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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis显示文摘AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this study.NASH was staged based on Brunt criterion.At a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ied.RESULTS:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several ROIs.An average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage 2.When a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,respectively.In addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management. | Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru Kikuchi Minoru Nomoto Yutaka Aoyagi | 2010 | World Journal of Gastroenterology2010，16，23： | 30 |
| 3 | Recent advances in the surgical treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed. | Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi Arakawa Rie Yoshida Masashi Isetani | 2014 | World Journal of Gastroenterology2014，20，39： | 24 |
| 4 | 伊藤法“单开门”颈椎椎管扩大椎板成形术的并发症及其原因分析显示文摘目的:探讨伊藤法“单开门”颈椎椎管扩大椎板成形术并发症的发生率及其原因。方法:对1983年2月~1992年3月行伊藤法“单开门”颈椎椎管扩大椎板成形术的87例患者的临床资料进行回顾性分析,通过查阅病历及门诊随访,确定其手术并发症。采用临床观察、影像学评价及统计学方法分析其原因。结果:随访2~14年,平均5.3年。39例(45%)患者出现轴性症状,4例(4.6%)出现神经根麻痹,颈部旋转受限48例(55.2%),过伸受限33例(37.9%),屈曲受限17例(18.3%),侧屈受限17例(18.3%)。颈椎曲度:术前平均14.8°,术后平均4.9°,平均减少9.9°。结论:伊藤法“单开门”颈椎椎管扩大椎板成形术后轴性症状较多见,术后颈椎前凸减小,尤其是颈椎后凸可能是产生轴性症状的原因之一。 | 刘洪 Hirokazu Ishihara 张腾云 | 2006 | 中国脊柱脊髓杂志2006，16，5： | 23 |
| 5 | Pure laparoscopic hepatectomy for hepatocellular carcinoma with chronic liver disease显示文摘Pure laparoscopic hepatectomy is a less invasive procedure than conventional open hepatectomy for the resection of hepatic lesions. Increases in experiences with the technique, in combination with advances in technology, have promoted the popularity of pure laparoscopic hepatectomy. However, indications for usage and potential contraindications of the procedure remain unresolved. The characteristics and specific advantages of the procedure, especially for hepatocellular carcinoma(HCC) patients with chronic liver diseases,are reviewed and discussed in this paper. For cirrhotic patients with liver tumors, pure laparoscopic hepatectomy minimizes destruction of the collateral blood and lymphatic flow from laparotomy and mobilization, and mesenchymal injury from compression. Therefore, pure laparoscopic hepatectomy has the specific advantage of minimal postoperative ascites production that leads to lowering the risk of disturbance in water or electrolyte balance and hypoproteinemia. It minimizes complications that routinely trigger postoperative serious liver failure. Under adequate patient positioning and port arrangement, the partial resection of the liver in the area of subphrenic space, peri-inferior vena cava area or next to the attachment of retro-peritoneum is facilitated in pure laparoscopic surgery by providing good vision and manipulation in the small operative field.Furthermore, the features of reduced post-operative adhesion, good vision, and manipulation within the small area between the adhesions make this procedure safer in the context of repeat hepatectomy procedures.These improved features are especially advantageous for patients with liver cirrhosis and multicentric and/or metachronous HCCs. | Zenichi Morise Norihiko Kawabe Jin Kawase Hirokazu Tomishige Hidetoshi Nagata Hisanori Ohshima Satoshi Arakawa Rie Yoshida Masashi Isetani | 2013 | World Journal of Hepatology2013，5，9： | 21 |
| 6 | Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer显示文摘AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain reaction (PCR). Eighty patients were divided into 3 groups; Group A (n=35):the depth of cancer invasion was less than the muscularis propria; Group B (n=31): the depth of cancer invasion was beyond the muscularis propria. Both group A and B were diagnosed as no cancer cells in peritoneal cytology and histology; Group C (n=14): disseminated nodule was histologically diagnosed or cancer cells were cytologically defi ned in the peritoneal cavity.RESULTS: The positive rates of methylation in CHFR, E-cadherin and BNIP3 were significantly different among the 3 groups and increased in order of group A, B and C (0%,0% and 21% in CHFR, P<0.05; 20%, 45% and 50% in E-cadherin, P<0.05;26%,35% and 71% in