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| 1 | Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells显示文摘Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ± 1.13, 2.34 ± 1.16 and 1.63 ± 1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96 ± 0.32 and 1.86 ± 0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes (CI) of 3.9 ± 1.1 and 4.1 ± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells. | Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun Mengchao Wu Weiping Zhou | 2008 | Cellular & Molecular Immunology2008，5，5： | 30 |
| 2 | An overview of the use of plastic-film mulching in China to increase crop yield and water-use efficiency显示文摘Since 1990,crop yields have stagnated in many parts of the world,posing a significant challenge to global food security[1].As such;innovative solutions are needed to increase the resource-use efficiency of cropping systems to produce more grains per unit area. | Dongbao Sun Haigang Li Enli Wang Wenqing He Weiping Hao Changrong Yan Yuzhong Li Xurong Mei Yanqing Zhang Zhanxiang Sun Zhikuan Jia Huaiping Zhou Tinglu Fan Xucheng Zhang Qin Liu Fengju Wang Chaochun Zhang Jianbo Shen Qingsuo Wang Fusuo Zhang | 2020 | National Science Review2020，7，10： | 19 |
| 3 | Identification and functional analysis of the MOC1 interacting protein 1显示文摘Rice tillering is one of the most important agronomic traits that determine grain yields.Our previous study has demonstrated that the MONOCULM1 (MOC1) gene is a key component that controls the formation of rice tiller buds.To further elucidate the molecular mechanism of MOC1 involved in the regulation of rice tillering,we performed a yeast-two-hybrid screening to identify MOC1 interacting proteins (MIPs).Here we reported that MIP1 interacted with MOC1 both in vitro and in vivo.The overexpression of MIP1 resulted in enhanced tillering and reduced plant height.In-depth characterization of the context of MIP1 and MOC1 would further our understanding of molecular regulatory mechanisms of rice tillering. | Fengli Sun Weiping Zhang Guosheng Xiong Meixian Yan Qian Qian Jiayang Li Yonghong Wang | 2010 | Journal of Genetics and Genomics2010，37，1： | 9 |
| 4 | Highly efficient base editing in human tripronuclear zygotes显示文摘 | Changyang Zhou Meiling Zhang Yu Wei Yidi Sun Yun Sun Hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 Hui Yang Zi-jiang Chen | 2017 | Protein & Cell2017，8，10： | 6 |
| 5 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 6 | Prediction and mitigation analysis of ground vibration caused by running high-speed trains on rigid-frame viaducts显示文摘In this study a 3D numerical analysis approach is developed to predict the ground vibration around rigid-frame viaducts induced by running high-speed trains.The train-bridge-ground interaction system is divided into two subsystems:the train-bridge interaction and the soil-structure interaction.First,the analytical program to simulate bridge vibration with consideration of train-bridge interaction is developed to obtain the vibration reaction forces at the pier bottoms.The highspeed train is described by a multi-DOFs vibration system and the rigid-frame viaduct is modeled with 3D beam elements.Second,applying these vibration reaction forces as input external excitations,the ground vibration is simulated by using a general-purpose program that includes soil-structure interaction effects.The validity of the analytical procedure is confirmed by comparing analytical and experimental results.The characteristics of high-speed train-induced vibrations,including the location of predominant vibration,are clarified.Based on this information a proposed vibration countermeasure using steel strut and new barrier is found effective in reducing train-induced vibrations and it satisfies environmental vibration requirements.The vibration screening efficiency is evaluated by reduction VAL based on 1/3 octave band spectral analysis. | Liangming Sun Weiping Xie Xingwen He Toshiro Hayashikawa | 2016 | Earthquake Engineering and Engineering Vibration2016，15，1： | 5 |
| 7 | Regulation of microbiota–GLP1 axis by sennoside A in diet-induced obese mice显示文摘Sennoside A(SA) is a bioactive component of Chinese herbal medicines with an activity of irritant laxative, which is often used in the treatment of constipation and obesity. However, its activity remains unknown in the regulation of insulin sensitivity. In this study, the impact of SA on insulin sensitivity was tested in high fat diet(HFD)-induced obese mice through dietary supplementation. At a dosage of 30 mg/kg/day, SA improved insulin sensitivity in the mice after 8-week treatment as indicated by HOMA-IR(homeostatic model assessment for insulin resistance) and glucose tolerance test(GTT). SA restored plasma level of glucagon-like peptide 1(GLP1) by 90% and mRNA expression of Glp1 by 80% in the large intestine of HFD mice. In the mechanism, SA restored the gut microbiota profile, short chain fatty acids(SCFAs), and mucosal structure