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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines显示文摘单性生殖的胚胎的茎(足) 细胞为学习位于印的 genomic 下面的分子的机制提供一个珍贵试管内模型系统。然而,足房间的 thepluripotency 和父亲一般地表示的印的基因的表示侧面一直不是充分探索了。在这研究,三根老鼠足房间线被建立,在扩大文化的这些房间的区别潜力被评估。无差别的房间有正常核型和同型结合的染色体,并且表示了 ES-cell-specific 分子的标记。房间在超过 50 个段落以后仍然保持无差别并且展出了 pluripotentdifferentiation 能力。确定的 ES 房间的所有三根线生产了 teratomas;ES 房间的二根线生产了怪物和细菌线传播。而且,在这些房间的父亲一般地表示的印的基因 Snrpn, U2af1-rs1, Peg3,影响, Zfp127, Dlk1 和 Mest 的激活被检测。父亲一般地表示的印的基因被发现在单性生殖的联盟者的胚囊阶段被表示的一些激活胚胎试管内,他们的表示水平与扩大的足细胞培养增加了。而且,我们在足房间的这些父亲一般地表示的印的基因的激活在 ther 的甲基化与一个变化被联系的数据表演鼓舞了差别 methylated 区域。这些调查结果为足房间的 thepluripotency 提供直接证据并且在足房间表明在脱氧核糖核酸甲基化模式和父亲一般地表示的印的基因的激活之间的协会。因此,确定的 ES 房间线为在哺乳动物的开发学习 epigenetic 规定提供一个珍贵模型。 | Hua Jiang Bowen Sun Weicheng Wang Zhihong Zhang Furong Gao Guilai Shi Bing Cui XiangyinKong Zhao He Xiaoyan Ding Ying Kuang Jian Fei Yi Juan Sun Yun Feng Ying Jin | 2007 | Cell Research2007，17，9： | 10 |
| 3 | Effects of strain rates on mechanical properties of limestone under high temperature显示文摘The experimental tests for limestone specimens at 700 °C in uniaxial compression were carried out to inves- tigate the mechanical effects of loading rates on limestone by using a MTS810 rock mechanics servo- controlled testing system considering the loading rate as a variable. The mechanical properties of limestone such as the stress-strain curve, variable characteristics of peak strength and the modulus of elasticity of limestone were studied under the strain rates ranging from 1.1 10à5 to 1.1 10à1 sà1. (1) Sharp decreases were shown for the peak strength and elastic modulus of limestone from 1.1 10à5 to 1.1 10à4 sà1 at 700 °C as well as a downward trend was shown from 1.1 10à4 to 1.1 10à1 sà1 with the rise of the strain rate. (2) The peak strain increased from 1.1 10à5 to 1.1 10à4 sà1, however, there was no obvious changes shown for the peak strain of limestone from 1.1 10à4 to 1.1 10à1 sà1. These results can provide valuable references for the rock blasting effect and design of mine. | Tang Furong Mao Xianbiao Zhang Lianying Yin Huiguang Li Yan | 2011 | Mining Science and Technology2011，21，6： | 10 |
| 4 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 5 | Multi-quasiparticle rotational bands in neutron-rich erbium isotopes显示文摘Multi-quasiparticle states and rotational bands in neutron-rich erbium isotopes have been investigated by the configuration-constrained pairing-deformation-frequency self-consistent total-Routhian-surface (TRS) method with particle-number-conserved pairing. Specifically, the recently observed Kn=4-bands in 168,170,172 Er have been found to experience a configuration change in our calculation. Some other multi-quasiparticle states with uncertain configuration assignments have been reinvestigated by calculating their collective rotations. The configuration-constrained TRS calculation can reproduce experimental data consistently. | FU XiMing JIAO ChangFeng XU FuRong ZHANG ZhenHua | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 8 |
| 6 | Economic optimization of smart distribution networks considering real-time pricing显示文摘With the development of smart meters,a realtime pricing(RTP)demand response is becoming possible for households in distribution networks.The power flow can be bidirectional in distribution networks which become smarter with distributed generators(DGs).It is expensive to import electricity from the generation far from load centers because of the cost of power loss and network use,so that it is more economical to use electricity generated by local distributed generators.Therefore,in order to curtail operating costs of distribution networks,this paper proposes a model of economic optimization conducted by distribution network operators.The electricity purchasing costs for distribution network operators are minimized by optimizing electric power from transmission systems and local distributed generators.Further,based on price elasticity,the formulations of load demand considering RTP are proposed with economic optimization of distribution networks.The economic optimization problems are resolved by an interior point method.The case study shows that peak load demand can be reduced about 3.5%because the household RTP and electricity purchasing costs of distribution network operators can save 28.86£every hour. | Hong ZHANG Dongmei ZHAO Chenghong GU Furong LI Bo WANG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，4： | 5 |
