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| 1 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 2 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 3 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 4 | Nutritional assessment with different tools in leukemia patients after hematopoietic stem cell transplantation显示文摘Objective:Correct nutritional assessment is essential for leukemia patients after hematopoietic stem cell transplantation(HSCT).This study aimed to investigate the best nutritional assessment method for leukemia patients after HSCT,and find the possible nutritional risk of the patients during the transplantation process in order to intervene in the patients with nutritional risks and undernourished patients timely,so that the entire transplantation process could be successfully completed.Methods:A prospective study was performed in 108 leukemia patients after HSCT,and different nutritional assessment methods,including nutritional risk screening 2002(NRS2002),mini nutritional assessment(MNA),subjective globe assessment(SGA)and malnutritional universal screening tools(MUST),were used.The associations between nutritional status of these patients and nutritional assessment methods were analyzed.Results:A total of 108 patients completed SGA,and 99 patients completed NRS2002,MNA and MUST.During the treatment process,85.2%of the patients lost weight,wherein,50%lost weight greater than5%,and 42.6%had significantly reduced food intake.For nutritional risk assessment,the positive rates of NRS2002,MNA and MUST were 100%,74.7%and 63.6%,respectively.There was a significant difference(P<0.05)among the positive rates of NRS2002,MNA and MUST.In undernutrition assessment,the positive rate of SGA(83.3%)was significantly higher than that of MNA(17.2%)(P<0.05),and the incidence rate of nutritional risk among leukemia patients≤30 years old was greater than that of patients>30 years old(P<0.05).Conclusions:Patients with leukemia were in poor nutritional status during and after HSCT.The leukemia patients≤30 years old had a greater incidence rate of nutritional risk.As nutritional risk screening tool,the specificity of NRS2002 is not high,but it can be used for evaluating nutritional deficiencies.MNA is a good nutritional risk screening tool,but not an adequate tool for nutritional assessment.If assessment of undernutrition is necessary,the combination of all these screening tools and clinical laboratory indicators should be applied to improve accuracy. | Boshi Wang Xia Yan Jingjing Cai Yu Wang Peng Liu | 2013 | Chinese Journal of Cancer Research2013，25，6： | 14 |
| 5 | Diagnosis-related Groups (DRG) pricing and payment policy in China: where are we?显示文摘Diagnosis-related Groups(DRG)is an internationally recognized advanced hospital management method.It was pioneered by Yale University in the late 1960s and has been used as the inpatient prospective payment system by the U.S.Medicare program since 1983(1,2).It has since been introduced in Australia,Germany,France,the UK,Japan,South Korea,and Scandinavia.It is widely used in the fields of pricing and payment,budget allocation,performance evaluation,and comparison(2).As a refined hospital management tool,DRG combined with the corresponding payment mechanism can effectively meet the requirements of health expenditure control,hospital management,and health insurance management(3).DRG is also crucial for promoting the shift of payment methods from retrospective payment to prospective payment and for improving the performance management of the healthcare system. | Lihua Yu Jingjing Lang | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 13 |
| 6 | Geochronology and Geochemistry of Li(Be)-Bearing Granitic Pegmatites from the Jiajika Superlarge Li-Polymetallic Deposit in Western Sichuan, China显示文摘Strategic emerging minerals such as lithium,beryllium,niobium and tantalum are the most important rare metals currently,especially with the increasing demand of emerging industries on rare metals in China.The Jiajika deposit with a complete Li-Be-Nb-Ta metallogenic series is the largest pegmatite type rare metal deposit in China at present.In this paper,systematic researches of geochronology and petrogeochemistry were carried out to understand the genetic relationships between mineralization and magma evolution in the Jiajika deposit,which might be helpful to further rare-element prospecting in Songpan-Garze area.Zircon LA-ICP-MS U-Pb dating yields a concordia age of 217±1.1 Ma and