in the colon. A mitochondrial stress was observed in the enterocytes of HFD mice with ATP elevation, structural damage, and complex dysfunction. The mitochondrial response was induced in enterocytes by the dietary fat as the same responses were induced by palmitic acid in the cell culture. The mitochondrial response was inhibited in HFD mice by SA treatment. These data suggest that SA may restore the function of microbiota–GLP1 axis to improve glucose metabolism in the obese mice. | Jiamei Le Xiaoying Zhang Weiping Jia Yong Zhang Juntao Luo Yongning Sun Jianping Ye | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 8 | A new era of nuclear astrophysics research in China显示文摘Nuclear astrophysics is a rapidly-growing interdisciplinary branch of physics involving a close collaboration among researchers in nuclear physics,astrophysics,and observational astronomy.The origin and fate of matter in our Universe are the primary questions in the nuclear | SUN Yang LIU WeiPing | 2012 | Chinese Science Bulletin2012，57，36： | 4 |
| 9 | Distribution and sources of heavy metals in the sediment of Xiangshan Bay显示文摘Heavy metals in the surface sediments and sediment core from the Xiangshan Bay, a mariculture base on the coast of the East China Sea, were determined by inductively coupled plasma mass spectrometry(ICP–MS) in order to evaluate their levels and sources. The results showed that the levels of Cu, Pb, Zn, and Cr in the sediments of the bay have been generally influenced by anthropogenic inputs since the founding of the People's Republic of China. In particular, Cu and Zn were polluted to some extent, as evidenced by high enrichment factors. Organic matter, grain size, wastewater discharge, and low energy hydrodynamic environment played dominant roles in the heavy metal enrichment in the sediments. The ratio of terrigenous source to marine biogenic deposit of trace metals in the sediments was calculated, revealing that terrigenous inputs were the main source of Cu, Pb, and Zn, while biological pellets contributed much more to the enrichment of Cr and Cd. Considering the influence of biological sources on the enrichment of Cd and Cr, and the fact that the sediment has been polluted by Cu and Zn, the development of mariculture and discharge of wastewater into the Bay should be restricted. | SUN Weiping YU Jianjun XU Xiaoqun ZHANG Weiyan LIU Ruijuan PAN Jianming | 2014 | Acta Oceanologica Sinica2014，33，4： | 4 |
| 10 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 11 | Boron-doped microporous nano carbon as cathode material for high-performance Li-S batteries显示文摘在这研究,做硼的多微孔的碳(BMC )/sulfur nanocomposite 为先进 Li-S 电池作为新奇阴极材料被综合并且适用。有这阴极的房间展出一个超离频的骑车稳定性和率能力。在激活以后, 749.5 mAh/g 的一个能力在 54 在 3.2 A/g 的分泌物电流的 th 周期。在 500 个周期以后, 561.8 mAh/g 的能力留下了(74.96% 保留) ,与 0.056% 的仅仅很小的平均能力腐烂。新奇的硫阴极的优秀可逆性和稳定性能被归因于的做硼的多微孔的碳宿主的能力身体上限制 polysulfides 并且化学上绑这些宿主表面上的种类。理论计算证实那做硼的碳比 undoped 碳能够和 polysulfide 种类的显著地更强壮的相互作用,由于硼的更低的 electronegativity 最可能。我们相信这做的策略能被扩大到另外的金属空气电池和燃料房间,和那它为许多不同应用有有希望的潜力。 | Feng Wu Ji Qian Weiping Wu Yusheng Ye Zhiguo Sun Bin Xu Xiaoguang Yang Yuhong Xu Jiatao Zhang Renjie Chen | 2017 | Nano Research2017，10，2： | 3 |
| 12 | Study on Ni/C catalysts for vapor phase carbonylation of ethanol显示文摘激活支持碳的 Ni 催化剂让乙醇的蒸汽阶段 carbonylation 当倡导者被调查,面对乙醇碘化物支撑离子的酸。在最佳反应条件下面,当时,碳一氧化物和乙醇的变换被测量分别地,是 81.4% 和 98.4% 选择为支撑离子的酸被发现是 98.65% 。催化剂在溪流上的 48 h 以内是稳定的。XRD 和 XPS 方法被用来描绘结构和新鲜、测试的催化剂的表面性质。描述结果显示镍粒子和催化剂表面上的镍碘化物的形成的聚集应该为催化剂的释放负责。 | Qing Zhang Huifang Wang Guosong Sun Kelin Huang Weiping Fang Yiquan Yang | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 3 |
| 13 | Tension-Torsion High-Cycle Fatigue Life Prediction of 2A12-T4 Aluminium Alloy by Considering the Anisotropic Damage:Model, Parameter Identification, and Numerical Implementation显示文摘To consider the anisotropic damage in fatigue, an improved boom-panel model is presented to simulate a representative volume element(RVE) in the framework of continuum damage mechanics. The anisotropic damage state of the RVE is described by the continuity extents of booms and panels, whose damage evolutions are assumed to be isotropic. The numerical implementation is proposed on the basis of damage mechanics and the finite element method. Finally,the approach is applied to the fatigue life prediction of 2A12-T4 aluminium alloy specimen under cyclic loading of tension-torsion. The results indicate a good agreement with the experimental data. | Linlin Sun Miao Zhang Weiping Hu Qingchun Meng | 2016 | Acta Mechanica Solida Sinica2016，29，4： | 2 |
