 fibrinolytic 酶(EFE ) 是在蚯蚓的消化的洞是广泛地分布式的复杂蛋白质酶。拥有的强壮的蛋白质水解作用活动, EFE 不仅血纤维蛋白上的直接效果,而且罐头激活 plasminogen。它的治疗学并且血栓相关的疾病上的预防效果临床上被证实了。最近,在那里被增加了对 EFE 的反肿瘤活动的兴趣。在这研究, EFE 的反肿瘤活动,从 Eisenia foetida 孤立,在人的 hepatoma 上,房间在 vitro 并且在包含的 vivo.The 潜力机制被评估也是在 vitro 实验的 studied.Methods 在四根人的 hepatoma 房间线被执行:有在各种各样的集中的 EFE 的 HLE, Huh7, PLC/PRF/5 和 HepG2.After 处理,房间增长的率的抑制被测量。为在里面 vivo 研究,有 Huh7 房间的忍受肿瘤的模特儿 xenografted 在裸体鼠标,然后鼠标被开发一天用 EFE 被喂一次 4 个星期,和接待的控制组仅仅盐。肿瘤生长上的禁止的效果被观察。另外, apoptosis 与流动 cytometric 试金被观察并且荧光灯与氮蒽橘子和 ethidium 溴化物(AO/EB ) 染色的染料。矩阵 metalloproteinase 的表示(MMP-2 ) 2 被西方的弄污的 assay.Results 与 EFE 的各种各样的集中在处理以后检测,所有 hepatoma 房间线的增长被压制到在 vitro 改变度。为 HLE, Huh7, PLC/PCF/5 和 HepG2 的 IC50 分别地是 2.11, 5.87, 25.29 和 17.30 uku/ml。在 EFE 的管理以后口头上地为 4 个星期,在裸体老鼠的 Huh7 房间的肿瘤异种皮移植的生长显著地在 vivo 被禁止。肿瘤在 EFE 500 uku/ 的禁止的率(kg 敨慰潴慭挠汥獬椠 ? 楶牴 ? 湡 ? 湩瘠? | CHEN Hong Shoichi Takahashi Michio Imamura Eiko Okutani ZHANG Zhi-guo Kazuaki Chayama CHEN Bao-an | 2007 | Chinese Medical Journal2007，，10： | 27 |
| 3 | Patients with early recurrence of hepatocellular carcinoma have poor prognosis显示文摘BACKGROUND: Early recurrence(ER) after hepatic resection(HR) is a poor prognostic factor for patients with hepatocellular carcinoma(HCC). This study aimed to identify the clinicopathological features, outcomes, and risk factors for ER after HR for small HCC in order to clarify the reasons why ER is a worse recurrence pattern.METHODS: We retrospectively examined 130 patients who underwent HR for small HCC(≤30 mm). Recurrence was classified into ER(<2 years) and late recurrence(LR)(≥2 years). The clinicopathological features, outcomes, and risk factors for ER were analyzed by multivariate analysis.RESULTS: ER was observed in 39 patients(30.0%). The survival rate of the ER group was significantly lower than that of the LR group(P<0.005), and ER was an independent prognostic factor for poor survival(P=0.0001). The ER group had a significantly higher frequency(P=0.0039) and shorter interval(P=0.027) of development to carcinoma beyond the Milan criteria(DBMC) compared with the LR group, and ER was an independent risk factor for DBMC(P<0.0001). Multi-nodularity, non-simple nodular type, and microvascular invasion were independent predictors for ER(P=0.012, 0.010, and 0.019, respectively).CONCLUSIONS: ER was a highly malignant recurrence pattern associated with DBMC and subsequent poor survival after HR for small HCC. Multi-nodularity, non-simple nodular type, and microvascular invasion predict ER, and taking these factors into consideration may be useful for the decision of the treatment strategy for small HCC after HR. | Tomoki Kobayashi Hiroshi Aikata Tsuyoshi Kobayashi Hideki Ohdan Koji Arihiro Kazuaki Chayama | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 15 |
| 4 | Clinical significance of type V_I pit pattern subclassification in determining the depth of invasion of colorectal neoplasms显示文摘AIM: To clarify whether subclassification of the type VI pit pattern on the basis of magnifying colonoscopy findings is useful in determining the type and depth of invasion of colorectal neoplasms.METHODS: We retrospectively analyzed 272 colorectal neoplasms (117 dysplasias and 155 submucosal invasive carcinomas; 228 patients) with a type V pit pattern [type VI, n = 202; type VN, n = 70 (Kudo and Tsuruta classification system)]. We divided lesions with a type VI pit pattern into two subclasses, mildly irregular lesions and severely irregular lesions, according to the prominent and detailed magnifying colonoscopy findings. We examined the relation between these two