a weighted mean 206 Pb/238 U age of 217±0.84 Ma for the aplite from the No.308 pegmatite.Cassiterite LA-MC-ICPMS dating yields concordant ages of 211±4.6 Ma for the No.308 pegmatite vein and198±4.4 Ma for the No.133 pegmatite vein,indicating that the rare metal mineralization mainly occurred in the Late Indosinian Period,further suggesting that the granites,aplites and pegmatites in Jiajika formed during a relatively stable stage after the intense orogeny of the Indosinian cycle.The rare metal-bearing granitic rocks and pegmatites show a clear linear relationship between A/CNK and A/NK and are enriched in total alkalis and depleted in CaO,FeO,MnO,MgO,Ba and Sr.All barren rocks and mineralized rocks feature similar rare earth element and trace element geochemical patterns.Thus,these characteristics indicate that the aplites and pegmatites represent the highly differentiated products of the two-mica granite(MaG)in this area,which is the most likely parent magma.During the evolution of magma,strong alkali metasomatism occurred between the melt phase and the volatile-rich fluid phase;as a result,large-scale rare metal mineralization occurred in certain structural zones of the pegmatite veins in the Jiajika deposit. | Hongzhang Dai Denghong Wang Lijun Liu Yang Yu Jingjing Dai | 2019 | Journal of Earth Science2019，30，4： | 12 |
| 7 | Seasonal Variations of Net-Phytoplankton Community Structure in the Southern Yellow Sea显示文摘Based on the field survey data of four cruises in 2011,all phytoplankton communities in the southern Yellow Sea (SYS) were investigated for the species composition,dominant species,abundance and diversity indices.A total of 379 species belonging to9 phyla were identified,of which the most abundant group was Bacillariophyta (60.9%) ,followed by Pyrrophyta (23.7%) and Haptophyta (6.9%) .The seasonal distribution of abundance was:summer (4137.1×103ind m 3) >spring (3940.4×103ind m 3) >winter (3010.6×103ind m 3) >autumn (340.8×103ind m 3) ,while the horizontal distribution showed a decreasing tendency from inshore to offshore regions.The dominant species of phytoplankton varied in different seasons.The dominant species were Thalassiosira pacifica,Skeletoema spp.and Chaetoceros cinctus in spring,Chaetoceros debbilis,Chaetoceros pseudocurvisetus and Chaetoceros curvisetus in summer,Thalassiosira curviseriata,Alexandrium catenella and Ceratium fusus in autumn,Paralia sulcata,Phaeocystis sp.and Bacillaria paradoxa in winter,respectively.In SYS,the group of temperate coastal species was the major ecotype,and the groups of the central SYS species and oceanic species were also important constituents.The average values of Shannon-Weaver diversity index (H’) and Pielou evenness index (J) were 2.37 and 0.65 respectively.The indices H’and J in the open sea were higher than those in coastal waters.Obvious co-variation tendencies between H’and J were observed in all but the summer cruise of this survey. | GAO Yu JIANG Zhibing LIU Jingjing CHEN Quanzhen ZENG Jiangning HUANG Wei | 2013 | Journal of Ocean University of China2013，12，4： | 10 |
| 8 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 9 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 10 | Techniques for detecting protein-protein interactions in living cells:principles, limitations, and recent progress显示文摘Detecting protein-protein interactions(PPIs) provides fundamental information for understanding biochemical processes such as the transduction of signals from one cellular location to another; however, traditional biochemical techniques cannot provide sufficient spatio-temporal information to elucidate these molecular interactions in living cells. Over the past decade, several new techniques have enabled the identification and characterization of PPIs. In this review, we summarize three main techniques for detecting PPIs in vivo, focusing on their basic principles and applications in biological studies. We place a special emphasis on their advantages and limitations, and, in particular, we introduced some uncommon new techniques, such as single-molecule FRET(smFRET), FRET-fluorescence lifetime imaging microscopy(FRET-FLIM), cytoskeleton-based assay for protein-protein interaction(CAPPI) and single-molecule protein proximity index(smPPI), highlighting recent improvements to the established techniques. We hope that this review will provide a valuable reference to enable researchers to select the most appropriate technique for detecting PPIs. | Yaning Cui Xi Zhang Meng Yu Yingfang Zhu Jingjing Xing Jinxing Lin | 2019 | Science China(Life Sciences)2019，62，5： | 9 |
