|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 2 | Relationship between the later strong gas-charging and the improvement of the reservoir capacity in deep Ordovician carbonate reservoir in Tazhong area, Tarim Basin显示文摘Some large-scale oil-gas fields have recently been discovered in marine carbonate in China, especially the significant discoveries in deep reservoir that reveals a favorable exploration prospect. Tazhong area is the first-order tectonic unit in Tarim Basin, where there are nearly trillion cubic meters of natural gas resources in the Ordovician limestone reef flat complex in Lianglitage Formation. The reservoir is shelf edge reef flat complex, characterized by ultra-low porosity, low permeability and strong heterogeneous, with a current burial depth of 4500―6500 m. Studies find that the formation and distribution of deep reservoir of the Lianglitage Formation were controlled not only by the early high-energy sedimentary facies and corrosion, but the fracture network formed by the strong gas-charging process since the Himalayan epoch, which played an important role in optimizing and improving reservoir properties. This paper discusses the relationship between the strong later gas-charging and the improvement of the reservoir capacity in deep Ordovician carbonate reservoir, and also builts the corresponding mechanisms and modes, which is favorable for the prediction and evaluation of the advantageous exploration targets. | ZHAO WenZhi ZHU GuangYou ZHANG ShuiChang ZHAO XueFeng SUN YuShan WANG HongJun YANG HaiJun HAN JianFa | 2009 | Chinese Science Bulletin2009，54，17： | 31 |
| 3 | Different Effects of Homocysteine and Oxidized Low Density Lipoprotein on Methylation Status in the Promoter Region of the Estrogen Receptor α Gene显示文摘我们调查了人的效果半胱氨酸(Hcy ) 和在雌激素受体高山的倡导者区域的 DNA methylation 上的氧化低密度脂蛋白(ox-LDL ) 哈(ERalpha ) 基因,和它在动脉粥样硬化的致病的潜在的机制。人的有教养的光滑的肌肉房间(SMC ) 被 Hcy 和 ox-LDL 为时间的不同经期与不同集中对待。DNA methylation 地位是由嵌套的 methylation 特定的聚合酶链反应的 assayed,在 SMC 和泡沫房间形成积累了的类脂化合物被检验,油红 O 染色。SMC 的增长是由 the3-(4,5-dimethylthiazol-2-yl ) 的 assayed -2,5-diphenyltetrazolium 溴化物方法。结果证明 ox-LDLin 节制导致的集中(10-40 mg/L ) 在 SMCs.However 的 ERagene 的倡导者区域的 de novo methylation, ox-LDL 的高集中(50 mg/L ) ,导致了时代的 demethylation。 Hcytreatment 与 aconcentration 在时代基因的倡导者区域导致了 de novo methylation --并且对待时间依赖者举止,并且在 SMCproliferation.These 数据上支持效果的一个剂量依赖者显示为动脉粥样硬化的二个风险因素有在 SMCs.However 的时代基因的倡导者区域导致 de novo methylation 的功能, ox-LDL 的高集中( 50 mg/L )导致了 demethylation ,显示有不同力量力量的动脉粥样硬化的不同风险因素在时代基因的倡导者区域引起不同异常 methylation 模式。Hcy 的 atherogenic 机制可能包含 hypermethylationof 时代基因,在动脉粥样硬化患者损害导致 SMC 的增长。 | Yushan HUANG~1 Kejun PENG~2 Juan SU~1 Yuping HUANG~3 Yizhon XU~1 and Shuren WANG~1 ~1Department of Pathophysiology,West China School of Preclinic Medical Sciences & Forensic Medicine,Sichuan University,Chengdu 610041.China ~2Department of Laboratory Medicine,Chengdu Medical College,Chengdu 610500,China ~3Department of Biochemistry and Molecular Bilogy,Gannan Medical College,Ganzhou 341000,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 25 |
| 4 | Evaluation of clinical application of ESICM acute gastrointestinal injury grading system: a single-center observational study显示文摘 | Zhang Dong Li Nan Dong Lihua Fu Yao Liu Zhongmin Wang Yushan | 2014 | Chinese Medical Journal2014，，10： | 26 |
| 5 | Prognostic value of clinical and pathological factors for surgically treated localized clear cell renal cell carcinoma显示文摘 | Teng Jingfei Gao Yi Chen Ming Wang Kai Cui Xingang Liu Yushan Xu Danfeng | 2014 | Chinese Medical Journal2014，，9： | 23 |
