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| 1 | Adapting liposomes for oral drug delivery显示文摘Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes,oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract,difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes. | Haisheng He Yi Lu Jianping Qi Quangang Zhu Zhongjian Chen Wei Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 23 |
| 2 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 3 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 4 | Early Uplift History of the Tibetan Plateau:Records from Paleocurrents and Paleodrainage in the Hoh Xil Basin显示文摘摘要:在领域工作收集的 Paleocurrent 指示物数据被用来在北西藏的高原在 Hoh Xil 盆学习早新生代地区性的 paleodrainage 模式。paleocurrent 方向始新世 Fenghuoshan 组显然证明流动是向北方与一个单向性的疏开模式。这可能在起始的盆免职时期期间反映 Qiangtang 地面的 uplift 并且显示 Tanggula Moutains 在至少作为地志的高地发生了始新世。渐新世 Yaxicuo 组的 Paleoflows 对北方主导地面向然后在它的迟了的免职期间向东流动了。Yaxicuo 组的 paleodrainage 模式的这地区性的可变性被解释从横向的河记录沉积的疏开风格到纵的河系统。渐新世山妨碍了由的 Kunlun 高举,这被推断向北方,到 orogenic 的 paleoflows 和创造的纵的河系统平行系上带子。paleodrainage 模式的时间、空间的变化建议西藏的高原的北边界在早新生代期间位于 Hoh Xil 区域,它的 uplift 整个时间向北进行了。 | YI Haisheng WANG Chengshan SHI Zhiqiang LIN Jinhui ZHU Lidong | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 7 |
| 5 | Influence of Tip Clearance on Performance of a Contra-Rotating Fan显示文摘Influences of tip clearance on the tip flow and associated loss mechanism in a contra-rotating axial flow fan hasbeen studied in the paper, based on three dimensional numerical results. The results with different tip clearanceare compared in terms of stage efficiency, relative total pressure loss coefficient, flow angle. It is found that theefficiency of the contra-rotating fan changes almost linearly with increment of the tip clearance, however, efficiencyof the rear rotor is observed to decrease more dramatically than that of the forward rotor given same tipclearance variation. The analysis on the flow structure indicates that the tip region flow field is qualitatively similarin both rotors. However, with the same clearance value, the leakage flow in the rear rotor is effected by a tipleakage vortex of greater intensity caused by relative loading levels and the inter rotor interaction. | Jian Xu Chunqing Tan Haisheng Chen Yangli Zhu Dongyang Zhang | 2009 | Journal of Thermal Science2009，18，3： | 6 |
| 6 | Distribution Characteristics of Cobalt-rich Ferromanganese Crust Resources on Submarine Seamounts in the Western Pacific显示文摘在西方的太平洋,基于五个海底的海底山省(链) 的调查数据充满钴的铁锰合金外壳资源的分发特征被使用相对引用数据并且使用热点并且 seafloor 传播的理论在这篇论文研究了。获得的主要研究结果如下:在学习区域的合作富人外壳厚度逐渐地从东方正在增加到西方并且从南方到向北有否定关联(r =? 0.59 ) 与经度和积极关联(r = 0.48 ) 与纬度。沿着经度和纬度变化的外壳厚度被热点并且 seafloor 传播影响。在学习区域的西北部分的海洋的外壳和海底山更旧,并且外壳资源比在东南部分的那些优异。深入地 < 1500 m, 15002000 m,在学习区域的 20002500 m,钴外壳厚度是分别地 5.45 厘米, 4.34 厘米和 3.55 厘米,并且深入地 25003000 m 和 30003500 m 的,它分别地落下到 2.84 厘米和 3.37 厘米。合作富人外壳资源主要深入地在海底山顶点边缘和上面的胁腹被集中 < 2500 m。有强壮的否定关联(r =? 0.67 ) 在钴外壳丰富和在 0 的斜坡的海底山, 75 kg/m2 和 50 kg/m2 的斜坡之间 ? 瑳条 ? 整摮 ? 潴猠慴楢楬敺吗?? | ZHANG Fuyuan ZHANG Weiyan ZHU Kechao GAO Shuitu ZHANG Haisheng ZHANG Xiaoyu ZHU Benduo | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 6 |
