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| 1 | Learning-based lensless imaging through optically thick scattering media显示文摘The problem of imaging through thick scattering media is encountered in many disciplines of science,ranging from mesoscopic physics to astronomy.Photons become diffusive after propagating through a scattering medium with an optical thickness of over 10 times the scattering mean free path.As a result,no image but only noise-like patterns can be directly formed.We propose a hybrid neural network for computational imaging through such thick scattering media,demonstrating the reconstruction of image information from various targets hidden behind a white polystyrene slab of 3 mm in thickness or 13.4 times the scattering mean free path.We also demonstrate that the target image can be retrieved with acceptable quality from a very small fraction of its scattered pattern,suggesting that the speckle pattern produced in this way is highly redundant.This leads to a profound question of how the information of the target being encoded into the speckle is to be addressed in future studies. | Meng Lyu Hao Wang Guowei Li Shanshan Zheng Guohai Situ | 2019 | Advanced Photonics2019，1，3： | 28 |
| 2 | Expression of p-STAT3 and vascular endothelial growth factor in MNNG-induced precancerous lesions and gastric tumors in rats显示文摘AIM: To investigate the dynamic expression of p-signal transducer and activator of transcription 3(STAT3) and vascular endothelial growth factor(VEGF) in the formation of gastric tumors induced by drinking water containing N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) in Wistar rats.METHODS: One hundred and twenty Wistar rats were randomly divided into two groups(60 in each group): Control group and Model group. The rats in each group were then randomly divided into three groups(20 in each group): C/M15, C/M25 and C/M40(15, 25 and 40 represent the number of feeding weeks from termination). Rats in the control group received normal drinking water and rats in the model group received drinking water containing 100 μg/m L MNNG. Stomach tissues were collected at the end of the 15 th, 25 th and 40 th week, respectively, for microscopic measurement using hematoxylin and eosin staining. The expression of p-STAT3 and VEGF in different pathological types of gastric tissue, including normal, inflammation, atrophy, hyperplasia and gastric stromal tumor, was observed by immunohistochemistry and Western blot, and the corelation between p-STAT3 and VEGF was analyzed. RESULTS:(1) The expression of p-STAT3 in tissue with gastritis, atrophy, dysplasia and gastric stromal tumor were significantly increased in the model group compared with the control group(2.5 ± 1.0, 2.75 ±0.36, 6.2 ± 0.45, 5.67 ± 0.55 vs 0.75 ± 0.36, P = 0.026, 0.035, 0.001, 0.002, respectively); the expression of p-STAT3 in tissue with dysplasia was higher than that in samples with gastritis or atrophy(6.2 ± 0.45 vs 2.5 ± 1.0, P = 0.006; 6.2 ± 0.45 vs 2.75 ± 0.36, P = 0.005, respectively); however, the expression of p-STAT3 in gastritis and atrophy was not significantly different(P > 0.05);(2) the expression of VEGF in tissue with gastritis, atrophy, dysplasia and gastric stromal tumor was significantly increased in the model group compared with normal gastric mucosa; and the expression of VEGF in tissue with dysplasia was higher than that in tissue with inflammation and atrophy(10.8 ± 1.96 vs 7.62 ± 0.25, P = 0.029; 10.8 ± 1.96 vs 6.26 ± 0.76, P = 0.033, respectively); similarly, the expression of VEGF in tissue with gastritis and atrophy was not significantly different(P > 0.05); and(3) the expression of VEGF was positively correlated with p-STAT3. CONCLUSION: p-STAT3 plays an important role in gastric cancer formation by regulating the expression of VEGF to promote the progression of gastric tumor from gastritis. | Xiao-Yan Wang Lou-Lei Wang Xuan Zheng Li-Na Meng Bin Lyu Hai-Feng Jin | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 14 |
| 3 | Hereditary Transthyretin Amyloidosis in Eight Chinese Families显示文摘 | Ling-Chao Meng He Lyu Wei Zhang Jing Liu Zhao-Xia Wang Yun Yuan | 2015 | Chinese Medical Journal2015，，21： | 12 |
| 4 | Organic-inorganic bismuth (lll)-based material: A lead- free, air-stable and solution-processable light-absorber beyond organolead perovskites显示文摘 | Miaoqiang Lyu Jung-Ho Yun Molang Cai Yalong Jiao Paul V. Bernhardt Meng Zhang Qiong Wang Aijun Du Hongxia Wang Gang Liu Lianzhou Wang | 2016 | Nano Research2016，9，3： | 8 |