| 6 | The transition from traditional banking to mobile internet finance:an organizational innovation perspective-a comparative study of Citibank and ICBC显示文摘The development of Financial Technology(FinTech)in areas such as mobile Internet,cloud computing,big data,search engines,and blockchain technology have significantly changed the financial industry.FinTech is expected to overturn the traditional banking business model,forcing banks to upgrade and transform.This study adopts a comparative case study method to contrast and analyze the Industrial and Commercial Bank of China(ICBC)and Citibank.It analyzes the strategies,organizations,HR systems,and product innovations adopted by these two banks in response to the impact of FinTech.This paper proposes an“electric vehicle”mode for ICBC and an“airplane mode”for Citibank.Further,it describes the difficulties encountered by the Chinese banking industry and proposes some feasible ways to upgrade.“Technology power”will become the core competitive concept for the financial institutions of the future. | Zhuming Chen Yushan Li Yawen Wu Junjun Luo | 2017 | Financial Innovation2017，3，1： | 19 |
| 7 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 8 | Sedimentary Response of Different Fan Types to the Paleogene-Neogene Basin Transformation in the Kuqa Depression,Tarim Basin,Xinjiang Province显示文摘A group of alluvial fans formed in the early Paleogene represent marginal sedimentary facies at the foot of the South Tianshan Mountain,Kuqa Depression,Tarim Basin,Xinjiang province. Two types of fans occurred in the middle-late Paleogene Kumugeliemu and Suweiyi formations:one alluvial,and the other fan delta deposited in a lacustrine setting.Within the early Neogene Jidike Formation,coastal subaqueous fans developed,probably in a deeper water lacustrine setting.The three types of fans are stacked vertically in outcrop with the sequence in ascending order:bottom alluvial,middle fan-delta,and top subaqueous.The subaqueous is a typical coarse-fan deposit occurring in the glutinite member of the Jidike Formation in some wells.Laterally,from the foreland to the lacustrine settings,the distribution pattern of sedimentary facies represents the same three fan types sequentially.The spatial distribution of these fans was controlled by the Paleogene-Neogene Basin transformation,and evolution with different types of fans developed in the Kuqa Depression in response.In the Paleogene,the Kuqa Depression was a rift basin where an alluvial fan was deposited in the foreland setting,which,by early Neogene,became a foreland basin when the lake level changed. With any rise in lake level,fan-deltas migrated from lacustrine to foreland settings,whereas when the lake level fell,fan migration was reversed.In the early Neogene,with increasing slope and rising lake level,fans progressed and covered the previous fan-delta and lacustrine mudstone.Eventually, subaqueous fans developed,forming the present spatial configuration of these three fan types. | GAO Zhiyong GUO Hongli ZHU Rukai ZHANG Lijuan SUN Yushan | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 10 |
| 9 | Magmatic Ni-Cu-(PGE) deposits in magma plumbing systems:Features,formation and exploration显示文摘为大、超级大的 magmatic 硫化物存款的形成的三个很关键的因素是:(1 ) 导出披风的 mafic-ultramafic 参予了存款的形成的大量岩浆;(2 ) 部分结晶化和外壳的污染,特别地从外壳的岩石的硫的输入,导致硫化物 immiscibility 和分离;并且(3 ) 在侵入预定硫化物集中。超级大的 magmatic Ni-Cu 硫化物存款在全世界在小 mafic-ultramafic 侵入被发现了,除了 Sudbury 存款。在过去的十年的研究在中国显示招待大、超级大的 magmatic 硫化物存款的侵入发生在岩浆水管,例如那些,包括 Jinchuan (Gansu ) , Yangliuping (四川) , Kalatongke (Xinjiang ) ,和 Hongqiling (吉林) 。开的岩浆系统提供完美的环境因为不能混合的硫化物的广泛的集中融化的岩浆水管,它被发现了沿着深地区性的差错发生。许多导出披风的岩浆的起源仔细与披风羽毛, intracontinental 裂缝,或 post-collisional 扩展被联系。尽管硫化物 immiscibility 源于外壳的污染,这被证实了,矿石也与父母岩浆,在硅酸盐岩浆之间的比率和不能混合的硫化物的性质有关的硫化物的等级融化,在硫化物之间的反应融化并且最新注射的硅酸盐岩浆,并且硫化物的分别融化。忍受矿石的侵入和硫化物矿石身体的地关系被墙岩石的地质的特征控制。在这份报纸,我们试图表明硫化物扔在将为进一步的探索提供指南的 magmatic 水管发生的 magmatic 的一般特征,形成机制,构造背景,和指示物。 | Xieyan Song Yushan Wang Liemeng Chen | 2011 | Geoscience Frontiers2011，2，3： | 9 |