| 7 | The journey to glory: receptor-like kinases in pollen tube growth显示文摘Double fertilization in angiosperm is a prerequisite for seed and fruit development and has been under close scrutiny in the past decades. Communications between male and female gametophytes are especially important in achieving successful reproduction, in which receptor-like kinases are dominant players. Here, we review progress on the functionality of receptor-like kinases(RLKs) in pollen tube growth and point out challenges facing the study of RLKs in pollen biology. | Sen Chai Furong Ge Sha Li Yan Zhang | 2016 | Science Bulletin2016，61，11： | 4 |
| 8 | NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc显示文摘Background:Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma(ESCC).NS1-binding protein(NS1-BP),a member of the BTB-kelch protein fam-ily,has been shown to inhibit the proliferation of Hela cells by suppressing c-Myc.In the present study,we examined the potential function role of NS1-BP expression in ESCC,and particularly,the sensitivity of ESCC to radiotherapy.Methods:NS1-BP expression was examined using immunohistochemistry in two cohorts(n=98 for the training cohort;n=46 for independent validation cohort)of ESCC patients receiving cisplatin-based chemotherapy and con-current radiotherapy.Normal esophageal mucosal tissue blocks were used as a control.We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over-expressing NS1-BP on ESCC cells,and particu-larly their sensitivity to ionizing irradiation.Results:In the training cohort,NS1-BP downregulation was observed in 59%(85/144)of the ESCC specimens.NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival(DSS)in both the training and validation cohorts.Over-expressing NS1-BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo.NS1-BP also significantly enhanced IR-induced apoptosis,and abrogated IR-induced G2/M cell-cycle arrest and ATM/Chk1 phosphorylation.Immunoprecipitation assays indicated that NS1-BP could interact with c-Myc promoter regions to inhibit its transcription.In ESCC tissues,c-Myc expression was inversely correlated with NS1-BP levels,and was associated with a shorter DSS.Conclusions:Our findings highlight the role and importance of NS1-BP in radiosensitivity of ESCC.Targeting the NS1-BP/c-Myc pathway may provide a novel therapeutic strategy for ESCC. | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2018 | Cancer Communications2018，38，1： | 4 |
| 9 | A 5D simulation method on post-earthquake repair process of buildings based on BIM显示文摘The post-earthquake repair process of buildings is one of the key components of building seismic resilience.Understanding the details of the repair process in advance will benefit the evaluation and decision making for the seismic resilience of buildings.To this end,a five-dimensional(5 D)simulation method on the post-earthquake repair process of buildings is proposed based on building information modeling(BIM),by which the repair activities can be presented in the way associated with a 3 D model,time(denoted as the fourth dimension),and the related costs(denoted as the fifth dimension).First,a decision-making model of repair schemes based on the interval index of the possibility degree is created to determine the optimal post-earthquake repair schemes for a damaged building.Subsequently,an algorithm based on separate flowrepetitive process is designed to automatically make the repair schedule on a BIM platform according to the determined repair schemes.Finally,an algorithm of automatic mapping between the components in BIM and their repair schedules is developed,so that a 5 D simulation of a post-earthquake repair process can be implemented.A six-story office building is selected as a case study,and the details of the post-earthquake repair process(e.g.,the costs of labor,material and equipment over the repair time)are presented by the proposed 5 D simulation method.The outcome of this study can be used to evaluate the seismic resilience of buildings and also to facilitate the decision making for seismically resilient buildings by providing the detailed guidance of the repair process. | Xu Zhen Zhang Furong Jin Wei Wu Yingying Qi Mingzhu Yang Yajun | 2020 | Earthquake Engineering and Engineering Vibration2020，19，3： | 4 |