| 5 | Dysferlin Gene Mutation Spectrum in a Large Cohort of Chinese Patients with Dysferlinopathy显示文摘 | Su-Qin Jin Meng Yu Wei Zhang He Lyu Yun Yuan Zhao-Xia Wang | 2016 | Chinese Medical Journal2016，，19： | 6 |
| 6 | Non-suicidal self-harm is linked to suicidal thoughts in Chinese adolescents with mood disorders:a cross-sectional report显示文摘Non-suicidal self-injury (NS SI) refers to any intentional,self-inflicted behavior that causes direct damage to body tissues (Kerr et al.,2010),and has emerged as a challenging public health issue worldwide,especially among adolescents.The most common presentations of NSSI include skin-cutting,severe scratching,and burning (Whitlock et al,2006). | Yixin WANG Jianbo LAI Chanchan HU Hongbo MENG Duo LYU Shaohua HU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 5 |
| 7 | Preparation of Titanium-silphenylene-siloxane Hybrid Polymers with High Refractive Index,Transmittance,and Thermal Stability显示文摘Vinyl-containingtitanium-silphenylene-sioxane oligomers(O1,O2,O3,andO4)withdifferent molar ratios of titanium to silicon were successfully synthesized in high yields by nonhydrolytic sol-gel reaction,and the obtained four oligomers were further crosslinked with methylphenyl hydro-silicone oil(4)to form corresponding polymers(P1,P2,P3,and P4)by hydrosilylation reaction.Their structures were characterized with spectroscopic characterization techniques including FTIR,1H-NMR,and Raman spectroscopy.The effect of titanium element on crosslinking behavior,thermal resistance,refractive index,transparency,thermal aging stability,glass transition temperature,and surface properties of the polymers were studied.Compared with titanium-free polymer P1,the thermal resistance,refractive index,and thermal aging stability of titanium-silphenylene-siloxane polymers(P2,P3,and P4)were significantly improved.The titanium-silphenylene-siloxane polymers achieved a high refractive index(n=1.580-1.584)and thermostability(Tsd>500℃).In thermal aging,the polymers exhibited superior performances with high optical transparency(~90%at 450 nm)and exhibited high thermal stability(~84%at 450 nm after thermal aging at 150℃for 120 h).These data indicate that the polymers have potential application in optical materials such as LED encapsulants. | Dong Zhao Shu-Xi Shan Meng Zhang Xiao-A Zhang Sheng-Ling Jiang Ya-Fei Lyu | 2020 | Chinese Journal of Polymer Science2020，38，9： | 5 |
| 8 | Simulated effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region of the Northern Hemisphere显示文摘Soil freeze-thaw process is closely related to surface energy budget,hydrological activity,and terrestrial ecosystems.In this study,two numerical experiments(including and excluding soil freeze-thaw process)were designed to examine the effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region in the Northern Hemisphere based on the state-of-the-art Community Earth System Model version 1.0.5.Results show that in response to soil freeze-thaw process,the area averaged soil temperature in the shallow layer(0.0175−0.0451 m)decreases by 0.35℃in the TP(Tibetan Plateau),0.69℃in CES(Central and Eastern Siberia),and 0.6℃in NA(North America)during summer,and increases by 1.93℃in the TP,2.28℃in CES and 1.61℃in NA during winter,respectively.Meanwhile,in response to soil freeze-thaw process,the area averaged soil liquid water content increases in summer and decrease in winter.For surface heat flux components,the ground heat flux is most significantly affected by the freeze-thaw process in both summer and winter,followed by sensible heat flux and latent heat flux in summer.In the TP area,the ground heat flux increases by 2.82 W/m2(28.5%)in summer and decreases by 3.63 W/m2(40%)in winter.Meanwhile,in CES,the ground heat flux increases by 1.89 W/m2(11.3%)in summer and decreases by 1.41 W/m2(18.6%)in winter.The heat fluxes in the Tibetan Plateau are more susceptible to the freeze-thaw process compared with the high-latitude frozen soil regions.Soil freeze-thaw process can induce significant warming in the Tibetan Plateau in winter.Also,this process induces significant cooling in high-latitude regions in summer.The frozen ground can prevent soil liquid water from infiltrating to deep soil layers at the beginning of thawing;however,as the frozen ground thaws continuously,the infiltration of the liquid water increases and the deep soil can store water like a sponge,accompanied by decreasing surface runoff.The influence of the soil freeze-thaw process on surface hydrologic and thermal fluxes varies seasonally and spatially. | Di Ma SiQiong Luo DongLin Guo ShiHua Lyu XianHong Meng BoLi Chen LiHui Luo | 2021 | Research in Cold and Arid Regions2021，13，1： | 4 |