| 7 | Effect of amino acid mutation at position 127 in 3A of a rabbitattenuated foot-and-mouth disease virus serotype Asia1 on viral replication and infection显示文摘An amino acid mutation(R127→I) in the 3A non-structural protein of an FMDV serotype Asia1 rabbit-attenuated ZB strain was previously found after attenuation of the virus. To explore the effects of this mutation on viral replication and infection, the amino acid residue isoleucine(I) was changed to arginine(R) in the infectious cDNA clone of the rabbit-attenuated ZB strain by sitedirected mutagenesis, and the R127-mutated virus was rescued. BHK monolayer cells and suckling mice were inoculated with the R127-mutated virus to test its growth property and pathogenicity, respectively. The effects of the R127 mutation on viral replication and virulence were analyzed. The data showed that there was a slight difference in plaque morphology between the R127-mutated and wild-type viruses. The growth rate of the mutated virus was lower in BHK-21 cells and its virulence in suckling mice was also attenuated. This study indicates that the R127 mutation in 3A may play an important role in FMDV replication in vitro and in pathogenicity in suckling mice. | Aiguo Xin Mingwang Zhu Qi Hu Haisheng Miao Zhenqi Peng Yuwen He Lin Gao Huachun Li | 2014 | Virologica Sinica2014，29，5： | 2 |
| 8 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 9 | Chemo-and Biostratigraphy of the Jurassic Oil Shales from the Qiangtang Basin,Northern Tibet,China:A Case Study of the Toarcian Oceanic Anoxic Event显示文摘The marine oil shales of the Qiangtang Basin, northern Tibet, exposed in the Biluo Co, Tuonamu, Shenglihe and Changsheshan areas are believed to be important petroleum source rocks. This work comprehensively analyzed the carbon isotopes, trace elements, and calcareous nannofosills, ammonites and bivalves of the Biluo Co section in the Qiangtang Basin. The organic carbon isotopes show a positive excursion close to 2.17‰(relative to PDB), which, albeit significantly smaller, may also be associated with other Early Toarcian Oceanic Anoxic Events(T-OAE) in the European epicontinental seas and the Tethyan continental margins. Coinciding with the Early Toarcian transgression, the oxygen deficiency in bottom water had led to dysoxic-anoxic conditions and deposition of black shales lacking benthic fauna. Under such condition, the redox-sensitive trace metals such as Mo, V, Ni, Cr, and U were enriched, in conjunction with high planktonic productivity of Watznaueriaceae calcareous nannofossils. Comparison of the results with the records of chemo-and biostratigraphy, as well as the palaeogeography during the Early Jurassic suggests that the anoxia linked to the Early Toarcian oceanic anoxic event was mainly caused by the high surface water temperature, sea-level rise and an increase of surface water productivity. | CHEN Lan XU Guiwen DA Xuejuan YI Haisheng ZHU Zhangxiong HUANG Zhaohui LI Xiaogang | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 10 | Identification of differentially expressed proteins between bull X and Y spermatozoa显示文摘 | Xiaoli Chen Huabin Zhu Chengjiang Wu Weidong Han Haisheng Hao Xueming Zhao Weihua Du Tong Qin Yan Liu Dong Wang | 2012 | Journal of Proteomics2012，，： | 1 |
| 11 | Phytoplankton and chlorophyll a relationships with ENSO in Prydz Bay, East Antarctica显示文摘The historical data of phytoplankton and chlorophyll a(Chl a)(1990–2002)obtained during the Chinese National Antarctic Research Expedition(CHINARE)in the Prydz Bay have been integrated.The results showed that the temperature,salinity,nutrients,and oxygen of seawater changed when El Nino/La Nina occurred.The variation of biological communities reflected the response of ecosystem to environmental changes.During El Ni?o period,Chl a concentration and phytoplankton community structure changed significantly,and the relative proportion of diatoms increased while dinoflagellates decreased.During La Ni?a period,the proportion of diatoms decreased,but the golden-brown algae and blue-green algae increased significantly.The variation of phytoplankton population directly affected the biodiversity of the