| 11 | Comprehensive evaluation of nutritional status before and after hematopoietic stem cell transplantation in 170 patients with hematological diseases显示文摘Objective: To investigate the nutritional status of patients before and after hematopoietic stem cell transplantation(HSCT), and explore optimal methods for assessing nutritional status in patients with hematological diseases.Methods: This cohort study enrolled 170 patients who were diagnosed with hematological diseases and underwent allogeneic HSCT in the Department of Hematology, Peking University People's Hospital between May2011 and April 2013. We used fixed-point continuous sampling and four nutritional screening tools, Nutritional Risk Screening 2002(NRS-2002), Mini Nutritional Assessment(MNA), Subjective Global Assessment(SGA) and Malnutrition Universal Screening Tools(MUST), in combination with body measurements, to extensively screen and evaluate nutritional risks and status in patients receiving HSCT before entering and after leaving laminar air flow rooms.Results: After HSCT, patients had significant reduction in weight, hip circumference, waist-hip ratio, calf circumference, mid-upper arm circumference, and suprailiac skinfold thickness compared with pre-HSCT measurements. Before HSCT, NRS-2002 identified that 21.2% of patients were at nutritional risks, compared with100% after HSCT. MUST indicated that before HSCT, 11.77% of patients were at high nutritional risk,compared with 59.63% after HSCT. MNA assessed that 0.06% of patients were malnourished before HSCT,compared with 19.27% after HSCT. SGA identified that before HSCT, 1.76% of patients had mild to severe malnutrition, which increased to 83.3% after HSCT. There is a significant increase in the nutritional risk and malnutrition in patients who received HSCT.Conclusions: Before HSCT, some patients already had nutritional risk or nutritional deficiencies, and prompt and close nutritional screening or assessment should be performed. The nutritional status of patients after HSCT was generally deteriorated compared with that before transplantation. Body measurements should be taken more frequently during the subsequent treatment window in the laminar air flow rooms. After HSCT, it is recommended to combine MNA and SGA to fully evaluate the nutritional status, and thus provide timely and reasonable nutritional support. | Peng Liu Boshi Wang Xia Yan Jingjing Cai Yu Wang | 2016 | Chinese Journal of Cancer Research2016，28，6： | 9 |
| 12 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 13 | Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy显示文摘Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications.Herein,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),respectively.Utilizing the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection.While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal clearance.Our work presents the great promise of 2D NMOFs for nanomedicine applications. | Wenjun Zhu Yu Yang Qiutong Jin Yu Chao Longlong Tian Jingjing Liu Ziliang Dong Zhuang Liu | 2019 | Nano Research2019，12，6： | 9 |
| 14 | Chemical characteristics of size-resolved aerosols in winter in Beijing显示文摘Size-resolved aerosols were continuously collected by a Nano Sampler for 13 days at an urban site in Beijing during winter 2012 to measure the chemical composition of ambient aerosol particles. Data collected by the Nano Sampler and an ACSM(Aerodyne Aerosol Chemical Speciation Monitor) were compared. Between the data sets,similar trends and strong correlations were observed,demonstrating the validity of the Nano Sampler. PM10 and PM2.5concentrations during the measurement were 150.5 ± 96.0 μg/m3(mean ± standard variation)and 106.9 ± 71.6 μg/m3,respectively. The PM2.5/PM10 ratio was 0.70 ± 0.10,indicating that PM2.5dominated PM10. The aerosol size distributions showed that three size bins of 0.5–1,1–2.5 and 2.5–10 μm contributed 21.8%,23.3% and 26.0% to the total mass concentration(TMC),respectively. OM(organic matter) and SIA(secondary ionic aerosol,mainly SO42-,NO3-and NH4+) were major components of PM2.5. Secondary compounds(SIA and secondary organic carbon) accounted for half of TMC(about 49.8%) in PM2.5,and suggested that secondary aerosols significantly contributed to the serious particulate matter pollution observed in winter. Coal burning,biomass combustion,vehicle emissions and SIA were found to be the main sources of PM2.5. Mass concentrations of water-soluble ions and undetected materials,as well as their fractions in TMC,strikingly increased with deteriorating particle pollution conditions,while OM and EC(elemental carbon) exhibited different variations,with mass concentrations slightly increasing but fractions in TMC decreasing. | Kang Sun Yu Qu Qiong Wu Tingting Han Jianwei Gu Jingjing Zhao Yele Sun Qi Jiang Ziqi Gao Min Hu Yuanhang Zhang Keding Lu Stephan Nordmann Yafang Cheng Li Hou Hui Ge Masami Furuuchi Mitsuhiko Hata Xingang Liu | 2014 | Journal of Environmental Sciences2014，26，8： | 9 |