| 9 | 软件工程专业物联网及嵌入式系统方向教学研究(英文)显示文摘当前,软件工程专业如何适应物联网及嵌入式系统领域的巨大需求,是一个亟待解决的问题。基于该问题,本文提出一个新方法进行该专业的课程安排及学习计划。首先,结合物联网基础设施技术,在软件工程教学中融入物联网及嵌入式系统的教学内容,分析学生惧怕物联网及嵌入式系统发展的原因;然后,提出循序渐进的由低级别嵌入式系统开发到高级别应用软件开发的学习路径;最后,分别剖析物联网及嵌入式系统方向的就业选择和职业规划。 | Ce Zhang Dianhui Chu Fanchao Meng Zhipeng Chen Xinsheng Wang Weigong Lyu | 2016 | 计算机教育2016，，8： | 4 |
| 10 | Validation of the Simplified Chinese-character Version of the International Physical Activity Questionnaire-Long Form in Urban Community-dwelling Adults:a Cross-sectional Study in Hangzhou,China显示文摘Objective To assess the test-retest reliability and criterion validity of the Simplified Chinese-character version of the International Physical Activity Questionnaire Long form(IPAQ-L) in urban community-dwelling adults in Hanghzou,China.Methods A total of 158 eligible participants aged 25-59 years from 6 neighbourhoods in two central districts of Hangzhou completed the IPAQ-L questionnaire twice within a 7-day interval.Half of the subjects wore pedometers during the first 7 days.Test-retest reliability was examined by comparing the first(Day 1) and the second(Day 9) survey of IPAQ-L.Criterion validity was assessed by comparing IPAQ-L with pedometer data.Results Modest to good test-retest reliability was found with intraclass correlation coefficients of 0.67 for total PA,0.37 to 0.73 for specific dimensions,and 0.56 to 0.71 for different intensities of PA.Total PA measured by IPAQ-L was moderately correlated with exercise levels(partial r = 0.27,P = 0.020) and walking distance(partial r = 0.31,P = 0.007),which were measured by a pedometer,after adjusting for gender,age,educational attainment and employment status.Conclusion Our results indicate that the IPAQ-L is a reliable and validated measure for assessing physical activity levels in this population and possibly the adult population in other mainland Chinese cities. | REN Yan Jun SU Meng LIU Qing Min TAN Ya Yun DU Yu Kun LI Li Ming LYU Jun | 2017 | Biomedical and Environmental Sciences2017，30，4： | 4 |
| 11 | The dynamic changes and mechanisms of Rehmanniae radix processing based on Maillard reaction显示文摘Background:Traditional Chinese medicines are usually processed before they are used for clinical treatment.This is done in a way associated with the Maillard reaction.Methods:Based on the Maillard reaction,this paper analyzed the degree of processing of rehmannia root(Rehmanniae radix)relative to the dynamic variation rules of Maillard reaction index parameters,including pH,A420,amino acids,and 5-hydroxymethylfurfural.Furthermore,this study introduced thermal analysis techniques and pyrolysis kinetics to assess the influence of the correlation between processing raw rehmannia root and the Maillard reaction during carbonization.It then went through the whole process of transforming the raw material to end-product in order to explain the scientific connotation of processing it.Results:The results showed that each time rehmannia root was processed,its pH value and amino acid content decreased,while the A420 value and 5-HMF increased.Processing with wine shows a significant difference in these experimental indexes.The position and intensity of the maximum thermal weight loss rate peak of processed rehmannia root at different degrees of processing are different.Comprehensive quantitative 221±0.2°C for processed rehmannia root carbonization was the processing temperature limit.Moreover,the kinetic solution verified that the activation energy corresponding to the carbonization temperature was close to the maximum value of the activation energy of the whole carbonization process,and the optimal mechanism function was g(α)=((1−α)−1/3−1)2.Conclusion:The Maillard reaction occurred during the processing of rehmannia root mixed with carbonization.With each increase of the number of steaming and drying cycles involved in the processing,the level of Maillard reaction increased significantly.The wine-steaming method had a significant effect on the quality of the processed product. | Xiang-Long Meng Bo Wang Xiao-Yan Zhang Chen-Zi Lyu Xiao-Juan Su Chen-Xu Ning Shuo-Sheng Zhang | 2021 | Traditional Medicine Research2021，6，1： | 3 |