BNIP3, P<0.05). In addition, the multigene methylation rate among CHFR, E-cadherin and BNIP3 was correlated with group A, B and C (9%,19% and 57%, P<0.001). Moreover, the prognosis was analyzed in group B, excluding 3 patients who underwent a non-curative resection. Two of the 5 patients with multigene methylation showed peritoneal recurrence after surgery, while those without or with a single gene methylation did not experience recurrence (P<0.05).CONCLUSION: This study suggested that gene methylation in the PF could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis. | Masatsugu Hiraki Yoshihiko Kitajima Seiji Sato Jun Nakamura Kazuyoshi Hashiguchi Hirokazu Noshiro Kohji Miyazaki | 2010 | World Journal of Gastroenterology2010，16，3： | 20 |
| 7 | Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer显示文摘AIM: To examine the expression of leptin and its receptor, OB-R, in normal gastric mucosa and neoplasia. METHODS: By immunohistochemical staining using specifi c antibodies, we evaluated the expression of leptin and OB-R in 207 gastric carcinomas (100 early and 107 advanced carcinomas) and analyzed their relationship with clinicopathological features. RESULTS: Both normal gastric epithelium and carci- noma cells expressed a significant level of leptin. In cases with OB-R staining, carcinoma cells showed OB-R- positive expression, but the intensity was weaker than that in normal mucosa. The expression of OB-R showed a signifi cant correlation with the level of leptin expres- sion. The expression levels of both leptin and OB-R tend- ed to increase as the depth of tumor invasion or TMN stage increased (P < 0.01). Lymph node metastasis was detected in 49.5% (47/95) of leptin-strong cases and in 50.5% (48/95) of OB-R-positive cases, and the rate was 33% (37/112) in leptin-weak cases and 17% (19/112) in OB-R-negative cases. Both venous and lymphatic inva- sion also tended to be observed frequently in positive tumors as compared with negative tumors. Interestingly, in the 96 leptin- or OB-R-positive tumors, hematogenous metastasis was detected preoperatively in 3 (3.1%) pa- tients. In contrast, none of the carcinomas that lacked expression of leptin and OB-R showed hematogenous metastasis. CONCLUSION: Overexpression of leptin and expres- sion of OB-R may play a positive role in the process of progression in gastric cancer. Functional upregulation of leptin/OB-R may have a positive role in the development and initial phase of progression in gastric cancer. | Makoto Ishikawa Joji Kitayama Hirokazu Nagawa | 2006 | World Journal of Gastroenterology2006，12，34： | 20 |
| 8 | 伊藤法“单开门”颈椎椎管扩大椎板成形术及其临床应用显示文摘目的:总结伊藤法“单开门”颈椎椎管扩大椎板成形术的临床应用效果。方法:对123例发育性颈椎管狭窄症、连续性颈椎后纵韧带骨化(OPLL)及多节段脊髓型颈椎病患者行伊藤法“单开门”颈椎椎管扩大椎板成形术,于开门侧将植骨块通过钢丝或尼龙线固定于掀起的椎板和小关节间。87例患者随访2~14年,平均5.3年。结果:术前JOA评分平均9.1分,随访时JOA评分平均14.4分,改善率平均为67.0%,其中优44例(50.6%),良26例(29.9%),可11例(12.6%),差6例(6.9%)。术后侧位X线片示椎管直径扩大1.5~7.0mm,平均4.1mm,椎管扩大率为15%~100%,平均40%。术后CT示植骨愈合良好,无再关门现象,MRI示脊髓受压解除。并发症包括轴性症状(颈部疼痛或僵硬57例次)、神经根麻痹(4例次)及颈部活动受限(旋转、过伸、屈曲或侧屈受限115例次)等。结论:伊藤法“单开门”颈椎椎管扩大椎板成形术是治疗发育性颈椎管狭窄症、连续性颈椎后纵韧带骨化(OPLL)及多节段脊髓型颈椎病安全有效的手术方法,椎管扩大稳定持久,但其并发症有待于进一步解决。 | 刘洪 Hirokazu Ishihara 智慧明 | 2005 | 中国脊柱脊髓杂志2005，15，9： | 19 |
| 9 | Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study显示文摘AIM: To evaluate clinical outcomes and risk factors for endoscopic perforation during endoscopic submucosal dissection (ESD) in a prospective study. METHODS: We investigated the clinical outcomes and risk factors for the development of perforation in 98 consecutive gastric neoplasms undergoing ESD regarding. Demographic and clinical parameters including patient-, tumor-, and treatment-related factors, clinical parameters, and duration of hospital stay were analyzed for risk factors for perforation. In subgroup analysis, we also compared the clinical outcomes between perforation and 'silent' free air without endoscopically visible perforation detected only by computed tomography.RESULTS: Perforation was identified in 8.2% of patients. All patients were managed conservatively by the administration of antibiotics. The mean procedure time was significantly longer in patients with endoscopic perforation than in those without. According to the receiver-operating characteristic analysis, the resulting cutoff