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| 1 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 2 | Corrosion Behavior of Mg-Zn-Y Alloy with Long-period Stacking Ordered Structures显示文摘Mg-Zn-Y alloys with long-period stacking ordered structures were prepared by an ingot casting method. The corrosion performance of Mg-Zn-Y alloys was studied by combining gas-collecting test, immersion test and electrochemical measurements in order to determine the corrosion rate and mechanism of the alloys. The results showed that the volume fraction of Mg(12)YZn phase increased and the shape of the Mg(12)YZn phase changed from discontinuous to continuous net-like with increasing Zn and Y content. The corrosion rate of the alloys greatly depended on the distribution and volume fraction of the Mg(12)YZn phase. Corrosion products appeared at the junction of Mg phase and Mg(12)YZn phase, indicating that the Mg(12)YZn phase accelerated galvanic corrosion of Mg matrix. Mg(97)Zn1Y2 alloy shows the lowest corrosion rate due to the continuous distribution of Mg(12)YZn phase. | Jinshan Zhang Jidong Xu Weili Cheng Changjiu Chen Jingjing Kang | 2012 | Journal of Materials Science & Technology2012，28，12： | 17 |
| 3 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 4 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 5 | Advanced data analytics for enhancing building performances: From data-driven to big data-driven approaches显示文摘Buildings have a significant impact on global sustainability.During the past decades,a wide variety of studies have been conducted throughout the building lifecycle for improving the building performance.Data-driven approach has been widely adopted owing to less detailed building information required and high computational efficiency for online applications.Recent advances in information technologies and data science have enabled convenient access,storage,and analysis of massive on-site measurements,bringing about a new big-data-driven research paradigm.This paper presents a critical review of data-driven methods,particularly those methods based on larger datasets,for building energy modeling and their practical applications for improving building performances.This paper is organized based on the four essential phases of big-data-driven modeling,i.e.,data preprocessing,model development,knowledge post-processing,and practical applications throughout the building lifecycle.Typical data analysis and application methods have been summarized and compared at each stage,based upon which in-depth discussions and future research directions have been presented.This review demonstrates that the insights obtained from big building data can be extremely helpful for enriching the existing knowledge repository regarding building energy modeling.Furthermore,considering the ever-increasing development of smart buildings and IoT-driven smart cities,the big data-driven research paradigm will become an essential supplement to existing scientific research methods in the building sector. | Cheng Fan Da Yan Fu Xiao Ao Li Jingjing An Xuyuan Kang | 2021 | Building Simulation2021，14，1： | 10 |
| 6 | Increased activity of MdFRK2, a high-affinity fructokinase, leads to upregulation of sorbitol metabolism and downregulation of sucrose metabolism in apple leaves显示文摘To investigate the functions of fructokinase(FRK)in apple(Malus domestica)carbohydrate metabolism,we cloned the coding sequences of MdFRK1 and MdFRK2 from the‘Royal Gala’apple.The results showed that MdFRK2 expression was extremely high in shoot tips and young fruit.Analyses of heterologously expressed proteins revealed that MdFRK2 had a higher affinity for fructose than did MdFRK1,with Km values of 0.1 and 0.62 mM for MdFRK2 and MdFRK1,respectively.The two proteins,however,exhibited similar Vmax values when their activities were significantly inhibited by high concentrations of fructose.MdFRK2 ectopic expression was associated with a general decrease in fructose concentration in transgenic lines.In leaves,increased FRK activity similarly resulted