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| 1 | Ghrelin and gastric acid secretion显示文摘Ghrelin, a novel growth hormone-releasing peptide, was originally isolated from rat and human stomach. Ghrelin has been known to increase the secretion of growth hormone (GH), food intake, and body weight gain when administered peripherally or centrally. Ghrelin is also known to stimulate the gastric motility and the secretion of gastric acid. In the previous studies, the action of ghrelin on acid secretion was shown to be as strong as that of histamine and gastrin in in-vivo experiment. In the studies, the mechanism for the action of ghrelin was also investigated. It was shown that vagotomy completely inhibited the action of ghrelin on the secretion of gastric acid suggesting that vagal nerve is involved in the mechanism for the action of ghrelin on acid secretion. As famotidine did not inhibit ghrelin-in-duced acid secretion in the study by Masuda et al, they concluded that histamine was not involved in the action of ghrelin on acid secretion. However, we have shown that famotidine completely inhibited ghrelin-induced acid secretion and histidine decarboxylase (HDC) mRNA was increased in gastric mucosa by ghrelin injection which is inhibited by vagotomy Our results indicate that histamine is involved in the action of ghrelin on acid secretion. Furthermore synergistic action of gastrin and ghrelin on gastric acid secretion was shown. Although gastrin has important roles in postprandial secretion of gastric acid, ghrelin may be related to acid secretion during fasting period or at night. However, further studies are needed to elucidate the physiological role of ghrelin in acid secretion. | Koji Yakabi Junichi Kawashima Shingo Kato | 2008 | World Journal of Gastroenterology2008，14，41： | 13 |
| 2 | Comparison of endoscopic stenting for malignant biliary obstruction: A single-center study显示文摘AIM: To evaluate the efficacy and safety of single-step endoscopic placement of self-expandable metallic stents(SEMS) for treatment of obstructive jaundice.METHODS: A retrospective study was performed among 90 patients who underwent transpapillary biliary metallic stent placement for malignant biliary obstruction(MBO) between April 2005 and October 2012. The diagnosis of primary disease and MBO was based on abdominal ultrasound, computed tomography, magnetic resonance imaging, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography with brush cytology, biopsy, and/or a combination of these modalities. The type of SEMS(covered or non-covered, 8 mm or 10 mm in diameter) was determined by the endoscopist. Ninety patients were divided into two groups: group 1(49 patients) who underwent a singlestep SEMS placement and group 2(41 patients) who underwent a two-step SEMS placement. The technical success rate, complication rate, stent patency, and patient survival rate were compared between the groups. In addition, to identify the clinical prognostic factors associated with patient survival, the following variables were evaluated in Cox-regression analysis: gender, age, etiology of MBO(pancreatic cancer or nonpancreatic cancer), clinical stage(Ⅳb; with distant metastases or Ⅳa >; without distant metastases), chemotherapy(with or without), patency of the stent, and the use of single-step or two-step SEMS. RESULTS: Immediate technical success was achieved in 93.9%(46/49) in group 1 and in 95.1%(39/41) in group 2, with no significant difference(P = 1.0). Similarly, there was no difference in the complication rates between the groups(group 1, 4.1% and group 2, 4.9%; P = 0.62). Stent failure was observed in 10 cases in group 1(20.4%) and in 16 cases in group 2(39.0%). The patency of stent and patient survival revealed no difference between the two groups with Kaplan-Meier analysis, with a mean patency of 111 ± 17 d in group 1 and 137 ± 19 d in group 2(P = 0.91), and a mean survival of 178 ± 35 d in group 1 and 222 ± 23 d in group 2(P = 0.57). On the contrary, the number of days of hospitalization associated with first-time SEMS placement in group 1 was shorter when compared with that number in group 2(28 vs 39 d; P < 0.05). Multivariate analysis revealed that a clinical stage of Ⅳa >(P = 0.0055), chemotherapy(P = 0.0048), and no patency of the stent(P = 0.011) were independent prognostic factors associated with patient survival.CONCLUSION: Our results showed that single-step endoscopic metal stent placement was safe and effective for treating obstructive jaundice secondary to various inoperable malignancies. | Ryuichi Yamamoto Masatomo Takahashi Yasuyo Osafune Katsuya Chinen Shingo Kato Sumiko Nagoshi Koji Yakabi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 12 |