value of the procedure time for perforation was 115 min (87.5% sensitivity, 56.7% specificity). Prolonged procedure time (≥ 115 min) was associated with an increased risk of perforation (odds ratio 9.15; 95%CI: 1.08-77.54; P = 0.04). Following ESD, body temperature and C-reactive protein level were significantly higher in patients with perforation than in those without (P = 0.02), whereas there was no difference between these patient groups on the starting day of oral intake or of hospitalization. In subgroup analysis, the post-ESD clinical course was not different between endoscopic perforation and silent free air. CONCLUSION: Only prolonged procedure time (≥ 115 min) was significantly associated with perforation. The clinical outcomes of perforation are favorable and are comparable to those of patients with or without silent free air. | Jiro Watari Toshihiko Tomita Fumihiko Toyoshima Jun Sakurai Takashi Kondo Haruki Asano Takahisa Yamasaki Takuya Okugawa Hisatomo Ikehara Tadayuki Oshima Hirokazu Fukui Hiroto Miwa | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 17 |
| 10 | A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B显示文摘Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal outcome.In this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and corticosteroid.In both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became undetectable.Entecavir treatment was continued.Generally,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few weeks.During this time lag,liver cell injury continued and the disease progressed.Corticosteroid suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B. | Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata | 2009 | World Journal of Gastroenterology2009，15，13： | 16 |
| 11 | Advances in understanding and treating liver diseases during pregnancy:A review显示文摘Liver disease in pregnancy is rare but pregnancyrelated liver diseases may cause threat to fetal and maternal survival.It includes pre-eclampsia;eclampsia;haemolysis,elevated liver enzymes,and low platelets syndrome;acute fatty liver of pregnancy;hyperemesis gravidarum;and intrahepatic cholestasis of pregnancy.Recent basic researches have shown the various etiologies involved in this disease entity.With these advances,rapid diagnosis is essential for severe cases since the decision of immediate delivery is important for maternal and fetal survival.The other therapeutic options have also been shown in recent reports based on the clinical trials and cooperation and information sharing between hepatologist and gynecologist is important for timely therapeutic intervention.Therefore,correct understandings of diseases and differential diagnosis from the pre-existing and co-incidental liver diseases during the pregnancy will help to achieve better prognosis.Therefore,here we review and summarized recent advances in understanding the etiologies,clinical courses and management of liver disease in pregnancy.This information will contribute to physicians for diagnosis of disease and optimum management of patients. | Kenya Kamimura Hiroyuki Abe Hirokazu Kawai Hiroteru Kamimura Yuji Kobayashi Minoru Nomoto Yutaka Aoyagi Shuji Terai | 2015 | World Journal of Gastroenterology2015，21，17： | 15 |
| 12 | 伴有侧凸的退变性腰椎管狭窄症中神经根病的特点显示文摘目的研究伴有侧凸的退变性腰椎管狭窄症(degenerativelumbarstenosiswithscoliosis,DLSS)中,受累神经根及其致压因素与脊柱侧凸之间的关系。方法回顾性分析22例伴有神经根病的DLSS患者的病例资料,男10例,女12例;;平均年龄71岁。通过疼痛分布区、神经学检查及神经根造影确定受累神经根,并通过术中所见及术后症状的改善证实。致压因素通过脊髓造影、椎间盘造影、CT造影或CT椎间盘造影、MR检查以及神经根造影确定。在正位X线片上确定上、下端椎,Cobb角及椎体的侧方移位。将椎体的侧方移位分为两组:移位组(≥10mm)和无移位组(<10mm)。结果受累神经根为L3神经根5个(14%)、L4神经根15个(42%)、L5神经根12个(33%)、S1神经根4个(11%),其中L3和L4神经根以及L5和S1神经根同时受累者分别为5例(23%)和4例(18%)。L3和L4神经根压迫多由椎间孔或其外侧狭窄引起,而L5和S1神经根多由侧隐窝狭窄引起(χ2=10.08,P<0.01)。L3和L4神经根多在侧凸凹侧受压,而L5和S1神经根多在凸侧受压(χ2=8.92,P<0.01)。L3和L4神经根受压者的Cobb角和侧方移位大于L5和S1受压者(t=8.843,P<0.01;;χ2=8.23,P<0.01)。结论DLSS中神经根的压迫不仅可以发生在脊柱侧凸的凹侧,也可以发生在凸侧。不同受累神经根的致压因素不同。 | 刘洪 Hirokazu Ishihara 李淳德 马忠泰 | 2004 | 中华骨科杂志2004，24，5： | 15 |
