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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Branched aliphatic alkanes of shell bar section in Qarhan Lake,Qaidam Basin and their paleoclimate significance显示文摘Biomarkers of paleolake deposits from Qarhan Salt Lake in Qaidam Basin,northwest China were sys-tematically analyzed and the A―C series compounds of branched aliphatic alkanes with quaternary substituted carbon atom(BAQCs) were identified. The homologous distinguished three series,A―C,were identified as 5,5-diethylalkanes,6,6-diethylalkanes and 5-butyl,5-ethylalkanes series,and their relative abundance was A > B > C. Series A and C were characterized by odd carbon numbers,whereas series B was characterized by even carbon numbers. The high values of series A corresponded with the high values of series B and C. Therefore,it can be concluded that series A,B and C possess a similar biological origin. The abundance of series A was relatively low in the lower part of the section compared with that in the upper part,implying that these series originated from bacteria and/or algae more prevalent in fresh-mesohaline water,and such kinds of bacteria and/or algae are most likely to be thermophilous species. The A25/nC25 ratio differences in the section show that such branched aliphatic alkanes can be treated as one kind of environmental change proxy for paleolake evolution and may provide important information for the climate reconstruction of the Late Pleistocene. | ZHANG HuCai CHANG FengQin LI Bin LEI GuoLiang CHEN Yue ZHANG WenXiang NIU Jie FAN HongFang YANG MingSheng | 2007 | Chinese Science Bulletin2007，52，9： | 13 |
| 3 | Clinical features and management of postural tachycardia syndrome in children: a single-center experience显示文摘 | Li Jiawei Zhang Qingyou Hao Hongjun Jin Hongfang Du Junbao | 2014 | Chinese Medical Journal2014，，21： | 11 |
| 4 | Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response显示文摘Hypoxic-ischemic brain damage(HIBD)is a common cause of infant death.The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells(PD-MSCs)in HIBD treatment.Seven-day-old rat pups were randomly divided into HIBD,PD-MSC,fibroblast,and control groups.Forty-eight hours after HIBD induction,cells at a density of 5×104 cells/10µl were injected into the cerebral tissue in the PD-MSC and fibroblast groups.The TNF-α,interleukin-17(IL-17),interferon-γ(IFN-γ),and IL-10 levels were detected through quantitative real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA).Regulatory T cell(Tregs)populations were detected through flow cytometry,and forkhead box P3(Foxp3)was measured through western blot analysis.Behavioral tests and gross and pathological examinations showed that PD-MSC treatment exerted significantly stronger neuroprotective effects than the other treatments.The expression levels of pro-inflammatory cytokines were substantially upregulated after HI injury.Compared with fibroblast treatment,PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of IL-10 in the ischemic hemispheres and peripheral blood serum(all P<0.01).Flow cytometry results showed a notable increase in the number of Tregs within the spleen of the HIBD group.Moreover,the number of Tregs and the Foxp3 expression levels were higher in the PD-MSC treatment group than in the HIBD and fibroblast groups(all P<0.01).Our research suggests that the mechanism of PD-MSC treatment for HIBD partially involves inflammatory response suppression. | Hongfang Ding Hui Zhang Huifang Ding Dong Li Xinhao Yi Xiaoxu Ma Ruijuan Li Mei Huang Xiuli Ju | 2017 | Cellular & Molecular Immunology2017，14，8： | 10 |
| 5 | Influence of oxygen gas content on the structural and optical properties of ZnO thin films deposited by RF magnetron sputtering at room temperature显示文摘Zinc oxide (ZnO) thin films were deposited on sapphire (0001) substrates at room temperature by radiofrequency (RF) magnetron sputtering at oxygen gas contents of 0%,25%,50% and 75%,respectively.The influence of oxygen gas content on the structural and optical properties of ZnO thin films was studied by a surface profile measuring system,X-ray diffraction analysis,atomic force microscopy,and UV spectrophotometry.It is found that the size of ZnO crystalline grains increases first and then decreases with the increase of oxygen gas content,and the maximum grain size locates at the 25% oxygen gas content.The crystalline quality and average optical transmittance (>90%) in the visible-light region of the ZnO film prepared at an oxygen gas content of 25% are better than those of ZnO films at the other contents.The obtained results can be attributed to the resputtering by energetic oxygen anions in the growing process. | LIU Baoting ZHOU Yang ZHENG Hongfang LI Mana GUO Zhe HAO Qingxun PENG Yingcai | 2011 | Rare Metals2011，30，2： | 6 |