| 10 | Catalytic methanation of syngas over Ni-based catalysts with different supports显示文摘Co-precipitation method was selected for the preparation of Ni/Al_2O_3, Ni/ZrO_2 and Ni/CeO_2 catalysts, and their performances in methanation were investigated in this study. The structure and surface properties of these catalysts were characterized by BET, XRD, H_2-TPD, TEM and H_2-TPR. The results showed that the catalytic activity at low temperature followed the order: Ni/Al_2O_3>Ni/ZrO_2>Ni/CeO_2. Ni/Al_2O_3 catalyst presented the best catalytic performance with the highest CH_4 selectivity of 94.5%. The characterization results indicated that the dispersion of the active component Ni was the main factor affecting the catalytic activity and the one with higher dispersion gave better performance. | Yincong Liu Lingjun Zhu Xiaoliu Wang Shi Yin Furong Leng Fan Zhang Haizhou Lin Shurong Wang | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 3 |
| 11 | A Comparative Study of Various Flow Instability Criteria in Processing Map of Superalloy GH4742显示文摘Hot compression tests were conducted on a Gleeble-1500D thermal simulating tester. Based on the deformatio behavior and microstructural evolution of superalloy GH4742, different types of instability criteria of Prasad Gegel, Malas, Murty and Semiatin were compared, and the physical significance of parameters was analyzed Meanwhile, the processing maps with different instability criteria were obtained. It was shown that instabilit did not occur when average power dissipation rate was larger than 50% in the temperature range of 1020e1130 C, corresponding to the strain rate range of 5 10 4e3.2 10 3s 1. The domain is appropriate fo the processing deformation of superalloy GH4742. | Ge Zhou Hua Ding Furong Cao Beijiang Zhang | 2014 | Journal of Materials Science & Technology2014，30，3： | 3 |
| 12 | High efficient catalytic oxidation of 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid under benign conditions with nitrogen-doped graphene encapsulated Cu nanoparticles显示文摘Selective oxidation of 5-hydroxymethylfurfual(HMF) to 2,5-furandicarboxylic acid(FDCA) as a bioplastics monomer is efficiently promoted by a simple system without noble-metal and base additives. In this work, graphene oxide(GO) was first synthesised by an electrochemical method with flexible graphite paper(FGP) as start carbon material, then, nitrogen-doped graphene(NG) layers encapsulated Cu nanoparticles(NPs) was prepared by one-step thermal treatment of GO supported Cu2+ in flowing NH3 atmosphere. Compared with NG supported Cu NPs prepared by the traditional impregnation method, enhanced catalytic activity was achieved over Cu/NG and an FDCA yield of 95.2% was achieved under mild reaction conditions with tert-butylhydroperoxide(t-BuOOH) as the oxidant. Control experiments with different catalysts and different addition procedure of t-BuOOH showed the yield of HMF and various intermediates during reaction. From the changing of intermediates concentrations and reaction rates, a reaction pathway through HMF-DFF-FFCA-FDCA was proposed. This work gives a more convenient, more green,more economical and effective method in encapsulated metal NPs preparation and high selectivity in HMF oxidation to FDCA under mild conditions. | Chaoxin Yang Xiao Li Zhenzhou Zhang Bohan Lv Jiachun Li Zhenjian Liu Wanzhen Zhu Furong Tao Guangqiang Lv Yongxing Yang | 2020 | Journal of Energy Chemistry2020，29，11： | 3 |
| 13 | NS1结合蛋白通过转录抑制c-Myc增强食管鳞状细胞癌的放疗敏感性显示文摘背景与目的基于顺铂的化疗联合放疗是晚期食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的标准疗法。NS1结合蛋白(NS1-binding protein,NS1-BP)是BTB-kelch蛋白家族中的一员,已被证明可通过抑制c-Myc进而抑制HeLa细胞增殖。在本研究中,我们检测NS1-BP表达在ESCC中的潜在作用,特别是其在ESCC放疗敏感性方面的作用。方法对于两组接受基于顺铂化疗且联合放疗的ESCC患者(研究组n=98;验证组n=46),采用免疫组化方法分别检测NS1-BP表达。使用正常食管黏膜组织块作为对照。我们也进行了一系列体外和体内实验来检测过表达NS1-BP对ESCC细胞各方面的潜在影响,尤其关注的是对电离辐射的敏感性方面的影响。结果在研究组中,59%(85/144)的ESCC样本观察到了NS1-BP下调。在研究组和验证组中,NS1-BP下调与放化疗抵抗和较短的疾病特异生存期(disease-specific survival,DSS)均具有相关性。体内和体外培养条件下过表达NS1-BP均能大幅度提高ECSS细胞对放疗的敏感性。NS1-BP也显著增强IR诱导的凋亡,阻断IR诱导的G2/M细胞周期阻滞和ATM/Chk1磷酸化。免疫沉淀反应显示NS1-BP可以与c-Myc启动子区相互作用从而抑制其转录。在ESCC组织中,c-Myc表达与NS1-BP水平负相关,与较短的疾病特异生存期相关。结论我们的研究结果显示了NS1-BP在ESCC放疗敏感性中的作用和重要性。以NS1-BP/c-Myc通路为靶标有望开发一种新的ESCC治疗策略。 | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2019 | 癌症2019，38，2： | 2 |