| 13 | A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers显示文摘Advances in molecular research in cancer have brought new therapeutic strategies into clinical usage.One new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) carcinomas.The concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new drugs.Type I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human malignancies.In this review,we focus on this promising therapeutic target,IGF-IR.The IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI cancers.Preclinical studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer treatments.These results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and pancreas.We also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical experiences.Several mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single agents.We summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug combinations.Thus,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcinomas. | Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura | 2010 | World Journal of Gastroenterology2010，16，46： | 14 |
| 14 | Pure laparoscopic hepatectomy as repeat surgery and repeat hepatectomy显示文摘AIM:To assess clinical outcomes of laparoscopic hepatectomy(LH) in patients with a history of upper abdominal surgery and repeat hepatectomy.METHODS:This study compared the perioperative courses of patients receiving LH at our institution that had or had not previously undergone upper abdominal surgery.Of the 80 patients who underwent LH,22 had prior abdominal surgeries,including hepatectomy(n = 12),pancreatectomy(n = 3),cholecystectomy and common bile duct excision(n = 1),splenectomy(n = 1),total gastrectomy(n = 1),colectomy with the involvement of transverse colon(n = 3),and extended hysterectomy with extensive lymph-node dissection up to the upper abdomen(n = 1).Clinical indicators including operating time,blood loss,hospital stay,and morbidity were compared among the groups.RESULTS:Eighteen of the 22 patients who had undergone previous surgery had severe adhesions in the area around the liver.However,there were no conversions to laparotomy in this group.In the 58 patients without a history of upper abdominal surgery,the median operative time was 301 min and blood loss was 150 m L.In patients with upper abdominal surgical history or repeat hepatectomy,the operative times were 351 and 301 min,and blood loss was 100 and 50 m L,respectively.The median postoperative stay was 17,13 and 12 d for patients with no history of upper abdominal surgery,patients with a history,and patients with repeat hepatectomy,respectively.There were five cases with complications in the group with no surgical history,compared to only one case in the group with a prior history.There were no statistically significant differences in the perioperative results between the groups with and without upper abdominal surgical history,or with repeat hepatectomy.CONCLUSION:LH is feasible and safe in patients with a history of upper abdominal surgery or repeat hepatectomy. | Masashi Isetani Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin Kawase Satoshi Arakawa | 2015 | World Journal of Gastroenterology2015，21，3： | 13 |
| 15 | 纤维素催化转化为高附加值化学品的研究进展(英文)显示文摘Currently,under huge pressure from energy demands and environmental problems,much attention is being paid to biomass conversion,which will play an important role in meeting the requirements for a sustainable society.As the most abundant biomass on earth, cellulose is usually used as the first research target for biomass conversion.In this review,the recalcitrant structure of cellulose is discussed and non-catalytic hydrolysis by hot-compressed water and catalytic hydrolysis using solid acids are then considered.We also review the catalytic conversion of cellulose into valuable chemicals including hexitols(sorbitol and mannitol),ethylene glycol,and related compounds using various heterogeneous catalysts. | Hirokazu KOBAYASHI Atsushi FUKUOKA | 2011 | 催化学报2011，32，5： | 13 |
| 16 | 一期前路病灶清除加植骨术治疗化脓性脊椎炎显示文摘 | 刘洪 Hirokazu Ishihara 马忠泰 Yoshiharu Kawaguchi | 2005 | 中华骨科杂志2005，25，11： | 12 |