| 6 | Enhanced pyrocatalysis of the pyroelectric BiFeO_(3)/g-C_(3)N_(4) heterostructure for dye decomposition driven by cold–hot temperature alternation显示文摘The BiFeO_(3)/g-C_(3)N_(4) heterostructure,which is fabricated via a simple mixing–calcining method,benefits the significant enhancement of the pyrocatalytic performance.With the growth of g-C_(3)N_(4) content in the heterostructure pyrocatalysts from 0 to 25%,the decomposition ratio of Rhodamine B(RhB)dye after 18 cold-hot temperature fluctuation(25-65℃)cycles increases at first and then decreases,reaching a maximum value of~94.2%at 10%while that of the pure BiFeO_(3) is~67.7%.The enhanced dye decomposition may be due to the generation of the internal electric field which strengthens the separation of the positive and negative carriers and further accelerates their migrations.The intermediate products in the pyrocatalytic reaction also have been detected and confirmed,which proves the key role of the pyroelectric effect in realizing the dye decomposition using BiFeO_(3)/g-C_(3)N_(4) heterostructure catalyst.The pyroelectric BiFeO_(3)/g-C_(3)N_(4) heterostructure shows the potential application in pyrocatalytically degrading dye wastewater. | Mingzi Chen Yanmin Jia Huamei Li Zheng Wu Tianyin Huang Hongfang Zhang | 2021 | Journal of Advanced Ceramics2021，10，2： | 6 |
| 7 | Encapsulating metal organic framework into hollow mesoporous carbon sphere as efficient oxygen bifunctional electrocatalyst显示文摘Applying metal organic frameworks(MOFs) in electrochemical systems is a currently emerging field owing to the rich metal nodes and highly specific surface area of MOFs. However, the problems for MOFs that need to be solved urgently are poor electrical conductivity and low ion transport. Here we present a facile in situ growth method for the rational synthesis of MOFs@hollow mesoporous carbon spheres(HMCS)yolk–shell-structured hybrid material for the first time. The size of the encapsulated Zeolitic Imidazolate Framework-67(ZIF-67) is well controlled to 100 nm due to the spatial confinement effect of HMCS, and the electrical conductivity of ZIF-67 is also increased significantly. The ZIF@HMCS-25% hybrid material obtained exhibits a highly efficient oxygen reduction reaction activity with 0.823 V(vs. reversible hydrogen electrode) half-wave potential and an even higher kinetic current density(JK= 13.8 m A cm-2) than commercial Pt/C. ZIF@HMCS-25% also displays excellent oxygen evolution reaction performance and the overpotential of ZIF@HMCS-25% at 10 m A cm-2 is 407 m V. In addition, ZIF@HMCS-25% is further employed as an air electrode for a rechargeable Zn–air battery, exhibiting a high power density(120.2 m W cm-2 at 171.4 m A cm-2) and long-term charge/discharge stability(80 h at 5 m A cm-2). This MOFs@HMCS yolk–shell design provides a versatile method for the application of MOFs as electrocatalysts directly. | Wanfeng Xiong Hongfang Li Hanhui You Minna Cao Rong Cao | 2020 | National Science Review2020，7，3： | 6 |
| 8 | Characterization of a Mutant of Alteromonas aurantia A18 and Its Application in Mariculture显示文摘Mutant J61321 with enhanced siderophore production of Alteromonas aurantia A18 was obtained after a series of chemical-physical mutageneses. It was found that the antibacterial activity against Vibrio anguillarum W-1 and siderophore produc- tion of the mutant were higher than those by the original strain A18 which had been used in mariculture. The results of the specific assay(Csáky and Arnow methods) of siderophore showed that the sidrophore with hydroxamate group was produced by mutant J61321 and the original strain A18, respectively, while the siderophore with catechol group was yielded by strain W-1 (Aibrio an- guillarum). Meanwhile, the siderophore yield, antibacterial activity and anti-chelator activity of strain J61321 were higher than those of its parent strain A18. | LI Junfeng CHI Zhenming LI Hongfang WANG Xianghong | 2008 | Journal of Ocean University of China2008，7，1： | 4 |
| 9 | Preparation of NiFe binary alloy nanocrystals for nonvolatile memory applications显示文摘In this work,an idea which applies binary alloy nanocrystal floating gate to nonvolatile memory application was introduced.The relationship between binary alloy’s work function and its composition was discussed theoretically.A nanocrystal floating gate structure with NiFe nanocrystals embedded in SiO2 dielectric layers was fabricated by magnetron sputtering.The micro-structure and composition deviation of the prepared NiFe nanocrystals were also investigated by TEM and EDS. | WANG Li,SUN HongFang,ZHOU HuiHua & ZHU Jing Beijing National Center for Electron Microscopy Laboratory,Department of Materials Science and Engineering,Tsinghua University,Beijing 100084,China | 2010 | Science China(Technological Sciences)2010，53，9： | 3 |