| 14 | Effect of Quercetin on Breeding and Apoptosis of Cervical Cancer HeLa Cell and on Growth of Transplanted Tumor in Nude Mice显示文摘Effect of quercetin on HeLa cell system of cervical cancer was studied by methods of MTT and Annexin V-FITC/PI. The results show that quercetin has functions of inhibiting breeding of HeLa cells and inducing apoptosis of the cells. The total apoptosis rate is positively proportional to reaction duration and concentration of quercetin used. The maximum apoptosis rate being (88.76±2.35)% was obtained when the concentration was 50.0 μmol/L and the cells were treated with quercetin for 72 hours. Based on establishing a model of tumor of cervical cancer transplanted into nude mice,quercetin of different concentrations was injected into abdominal cavity of nude mice and situation of tumor growth was reviewed. The result showed that with quercetin concentration increasing from 0 to 100.0 μmol/L,the transplantation volume and weight of the tumors decreased from (279.59±70.58) mm3 and ( 0.145±0.019) g to (128.72±36.12) mm3 and (0.089± 0.019) g respectively,while apoptosis rate of the transplanted tumor increased from (9.63±1.85)% to (34.98±0.47)%,which proved that quercetin inhibited increment of volume and weight of transplanted tumor in nude mice bodies. | ZHANG Wei XU Xiaoxia CHEN Hong ZHANG Jie ZHANG Xiaobing LUO Ruoyu FANG Furong | 2007 | Wuhan University Journal of Natural Sciences2007，12，3： | 2 |
| 15 | Economic Dispatch of Smart Distribution Networks for Electricity Cost Reduction显示文摘Consumers' electricity cost keeps increasing over the time in most countries across the world. The main reason is that importing electricity from generation plants far from a load center is relatively expensive, as costs are paid not only for generation but also for energy loss and network use. To this end, it is more economical to use electricity generated by local distributed generations. In order to reduce customers' electricity cost, a new economic dispatch of smart distribution networks is proposed. Economic dispatch of smart distribution network is to meet load demand with the least consumers' electricity cost considering distributed generators, while recognizing all operational limits of generation and transmission facilities in a distribution network. Case study shows that consumers' electricity cost can be reduced by about 20% through economic dispatch of distribution network. Further, generation cost and emission of distribution network are reduced as well. | Zhang Hong Zhao Dongmei Li Furong Gu Chenghong | 2014 | Electricity2014，25，2： | 2 |
| 16 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 17 | Power to gas:addressing renewable curtailment by converting to hydrogen显示文摘Renewable energy is the key to meeting increasing electricity demand and the decarburization targets in the generation mix.However,due to constrained power network capacity,a large volume of renewable generation is curtailed particularly from wind power, which is a huge waste of resources.There are typically three approaches to addressing excessive renewable:direct curtailment,the reinforcement of networks to expand transfer capacity,and the conversion of excessive renew-able into other energy types,such as hydrogen,to transport.The costs and benefits of the three approaches could vary significantly across location,time,and penetration of renewable energy.This paper conducts a cost-benefit analysis and comparison of the three techni- ques to address wind curtailment.It uses a reduced 16- busbar UK transmission network to analyze the performance of the three approaches.The UK 2020generation mix is used to quantify the saved renewable energy and incurred costs.The payback time and net present value of the two investment techniques are compared.From demonstration,it is reasonable to conclude that converting excessive wind power into hydrogen to transport is an environmentally friendly and cost-effective way to address wind curtailment. | Xiaohe YAN Xin ZHANG Chenghong GU Furong LI | 2018 | Frontiers in Energy2018，12，4： | 2 |
| 18 | Local Energy and Planned Ramping Product Joint Market Based on a Distributed Optimization Method显示文摘High penetration of renewable energy generation(REG)in the distribution system increases both the power uncertainty at a given interval and the power variation between two intervals.Reserve markets addressing power uncertainty have been widely investigated.However,there is a lack of market mechanisms regarding the power variation of the load and REGs.This paper thus defines a planned ramping(PR)product to follow the net load variation and extends the local energy market to include the trading of PR products.Players are economically compensated for their PR products.Bidding models of dispatchable generators and flexible load aggregators in the joint market are investigated.To solve the market problem in polynomial time,a distributed market clearing method is developed based on the ADMM algorithm.The joint market is tested on a modified IEEE 33-bus system.It verifies that introducing the PR market can encourage flexible loads to provide more PR service to accommodate the net load variation.As such,the ramping cost of dispatchable generators is reduced by 29.09%in the test case.The planned energy curtailment from REG is also reduced.The computational efficiency of the proposed distributed clearing method is validated by comparing it with a centralized method. | Zhong Zhang Furong Li Sung-Won Park Sung-Yong Son | 2021 | CSEE Journal of Power and Energy Systems2021，7，6： | 2 |
