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| 1 | Current understanding of Th2 cell differentiation and function显示文摘Helper T cell(Th)has been identified as a critical immune cell for regulating immune response since 1980s.The type 2 helper Tcell(Th2),characterized by the production of interleukin-4(IL-4),IL-5 and IL-13,plays a critical role in immune response against helminths invading cutaneous or mucosal sites.It also has a functional role in the pathophysiology of allergic diseases such as asthma and allergic diarrhea.Currently,most studies have shed light on Th2 cell function and behavior in specific diseases,such as asthma and helminthes inflammation,but not on Th2 cell itself and its differentiation.Based on different cytokines and specific behavior in recent research,Th2 cell is also regarded as new subtypes of T cell,such as IL-9 secreting T cell(Th9)and CXCR5+T follicular helper cells.Here,we will discuss the latest view of Th2 cell towards their function and the involvement of Th2 cell in diseases. | Zhenhu Li Yuan Zhang Bing Sun | 2011 | Protein & Cell2011，2，8： | 11 |
| 2 | Doxorubicin-Ioaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging- guided chemo-photothermal therapy of breast cancer显示文摘 | Wensheng Xie Qin Gao Dan Wang Zhenhu Guo Fei Gao Xiumei Wang Qiang Cai Si-shen Feng Haiming Fan Xiaodan Sun Lingyun Zhao | 2018 | Nano Research2018，11，5： | 4 |
| 3 | Extracellular Polysaccharide from Rhizopus nigricans Inhibits Hepatocellular Carcinoma via miR-494-3p/TRIM36 Axis and Cyclin E Ubiquitination显示文摘Background and Aims:This study was designed to uncov-er the mechanism for extracellular polysaccharide(EPS1-1)-mediated effects on hepatocellular carcinoma(HCC)devel-opment.Methods:HCC cells were treated with EPS1-1,miR-494-3p mimic,sh-TRIM36,and pcDNA3.1-TRIM36.The levels of miR-494-3p and TRIM36 were measured in nor-mal hepatocytes,THLE-2,and HepG2 and HuH7HCC cell lines,along with the protein expression of cyclin D/E and p21.The proliferation,cell cycle,and apoptosis of HCC cells were assayed.The interactions between miR-494-3p and TRIM36,and between TRIM36 and cyclin E were assessed.Finally,the expression and localization of TRIM36 and cyclin E were monitored,and tumor apoptosis was detected,in tumor xenograft model.Results:EPS1-1 suppressed HCC cell proliferation and cyclin D/E expression and promoted apoptosis and p21 expression.miR-494-3p was upregulated and TRIM36 was downregulated in HCC cells.Transfection with miR-494-3p mimic or sh-TRIM36 facilitated HCC cell proliferation and the expression of cyclin D/E protein but they inhibited apoptosis and p21 expression in the pres-ence of EPS1-1.Overexpression of TRIM36 further con-solidated EPS1-1-mediated inhibition of HCC proliferation,cyclin D/E,and the promotion of apoptosis and p21 expres-sion.Those effects were reversed by miR-494-3p overex-pression.TRIM36 was a target gene of miR-494-3p,and TRIM36 induced cyclin E ubiquitination.EPS1-1 suppressed cyclin E expression,promoted TRIM36 expression and tu-mor apoptosis,all of which were abrogated by increasing the expression of miR-494-3p in vivo.Conclusions:EPS1-1 protected against HCC by limiting its proliferation and sur-vival through the miR-494-3p/TRIM36 axis and by inducing cyclin E ubiquitination. | Haixiong Yan XiaoQian Ma Ze Mi Zhenhu He Pengfei Rong | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 2 |