bay,which were also quite sensitive to the marine environment changes.Meanwhile,the satellite remote sensing data of 2002–2011(December–March)have been used to study the temporal connection change of Chl a and phytoplankton in the Prydz Bay.We found that there were significant differences in the monthly variation characteristics of satellite remote sensing Chl a and sea surface temperature(SST),which had some links with sea ice melting and El Ni?o/La Ni?a events.We found that the start time of bloom advanced,lagged or synchronized with the changes of the SST,and we also found the occurrence time of phytoplankton bloom corresponded with the sea ice melting inner bay.To some extent,this study will help us understand the relationships between ENSO events and the phytoplankton bloom in the Southern Ocean. | ZHANG HaiSheng HAN ZhengBing ZHAO Jun YU PeiSong HU ChuanYu SUN WeiPing Yang Dan ZHU GenHai LU Bing Hans-UIrich PETER Walter VETTER | 2014 | Science China Earth Sciences2014，57，12： | 1 |
| 12 | Study on Soilless Culture of Facility Strawberry 显示文摘 | Li Yongping Zhu Haisheng Ma Hongqi | 2014 | gricuhural Science&Technology2014，15，7： | 1 |
| 13 | Constraints on the early uplift history of the Tibetan Plateau显示文摘 | Wang Chengshan Zhao Xixi Liu Zhifei Lippert P C Graham S A Coe R S Yi Haisheng Zhu Lidong Liu Shun Li Yalin | 2008 | PNAS2008，105，13： | 1 |
| 14 | The dispersal of sedimentary terrestrial organic matter in the East China Sea (ECS) as revealed by biomarkers and hydro-chemical characteristics显示文摘 | Chun Zhu Bin Xue Jianming Pan Haisheng Zhang Thomas Wagner Richard D. Pancost | 2008 | Organic Geochemistry2008，，8： | 1 |
| 15 | Study on soilless culture of facility strawberry显示文摘 | Li Yongping Zhu Haisheng Ma Hongqi | 2014 | Agric Sci Technol2014，15，7： | 1 |
| 16 | Hydrogen production from rice winery wastewater in an upflow anaerobic reactor by using mixed anaerobic cultures显示文摘 | Hanqing Yu Zhenhu Zhu Wenrong Hu Haisheng Zhang | 2002 | International Journal of Hydrogen Energy2002，，11： | 1 |
| 17 | Highly active nitrogen-doped carbon nanotubes for oxy- gen reduction reaction in fuel cell applications 显示文摘 | CHEN Zhu HIGGINS Drew TAO Haisheng | 2009 | The Journal of Physical Chemistry C2009，113，21： | 1 |
| 18 | Organic geochemistry characteristics of Jurassic black shales from the Amdo area, northern Tibet, China显示文摘The Jurassic black shales of the Qiangtang Basin,northern Tibet are known to be amongst the most important source rocks.To date,there is no detailed study on the organic geochemistry of the Bathonian/Callovian coccolith-bearing sediments and their source-rock characteristics.Here,we focus on the black limestones,marls,and shales at the Amdo 114 station section using Rock–Eval pyrolysis and biomarkers for sources,types,and thermal maturity of organic matter and the reconstructed depositional environment.All samples are characterized by(1)relatively high TOC values(0.20–2.56 wt%)and relatively low Tmax values between 428 and 452℃;(2)shortchain n-alkanes with a maximum at C_(14) to C_(18) and Pr/Ph>1;(3)31–35 homohopanes and gammacerane with lower abundance;and (4)C_(27)–C_(28)–C_(29) regular steranes with C_(29) being slightly dominant.The organic matter is TypeⅡand thus dominantly derived from phytoplankton,especially algae.Thermal maturity indicators include the Ts/(Ts+Tm),C_(31)22S/(22S+2R),C_(29)aaa20S/(20S+0R),C_(29)ββ/(ββ+aa)and C_(27)Dia/(Dia+Reg),which are regarded as immature to very early mature.Additionally,the high Pr/Ph,Pr/nC_(17),and Ph/nC_(18) ratios,Pr/Ph vs Gammacerane index suggest that these black shales were deposited in unstratified marine waters of normal salinity under dysoxic to weakly reduced conditions. | Guiwen Xu Lan Chen Weiguang Zhu Xuejuan Da Zhangxiong Zhu Haisheng Yi | 2022 | Acta Geochimica2022，41，3： | 0 |