| 14 | Parametrization of woods-saxon potential for heavy-ion systems显示文摘Several elastic scattering angular distributions of ^(12)C from target nuclei of A ≥39 are analyzed to extract the Woods-Saxon potential parameters with the fixed imaginary potential and Coulomb radius parameters.Using the best fitted diffuseness parameters,the correlations of the real part parameters with A_1^(1/3)+ A_2^(1/3) and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction.The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by ^(12)C,but also many elastic scattering angular distributions induced by the projectiles other than ^(12)C,thus providing important inputs for the study of nuclear reactions of heavy-ion systems. | Lin Gan ZhiHong Li HuiBin Sun DanYang Pang Bing Guo YunJu Li Jun Su ShengQuan Yan ErTao Li YouBao Wang Gang Lian ZhiYu Han XinYue Li DongHui Li TianLi Ma ChangJin Pei YangPing Shen Yi Su Sheng Zeng Yong Zhou WeiPing Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 2 |
| 15 | Glial scar size, inhibitor concentration, and growth of regenerating axons after spinal cord transection显示文摘A mathematical model has been formulated in accordance with cell chemotaxis and relevant experimental data. A three-dimensional lattice Boltzmann method was used for numerical simulation. The present study observed the effects of glial scar size and inhibitor concentration on regenerative axonal growth following spinal cord transection. The simulation test comprised two parts: (1) when release rates of growth inhibitor and promoter were constant, the effects of glial scar size on axonal growth rate were analyzed, and concentrations of inhibitor and promoters located at the moving growth cones were recorded. (2) When the glial scar size was constant, the effects of inhibitor and promoter release rates on axonal growth rate were analyzed, and inhibitor and promoter concentrations at the moving growth cones were recorded. Results demonstrated that (1) a larger glial scar and a higher release rate of inhibitor resulted in a reduced axonal growth rate. (2) The axonal growth rate depended on the ratio of inhibitor to promoter concentrations at the growth cones. When the average ratio was < 1.5, regenerating axons were able to grow and successfully contact target cells. | Weiping Zhu Yanping Sun Xuning Chen Shiliang Feng | 2012 | Neural Regeneration Research2012，7，20： | 2 |
| 16 | The protective role of hydrogen-rich saline in experimental liver injury in mice显示文摘 | HanYong Sun Lei Chen WeiPing Zhou Liang Hu Liang Li QianQian Tu YanXin Chang Qu Liu XueJun Sun MengChao Wu HongYang Wang | 2010 | Journal of Hepatology2010，，3： | 2 |
| 17 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 2 |
| 18 | Immediate or delayed repair of pelvic fracture urethral disruption defects in young boys: twenty years of comparative experience显示文摘 | Qu Yanchao Zhang Weiping Sun Ning Huang Chengru Tian Jun Li Minglei, Song Hongcheng Li Ning | 2014 | Chinese Medical Journal2014，，19： | 2 |
| 19 | Effects of different forms of nitrogen addition on microbial extracellular enzyme activity in temperate grassland soil显示文摘Background:Nitrogen(N)deposition alters litter decomposition and soil carbon(C)sequestration by influencing the microbial community and its enzyme activity.Natural atmospheric N deposition comprises of inorganic N(IN)and organic N(ON)compounds.However,most studies have focused on IN and its effect on soil C cycling,whereas the effect of ON on microbial enzyme activity is poorly understood.Here we studied the effects of different forms of externally supplied N on soil enzyme activities related to decomposition in a temperate steppe.Ammonium nitrate was chosen as IN source,whereas urea and glycine were chosen as ON sources.Different ratios of IN to ON(Control,10:0,7:3,5:5,3:7,and 0:10)were mixed with equal total amounts of N and then used to fertilize the grassland soils for 6 years.Results:Our results show that IN deposition inhibited lignin-degrading enzyme activity,such as phenol oxidase(POX)and peroxidase(PER),which may restrain decomposition and thus induce accumulation of recalcitrant organic C in grassland soils.By contrast,deposition of ON and mixed ON and IN enhanced most of the C-degrading enzyme activities,which may promote the organic matter decomposition in grassland soils.In addition,theβ-N-acetyl-glucosaminidase(NAG)activity was remarkably stimulated by fertilization with both IN and ON,maybe because of the elevated N availability and the lack of N limitation after long-term N fertilization at the grassland site.Meanwhile,differences in soil pH,soil dissolved organic carbon(DOC),and microbial biomass partially explained the differential effects on soil enzyme activity under different forms of N treatments.Conclusions:Our results emphasize the importance of organic N deposition in controlling soil processes,which are regulated by microbial enzyme activities,and may consequently change the ecological effect of N deposition.Thus,more ON deposition may promote the decomposition of soil organic matter thus converting C sequestration in grassland soils into a C source. | Lili Dong Björn Berg Weiping Gu Zhengwen Wang Tao Sun | 2022 | Ecological Processes2022，11，1： | 1 |
| 20 | The Existence of Positive for a Class of Nonlinear Boundary Value Problems 显示文摘 | Sun Weiping Ge Weigo | 2001 | Acta Mathematic Sinica2001，44，4： | 1 |
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