in reduced concentrations of glucose and sucrose but no alterations in sorbitol concentration.When compared with those in the untransformed control,genes involved in sorbitol synthesis(A6PR)and the degradation pathway(SDH1/2)were significantly upregulated in transgenic lines,whereas those involved in sucrose synthesis(SPS1)and other degradation processes(SUSY4,NINV1/2,and HxK2)were downregulated.The activity of enzymes participating in carbohydrate metabolism was proportional to the level of gene expression.However,the growth performance and photosynthetic efficiency did not differ between the transgenic and wild-type plants.These results provide new genetic evidence to support the view that FRK plays roles in regulating sugar and sorbitol metabolism in Rosaceae plants. | Jingjing Yang Lingcheng Zhu Weifang Cui Chen Zhang Dongxia Li Baiquan Ma Lailiang Cheng Yong-Ling Ruan Fengwang Ma Mingjun Li | 2018 | Horticulture Research2018，5，1： | 9 |
| 7 | Chemical characteristics of size-resolved aerosols in winter in Beijing显示文摘Size-resolved aerosols were continuously collected by a Nano Sampler for 13 days at an urban site in Beijing during winter 2012 to measure the chemical composition of ambient aerosol particles. Data collected by the Nano Sampler and an ACSM(Aerodyne Aerosol Chemical Speciation Monitor) were compared. Between the data sets,similar trends and strong correlations were observed,demonstrating the validity of the Nano Sampler. PM10 and PM2.5concentrations during the measurement were 150.5 ± 96.0 μg/m3(mean ± standard variation)and 106.9 ± 71.6 μg/m3,respectively. The PM2.5/PM10 ratio was 0.70 ± 0.10,indicating that PM2.5dominated PM10. The aerosol size distributions showed that three size bins of 0.5–1,1–2.5 and 2.5–10 μm contributed 21.8%,23.3% and 26.0% to the total mass concentration(TMC),respectively. OM(organic matter) and SIA(secondary ionic aerosol,mainly SO42-,NO3-and NH4+) were major components of PM2.5. Secondary compounds(SIA and secondary organic carbon) accounted for half of TMC(about 49.8%) in PM2.5,and suggested that secondary aerosols significantly contributed to the serious particulate matter pollution observed in winter. Coal burning,biomass combustion,vehicle emissions and SIA were found to be the main sources of PM2.5. Mass concentrations of water-soluble ions and undetected materials,as well as their fractions in TMC,strikingly increased with deteriorating particle pollution conditions,while OM and EC(elemental carbon) exhibited different variations,with mass concentrations slightly increasing but fractions in TMC decreasing. | Kang Sun Yu Qu Qiong Wu Tingting Han Jianwei Gu Jingjing Zhao Yele Sun Qi Jiang Ziqi Gao Min Hu Yuanhang Zhang Keding Lu Stephan Nordmann Yafang Cheng Li Hou Hui Ge Masami Furuuchi Mitsuhiko Hata Xingang Liu | 2014 | Journal of Environmental Sciences2014，26，8： | 9 |
| 8 | Paleomagnetic data from the Late Carboniferous-Late Permian rocks in eastern Tibet and their implications for tectonic evolution of the northern Qiangtang-Qamdo block显示文摘We report paleomagnetic results from the Late Carboniferous-Late Permian strata in eastern Tibet (China), and aim to clarify the tectonic and paleogeographic evolution of the northern Qiangtang-Qamdo block, which is the key to the study of plate boundary between the Gondwanaland and the Eurasia during the late Paleozoic. Two hundred and nineteen samples-including limestone, muddy siltstone, basalt, lava, and tuff-were collected at 24 sites in the Upper Carboniferous and Middle-Upper Permian successions. A systematic study of rock magnetism and paleomagnetism yields three reliable paleomagnetic pole positions. Both hematite and magnetite occurred in the Late Carboniferous limestone samples. The demagnetization curve shows a characteristic double-component, with the remanent magnetization (ChRM) exhibiting a positive polarity (negative inclination). In the Late Permian limestone, tuff, and basalt, magnetic information were recorded primarily in magnetite, although a small fraction of them was found in