| 12 | Phase imaging with an untrained neural network显示文摘Most of the neural networks proposed so far for computational imaging(CI)in optics employ a supervised training strategy,and thus need a large training set to optimize their weights and biases.Setting aside the requirements of environmental and system stability during many hours of data acquisition,in many practical applications,it is unlikely to be possible to obtain sufficient numbers of ground-truth images for training.Here,we propose to overcome this limitation by incorporating into a conventional deep neural network a complete physical model that represents the process of image formation.The most significant advantage of the resulting physics-enhanced deep neural network(PhysenNet)is that it can be used without training beforehand,thus eliminating the need for tens of thousands of labeled data.We take single-beam phase imaging as an example for demonstration.We experimentally show that one needs only to feed PhysenNet a single diffraction pattern of a phase object,and it can automatically optimize the network and eventually produce the object phase through the interplay between the neural network and the physical model.This opens up a new paradigm of neural network design,in which the concept of incorporating a physical model into a neural network can be generalized to solve many other CI problems. | Fei Wang Yaoming Bian Haichao Wang Meng Lyu Giancarlo Pedrini Wolfgang Osten George Barbastathis Guohai Situ | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 13 | Low-temperature processed solar cells with formamidinium tin halide perovskite/fullerene heterojunctions显示文摘一种新类型无铅, formamidinium (FA ) 基于卤化物 perovskites, FASnI 2 Br,与不同配置为低温度的处理 p-i-n 异质接面太阳能电池作为轻收获的材料被调查。FASnI 2 与 1.68 eV 的乐队差距, Br perovskite 在在 75 | Meng Zhang Miaoqiang Lyu Jung-Ho Yun MahirNoori Xiaojing Zhou Nathan A. Cooling Qiong Wang Hua Yu Paul C. Dastoor Lianzhou Wang | 2016 | Nano Research2016，9，6： | 2 |
| 14 | A deterministic FE contact analysis of 3D rough surfaces with textures and comparison with classic statistical contact models显示文摘Accurate contact calculations of real rough surfaces are fundamental but complicated. The model-based methods are convenient and straightforward. But these methods ignore some factors and may lead to less accurate results. This is especially true when considering multi-scale topographic features of engineering rough surfaces. Based on artificially generated rough surfaces, the deterministic contact analysis of two 3D rough surfaces is conducted by the finite element method(FEM). The calculations show that when the separation between surfaces reduces, results of classic model-based methods are quite different from those of this study, especially when the roughness distribution and textures are considered. As friction pairs are working under increasing harsh conditions, the accurate contact calculation in this paper will be of great significance. | ZHANG Rui MENG XiangHui LYU BuGao SUN Kai | 2021 | Science China(Technological Sciences)2021，64，2： | 2 |
| 15 | Effects of processing technology on essential oil and pharmacological action of frankincense显示文摘Background:According to the traditional Chinese medicine theory,the common processing methods for Ruxiang(frankincense)include stir-frying processing and vinegar processing.Methods:With network pharmacology and thermal analysis methods,we selected and identified the main and irritating ingredients,established the pyrolysis characteristic parameters for identifying frankincense quality,quantified the starting and optimum temperature limits for processing frankincense,and analyzed the influences of processing adjuvants(vinegar)on combustion pyrolysis characteristics of frankincense.By applying Fourier transformation infrared spectrometry,high performance liquid chromatography,gas chromatography and UV-visible spectrometry,we evaluated the processing technology developed in our study of frankincense and its processed products.Results:Based on network pharmacology,we can find that the classical compounds of essential oil are the main pharmacodynamics components of frankincense possessing the anti-inflammatory,analgesia,anti-tumor,anti-ulcer and ant-inflammatory bowel disease effects.The pyrolysis combustion rate peaks of frankincense at 285.27±7.05℃and 476.99±13.46℃were the characteristic peaks used to identify frankincense quality.The specific temperature of slow-fire processing,including the vinegar processing and stir-frying processing,was 148.72±5.09℃.Heating for 5.67±0.98 min after reaching processing temperature was needed for processing frankincense with vinegar.The kinetics analysis showed that both frankincense and its vinegar mixture exhibited good linear relationships.The