subclasses and histology/invasion depth.RESULTS: One hundred and four lesions (51.5%) were judged to be mildly irregular, and 98 lesions (48.5%) were judged to be severely irregular. Ninety-seven (93.3%) mildly irregular lesions showed dysplasias or submucosal invasion of less than 1000 μm (SM < 1000 μm). Fifty-five (56.1%) severely irregular lesions showed submucosal invasion equal to or deeper than 1000 μm (SM ≥ 1000 μm). Mild irregularity was found significantly more often in dysplasias or lesions with SM < 1000 μm than in lesions with SM ≥ 1000 μm (P < 0.01).CONCLUSION: Subclassification of the type VI pit pattern is useful for identifying dysplasias or lesions with SM < 1000 μm. | Hiroyuki Kanao Shinji Tanaka Shiro Oka Iwao Kaneko Shigeto Yoshida Koji Arihiro Masaharu Yoshihara Kazuaki Chayama | 2008 | World Journal of Gastroenterology2008，14，2： | 15 |
| 5 | Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer显示文摘AIM: To clarify the usefulness of immunohistochemical molecular markers in predicting lymph node metastasis of submucosal colorectal cancer. METHODS: We examined microvessel density, lymphatic vessel density, the Ki-67 labeling index, expression of MUC1 and Matrix metalloproteinase-7 (MMP-7) in tumor cells, and expression of cathepsin D in stromal cells at the invasive front by immunostaining of samples resected from 214 patients with submucosal colorectal cancer. Pathologic features were assessed on hematoxylin-eosin- stained samples. We evaluated the relations between clinicopathologic/immunohistochemical features and lymph node metastasis. RESULTS: Lesions of the superficial type, with an unfavorable histologic grade, budding, lymphatic involvement, high microvessel density (≥ 40), high lymphatic vessel density (≥ 9), high Ki-67 labeling index (≥ 42), and positivity of MUC1, cathepsin D, and MMP-7 showed a significantly high incidence of lymph node metastasis. Multivariate analysis revealed that high microvessel density, unfavorable histologic grade, cathepsin D positivity, high lymphatic vessel density, superficial type, budding, and MUC1 positivity were independent risk factors for lymph node metastasis.A combined examination with four independent immunohistochemical markers (microvessel density, cathepsin D, lymphatic vessel density, and MUC1) revealed that all lesions that were negative for all markers or positive for only one marker were negative for lymph node metastasis. CONCLUSION: Analysis of a combination of immuno- histochemical molecular markers in endoscopically resected specimens of submucosal colorectal cancer allows prediction of curability regardless of the pathologic features visible of hematoxylin-eosin-stained sections. | Iwao Kaneko Shinji Tanaka Shiro Oka Shigeto Yoshida Toru Hiyama Koji Arihiro Fumio Shimamoto Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，28： | 12 |
| 6 | Strategy for treatment of nonerosive reflux disease in Asia显示文摘The paper is to review the clinical and pathophysiologic differences between of nonerosive reflux disease (NERD) and reflux esophagitis (RE), and to propose a treatment strategy for NERD, especially for patients in Asia. A Medline search was performed regarding the clinical and pathophysiologic differences between NERD and RE, and treatment of NERD and RE. The characteristics of NERD patients in Asia are as follows: (1) high proportion of female patients, (2) low frequency of hiatal hernia, (3) high frequency of H pylori infection, (4) severe glandular atrophy of the gastric mucosa, and (5) frequent resistance to proton pump inhibitor (PPI) therapy. In Asian NERD patients, exposure of the esophagus to acid is not increased, and esophageal motility is normal. These characteristics are similar to those of patients in Western countries. Our recommended first-choice treatment is administration of PPI in combination with a prokinetic agent. However, at present, because there is limited evidence regarding effective treatments for NERD, it is best to try several different treatment strategies to find the best treatment for each patient. | Toru Hiyama Masaharu Yoshihara Shinji Tanaka Ken Haruma Kazuaki Chayama | 2008 | World Journal of Gastroenterology2008，14，20： | 10 |
| 7 | Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis显示文摘许多流行病学的报告显示感染玩的那 Helicobacter pylori (H pylori ) 在胃的致癌作用的一个重要角色。几基因、渐成说的改变以一种多步方式贡献癌症房间的开始,提升,和前进。H pylori 被知道在胃粘膜导致慢性炎。包括超级氧化物,它的产品参予开始跟随的 DNA 损坏,并且导出发炎的 cytokines 和生长因素贡献胃的致癌作用的提升。由根除 H pylori,胃的发炎能被治好;治疗减少不仅煽动性的房间渗入,而且 atrophy/intestinal 组织变形的层次部分地。使随机化的控制试用表明根除治疗减少了在没有癌症前期的条件的情况中的胃的癌症流行。另外,从日本组的最近的流行病学的研究证明特别肠的类型,胃的癌症的发展被成功的根除治疗减少,尽管这些以一种非使随机化的方式被设计。然而,内视镜的察觉是评估胃的致癌作用的度的唯一的方法,这应该被提及。我们报导了内视镜、组织学的形态学能被根除治疗修改,它可能贡献胃的癌症开发的流行。就癌症房间增长的生物性质而言,足够地长期的后续将是必要的讨论根除治疗的反癌症效果,这被考虑。 | Masanori Ito Shinji Tanaka Tomoari Kamada Ken Haruma Kazuaki Chayama | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 8 | Defensive medicine practices among gastroenterologists in Japan显示文摘AIM: To clarify the prevalence of defensive medicine and the specific defensive medicine practices among gastro-enterologists in Japan.METHODS: A survey of gastroenterologists in Hiroshi-ma, Japan, was conducted by mail in March 2006. The number of gastroenterologists reporting defensive medi-cine behaviors or changes in their scope of practice and the reported defensive medicine practices, i.e., assurance and avoidance behaviors, were examined.RESULTS: A total of 131 (77%) out of 171 gastroenter-ologists completed the survey. Three (2%) respondents were sued, and most respondents (96%) had liability insurance. Nearly all respondents (98%) reported prac-ticing defensive medicine. Avoidance behaviors, such as avoiding certain procedures or interventions and avoiding caring for high-risk patients, were very common (96%). Seventy-five percent of respondents reported often avoiding certain procedures or interventions. However, seasoned gastroenterologists (those in practice for more than 20 years) adopted avoidance behaviors significantly less often than those in practice for less than 10 years. Assurance behaviors, i.e., supplying additional services of marginal or no medical value, were also widespread (91%). Sixty-eight percent of respondents reported that they sometimes or often referred patients to other spe-cialists unnecessarily.CONCLUSION: Defensive medicine may be highly prev-alent among gastroenterologists throughout Japan, withpotentially serious implications regarding costs, access, and both technical and interpersonal quality of care. | Toru Hiyama Masaharu Yoshihara Shinji Tanaka Yuji Urabe Yoshihiko Ikegami Tatsuma Fukuhara Kazuaki Chayama | 2006 | World Journal of Gastroenterology2006，12，47： | 7 |
| 9 | Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer显示文摘 | Shiro Oka Shinji Tanaka Iwao Kaneko Ritsuo Mouri Mayuko Hirata Toru Kawamura Masaharu Yoshihara Kazuaki Chayama | 2006 | Gastrointestinal Endoscopy2006，，6： | 6 |