| 17 | Deformation behaviors of magnesium alloy AZ31 sheet in cold deep drawing显示文摘To investigate how the popular magnesium alloy AZ31 sheet(aluminum 3%,zinc 1%)behaves in cold working,deep drawing experiments at room temperature,along with finite element(FE)simulation,were performed on the cold forming sheet of the AZ31 alloy after being annealed under various conditions.The activities were focused on the fracture pattern,limit drawing ratio(LDR),deformation load,thickness distribution,anisotropic effect,as well as the influences of the annealing conditions and tool configuration on them.The results display that punch shoulder radius instead of die clearance,has much influence on the thickness distribution.The anisotropy is remarkable in cold working,which adversely impacts the LDR.The fracture often happens on the side wall at an angle to axis of the deformed specimen.The results also imply that the LDR for the material under present experimental conditions is 1.72,and annealing the material at 450 ℃ for 1 h may be preferable for the cold deep drawing. | 杨连发 MORI Ken-ichiro TSUJI Hirokazu | 2008 | 中国有色金属学会会刊:英文版2008，18，1： | 11 |
| 18 | Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men显示文摘瞄准:决定在浆液类脂化合物层次和结肠的息肉形成之间的真实协会。方法:我们执行了大规模分析在表面的腺瘤或癌和禁食浆液在为为结肠癌屏蔽经历了全部的结肠镜检查的病人全部的胆固醇(TC ) 和 triglycerides (TG ) 铺平的肤色的发生之间的关联的回顾的学习。结果:没有任何肿瘤的损害,两水平显著地作为与病人相比与腺瘤在病人被提高(TC 207.6+/-29.5 对 199.5+/-34.3, n=4883, P<0.001;TG 135.0+/-82.2 对 108.7+/-71.5, n=4874, P<0.001 ) 。差别在有管状腺瘤然而并非在那些与的病人是重要的覆有一层绒毛或 serrated 腺瘤。包括年龄和性别的多重逻辑回归分析表明 TG 是在男性(P<0.01 ) ,然而并非在女病人的一个独立关联因素。在有侵略的癌的病人的 TG 的水平没与腺瘤在病人从那显示出重要举起。这些调查结果建议 hypertriglyceridemia 是为在人的结肠的腺瘤的一个独立风险因素。结论:尽管浆液甘油三酸酯的高水平不看起来机械地涉及癌的发展,有全部的结肠镜检查的浆液 TG 和集中的监视的减小可以与 hypertriglyceridemia 在人有利益。 | Masafumi Tabuchi Joji Kitayama Hirokazu Nagawa | 2006 | World Journal of Gastroenterology2006，12，8： | 11 |
| 19 | Development of underground mine monitoring and communication system integrated ZigBee and GIS显示文摘An automated underground mine monitoring and communication system based on the integration of new technologies is introduced to promote safety and health,operational management and cost-effectiveness.The proposed system integration considering Wireless Sensor Network(WSN) assisted Geographic Information System(GIS) enables to monitor and control underground mining applications from surface office.Based on the capabilities of WSNs,ZigBee network is adapted for near real-time monitoring,ventilation system control and emergency communication in underground mine.ZigBee nodes were developed to sense environmental attributes such as temperature,humidity and gases concentration;switching ON and OFF ventilation fans;and texting emergency messages.A trigger action plan for monitored attributes above normal and threshold value limits is programmed in the surface GIS management server.It is designed to turn the auxiliary fans on remotely or automatically in orange condition and sending evacuation messages for underground miners in unsafe(red) condition.Multi-users operation and 3D visualisations are other successful achievements of the proposed system for the underground monitoring and communication. | Moridi Mohammad Ali Kawamura Youhei Sharifzadeh Mostafa Chanda Emmanuel Knox Wagner Markus Jang Hyongdoo Okawa Hirokazu | 2015 | International Journal of Mining Science and Technology2015，25，5： | 11 |
| 20 | Staging systems for hepatocellular carcinoma: Current status and future perspectives显示文摘Hepatocellular carcinoma(HCC) is a major health concern worldwide and the third cause of cancer-related death. Despite advances in treatment as well as careful surveillance programs, the mortality rates in most countries are very high. In contrast to other cancers, the prognosis and treatment of HCC depend on the tumor burden in addition to patient's underlying liver disease and liver functional reserve. Moreover, thereis considerable geographic and institutional variation in both risk factors attributable to the underlying liver diseases and the management of HCC. Therefore, although many staging and/or scoring systems have been proposed, there is currently no globally accepted system for HCC due to the extreme heterogeneity of the disease. The aim of this review is to focus on currently available staging systems as well as those newly reported in the literatures since 2012. Moreover, we describe problems with currently available staging systems and attempts to modify and/or add variables to existing staging systems. | Akiyoshi Kinoshita Hiroshi Onoda Nao Fushiya Kazuhiko Koike Hirokazu Nishino Hisao Tajiri | 2015 | World Journal of Hepatology2015，7，3： | 10 |
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