feasibility and practicability for our processing technology were verified through the determination of medicinal compounds by Fourier transformation infrared spectrometry,high performance liquid chromatography,gas chromatography and UV.Conclusion:Frankincense essential oils were the main active components of frankincense,which also can be taken as the internal chemical control indexes to judge the quality control and to optimize the processing technology of frankincense.The pyrolysis combustion rate peaks of frankincense at 285.27±7.05℃and 476.99±13.46℃were the characteristic peaks that can be used to identify frankincense quality.The optimum processing conditions of vinegar-processed frankincense with were as follows:with vinegar,20%;heating temperature,148.72±5.09℃;and heating time,5.67±0.98 min.Under these conditions,frankincense essential oil could cause a moderate effect on combustion pyrolysis characteristics to exert its corresponding pharmacological effects. | Xiang-Long Meng Yong-Lin Liang Chen-Zi Lyu Xiao-Juan Su Cong Hu Chen-Xu Ning Shuo-Sheng Zhang | 2021 | Traditional Medicine Research2021，6，3： | 2 |
| 16 | An improvement of soil temperature simulations on the Tibetan Plateau显示文摘The simulation of soil temperature on the Tibetan Plateau(TP) plays a dominant role in the performance of both global climate and numerical weather forecast models. To improve the simulation of soil temperature on the TP, the Johansen soil thermal conductivity parameterization scheme was introduced into Community Land Model 3.5(CLM3.5) and Regional Climatic Model 4(Reg CM4). The improved CLM3.5 and Reg CM4-CLM were utilized to conduct offline and regional simulation experiments on the TP. Comparison of the new and old schemes revealed that CLM3.5 provides high thermal conductivity parameters of mineral soil solid on the TP. The Johansen scheme is more practical for the TP than the soil thermal conductivity parameterization in CLM3.5. The simulation of soil temperature and liquid water content was improved in offline experiment. The improved parameterization scheme can also reduce the simulation error of soil temperature in winter throughout the entire TP. | SiQiong Luo BoLi Chen ShiHua Lyu XueWei Fang JingYuan Wang XianHong Meng LunYu Shang ShaoYing Wang Di Ma | 2018 | Research in Cold and Arid Regions2018，10，1： | 2 |
| 17 | M2 macrophages,but not Ml macrophages,support megakaryopoiesis by upregulating PI3K-AKT pathway activity显示文摘Dysfunctional megakaryopoiesis hampers platelet production,which is closely associated with thrombocytopenia(PT).Macrophages(MΦs)are crucial cellular components in the bone marrow(BM)microenvironment.However,the specific effects of M1 MΦs or M2 MΦs on regulating megakaryocytes(MKs)are largely unknown.In the current study,aberrant BM-M1/M2 MO polarization,characterized by increased M1 MΦs and decreased M2 MΦs and accompanied by impaired megakaryopoiesis-supporting abilities,was found in patients with PT post-allotransplant.RNA-seq and western blot analysis showed that the PI3K-AKT pathway was downregulated in the BM MΦs of PT patients.Moreover,in vitro treatment with PI3K-AKT activators restored the impaired megakaryopoiesis-supporting ability of MΦs from PT patients.Furthermore,we found M1 MΦs suppress,whereas M2 MCDs support MK maturation and platelet formation In humans.Chemical inhibition of PI3K-AKT pathway reduced megakaryopoiesis-supporting ability of M2 MΦs,as indicated by decreased MK count,colony-forming unit number,high-ploidy distribution,and platelet count.Importantly,genetic knockdown of the PI3K-AKT pathway impaired the megakaryopoiesis-supporting ability of MΦs both in vitro and in a MO-specific PI3K-knockdown murine model,indicating a critical role of PI3K-AKT pathway in regulating the megakaryopoiesis-supporting ability of M2 M(Ds.Furthermore,our preliminary data indicated that TGF-β released by M2 MΦs may facilitate megakaryopoiesis through upregulation of the JAK2/STAT5 and MAPK/ERK pathways in MKs.Taken together,our data reveal that M1 and M2 MΦs have opposing effects on MKs in a PI3K-AKT pathway-dependent manner,which may lead to new insights into the pathogenesis of thrombocytopenia and provide a potential therapeutic strategy to promote megakaryopoiesis. | Hong-Yan Zhao Yuan-Yuan Zhang Tong Xing Shu-Qian Tang Qi Wen Zhong-Shi Lyu Meng Lv Yu Wang Lan-Ping Xu Xiao-Hui Zhang Yuan Kong Xiao-Jun Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 2 |