| 10 | Selective decrease in colonic CD56^+ T and CD161^+ T cells in the inflamed mucosa of patients with ulcerative colitis显示文摘AIM: To investigate the role of local colonic mucosal NK receptor-positive T (NKR+ T) cells in the regulation of intestinal inflammation, we analyzed the population and function of these cells in ulcerative colitis (UC). METHODS: Colonic mucosal tissues were obtained from colonoscopic biopsies of the descending colon from 96 patients with UC (51 endoscopically uninfl amed, 45 inflamed) and 18 normal controls. Endoscopic appearance and histologic score at the biopsied site were determined by Matts’ classification. A single cell suspension was prepared from each biopsy by collagenase digestion. Two NKR+ T cell subsets, CD56+ (CD56+CD3+) T cells and CD161+ (CD161+CD3+) T cells, were detected by flow cytometric analysis. Intracellular cytokine analysis for anti-in? ammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate- acetate (PMA) and ionomycin. RESULTS: CD56+ T cells and CD161+ T cells are present in the normal human colon and account for 6.7% and 21.3% of all mononuclear cells, respectively. The populations of both CD56+ T cells and CD161+ T cells were decreased significantly in the inflamed mucosa of UC. In contrast, the frequency of conventional T cells (CD56-CD3+ cells and CD161-CD3+ cells) was similar among the patient and control groups. The populations of NKR+ T cells were correlated inversely with the severity of infl ammation, which was classif ied according to the endoscopic and histologic Matts’ criteria. Interestingly, approximately 4% of mucosal NKR+ T cells expressing IL-10 were detected by in vitro stimulation with PMA and ionomycin.CONCLUSION: Selective reduction in the population of colonic mucosal NKR+T cells may contribute to the development of intestinal inflammation in UC. | Masaru Shimamoto Yoshitaka Ueno Shinji Tanaka Toshiko Onitake Rie Hanaoka Kyoko Yoshioka Tsuyoshi Hatakeyama Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，45： | 6 |
| 11 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 12 | Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization显示文摘 | Shinji Tanaka Shiro Oka Iwao Kaneko Mayuko Hirata Ritsuo Mouri Hiroyuki Kanao Shigeto Yoshida Kazuaki Chayama | 2007 | Gastrointestinal Endoscopy2007，，1： | 5 |
| 13 | Genome-wide scan revealed that polymorphisms in the PNPLA3 , SAMM50 , and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan显示文摘 | Takuya Kitamoto Aya Kitamoto Masato Yoneda Hideyuki Hyogo Hidenori Ochi Takahiro Nakamura Hajime Teranishi Seiho Mizusawa Takato Ueno Kazuaki Chayama Atsushi Nakajima Kazuwa Nakao Akihiro Sekine Kikuko Hotta | 2013 | Human Genetics2013，，7： | 5 |
| 14 | Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: Seven cases显示文摘The combination of intra-arterial low-dose cisplatin and 5-fluorouracil (5-FU) is effective against advanced hepatocellular carcinoma (HCC). Systemic gemcitabine chemotherapy seems effective in many cancers. We report the results of combination therapy with systemic gemcitabine, intra-arterial low-dose cisplatin and 5-FU (GEMFP). Seven patients with non-resectable advanced HCC were treated with GEMFP. One course of chemotherapy consisted of daily intra-arterial cisplatin (20 mg/body weight/hour on d 1, 10 mg/body weight per 0.5 h on d 2-5 and 8-12), followed by 5-FU (250 mg/body weight per 5 h on d 1-5 and 8-12) via an injection port. Gemcitabine at 1000 mg/m2 was administered intravenously at 0.5 h on d 1 and 8. The objective response was 57%. The response to GEMFP was as follows: complete response (no patients), partial response (four patients), stable disease (three patients), and progressive disease (no patients). The median survival period was 8 mo (range, 5-55). With regard to the National Cancer Institute