hematite in basalt. The demagnetization curve illustrates a double or single component, with the ChRM showing a negative polarity (positive inclination), which has passed the classic fold test successfully. The single polarity features of the ChRM directions of the Late Carboniferous and Middle-Late Permian rocks are respectively related to the Kiaman positive and reversed polarities under the stratigraphic coordinates. This, in turn, indicates that both ChRMs directions represent the original remanence directions. By comparison with the previously published paleomagnetic results from the late Paleozoic rocks in the northern Qiangtang Range, we suggest that: (1) Qamdo and northern Qiangtang block were independent of each other during the Late Carboniferous to the Early Permian periods. The north Lancangjiang ocean basin between the two blocks may have closed before the Middle Permian and been involved in the continent-continent collision stage in the Late Permian-Early Triassic periods. (2) The northern Qiangtang-Qamdo Block paleogeographically was situated at low to intermediate latitudes in the Southern Hemisphere in the Late Carboniferous-Late Permian periods, and began to displace northward in the Early Triassic, with an amount of more than 5000 km northward transport from its current location. | CHENG Xin WU HanNing DIAO ZongBao WANG HaiJun MA Lun ZHANG XiaoDong YANG Gang HONG JingJing JI WenHua LI RongShe CHEN ShouJian ZHAO ZhenMing | 2013 | Science China Earth Sciences2013，56，7： | 8 |
| 9 | Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model显示文摘Background:Neuron-microglia communication plays a crucial role in the motor neurons(MNs)death in amyotrophic lateral sclerosis(ALS).Neurons can express chemokine(C-X3-C motif)ligand 1(CX3CL1),which mediates microglial activation via interacting with its sole receptor CX3CR1 in microglia.In the present study,we aimed to investigate the dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and MNs loss in SOD1G93A mouse model of ALS.Methods:qPCR,western blot and immunofluorescent staining were used to examine the mRNA and protein levels and localization of CX3CL1/CX3CR1 in the anterior horn region of spinal cord in both SOD1G93A mice and their agematched wild type(WT)littermates at 40,60,90 and 120 days of age.The M1/M2 microglial activation in the spinal cord tissues of SOD1G93A mice and WT mice were evaluated by immunofluorescent staining of M1/M2 markers and further confirmed by qPCR analysis of M1/M2-related cytokines.Results:The immunofluorescent staining revealed that CX3CL1 was predominately expressed in MNs,while CX3CR1 was highly expressed in microglia in the anterior horn region of spinal cord.Compared with age-matched WT mice,CX3CL1 mRNA level was elevated at 40 days but decreased at 90 and 120 days in the anterior horn region of spinal cords in ALS mice.Consistently,CX3CR1 mRNA level was increased at 90 and 120 days.Western blot assay further confirmed the dynamic changes of CX3CL1/CX3CR1 axis in ALS mice.Additionally,the levels of M1/M2 markers of microglia and their related cytokines in the anterior horn region of spinal cord in ALS mice were increased at 90 and 120 days.Moreover,while M1-related cytokines in ALS mice were persistently increased at 120 days,the upregulated M2-related cytokines started to decline at 120 days,suggesting an altered microglial activation.Conclusions:Our data revealed the dynamic changes of CX3CL1/CX3CR1 axis and an imbalanced M1/M2 microglial activation during ALS pathological progression.These findings may help identify potential molecular targets for ALS therapy. | Jingjing Zhang Yufei Liu Xinyao Liu Song Li Cheng Cheng Sheng Chen Weidong Le | 2018 | Translational Neurodegeneration2018，7，1： | 7 |