| 10 | Characterization of a Bacteriocin-Like Substance Produced from a Novel Isolated Strain of Bacillus subtilis SLYY-3显示文摘In the present research, the strain SLYY-3 was isolated from sediments of Jiaozhou Bay, Qingdao, China. The strain SLYY-3, which produced a bacteriocin-like substance(BLS), was characterized to be a strain of Bacillus subtillis by biochemical profiling and 16 S r DNA sequence analysis. It is the first time to report that Bacillus subtilis from Jiaozhou Bay sediments could produce a BLS. The BLS of B. subtillis SLYY-3 exhibited strong inhibitory activity against gram-positive bacteria(including Staphylococcus aureus and B. subtillis) and some fungi(including Penicillium glaucum, Aspergillus niger and Aspergillus flavus). The antimicrobial activity was detected from culture in the exponential growth phase and reached its maximum when culture entered into stationary growth phase. It was thermo-tolerant even when being kept at 100℃ for 60 min without losing any activity and stable over a wide p H range from 1.0 to 12.0 while being inactivated by proteolytic enzyme and trypsin, indicating the proteinaceous nature of the BLS. The BLS was purified by precipitation with hydrochloric acid(HCl) and gel filteration(Sephadex G-100). SDS-PAGE analysis of the extracellular peptides of SLYY-3 revealed a bacteriocin-like protein with a molecular mass of 66 k Da. Altogether, these characteristics indicate the potential of the BLS for food industry as a protection against pathogenic and spoilage microorganisms. | LI Junfeng LI Hongfang ZHANG Yuanyuan DUAN Xiaohui LIU Jie | 2014 | Journal of Ocean University of China2014，13，6： | 3 |
| 11 | Pingwei capsules improve gastrointestinal motility in rats with functional dyspepsia显示文摘OBJECTIVE: To investigate the mechanism of Ping-wei capsules(PWC) in improving gastrointestinal m otility in rats with functional dyspepsia(FD).METHODS: We established an FD model by stimu-lating semi-starvation rats via tail damping, provo-cation, and forced exercise fatigue. The FD model group was further divided into five groups accord-ing to the treatment received: normal saline, dom-peridone, low-dose PWC, mid-dose PWC, or highdose PWC. The effect of PWC on FD was evaluated by measuring gastrointestinal motility. Changes in leptin and cholecystokinin(CCK) were detected through enzyme-linked immunosorbent assay, re-verse transcription-polymerase chain reaction, and immunohistochemistry.RESULTS: PWC significantly increased gastrointesti-nal m otility in FD rats. Furthermore, PWC signifi-cantly increased CCK m RNA and protein concentra-tions in the duodenum and antrum, decreased leptin protein concentrations in the duodenum, an-trum, and hypothalamus, and decreased CCK pro-tein concentration in the hypothalamus.CONCLUSION: PWC improves gastrointestinal mo-tor function in FD rats by decreasing the leptin con-centration in serum and the brain-gut axis, and by increasing the CCK concentration in gastrointesti-nal tissue. Our findings help to elucidate the mech-anism of FD and provide further insight into the pharmacokinetics of PWC. | Liang Qiankun Mao Lanfang Du Xiaojuan Li Yunxia Yan Yuan Liang Jingjing Liu Junhong Wang Longde Li Hongfang | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 3 |
| 12 | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1显示文摘As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor activities.The clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural optimization.Target identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target prediction.However,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising activities.Here,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired compounds.Then peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal cancer.Our solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with PRDX1.New derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure analysis.Both Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer cells.The anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer cells.Several downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 treatment.Our findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer. | Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 3 |
| 13 | Synergistic effect between expandable graphite and ammonium polyphosphate on flame retarded polylactide显示文摘 | Hongfang Zhu Qiliang Zhu Juan Li Kang Tao Lixin Xue Qing Yan | 2010 | Polymer Degradation and Stability2010，，2： | 2 |