Common Toxicity Criteria (NCI-CTC) grade 3 or 4 adverse reactions, seven (100%), seven, six (86%) and one (14%) patients developed leukopenia, neutropenia, thrombocytopenia and anemia, respectively. GEMFP may potentially be effective for non- resectable advanced HCC, but it has severe hematologic toxicity. | Kiminori Uka Hiroshi Aikata Shintaro Takaki Tomokazu Kawaoka Hiromi Saneto Daiki Miki Shoichi Takahashi Naoyuki Toyota Katsuhide Ito Kazuaki Chayama | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 15 | Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH显示文摘 | Yuki Kimura Hideyuki Hyogo Sho-ichi Yamagishi Masayoshi Takeuchi Tomokazu Ishitobi Yoshitaka Nabeshima Koji Arihiro Kazuaki Chayama | 2010 | Journal of Gastroenterology2010，，7： | 3 |
| 16 | Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development显示文摘AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. | Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada | 2015 | World Journal of Hepatology2015，7，27： | 3 |
| 17 | Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study显示文摘 | Yuichiro Eguchi Hideyuki Hyogo Masafumi Ono Toshihiko Mizuta Naofumi Ono Kazuma Fujimoto Kazuaki Chayama Toshiji Saibara | 2012 | Journal of Gastroenterology2012，，5： | 3 |
| 18 | Effects of a 24-week course of interferon-αtherapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma显示文摘AIM:To assess whether a 24-wk course of interferon (IFN)could prevent hepatocellular carcinoma(HCC) recurrence and worsening of liver function in patients with hepatitis C virus(HCV)-infected patients after receiving curative treatment for primary HCC. METHODS:Outcomes in 42 patients with HCV infection treated with IFN-α,after curative treatment for primary HCC(IFN group),were compared with 42 matched curatively treated historical controls not given IFN(non- IFN group). RESULTS:Although the rate of initial recurrence did not differ significantly between IFN group and non-IFN group (0%,44%,61%,and 67% vs 4.8%,53%,81%,and 87% at 1,3,5,and 7 years,P=0.153,respectively), IFN group showed a lower rate than the non-IFN group for second recurrence(0%,10.4%,28%,and 35% vs 0%,30%,59%,and 66% at 1,3,5 and 7 years, P=0.022,respectively).Among the IFN group,patients with sustained virologic response(SVR)were less likely to have a second HCC recurrence than IFN patients without an SVR,or non-IFN patients.Multivariate analysis identified the lack of SVR as the only independent risk factor for a second recurrence,while SVR and Child-Pugh class A independently favored overall survival. CONCLUSION:Most intrahepatic recurrences of HCV- related HCC occurred during persistent viral infection. Eradication of HCV is essential for the prevention of HCC recurrence and improvement of survival. | Soo Cheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro Takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 19 | Involvement of micro RNA ‐224 in cell proliferation, migration, invasion, and anti‐apoptosis in hepatocellular carcinoma显示文摘 | Yizhou Zhang Shoichi Takahashi Akiko Tasaka Tadahiko Yoshima Hidenori Ochi Kazuaki Chayama | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 20 | Characteristics of Metachronous Gastric Tumors after Endoscopic Submucosal Dissection for Gastric Intraepithelial Neoplasms显示文摘 | Tomoyuki Boda Masanori Ito Shiro Oka Yoko Kitamura Norifumi Numata Yoji Sanomura Taiji Matsuo Shinji Tanaka Masaharu Yoshihara Koji Arihiro Kazuaki Chayama Sergio Morini | 2014 | Gastroenterology Research and Practice2014，，： | 2 |
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