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| 1 | State-of-the-art review of soft computing applications in underground excavations显示文摘Soft computing techniques are becoming even more popular and particularly amenable to model the complex behaviors of most geotechnical engineering systems since they have demonstrated superior predictive capacity,compared to the traditional methods.This paper presents an overview of some soft computing techniques as well as their applications in underground excavations.A case study is adopted to compare the predictive performances of soft computing techniques including eXtreme Gradient Boosting(XGBoost),Multivariate Adaptive Regression Splines(MARS),Artificial Neural Networks(ANN),and Support Vector Machine(SVM) in estimating the maximum lateral wall deflection induced by braced excavation.This study also discusses the merits and the limitations of some soft computing techniques,compared with the conventional approaches available. | Wengang Zhang Runhong Zhang Chongzhi Wu Anthony Teck Chee Goh Suzanne Lacasse Zhongqiang Liu Hanlong Liu | 2020 | Geoscience Frontiers2020，11，4： | 33 |
| 2 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 3 | Memristors with organic-inorganic halide perovskites显示文摘Organic-inorganic halide perovskites(OHPs)have been intensively studied for application in solar cells with high conversion efficiency exceeding 22%.The unique electrical and optical properties of OHPs have led to their use in optoelectronic device applications beyond photovoltaics,such as light-emitting diodes,photodetectors,transistors.New information storage technologies and computing architectures are being researched extensively with the aim of addressing the growing challenge of approaching end of Moore's law and von Neumann bottleneck.As the fourth basic circuit element,memristor is a leading candidate with powerful capabilities in information storage and neuromorphic computing applications.Recently,OHPs have received growing attention as promising materials for memristors.In particular,their mixed ionic-electronic conduction ability paired with light sensitivity provide OHPs with the opportunity to display novel functions such as optical-erase memory,optogenetics-inspired synaptic functions,and lightaccelerated learning capability.This review covers recent advances in OHP-based memristors development including memristive mechanism and analytical models,universal memristive characteristics for memory and neuromorphic computing applications,and novel multi-functionalization.Challenges and future prospects of OHP-based memristors are also discussed. | Xiaoning Zhao Haiyang Xu Zhongqiang Wang Ya Lin Yichun Liu | 2019 | InfoMat2019，1，2： | 10 |
| 4 | Detection of Salmonella and several common Salmonella serotypes in food by loop-mediated isothermal amplification method显示文摘Salmonella Choleraesuis,S.Enteritidis and S.Typhimurium are the main pathogens that contaminate animal products and cause human Salmonella food poisoning.To establish the loop-mediated isothermal amplification(LAMP)method for the rapid detection of Salmonella and 3 common Salmonella serotypes,inner and outer primer sets targeting Salmonella invE gene and 3 serotype-specific genes fliC,lygD and STM4495 were designed.The LAMP reaction conditions were optimized.The specificity of LAMP primers was identified by testing 10 different bacterial strains including S.Choleraesuis,S.Enteritidis and S.Typhimurium.Take S.Choleraesuis as example,the detection limit of LAMP assay was 1.33×10^1 CFU/mL for bacteria culture and 2.0×10^1 CFU/mL for simulated pork sample.The results show that LAMP is a rapid,sensitive and specific method for Salmonella detection and can be used for the rapid detection of Salmonella in food. | Zhongqiang Chen Ke Zhang Huan Yin Qi Li Lan Wang Zhiguo Liu | 2015 | Food Science and Human Wellness2015，4，2： | 8 |
| 5 | Study about thermal runaway behavior of high specific energy density Li-ion batteries in a low state of charge显示文摘Lithium-ion batteries are widely used in electric vehicles and electronics, and their thermal safety receives widespread attention from consumers. In our study, thermal runaway testing was conducted on the thermal stability of commercial lithium-ion batteries, and the internal structure of the battery was analyzed with an in-depth focus on the key factors of the thermal runaway. Through the study of the structure and thermal stability of the cathode, anode, and separator, the results showed that the phase transition reaction of the separator was the key factor affecting the thermal runaway of the battery for the condition of a low state of charge. | Shiqiang Liu Tianyi Ma Zhen Wei Guangli Bai Huitian Liu Dapeng Xu Zhongqiang Shan Fang Wang | 2021 | Journal of Energy Chemistry2021，30，1： | 6 |