| 10 | ANALYSIS ON LAPPING AND POLISHING PRESSURE DISTRIBUTION OF HARD MAGNETIC DISK SUBSTRATE显示文摘0INTRODUCTIONInthemagneticrecordingsystem,thelowertherecordingflyingheightbetweenthemagneticheadanddisk,thehighertheareareco... | Cai, Guangqi Cai, Rui Lu, Yushan Min, Xinli | 1998 | Chinese Journal of Mechanical Engineering1998，11，4： | 8 |
| 11 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 12 | Bionic Mosaic Method of Panoramic Image Based on Compound Eye of Fly显示文摘 | Haipeng Chen Xuanjing Shen Xiaofei Li Yushan Jin | 2011 | Journal of Bionic Engineering2011，8，4： | 8 |
| 13 | Interface electron collaborative migration of Co–Co3O4/carbon dots:Boosting the hydrolytic dehydrogenation of ammonia borane显示文摘Ammonia borane(AB)is an excellent candidate for the chemical storage of hydrogen.However,its practical utilization for hydrogen production is hindered by the need for expensive noble-metal-based catalysts.Herein,we report Co-Co3O4 nanoparticles(NPs)facilely deposited on carbon dots(CDs)as a highly efficient,robust,and noble-metal-free catalyst for the hydrolysis of AB.The incorporation of the multiinterfaces between Co,Co3O4 NPs,and CDs endows this hybrid material with excellent catalytic activity(rB=6816 mLH2 min^-1 gCo^-1)exceeding that of previous non-noble-metal NP systems and even that of some noble-metal NP systems.A further mechanistic study suggests that these interfacial interactions can affect the electronic structures of interfacial atoms and provide abundant adsorption sites for AB and water molecules,resulting in a low energy barrier for the activation of reactive molecules and thus substantial improvement of the catalytic rate. | Han Wu Min Wu Boyang Wang Xue Yong Yushan Liu Baojun Li Baozhong Liu Siyu Lu | 2020 | Journal of Energy Chemistry2020，29，9： | 7 |
| 14 | Effectiveness of a Subsurface Constructed Wetland on the Treatment of Saline Wastewater显示文摘 | Yushan Zhang Jing Wang Jinquan Qiu | 2010 | Journal of Environmental Science and Engineering2010，4，1： | 7 |
| 15 | Mitoxantrone-Mediated Apoptotic B16-F1 Cells Induce Specific Anti-tumor Immune Response显示文摘In the process of cell apoptosis induced by specific reagents,calreticulin(CRT)in endoplasmic reticulum is transferred and coated onto the cell membrane.As a sort of specific ligand,the CRT on the surface of apoptotic cells could mediate recognition and clearance of apoptotic cells by phagocytes.In this research we discovered that mitoxantrone could induce apoptosis of mouse melonoma B16-F1 tumor cells,accompanied by the membrane translocation and coating of CRT.When mitoxantrone-treated B16-F1 cells were used as antigen to inoculate mice,the mice acquired an ability to suppress proliferation of homologous tumor cells.Splenocytes from these mice showed an increased cytolytic effect on homologous B16-F1 cells but no such effect on non-homologous H22 tumor cells.All these results suggested that mitoxantrone-treated apoptotic B16-F1 cells could be used as a sort of cell vaccine to initiate effective anti-tumor immunoresponse in mice. | Chunyu Cao Yu Han Yushan Ren Yanlin Wang | 2009 | Cellular & Molecular Immunology2009，6，6： | 7 |