| 4 | NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy显示文摘Oral squamous cell carcinoma(OSCC)is the most common type of oral malignancy,and metastasis accounts for the poor prognosis of OSCC.Autophagy is considered to facilitate OSCC development by mitigating various cellular stresses;nevertheless,the mechanisms of autophagy in OSCC cell proliferation and metastasis remain unknown.In our study,high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1(NUPR1)as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis. | Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 5 | Enhancing enzymatic digestibility of switchgrass by microwave-assisted alkali pretreatment显示文摘 | Hu Zhenhu Wen Zhiyou | 2008 | Biochemical Engineering Journal2008，38，： | 1 |
| 6 | Fabrication of exfoliated graphene-based polypropylene nanocomposites with enhanced mechanical and thermal properties显示文摘 | Song Pingan Cao Zhenhu Cai Yuanzheng | 2011 | Polymer2011，52，： | 1 |
| 7 | Preparation and evaluation of porous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) hydroxyapatite composite scaffolds显示文摘 | Jing Xi Ling Zhang Zhenhu An Zheng | | 0，，04： | 1 |
| 8 | Hydrogen production from rice winery wastewater in an upflow anaerobic reactor by using mixed anaerobic culture显示文摘 | Yu Hanqing Zhu Zhenhu Hu Wenrong | 2002 | Int J Hydrogen Energy2002，27，： | 1 |
| 9 | Multiscale rescaled range analysis of EEG recordings in sevoflurane anesthesia显示文摘 | Zhenhu Liang Duan Li Gaoxiang Ouyang Yinghua Wang Logan J. Voss Jamie W. Sleigh Xiaoli Li | 2011 | Clinical Neurophysiology2011，，4： | 1 |
| 10 | Analysis of depth of anesthesia with Hilbert–Huang spectral entropy显示文摘 | Xiaoli Li Duan Li Zhenhu Liang Logan J. Voss Jamie W. Sleigh | 2008 | Clinical Neurophysiology2008，，11： | 1 |
| 11 | Blocking the CDn0-CD40 L interaction by CD40-Ig reduces disease progress in murine myocarditis induced by CVB3显示文摘 | Bo H Zhenhu L Lijian Z | | 0，，06： | 1 |
| 12 | 显示文摘 | Zhou Zhenhu Wang Suli Zhou Weijiang | 2003 | Chem Commun2003，3，： | 1 |
| 13 | The new rural-urban labor mobility in China: causes and implication s显示文摘 | MICHAEL C SEEBORG ZHENHU JIN YIPING ZHU | 2000 | Journal of Socio-Economies2000，，29： | 1 |
| 14 | Organic-free synthesis of boehmite nanofi bers by Al2(SO4)3·18H2O with high pore volume显示文摘 | Song Jiaqing Li Zhenhu Xu Xiangyu | 2013 | Ind Eng Chem Res2013，52，23： | 1 |
| 15 | The new rural-urban la- bor mobility in China: Causes and implications 显示文摘 | Michael C Seeborg Zhenhu Jin Yiping Zhu | 2000 | Journal of Socio-Economics2000，29，1： | 1 |
| 16 | Blocking the CD40-CD40L interaction byCD40-1g reduces disease progress in murine myocarditis induced by CVB3显示文摘 | Bo H Zhenhu L Lijian Z | 2010 | Cardiovasc Pathol2010，19，6： | 1 |
| 17 | Blocking the CD40-CD40L interaction by CD40-Ig reduces disease progress in murine myocarditis induced by CVB3显示文摘 | Bo H Zhenhu L Lijian Z | | 0，，6： | 1 |
| 18 | Expression of E1 Gene of A Hepatitis C Virus in E. coli and Protein Purification显示文摘ExpressionofE1GeneofAHepatitisCVirusinE.coliandProteinPurification￥YeLinbai;GaoJinrong;MengXlaolin;XuJinping;ZbuYingHudin;Min... | Ye Linbai Gao Jinrong Meng Xiaolin Xu Jinping Zhu Ying Hu Min Min Lei Ye Chanying Wu Zhenhue | 1996 | Wuhan University Journal of Natural Sciences1996，1，2： | 1 |
| 19 | Blocking the CD40-CD40L interaction by CD40-Ig reduces disease progress in murine myocarditis induced by CVB3 显示文摘 | Bo H Zhenhu L Lijian Z | 2010 | Cardiovasc Pathol2010，19，6： | 1 |
| 20 | Fabrication of exfoliated graphene-based polyprepylene nanocomposites with enhanced mechanical and thermal properties 显示文摘 | Song Pingan Cao Zhenhu Cai Yuanzheng | 2011 | Polymer2011，52，18： | 1 |
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