| 15 | Atmospheric correction of HJ-1A/B CCD images over Chinese coastal waters using MODIS-Terra aerosol data显示文摘This paper demonstrates an atmospheric correction method to process HJ-1A/B CCD images over Chinese coastal waters with the aid of MODIS-Terra aerosol information.Based on the assumption of zero water-leaving radiance at the two near-infrared (NIR)bands or the shortwave infrared(SWIR)bands,the atmospheric aerosol optical depth(AOD)is firstly retrieved from MODIS-Terra with a simple extension of the NIR-SWIR combined atmospheric correction approach embedded in SeaDAS (SeaWiFS data analysis system).Then the'turbid'and'non-turbid'waters are separated by the turbid water index.Maximum probability of AOD at 551 nm band is derived based on the NIR information over'non-turbid'waters and FLAASH model is selected to do the atmospheric correction of the HJ-1A/B CCD imagery using the AOD values of highest probabilities as input.Similarly,according to the histogram of the AOD distribution at 551 nm band,the studied turbid water area is divided into several blocks and HJ-1A/B CCD imagery is corrected with the corresponding AOD values displayed with the highest frequency in each block.This method has been applied to several HJ-1A/B images over Chinese coastal waters and validated by synchronous in-situ data.The results have shown that this method is effective in the atmospheric correction process of HJ-1A/B CCD images for ocean color remote sensing study and application in the coastal waters. | TIAN LiQiao 1,LU JianZhong 1,CHEN XiaoLing 1,2,3,YU ZhiFeng 1,XIAO JingJing 1,QIU Feng 1 & ZHAO Xi 1 1 State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan 430079,China 2Key Laboratory of Poyang Lake Wetland and Watershed Research,Ministry of Education,Jiangxi Normal University,Nanchang 330022,China 3 The Key Laboratory of Poyang Lake Environment and Resource Utilization,Ministry of Education,Nanchang University,Nanchang 330031,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 8 |
| 16 | Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction显示文摘Myocardial infarction(MI)is one of cardiovascular diseases that pose a serious threat to human health.The pathophysiology of MI is complex and contains several sequential phases including blockage of a coronary artery,necrosis of myocardial cells,inflammation,and myocardial fibrosis.Aiming at the treatment of different stages of MI,in this work,an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor(VEGF)and silk fibroin(SF)microspheres containing bone morphogenetic protein 9(BMP9)for releasing VEGF and BMP9 to realize their respective functions.The results of in vitro experiments indicate a rapid initial release of VEGF during the first few days and a relatively slow and sustained release of BMP9 for days,facilitating the formation of blood vessels in the early stage and inhibiting myocardial fibrosis in the long-term stage,respectively.Intramyocardial injection of such composite hydrogel into the infarct border zone of mice MI model via multiple points promotes angiogenesis and reduces the infarction size.Taken together,these results indicate that the dual-release of VEGF and BMP9 from the composite hydrogel results in a collaborative effect on the treatment of MI and improvement of heart function,showing a promising potential for cardiac clinical application. | Yong Wu Tianqi Chang Weiqian Chen Xiaoyu Wang Jingjing Li Yueqiu Chen You Yu Zhenya Shen Qian Yu Yanxia Zhang | 2021 | Bioactive Materials2021，6，2： | 7 |