| 19 | Reconsideration of the sediment characteristics of the second member of the Triassic Xujiahe Formation in Sanhuiba,Huaying Mountain显示文摘The second member of the Triassic Xujiahe Formation in the Sanhuiba area in Huaying Mountain is an important section of sedimentary delta facies in the Chongqing Tianfu Geological Survey and Training Base. In spite of some initial efforts on its lithology and lithofacies, the existing research is yet to be completed and suffers from contradictory conclusions and inadequate evidence. Starting from the sedimentary microfacies types and cyclic features, we analyzed the vertical sequence of a sedimentary delta model and discovered that this section is a constructional delta deposit. Eight incomplete and asymmetric regressive cycles are marked off, given that frequent erosion surfaces appeared in the section. Based on the analysis of structural characteristics of every monocycle, we summarized the system of cycles, tracts and sequence characteristics of the overall section. In view of this systematic series of cycles, we discussed the features of the syndepositional tectonic movements in the area and conclude that, due to frequent erosion, migration and diversion of a sub-channel branch was brought about by oscillating movements of the crust. In a comparison with neighboring sections, we explored the cause of erosion and the relations between erosion and cycles. This study greatly strengthens existing research and theories, makes an important and comprehensive contribution to geological surveys and training in the area and provides essential suggestions for coal exploration, oil and gas evaluation and in general to exploration and development in the target stratum. | LIAO Taiping HU Jingjing ZHANG Furong LIU Lijing | 2010 | Mining Science and Technology2010，20，4： | 2 |
| 20 | In vivo electrochemical recording of continuous change of magnesium in medial vestibular nucleus following vertigo induced by ice water vestibular stimulation显示文摘Vertigo is one of the most common clinical symptoms. However, the chemical processes involved in the pathological mechanism of vertigo remain to be fully understood. In this study, we investigate the dynamic changes in the magnesium (Mg 2+ ) concentration in medial vestibular nucleus (MVN) of guinea pigs following vertigo induced by vestibular ice water stimulation with an electrochemical detection method consisting of in vivo microdialysis and on-line selective electrochemical detection. Electrochemical detection of Mg 2+ was accomplished based on the current enhancement of Mg 2+ towards the electrocatalytic oxidation of NADH at the electrodes modified with the polymerized film of toluidine blue O (TBO). Selectivity for the on-line electrochemical detection against Ca 2+ was achieved by using ethyleneglcol-bis(2-aminoethylether) tetraacetic acid (EGTA) as the selective masking agent for Ca 2+ . The basal level of the extracellular Mg 2+ in the MVN of guinea pigs was determined to be 759.7 ± 176.2 M(n = 16). Upon ice water irrigation of the left external ear canal, the concentration of Mg 2+ in the MVN decreases significantly, reaches 72 ± 6% (n = 8) of the basal level, and maintains for at least 1000 s. Control experiments reveal that neither warm water irrigation of the external ear canal nor ice water irrigation of the auricle induces the decrease in the concentration of Mg 2+ in the MVN. These results demonstrate that the extracellular Mg 2+ in the MVN decreases significantly following vertigo induced by vestibular ice water stimulation. This demonstration suggests that Mg 2+ might play an important role in the pathological mechanism of vertigo. | XIN Ying ZHANG ZiPin YU Ping MA FuRong MAO LanQun | 2013 | Science China Chemistry2013，56，2： | 2 |
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