| 10 | Albedo of Coastal Landfast Sea Ice in Prydz Bay,Antarctica:Observations and Parameterization显示文摘The snow/sea-ice albedo was measured over coastal landfast sea ice in Prydz Bay, East Antarctica(off Zhongshan Station)during the austral spring and summer of 2010 and 2011. The variation of the observed albedo was a combination of a gradual seasonal transition from spring to summer and abrupt changes resulting from synoptic events, including snowfall, blowing snow, and overcast skies. The measured albedo ranged from 0.94 over thick fresh snow to 0.36 over melting sea ice. It was found that snow thickness was the most important factor influencing the albedo variation, while synoptic events and overcast skies could increase the albedo by about 0.18 and 0.06, respectively. The in-situ measured albedo and related physical parameters(e.g., snow thickness, ice thickness, surface temperature, and air temperature) were then used to evaluate four different snow/ice albedo parameterizations used in a variety of climate models. The parameterized albedos showed substantial discrepancies compared to the observed albedo, particularly during the summer melt period, even though more complex parameterizations yielded more realistic variations than simple ones. A modified parameterization was developed,which further considered synoptic events, cloud cover, and the local landfast sea-ice surface characteristics. The resulting parameterized albedo showed very good agreement with the observed albedo. | Qinghua YANG Jiping LIU Matti LEPPRANTA Qizhen SUN Rongbin LI Lin ZHANG Thomas JUNG Ruibo LEI Zhanhai ZHANG Ming LI Jiechen ZHAO Jingjing CHENG | 2016 | Advances in Atmospheric Sciences2016，33，5： | 7 |
| 11 | Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty显示文摘童年肥胖和肥胖相关的新陈代谢的复杂并发症被一本高脂肪的出生后的食谱导致。然而,一个合适的动物模型的缺乏在肥胖研究仍然是可观的挑战。在当前的学习,我们在断奶以后在哺乳期间并且到小狗提供了高脂肪的饮食(HFD ) 给水坝。我们也与导致 HFD 的出生后的肥胖开发了 C57BL/6J 老鼠小狗的一个新奇模型。结果证明用 HFD 喂在小狗导致胖免职和肥胖。而且, HFD 更 potently 比女小狗增加了男性的身体重量(BW ) 。喂 HFD 的女小狗是肥胖的,经历了早熟的发身,并且显示出在视下丘的增加的 kisspeptin 表示。然而,父母肥胖和早熟的发身没在导致 HFD 的出生后的重量获得和小狗的发身发作上施加 synergistic 效果。有趣地,有正常 BW 的一些喂 HFD 的崽也展出了早熟的发身。这发现建议了那篇食谱作文然而并非 BW 扳机发身发作。我们的模型建议肥胖和早熟的发身的好构造有效性。而且,我们的模型能也被用来探索在 dietinduced 之间的相互的相互作用出生后的童年肥胖和发身。 | Rahim Ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 12 | A new species of the genus Crocidura from China based on molecular and morphological data(Eulipotyphla: Soricidae)显示文摘A new species of white-toothed shrew,Crocidura anhuiensis Zhang,Zhang&Li,sp.nov.is described from Mount Huang,China.Genetic sequence(mt DNA Cyt b gene)and morphological(external and skull)data are used to distinguish this newly discovered species.The phylogenetic analysis shows that the materials of this work are monophyletic and allied to C.attenuata by the uncorrected genetic distance 4.9–5.1%,which suggests a species-level divergence.Morphologically,the materials are different from C.attenuata by presenting a greater proportion of tail-to-body ratio and the presence of an obvious tooth root in the mandible.Based on those data,the unnamed species is described as a new species which is currently known only from the Wild Monkey Valley,Mount Huang,Anhui Province,China. | Heng Zhang Guiyou Wu Yanqing Wu Jianfei Yao Shuo You Chencheng Wang Feng Cheng Jingjing Chen Mingxia Tang Chunlin Li Baowei Zhang | 2019 | Zoological Systematics2019，44，4： | 5 |
| 13 | Synchrotron radiation X-ray powder diffraction techniques applied in hydrogen storage materials--A review显示文摘Synchrotron radiation is an advanced collimated light source with high intensity. It has particular advantages in structural characterization of materials on the atomic or molecular scale. Synchrotron radiation X-ray powder diffraction(SR-XRPD) has been successfully exploited to various areas of hydrogen storage materials. In the paper, we will give a brief introduction on hydrogen storage materials, X-ray powder diffraction(XRPD), and synchrotron radiation light source. The applications of ex situ and in situ time-resolved SR-XRPD in hydrogen storage materials, are reviewed in detail. Future trends and proposals in the applications of the advanced XRPD techniques in hydrogen storage materials are also discussed. | Honghui Cheng Chen Lu Jingjing Liu Yongke Yan Xingbo Han Huiming Jin Yu Wang Yi Liu Changle Wu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 5 |