| 17 | Erratum to: Sn^(4+) precursor enables 12.4% efficient kesterite solar cell from DMSO solution with open circuit voltage deficit below 0.30 V (vol 64, issue 1, page 52, 2021)显示文摘In the version of the article originally published in volume 64,issue 1,2021 of Sci China Mater(2021,64(1):52–60,http://gffzzd3cc09b8251d45dfskpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn/10.1007/s40843-020-1408-x),the chemical formula of Sn(DMSO)_(4)Cl_(4)(page 54,8^(th) line in the left column;page 56,4^(th) and 6^(th) lines from the bottom of left column and in Equations(6 and 7)in the right column)was miswritten.The correct formula should be as below:SN(DMSO)_(2)CL_(4). | Yuancai Gong Yifan Zhang Erin Jedlicka Rajiv Giridharagopal James A.Clark Weibo Yan Chuanyou Niu Ruichan Qiu Jingjing Jiang Shaotang Yu Sanping Wu Hugh W.Hillhouse David S.Ginger Wei Huang Hao Xin | 2021 | Science China Materials2021，64，5： | 7 |
| 18 | Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model显示文摘Toutongning capsule is used for the treatment of migraine headaches,and has yielded therapeutically beneficial effects.However,whether Toutongning capsule exerts its effects via endogenous opioid peptides remains poorly understood.This study investigated the effects of Toutongning capsule on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine headache at the mRNA and protein levels.Results confirmed that proenkephalin mRNA levels were significantly upregulated following treatment with Toutongning capsule.The numbers of methionine-enkephalin and leucine-enkephalin-positive cells were significantly greater in the migraine headache rats following treatment with Toutongning capsule compared with the model group.Taken together,these results show that Toutongning capsule exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine headache rats. | Gang Yao Yuhong Man Jingjing Qi Tingmin Yu Dihui Ma | 2011 | Neural Regeneration Research2011，6，9： | 7 |
| 19 | Histone Deacetylase HDA9 and WRKY53 Transcription Factor Are Mutual Antagonists in Regulation of Plant Stress Response显示文摘Epigenetic regulation of gene expression is important for plant adaptation to environm ental changes.Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is known to function in repressing plant response to stress in Arabidopsis.However,how HDA9 targets to specific chromatin loci and controls gene expression netw orks involved in plant response to stress remains largely unclear.Here,we show that HDA9 represses stress tolerance response by interacting with and regulating the DNA binding and transcriptional activity of WRKY53,which functions as a high-hierarchy positive regulator of stress response.We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites,some of which are removed by HDA9,resulting in inhibition of WRKY53 transcription activity.Conversely,WRKY53 negatively regulates HDA9 histone deacetylase activity.Collectively,our results indicate that HDA9 and WRK53 are reciprocal negative regulators of each other's activities,illustrating how the functional interplay between a chromatin regulator and a transcription factor regulates stress tolerance in plants. | Yu Zheng Jingyu Ge Chun Bao Wenwen Chang Jingjing Liu Jingjie Shao Xiaoyun Liu Lufang Su Lei Pan Dao-Xiu Zhou | 2020 | Molecular Plant2020，13，4： | 6 |
| 20 | Zr-MOFs loaded on polyurethane foam by polydopamine for enhanced dye adsorption显示文摘Zirconium-based metal-organic frameworks(Zr-MOFs)have attracted widespread attention due to their high specific surface area,high porosity,abundant metal active sites and excellent hydrothermal stability.However,Zr-MOFs materials are mostly powdery in nature and thus difficult to separate from aqueous media,which limits their application in wastewater treatment.In this study,PDA/Zr-MOFs/PU foam was constructed by growing Zr-MOFs nanoparticles on a dopamine-modified polyurethane foam substrate by in-situ hydrothermal synthesis as an adsorbent for removing dyes from wastewater.The results demonstrated that the polydopamine coating improves the dispersion of the Zr-MOFs nanoparticles on the substrate and enhances the interaction between the Zr-MOFs nanoparticles and the PU foam substrate.As a result,compared with Zr-MOFs/PU foam,the prepared PDA/ZrMOFs/PU foam exhibits higher adsorption capacity for crystal violet(CV)(63.38 mg/g)and rhodamine B(RB)(67.73 mg/g),with maximum adsorption efficiencies of CV and RB of 98.4%(pH=11)and 93.5%(pH=7),respectively,at a concentration of 10 mg/L.The PDA/Zr-MOFs/PU foam can simultaneously remove CV and RB from the mixed solution.Moreover,the PDA/ZrMOFs/PU foam still exhibits high stability and reusability after five cycles. | Jingjing Zhao Linqiong Xu Yaozhuo Su Hongwei Yu Hui Liu Shaoping Qian Wenge Zheng Yongqing Zhao | 2021 | Journal of Environmental Sciences2021，33，3： | 6 |
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