| 19 | A Surrogate Model for a CAES Radial Inflow Turbine with Test Data-Based MLP Neural Network Algorithm显示文摘It is usually to conduct a full-scale three-dimensional flow analysis for a radial turbine to find a way to increase the efficiency of a Compressed Air Energy Storage(CAES)system.However,long solving time and huge consumption of computing resources become a major obstacle to the analysis.Therefore,in present study,a surrogate model with test data-based multi-layer perceptron(MLP)Neural Network is proposed to overcome the difficulty.Instead of complex flow field solving process,it provides reliable turbine aerodynamic performance and flow field distribution characteristics in a short solution time by“learning the measurement results”.The validation results illustrated that the predicted maximum relative errors of isentropic efficiency,corrected mass flow rate and corrected power are only 0.03%,0.22%and 0.26%respectively.The predicted flow distribution parameters in chamber,shroud cavity and outlet region of rotor are also basically consistent with the experimental results.In the chamber,it can be found that a pressure stagnation point is observed at circumferential angle of 270°when total pressure ratio is decreased.In the shroud cavity,obvious pressure variation is found near outlet of shroud cavity which although labyrinth seals exist.At outlet of rotor,obvious variations of velocity and pressure are found in the 0.0–0.4 and 0.6–0.8 of blade height.At the same time,obvious variations of velocity and pressure are found in the 0.0–0.4 and 0.6–0.8 of blade height and this is because the influence of upper passage vortex,lower passage vortex and end wall secondary flow.The present study can provide further reference for the dynamic performance evaluation of CAES radial inflow turbine. | WANG Xing ZHU Yangli LI Wen ZUO Zhitao CHEN Haisheng | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 20 | Biomimetic copper single-atom nanozyme system for self-enhanced nanocatalytic tumor therapy显示文摘Single-atom nanozymes(SAZs)with peroxidase(POD)-like activity have good nanocatalytic tumor therapy(NCT)capabilities.However,insufficient hydrogen peroxide(H2O2)and hydrogen ions in the cells limit their therapeutic effects.Herein,to overcome these limitations,a biomimetic single-atom nanozyme system was developed for self-enhanced NCT.We used a previously described approach to produce platelet membrane vesicles.Using a high-temperature carbonization approach,copper SAZs with excellent POD-like activity were successfully synthesized.Finally,through physical extrusion,a proton pump inhibitor(PPI;pantoprazole sodium)and the SAZs were combined with platelet membrane vesicles to create PPS.Both in vivo and in vitro,PPS displayed good tumor-targeting and accumulation abilities.PPIs were able to simultaneously regulate the hydrogen ion,glutathione(GSH),and H2O2 content in tumor cells,significantly improve the catalytic ability of SAZs,and achieve self-enhanced NCT.Our in vivo studies showed that PPS had a tumor suppression rate of>90%.PPS also limited the synthesis of GSH in cells at the source;thus,glutamine metabolism therapy and NCT were integrated into an innovative method,which provides a novel strategy for multimodal tumor therapy. | Daoming Zhu Ruoyu Ling Hao Chen Meng Lyu Haisheng Qian Konglin Wu Guoxin Li Xianwen Wang | 2022 | Nano Research2022，15，8： | 0 |
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