| 14 | Toll-Like Receptor 4 Deficiency Causes Reduced Exploratory Behavior in Mice Under Approach-Avoidance Conflict显示文摘Abnormal approach-avoidance behavior has been linked to deficits in the mesolimbic dopamine(DA)system of the brain. Recently, increasing evidence has indicated that toll-like receptor 4(TLR4), an important pattern-recognition receptor in the innate immune system,can be directly activated by substances of abuse, resulting in an increase of the extracellular DA level in the nucleus accumbens. We thus hypothesized that TLR4-dependent signaling might regulate approach-avoidance behavior. To test this hypothesis, we compared the novelty-seeking and social interaction behaviors of TLR4-deficient(TLR4^(-/-))and wild-type(WT) mice in an approach-avoidance conflict situation in which the positive motivation to explore a novel object or interact with an unfamiliar mouse was counteracted by the negative motivation to hide in exposed,large spaces. We found that TLR4^(-/-)mice exhibitedreduced novelty-seeking and social interaction in the large open spaces. In less stressful test apparatuses similar in size to the mouse cage, however, TLR4^(-/-)mice performed normally in both novelty-seeking and social interaction tests. The reduced exploratory behaviors under approachavoidance conflict were not due to a high anxiety level or an enhanced fear response in the TLR4^(-/-)mice, as these mice showed normal anxiety and fear responses in the open field and passive avoidance tests, respectively. Importantly,the novelty-seeking behavior in the large open field induced a higher level of c-Fos activation in the nucleus accumbens shell(NAc Sh) in TLR4^(-/-)mice than in WT mice. Partially inactivating the NAc Sh via infusion of GABA receptor agonists restored the novelty-seeking behavior of TLR4^(-/-)mice. These data suggested that TLR4 is crucial for positive motivational behavior under approach-avoidance conflict. TLR4-dependent activation of neurons in the NAc Sh may contribute to this phenomenon. | Chunlu Li Yixiu Yan Jingjing Cheng Gang Xiao Jueqing Gu Luqi Zhang Siyu Yuan Junlu Wang Yi Shen Yu-Dong Zhou | 2016 | Neuroscience Bulletin2016，32，2： | 5 |
| 15 | NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc显示文摘Background:Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma(ESCC).NS1-binding protein(NS1-BP),a member of the BTB-kelch protein fam-ily,has been shown to inhibit the proliferation of Hela cells by suppressing c-Myc.In the present study,we examined the potential function role of NS1-BP expression in ESCC,and particularly,the sensitivity of ESCC to radiotherapy.Methods:NS1-BP expression was examined using immunohistochemistry in two cohorts(n=98 for the training cohort;n=46 for independent validation cohort)of ESCC patients receiving cisplatin-based chemotherapy and con-current radiotherapy.Normal esophageal mucosal tissue blocks were used as a control.We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over-expressing NS1-BP on ESCC cells,and particu-larly their sensitivity to ionizing irradiation.Results:In the training cohort,NS1-BP downregulation was observed in 59%(85/144)of the ESCC specimens.NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival(DSS)in both the training and validation cohorts.Over-expressing NS1-BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo.NS1-BP also significantly enhanced IR-induced apoptosis,and abrogated IR-induced G2/M cell-cycle arrest and ATM/Chk1 phosphorylation.Immunoprecipitation assays indicated that NS1-BP could interact with c-Myc promoter regions to inhibit its transcription.In ESCC tissues,c-Myc expression was inversely correlated with NS1-BP levels,and was associated with a shorter DSS.Conclusions:Our findings highlight the role and importance of NS1-BP in radiosensitivity of ESCC.Targeting the NS1-BP/c-Myc pathway may provide a novel therapeutic strategy for ESCC. | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2018 | Cancer Communications2018，38，1： | 4 |
