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| 1 | Brain metastasis in non-small cell lung cancer (NSCLC) patients with uncommon EGFR mutations: a report of seven cases and literature review显示文摘Brain metastasis(BM)arising from non-small cell lung cancer(NSCLC)with rare epidermal growth factor receptor(EGFR)mutations is quite rare.The prognosis and therapeutic effects of BM remain enigmatic.To the best of our knowledge,this is the first report to make a separate analysis of BM from NSCLC patients with original uncommon EGFR mutations.We retrospectively reviewed 7 cases of BM arising from 42 cases of uncommon EGFR mutated lung cancer in Tianjin Medical University Cancer Institute and Hospital.We also performed a literature review to assess therapeutic features and outcomes. | Puchun Er Tian Zhang Jing Wang Qingsong Pang Ping Wang | 2017 | Cancer Biology & Medicine2017，14，4： | 5 |
| 2 | NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc显示文摘Background:Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma(ESCC).NS1-binding protein(NS1-BP),a member of the BTB-kelch protein fam-ily,has been shown to inhibit the proliferation of Hela cells by suppressing c-Myc.In the present study,we examined the potential function role of NS1-BP expression in ESCC,and particularly,the sensitivity of ESCC to radiotherapy.Methods:NS1-BP expression was examined using immunohistochemistry in two cohorts(n=98 for the training cohort;n=46 for independent validation cohort)of ESCC patients receiving cisplatin-based chemotherapy and con-current radiotherapy.Normal esophageal mucosal tissue blocks were used as a control.We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over-expressing NS1-BP on ESCC cells,and particu-larly their sensitivity to ionizing irradiation.Results:In the training cohort,NS1-BP downregulation was observed in 59%(85/144)of the ESCC specimens.NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival(DSS)in both the training and validation cohorts.Over-expressing NS1-BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo.NS1-BP also significantly enhanced IR-induced apoptosis,and abrogated IR-induced G2/M cell-cycle arrest and ATM/Chk1 phosphorylation.Immunoprecipitation assays indicated that NS1-BP could interact with c-Myc promoter regions to inhibit its transcription.In ESCC tissues,c-Myc expression was inversely correlated with NS1-BP levels,and was associated with a shorter DSS.Conclusions:Our findings highlight the role and importance of NS1-BP in radiosensitivity of ESCC.Targeting the NS1-BP/c-Myc pathway may provide a novel therapeutic strategy for ESCC. | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2018 | Cancer Communications2018，38，1： | 4 |
| 3 | NS1结合蛋白通过转录抑制c-Myc增强食管鳞状细胞癌的放疗敏感性显示文摘背景与目的基于顺铂的化疗联合放疗是晚期食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的标准疗法。NS1结合蛋白(NS1-binding protein,NS1-BP)是BTB-kelch蛋白家族中的一员,已被证明可通过抑制c-Myc进而抑制HeLa细胞增殖。在本研究中,我们检测NS1-BP表达在ESCC中的潜在作用,特别是其在ESCC放疗敏感性方面的作用。方法对于两组接受基于顺铂化疗且联合放疗的ESCC患者(研究组n=98;验证组n=46),采用免疫组化方法分别检测NS1-BP表达。使用正常食管黏膜组织块作为对照。我们也进行了一系列体外和体内实验来检测过表达NS1-BP对ESCC细胞各方面的潜在影响,尤其关注的是对电离辐射的敏感性方面的影响。结果在研究组中,59%(85/144)的ESCC样本观察到了NS1-BP下调。在研究组和验证组中,NS1-BP下调与放化疗抵抗和较短的疾病特异生存期(disease-specific survival,DSS)均具有相关性。体内和体外培养条件下过表达NS1-BP均能大幅度提高ECSS细胞对放疗的敏感性。NS1-BP也显著增强IR诱导的凋亡,阻断IR诱导的G2/M细胞周期阻滞和ATM/Chk1磷酸化。免疫沉淀反应显示NS1-BP可以与c-Myc启动子区相互作用从而抑制其转录。在ESCC组织中,c-Myc表达与NS1-BP水平负相关,与较短的疾病特异生存期相关。结论我们的研究结果显示了NS1-BP在ESCC放疗敏感性中的作用和重要性。以NS1-BP/c-Myc通路为靶标有望开发一种新的ESCC治疗策略。 | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2019 | 癌症2019，38，2： | 2 |
| 4 | Functional promoter variant rs2868371 of hspblis associated with risk of radiation pneumonitisafter chemoradiation for non-small cell lung cancer 显示文摘 | PANG Qingsong WEI Qing xu Ting | 2013 | International Journal of Radiation Oneology Biology Physics2013，85，5： | 1 |
| 5 | Advantages of nasogastric tube feeding during neoadjuvant concurrent chemoradiotherapy for esophageal cancer:A retrospective study显示文摘ObjectiveTo compare the effects of oral intake and nasogastric tube(NG)feeding on nutritional status,complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma(ESCC)patients.MethodsA total of 61 ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled,including(38 in oral intake group,and 22 in NG feeding group.Disease characteristics and baseline nutritional markers were collected in both groups.Nutritional status,complication and completion rate of chemoradiotherapy in both groups were evaluated.ResultsCompared with the oral intake group,patients in the NG feeding group had a later T stage(P=0.027)and clinical stage(P=0.014).The levels