| 6 | Genome-Wide Identification of Zn_(2)Cys_(6 ) Class Fungal-Specific Transcription Factors(ZnFTFs)and Functional Analysis of UvZnFTFI in Ustilaginoidea virens显示文摘Transcription factors(TFs)orchestrate the regulation of cellular gene expression and thereby determine cell functionality.In this study,we analyzed the distribution of TFs containing domains,which named as ZnFTFs,both in ascomycete and basidiomycete fungi.We found that ZnFTFs were widely distributed in these fungal species,but there was more expansion of the ZnFTF class in Ascomycota than Basidiomycota.We identified 40 ZnFTFs in Ustilaginoidea virens,and demonstrated the involvement of UvZnFTF1 in vegetative growth,conidiation,pigment biosynthesis and pathogenicity.RNA-Seq analysis suggested that UvZnFTF1 may regulate different nutrient metabolism pathways,the production of secondary metabolites,and the expression of pathogen-host interaction genes and secreted protein-encodi ng genes.Analysis of the distributi on of differe nt fungal TFs in U.virens further dem on strated that UvZnFTFs make up a large TF family and may play essential biological roles in U.virens. | SONG Tianqiao ZHANG Xiong ZHANG You LIANG Dong YAN Jiaoling YU Junjie YU Mina CAO Huijuan YONG Mingli PAN Xiayan QI Zhongqiang DU Yan ZHANG Rongsheng LIU Yongfeng | 2021 | Rice science2021，28，6： | 4 |
| 7 | Effects of ZnO nanoparticles on perfluorooctane sulfonate induced thyroid-disrupting on zebrafish larvae显示文摘Perfluorooctane sulfonate(PFOS) and ZnO nanoparticles(nano-ZnO) are widely distributed in the environment.However,the potential toxicity of co-exposure to PFOS and nano-ZnO remains to be fully elucidated.The test investigated the effects of co-exposure to PFOS and nano-ZnO on the hypothalamic–pituitary–thyroid(HPT) axis in zebrafish.Zebrafish embryos were exposed to a combination of PFOS(0.2,0.4,0.8 mg/L) and nano-ZnO(50 mg/L)from their early stages of life(0–14 days).The whole-body content of TH and the expression of genes and proteins related to the HPT axis were analyzed.The co-exposure decreased the body length and increased the malformation rates compared with exposure to PFOS alone.Co-exposure also increased the triiodothyronine(T3) levels,whereas the thyroxine(T4)content remained unchanged.Compared with the exposure to PFOS alone,exposure to both PFOS(0.8 mg/L) and nano-ZnO(50 mg/L) significantly up-regulated the expression of corticotropin-releasing factor,sodium/iodidesymporter,iodothyronine deiodinases and thyroid receptors and significantly down-regulated the expression of thyroid-stimulating hormone,thyroglobulin(TG),transthyretin(TTR) and thyroid receptors.The protein expression levels of TG and TTR were also significantly down-regulated in the co-exposure groups.In addition,the expression of the thyroid peroxidase gene was unchanged in all groups.The results demonstrated that PFOS and nano-ZnO co-exposure could cause more serious thyroid-disrupting effects in zebrafish than exposure to PFOS alone.Our results also provide insight into the mechanism of disruption of the thyroid status by PFOS and nano-ZnO. | Jia Du Shutao Wang Hong You Zhongqiang Liu | 2016 | Journal of Environmental Sciences2016，28，9： | 3 |
| 8 | Modelling of shallow landslides with machine learning algorithms显示文摘This paper introduces three machine learning(ML)algorithms,the‘ensemble'Random Forest(RF),the‘ensemble'Gradient Boosted Regression Tree(GBRT)and the Multi Layer Perceptron neural network(MLP)and applies them to the spatial modelling of shallow landslides near Kvam in Norway.In the development of the ML models,a total of 11 significant landslide controlling factors were selected.The controlling factors relate to the geomorphology,geology,geo-environment and anthropogenic effects:slope angle,aspect,plan curvature,profile curvature,flow accumulation,flow direction,distance to rivers,water content,saturation,rainfall and distance to roads.It is observed that slope angle was the most significant controlling factor in the ML analyses.The performance of the three ML models was evaluated quantitatively based on the Receiver Operating Characteristic(ROC)analysis.The results show that the‘ensemble'GBRT machine learning model yielded the most promising results for the spatial prediction of shallow landslides,with a 95%probability of landslide detection and 87%prediction efficiency. | Zhongqiang Liu Graham Gilbert Jose Mauricio Cepeda Asgeir Olaf Kydland Lysdahl Luca Piciullo Heidi Hefre Suzanne Lacasse | 2021 | Geoscience Frontiers2021，12，1： | 3 |
| 9 | Neutron irradiation-induced effects on the reliability performance of electrochemical metallization memory devices显示文摘In this work,electrochemical metallization memory(ECM)devices with an Ag/AgInSbTe(AIST)/amorphous carbon(a-C)/Pt structure were irradiated with 14 MeV neutrons.The switching reliability performance before and after neutron irradiation was compared and analyzed in detail.The results show that the irradiated memory cells functioned properly,and the initial resistance,the resistance at the low-resistance state(LRS),the RESET voltage and the data retention performance showed little degradation even when the total neutron fluence was as high as 2.5×1011 n/cm2.Other switching characteristics such as the forming voltage,the resistance at the high-resistance state(HRS),and the SET voltage were also studied,all of which merely showed a slight parameter drift.Irradiation-induced Ag ions doping of the a-C layer is proposed to explain the damaging effects of neutron irradiation.The excellent hard characteristics of these Ag/AIST/a-C/Pt-based ECM devices suggest potential beneficial applications in the aerospace and nuclear industries. | Ye Tao Xuhong Li Zhongqiang Wang Gang Li Haiyang Xu Xiaoning Zhao Ya Lin Yichun Liu | 2021 | Journal of Semiconductors2021，42，1： | 2 |