| 16 | A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy显示文摘The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–guest complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment. | Yihan Wu Jingjing Li Xuemei Zhong Jinfeng Shi Yanfen Cheng Chenglin He Jiaxin Li Liang Zou Chaomei Fu Meiwan Chen Jinming Zhang Huile Gao | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，2： | 4 |
| 17 | Crystal structure and nucleotide selectivity of human IFIT5/ISG58显示文摘 | Feng Feng LingminYuan Yao E Wang Christopher Crowley Zongyang Lv Jingjing Li Yingfang Liu Genhong Cheng Su Zeng Huanhuan Liang | 2013 | Cell Research2013，23，8： | 4 |
| 18 | Superior electrochemical performance of La-Mg-Ni-based alloys with novel A_(2)B_(7)-A_(7)B_(23) biphase superlattice structure显示文摘Nickel metal hydride(Ni-MH) rechargeable batteries hold an important position in the new-energy vehicle market owing to their key technology advantages. Their negative electrode materials—hydrogen storage alloys(HSAs) are always on the spotlight and are the key to compete with the burgeoning Li-ion batteries. Here, for the first time we report a series of biphase supperlattice HSAs with a(La,Mg)_(2)Ni_7 matrix phase and a novel(La,Mg)_(7)Ni_(23) secondary phase. The biphase alloys show discharge capacities of402–413 m Ahg^(-1) compared with 376–397 mAhg^(-1) of the other multi-or single-phase alloys. These values are among the highest for superlattice HSAs. In addition, the alloy with 15.4 wt.%(La,Mg)_(7)Ni_(23) phase exhibits good high rate dischargeability due to the proper compromise between the amount of crystal boundaries and equilibrium plateau voltage. The cycling stability of the biphase alloys is lower than that of the single-phase alloy but is till higher than the multiphase alloy. The novel superlattice biphase alloys with superior overall electrochemical properties are expected to inspire further design and development of HSAs as advanced electrode materials for power batteries. | Jingjing Liu Shuai Zhu Xiangyu Chen Jie Xu Lu Zhang Kai Yan Wei Chen Honghui Cheng Shumin Han | 2021 | Journal of Materials Science & Technology2021，，21： | 4 |
| 19 | Grating lobes suppression method for stepped frequency GB-SAR system显示文摘A grating lobes suppression method for chirp-subpulse stepped frequency(CSSF) signals is proposed, which is applied to deformation monitoring using the ground based synthetic aperture radar(GB-SAR) system. This method is based on accurate estimation and correction of the phase and amplitude error along two dimensions(range and azimuth), i.e., the error estimation inside the subpulse(in-subpulse error) and across the stepped frequency subpulses(cross-subpulse error) of transmitted CSSF signals. Validated both with simulated data and experimental data recorded in the deformation monitoring campaign, it can be seen that the method as well as the relative conclusions can be fully and effectively applied to most of the stepped frequency systems. | Tao Zeng Cong Mao Cheng Hu Mao Zhu Weiming Tian Jingjing Ren | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 3 |
| 20 | Modeling Experiment of Break of Debris-Flow Dam显示文摘Glaciers are extensively developed in the southwest of Tibet and the moraines are widely distributed with large depth. Large-scale debris flows are often reported which blocked rivers and formed dams. In this paper,seven large debris flows in four valleys are discussed,among which five dams developed. 13 sets of ex-periments have been conducted in laboratory to simulate the forma-tion and failure of the dam. Finally,a model of dam failure is pro-posed and a formula is established to calculate the flood discharge:Q k bh hk BG0.41= T L,where bk is the outlet width of the dam at the original water level,hk the erosive depth,T the time from overflow to final state of failure,the average width of lake;L the length of the lake,and G the total potential energy of the water in the lake. | CHENG Zunlan GENG Xueyong DANG Chao LIU Jingjing | 2007 | Wuhan University Journal of Natural Sciences2007，12，4： | 3 |
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