| 18 | The early Japanese books reorganization by combining image processing and deep learning显示文摘Many early Japanese books record a large amount of information,including historical politics,economics,culture,and so on,which are all valuable legacies.These books are waiting to be reorganized at the moment.However,a large amount of the books are described by Kuzushiji,a type of handwriting cursive script that is no longer in use today and only readable by a few experts.Therefore,researchers are trying to detect and recognise the characters from these books through modern techniques.Unfortunately,the characteristics of the Kuzushiji,such as Connect-Separate-characters and Manyvariation,hinder the modern technique assisted re-organisation.Connect-Separatecharacters refer to the case of some characters connecting each other or one character being separated into unconnected parts,which makes character detection hard.Manyvariation is one of the typical characteristics of Kuzushiji,defined as the case that the same character has several variations even if they are written by the same person in the same book at the same time,which increases the difficulty of character recognition.In this sense,this paper aims to construct an early Japanese book reorganisation system by combining image processing and deep learning techniques.The experimentation has been done by testing two early Japanese books.In terms of character detection,the final Recall,Precision and F-value reaches 79.8%,80.3%,and 80.0%,respectively.The deep learning based character recognition accuracy of Top3 reaches 69.52%,and the highest recognition rate reaches 82.57%,which verifies the effectiveness of our proposal. | Bing Lyu Hengyi Li Ami Tanaka Lin Meng | 2022 | CAAI Transactions on Intelligence Technology2022，7，4： | 1 |
| 19 | Highly compact and uniform CH3NH3Sn0.5Pb0.5I3 films for efficient panchromatic planar perovskite solar cells显示文摘An efficient panchromatic planar perovskite solar cell is developed based on highly uniform,lead-reduced CH3NH3Sn0.5Pb0.5I3 perovskite films with full film-coverage on the substrates.We demonstrate here that full-coverage of the CH3NH3Sn0.5Pb0.5I3 films can be developed by a facile chlorobenzene-assisted spin-coating method.A power conversion efficiency of 7 % is achieved using low-temperature processes,which is among the best-reported performance for panchromatic planar perovskite solar cells with a light-absorption over 1,000 nm. | Miaoqiang Lyu Meng Zhang Nathan A. Cooling Yalong Jiao Qiong Wang Jung-Ho Yun Ben Vaughan Gerry Triani Peter Evans Xiaojing Zhou Krishna Feron Aijun Du Paul Dastoor Lianzhou Wang | 2016 | Science Bulletin2016，61，20： | 1 |
| 20 | PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)-a population-based prospective cohort study: rationale, design and baseline participant characteristics显示文摘Background and purpose Cardiovascular diseases and dementia are two major diseases in the elderly.Atherosclerosis is associated with future vascular events and cognitive impairment.The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events(PRECISE)study is a population-based prospective cohort study with comprehensive evaluation of multiterritorial artery stenosis and plaque using advanced vascular imaging techniques and prospective collection of vascular events and cognitive assessments.Methods Between May 2017 and September 2019,the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in China.Data are collected in face-to face interviews at baseline,2-year and 4-year follow-up visits.Brain MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 years.Cardiovascular/cerebrovascular events and cognitive assessment will be prospectively collected after the enrollment.Blood and urine samples were collected and biomarkers were tested at baseline.Results A total of 3067 subjects were enrolled,among which 53.5%were female with an average age of 61.2±6.7 years.Among them,2.8%,8.1%,43.1%and 21.6%had a history of stroke,coronary heart diseases,hypertension and diabetes mellitus,respectively.Conclusions The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging techniques.Data from this cohort provide us an opportunity to precisely evaluate polyvascular atherosclerosis and its association with future vascular events and cognitive impairment. | Yuesong Pan Jing Jing Xueli Cai Yilong Wang Suying Wang Xia Meng Chunlai Zeng Jiong Shi Jiansong Ji Jinxi Lin Lingchun Lyu Zhe Zhang Lerong Mei Shiping Li Shan Li Wanlin Zhu Hao Li Tiemin Wei Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 1 |
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