| 16 | Seasonal Variation of Biochemical Components in Clam (Saxidomuspurpuratus Sowerby 1852) in Relation to Its Reproductive Cycle and the Environmental Condition of Sanggou Bay, China显示文摘Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycle of clam.According to the histological analysis,the reproductive cycle of S.purpuratus includes two distinctive phases:a total spent and inactive stage from November to January,and a gametogenesis stage,including ripeness and spawning,during the rest of the year.Gametes were generated at a low temperature(2.1℃) in February.Spawning took place once a year from June to October.The massive spawning occurred in August when the highest water temperature and chlorophyll a level could be observed.The key biochemical components(glycogen,protein and lipid) in five tissues(gonad,foot,mantle,siphon and adductor muscle) were analyzed.The glycogen content was high before gametogenesis,and decreased significantly during the gonad development in the gonad,mantle and foot of both females and males,suggesting that glycogen was an important energy source for gonad development.The protein and lipid contents increased in the ovary during the gonad development,demonstrating that they are the major organic components of oocytes.The lipid and protein contents decreased in the testis,implying that they can provide energy and material for spermatogenesis.The results also showed that protein stored in the mantle and foot could support the reproduction after the glycogen was depleted. | BI Jinhong LI Qi ZHANG Xinjun ZHANG Zhixin TIAN Jinling XU Yushan LIU Wenguang | 2016 | Journal of Ocean University of China2016，15，2： | 6 |
| 17 | Caspase cleavage of cytochrome cl disrupts mitochondrial function and enhances cytochrome c release显示文摘 | Yushan Zhu Min Li Xiaohui Wang Haijing Jin Shusen Liu Jianxin Xu Quan Chen | 2012 | Cell Research2012，22，1： | 6 |
| 18 | Allele-aware chromosome-scale assembly of the allopolyploid genome of hexaploid Ma bamboo(Dendrocalamus latiflorus Munro)显示文摘Dendrocalamus latiflorus Munro is a woody clumping bamboo with rapid shoot growth.Both genetic transformation and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing techniques are available for D.latiflorus,enabling reverse genetic approaches.Thus,D.latiflorus has the potential to be a model bamboo species.However,the genome sequence of D.latiflorus has remained unreported due to its polyploidy and large genome size.Here,we sequenced the D.latiflorus genome and assembled it into three allele-aware subgenomes(AABBCC),representingthe largest genome of a major bamboo species.We assembled 70 allelic chromosomes(2,737 Mb)for hexaploid D.latiflorus using both singlemolecule sequencing from the Pacific Biosciences(Pac Bio)Sequel platform and chromosome conformation capture sequencing(Hi-C).Repetitive sequences comprised 52.65%of the D.latiflorus genome.We annotated 135231 protein-coding genes in the genome based on transcriptomes from eight different tissues.Transcriptome sequencing using RNA-Seq and Pac Bio singlemolecule real-time long-read isoform sequencing revealed highly differential alternative splicing(AS)between non-abortive and abortive shoots,suggesting that AS regulates the abortion rate of bamboo shoots.This high-quality hexaploid genome and comprehensive strand-specific transcriptome datasets for this Poaceae family member will pave the way for bamboo research using D.latiflorus as a model species. | Yushan Zheng Deming Yang Jundong Rong Liguang Chen Qiang Zhu Tianyou He Lingyan Chen Jing Ye Lili Fan Yubang Gao Hangxiao Zhang Lianfeng Gu | 2022 | Journal of Integrative Plant Biology2022，64，3： | 6 |
| 19 | Adaptive PID control system for an autonomous underwater vehicle显示文摘 | 王波 Su Yumin Wan Lei Sun Yushan | 2011 | High Technology Letters2011，17，1： | 5 |
| 20 | Molecular distribution and seasonal variation of hydrocarbons in PM_(2.5) from Beijing during 2006显示文摘正常(n) 链烷和多不的芳香的烃(哼) 在 2006 从北京在 PM2.5 被收集并且分析了使用一种热 desorption-GC/MS 技术。n 链烷的年度平均集中并且哼 282 是 ????????????? ? ㈠ ?? 朠洯″ ???? ?? | Yushan Li Junji Cao Jianjun Li Jiamao Zhou Hongmei Xu Renjian Zhang Zhiyun Ouyang | 2013 | Particuology2013，11，1： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员