| 14 | Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice显示文摘 | Yanfei Wang Xia Zhao Hongfang Jin Hongling Wei Wei Li Dingfang Bu Xiuying Tang Yali Ren Chaoshu Tang Junbao Du | 2009 | Arteriosclerosis Thrombosis and Vascular Biology2009，，2： | 2 |
| 15 | Preparation of BST nanocrystals embedded in SiO_2 film by magnetron sputtering for nonvolatile memory applications显示文摘We develop a method that uses magnetron sputtering to fabricate barium strontium titanate (BST) nanocrystals embedded in dielectric SiO2 films.Transmission electron microscope images show that the BST nanocrystals have an average diameter of 5 nm and are well distributed in the SiO2 film.In addition,we also analyze the BST nanocrystals composition deviation during the sputtering process by electron dispersive spectroscopy. | WANG Li SUN HongFang ZHOU HuiHua ZHU Jing | 2011 | Chinese Science Bulletin2011，56，11： | 2 |
| 16 | Delay-Differentiated Scheduling in Optical Packet Switches for Cloud Data Centers显示文摘We consider differentiated timecritical task scheduling in a N×N input queued optical packet s w itch to ens ure 100% throughput and meet different delay requirements among various modules of data center. Existing schemes either consider slot-by-slot scheduling with queue depth serving as the delay metric or assume that each input-output connection has the same delay bound in the batch scheduling mode. The former scheme neglects the effect of reconfiguration overhead, which may result in crippled system performance, while the latter cannot satisfy users' differentiated Quality of Service(Qo S) requirements. To make up these deficiencies, we propose a new batch scheduling scheme to meet the various portto-port delay requirements in a best-effort manner. Moreover, a speedup is considered to compensate for both the reconfiguration overhead and the unavoidable slots wastage in the switch fabric. With traffic matrix and delay constraint matrix given, this paper proposes two heuristic algorithms Stringent Delay First(SDF) and m-order SDF(m-SDF) to realize the 100% packet switching, while maximizing the delay constraints satisfaction ratio. The performance of our scheme is verified by extensive numerical simulations. | LI Yaofang XIAO Jie WU Bin WEN Hong YU Hongfang YANG Shu XIN Shanshan GUO Jianing | 2015 | China Communications2015，12，8： | 2 |
| 17 | Dual confinement of polysulfides in boron-doped porous carbon sphere/graphene hybrid for advanced Li-S batteries显示文摘由做硼的多孔的碳范围和 graphene (BPCS-G ) 组成的混合结构被设计了并且向解决 polysulfide 梭问题综合了,它是当前的 Li-S 电池的最关键的问题。显示出高表面区域的建议混合结构(870 m 2??????????????? ? €畧湡湩?? 挠瑹獯湩 ?????? ㄠ‰ ????????????? 吠 ?? €?‰ ??????? ‰ ?????????????????????????? ￡桴?? | Wei Ai Jiewei Li Zhuzhu Du Chenji Zou Hongfang Du Xin Xu Yu Chen Hongbo Zhang Jianfeng Zhao Changming Li Wei Huang Ting Yu | 2018 | Nano Research2018，11，9： | 2 |
| 18 | Synergistic effect between expandable graphite and ammonium polyphosphate on flame retarded polylactide显示文摘 | Hongfang Zhu Qiliang Zhu Juan Li Kang Tao Lixin Xue Qing Yan | 2010 | Polymer Degradation and Stability2010，，2： | 2 |
| 19 | Traffic-Aware VDC Embedding in Data Center: A Case Study of FatTree显示文摘Virtualization is a common technology for resource sharing in data center.To make efficient use of data center resources,the key challenge is to map customer demands(modeled as virtual data center,VDC) to the physical data center effectively.In this paper,we focus on this problem.Distinct with previous works,our study of VDC embedding problem is under the assumption that switch resource is the bottleneck of data center networks(DCNs).To this end,we not only propose relative cost to evaluate embedding strategy,decouple embedding problem into VM placement with marginal resource assignment and virtual link mapping with decided source-destination based on the property of fat-tree,but also design the traffic aware embedding algorithm(TAE) and first fit virtual link mapping(FFLM) to map virtual data center requests to a physical data center.Simulation results show that TAE+FFLM could increase acceptance rate and reduce network cost(about 49%in the case) at the same time.The traffic aware embedding algorithm reduces the load of core-link traffic and brings the optimization opportunity for data center network energy conservation. | LUO Shouxi YU Hongfang LI Lemin LIAO Dan SUN Gang | 2014 | China Communications2014，11，7： | 2 |
| 20 | Experimental investigation on heat transfer and pressure drop of kerosene at supercritical pressure in square and circular tube with artificial roughness显示文摘 | Haijun Wang Yushan Luo Hongfang Gu Hongzhi Li Tingkuan Chen Jianhua Chen Haibo Wu | 2012 | Experimental Thermal and Fluid Science2012，，： | 2 |
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