| 3 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 4 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 5 | Double balloon enteroscopy to retrieve an accidentally swallowed dental reamer deep in the jejunum显示文摘Accidentally swallowed foreign objects are not uncommon but difficult to manage without complications. We describe the case of a 68 year old man who accidentally a swallowed sharp-pointed dental reamer that had reached deep in his jejunum. Double balloon enteroscopic retrieval was performed with polypectomy snare but the reamer was entangled in the wire loop of the snare and penetrated the jejunal wall. After releasing the reamer by pushing and pulling the snare for approximately 30 min, the reamer was retrieved with biopsy forceps. This is the first report of double balloon enteroscopic removal of a dental reamer. Furthermore, this is a novel case with regard to decision making in situations when sharp objects are swallowed. | Shingo Kato Kazuhito Kani Hidehiko Takabayashi Ryuichi Yamamoto Koji Yakabi | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，4： | 4 |
| 6 | Erythropoietin -induced proliferation of gastric mucosal cells显示文摘瞄准:在胃的标本上分析红细胞生成素受体的本地化并且用一个猪的胃的上皮的房间文化模型在正常胃的上皮的增长上描绘红细胞生成素的效果。方法:红细胞生成素受体被 RT-PCR,西方的弄污和 immunohistochermistry 检测。有教养的胃的粘膜房间上的红细胞生成素的生长刺激效果被 ELISA 用 bromodeoxyuridine (BrdU ) 决定。结果:红细胞生成素受体在有教养的猪的胃的粘膜上皮细胞上被检测。红细胞生成素受体也在胃的粘膜上皮的底组织化学地被检测。BrdU 试金由红细胞生成素的管理在有教养的猪的胃的粘膜上皮细胞的生长潜力表明了剂量依赖者增加,以及这些效果被反的管理禁止 -- 红细胞生成素抗体(P<0.01 ) 。结论:这些调查结果显示红细胞生成素有一个潜力增殖经由红细胞生成素的胃的粘膜上皮受体。 | Kazuro Itoh Yoshio Sawasaki Kyoko Takeuchi Shingo Kato Nobuhiro Imai Yoichiro Kato Noriyuki Shibata Makio Kobayashi Yoshiyuki Moriguchi Masato Higuchi Fumio Ishihata Yushi Sudoh Soichiro Miura | 2006 | World Journal of Gastroenterology2006，12，2： | 3 |
| 7 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 8 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 9 | Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer显示文摘 | Kenichi Sugihara M.D. Hirotoshi Kobayashi M.D. Tomoyuki Kato M.D. Takeo Mori M.D. Hidetaka Mochizuki M.D. Shingo Kameoka M.D. Kazuo Shirouzu M.D. Tetsuichiro Muto M.D | 2006 | Diseases of the Colon & Rectum2006，，11： | 2 |
| 10 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 11 | Assessment of Coronary Artery Disease Using Magnetic Resonance Coronary Angiography显示文摘 | Shingo Kato Kakuya Kitagawa Nanaka Ishida Masaki Ishida Motonori Nagata Yasutaka Ichikawa Kazuhiro Katahira Yuji Matsumoto Koji Seo Reiji Ochiai Yasuyuki Kobayashi Hajime Sakuma | 2010 | Journal of the American College of Cardiology2010，，12： | 1 |
| 12 | Increased expression of galectin-3 in primary gastric cancer and themetastatic lymph nodes显示文摘 | Junichi Miyazaki Ryota Hokari Shingo Kato Yoshikazu Tsuzuki Atushi Kawaguchi Shigeaki Nagao Kazuro Itoh Soichiro Miura | 2002 | Oncology Reports2002，，6： | 1 |
| 13 | As?sessment of Coronary Artery Disease Using Magnetic Resonance Coronary Angiography: A National Multi?center Trial显示文摘 | Shingo Kato Kakuya Kitagawa N anaka Ishida | 2010 | Journal of the American College of Cardiology2010，56，12： | 1 |
| 14 | Is Total Mesorectal Excision Always Necessary for T1–T2 Lower Rectal Cancer?显示文摘 | Hirotoshi Kobayashi MD Hidetaka Mochizuki MD Tomoyuki Kato MD Takeo Mori MD Shingo Kameoka MD Kazuo Shirouzu MD Yukio Saito MD Masahiko Watanabe MD Takayuki Morita MD Jin-ichi Hida MD Masashi Ueno MD Masato Ono MD Masamichi Yasuno MD Kenichi Sugihara MD | 2010 | Annals of Surgical Oncology2010，，4： | 1 |
| 15 | Increased Expression of Long Pentraxin PTX3 in Inflammatory Bowel Diseases显示文摘 | Shingo Kato Mitsuko Ochiai Tomoya Sakurada Shino Ohno Kyoko Miyamoto Mina Sagara Masataka Ito Kyoko Takeuchi Junko Imaki Kazuro Itoh Koji Yakabi | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 16 | Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis显示文摘 | Junichi Kawashima Shino Ohno Tomoya Sakurada Hidehiko Takabayashi Mitsuko Kudo Shoki Ro Shingo Kato Koji Yakabi | 2009 | Journal of Gastroenterology2009，，10： | 1 |
| 17 | Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy显示文摘 | Yosuke Makuuchi Kazufumi Honda Yoshiaki Osaka Ken Kato Takashi Kojima Hiroyuki Daiko Hiroyasu Igaki Yoshinori Ito Sumito Hoshino Shingo Tachibana Takafumi Watanabe Koh Furuta Shigeki Sekine Tomoko Umaki Yukio Watabe Nami Miura Masaya Ono Akihiko Tsuchida | 2013 | Cancer Sci2013，，8： | 1 |
| 18 | Chromoendoscopy with indigo carmine dye added to acetic acid in the diagnosis of gastric neoplasia: a prospective comparative study显示文摘 | Yuzo Sakai Reiko Eto Junji Kasanuki Fukuo Kondo Kazuki Kato Makoto Arai Takuto Suzuki Michiko Kobayashi Tomoaki Matsumura Dan Bekku Kenichi Ito Shingo Nakamoto Takeshi Tanaka Osamu Yokosuka | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 19 | New prognostic factors associated with long-term survival in node-negative breast cancer patients显示文摘 | Takao Kato Tsunehito Kimura Nobue Takami Ryuhei Miyakawa Schinichi Tanaka Hiroshi Muraki Takako Kamio Akiho Fujii Kazuko Yamamoto Shingo Kameoka Toshio Nishikawa Takeshi Kasajima | 1999 | Breast Cancer1999，，4： | 1 |
| 20 | High mobility of pentacene field-effect transistors with polyimide gate dielectric layers显示文摘 | YUSAKU Kato SHINGO Lba RYOHEI Terarnoto | 2004 | Appl Phys Lett2004，84，19： | 1 |
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