of energy intake(P=0.033),serum prealbumin(P<0.001),albumin(P=0.017)and hemoglobin(P=0.015)before treatment in NG group were significantly lower than those in oral intake group.Furthermore,patient-generated subjective global assessment(PG-SGA)score(P=0.016)and the levels of serum C-reactive protein(P=0.014)of NG feeding group were significantly higher than those of oral intake group.However,at the end of treatment,PG-SGA scores were increased in oral intake group and decreased in NG feeding group.In addition,the NG feeding group had a lower incidence of grade≥2 esophagitis(P=0.037),and higher completion rate of chemotherapy compared with oral intake group(P=0.034).Meanwhile,the proportion of parenteral nutrition(P=0.008)and anti-inflammatory(P=0.022)treatment in NG feeding group was significantly lower than that in oral intake group.Although patients in the NG feeding group had a worse prognosis,there were no statistically significant differences in overall survival(OS)and progression-free survival(PFS)between the two groups(P>0.05).ConclusionsAs a safe and effective enteral nutrition approach to improving nutrition,nasogastric tube feeding could increase treatment completion rate and reduce the incidence of≥grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy. | Jie Dong Qingwu Du Tian Zhang Xi Chen Wencheng Zhang Yajun Chen Yaqi Zeng Chunlei Li Yueying Li Yujie Wang Kun Wang Qingsong Pang | 2023 | Radiation Medicine and Protection2023，4，2： | 0 |
| 6 | Selective Laser Melting under Variable Ambient Pressure: A Mesoscopic Model and Transport Phenomena显示文摘Recent reports on the selective laser melting(SLM)process under a vacuum or low ambient pressure have shown fewer defects and better surface quality of the as-printed products.Although the physical process of SLM in a vacuum has been investigated by high-speed imaging,the underlying mechanisms governing the heat transfer and molten flow are still not well understood.Herein,we first developed a mesoscopic model of SLM under variable ambient pressure based on our recent laser-welding studies.We simulated the transport phenomena of SLM 316L stainless steel powders under atmospheric and 100 Pa ambient pressure.For typical process parameters(laser power:200W;scanning speed:2m∙s^(-1);powder diameter:27 lm),the average surface temperature of the cavity approached 2800 K under atmospheric pressure,while it came close to 2300 K under 100 Pa pressure.More vigorous fluid flow(average speed:4m∙s^(-1))was observed under 100 Pa ambient pressure,because the pressure difference between the evaporation-induced surface pressure and the ambient pressure was relatively larger and drives the flow under lower pressure.It was also shown that there are periodical ripple flows(period:14ls)affecting the surface roughness of the as-printed track.Moreover,the molten flow was shown to be laminar because the Reynolds number is less than 400 and is far below the critical value of turbulence;thus,the viscous dissipation is significant.It was demonstrated that under a vacuum or lower ambient pressure,the ripple flow can be dissipated more easily by the viscous effect because the trajectory length of the ripple is longer;thus,the surface quality of the tracks is improved.To summarize,our model elucidates the physical mechanisms of the interesting transport phenomena that have been observed in independent experimental studies of the SLM process under variable ambient pressure,which could be a powerful tool for optimizing the SLM process in the future. | Renzhi Hu Manlelan Luo Anguo Huang Jiamin Wu Qingsong Wei Shifeng Wen Lichao Zhang Yusheng Shi Dmitry Trushnikov V.Ya.Belenkiy I.Yu.Letyagin K.P.Karunakaran Shengyong Pang | 2021 | Engineering2021，7，8： | 0 |
| 7 | Evaluation of the Curative Effect of External Beam Radiotherapy and Brachytherapy for Tongue Carcinoma显示文摘OBJECTIVE To evaluate the curative effect of external beam radiothera-py (EBRT) and brachytherapy (BT) for tongue carcinoma. METHODS From 1991 to 2003, 35 patients received EBRT and BT in our department. We analyzed their curative and side effects retrospectively. RESULTS Local control was 80%. The 3-year overall (OS) and disease specific survival (DSS) rates were 75% and 79%. One patient developed metastases. Three patients (9%) developed different late complications. CONCLUSIONS Local regional control, survival, and complications in patients with tongue carcinoma treated by EBRT and BT have been satis-factory. | Ping Wang Qingsong Pang | 2007 | Chinese Journal of Clinical Oncology2007，4，3： | 0 |
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