| 10 | Hydrogen Bonding-Assisted Synthesis of Silica/Oxidized Mesocarbon Microbeads Encapsulated in Amorphous Carbon as Stable Anode for Optimized/Enhanced Lithium Storage显示文摘The practical application of silica-based composites as an alternative to commercial graphite anode materials is hampered by their large volumetric expansion,poor conductivity,and low Coulombic efficiency.In this work,a novel silica/oxidized mesocarbon microbead/amorphous carbon(SiO2/O’MCMB/C)hierarchical structure in which SiO2 is sandwiched between spherical graphite and amorphous carbon shell was succes sfully fabricated through hydrogen bonding-assisted self-assembly and post-carbon coating method.The obtained three-layer hierarchical structure effectively accommodates the volumetric expansion of SiO2 and significantly enhances the electronic conductivity of composite materials.Moreover,the outer layer of amorphous carbon effectively increases the diffusion rate of lithium ions and promotes the formation of stable SEI film.As a result,the SiO2/O’MCMB/C composite exhibits superior electrochemical performance with a reversible capacity of 459.5 mA h/g in the first cycle,and the corresponding Coulombic efficiency is 62.8%.After 300 cycles,the capacity climbs to around 600 mA h/g.This synthetic route provides an efficient method for preparing SiO2 supported on graphite with excellent electrochemical performance,which is likely to promote its commercial applications. | Zongjie Cao Huitian Liu Wenlong Huang Peng Chen Yuansheng Liu Yu Yu Zhongqiang Shan Shuxian Meng | 2020 | Transactions of Tianjin University2020，26，1： | 2 |
| 11 | Experimental control of banana scab disease using different fungicides显示文摘 | Zeng ZhongQiang Liu GuoQiang Lin ZhiQing | 2003 | China Fruits2003，1，： | 1 |
| 12 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 13 | Surface modified polyimide fiber-filled ethylene-propylene-diene monomer insulations for a solid rocket motor:processing,morphology,and properties显示文摘 | Han Zhongqiang Qi Shengli Liu Wei | | 0，，03： | 1 |
| 14 | A Writable Polypeptide–DNA Hydrogel with Rationally Designed Multi‐modification Sites显示文摘 | Chuang Li Ping Chen Yu Shao Xu Zhou Yuzhou Wu Zhongqiang Yang Zhibo Li Tanja Weil Dongsheng Liu | 2015 | Small2015，，9： | 1 |
| 15 | Comparison between two types of"Scheuermann disease-like people": thoracolumbar disc herniation patients and healthy volunteers with radiological signs of Scheuermann's disease显示文摘 | Guo Xinhu Chen Zhongqiang Liu Ning Guo Zhaoqing Qi Qiang Li Weishi Zeng Yan Sun Chuiguo | 2014 | Chinese Medical Journal2014，，22： | 1 |
| 16 | Rapid Formation of a Supramolecular Polypeptide–DNA Hydrogel for In Situ Three‐Dimensional Multilayer Bioprinting显示文摘 | Chuang Li Alan Faulkner‐Jones Alison R. Dun Juan Jin Ping Chen Yongzheng Xing Zhongqiang Yang Zhibo Li Wenmiao Shu Dongsheng Liu Rory R. Duncan | 2015 | Angew. Chem. Int. Ed2015，，13： | 1 |
| 17 | Effect of the Decompressive Extent on the Magnitude of the Spinal Cord Shift after Expansive Open-door Laminoplasty显示文摘 | Qingquan Kong Li Zhang Limin Liu Tao Li Quan Gong Jiancheng Zeng Yueming Song Hao Liu Shaobo Wang Yu Sun Fengshan Zhang Mai Li Zhongqiang Chen | 2011 | Spine2011，，13： | 1 |
| 18 | Interannual Variations of Phytoplankton, Zooplankton and Chlorophyll a in the Arctic Seas and Their Relations to ENSO and AO显示文摘To study effects of variations in climate-marine environment in the Arctic Ocean on ecology,based on the actual and reestablished data by biomarkers of algae in sediment in 1997,1999,2003,2008,and 2010,the interannual and spatial variations of phytoplankton,zooplankton and chlorophyll a concentration in the Chukchi Sea and the Bering Sea as well as their relations to El Nino-Southern Oscillation( ENSO) and Arctic Oscillation( AO) were analyzed. The results show that there were spatial and temporal anomalies in the phytoplankton community structure reestablished by biomarkers of algae in the Chukchi Sea and the Bering Sea in 1999 and 2010. The total content of biomarkers( brassicasterol,dinosterol,C37 alkenones and chlesterol) in sediment collected in 2010 was far lower than that in 1999,but brassicasterol was dominant in the two years,that is,diatom was dominant,which was consistent with the actual structure and distribution of phytoplankton community in 1999 and 2010; there were great changes in the dominant species of plankton in the two seas in 1999 and 2010,which could be regarded as the ecological response of the North Pole under the background of global warming. Chlorophyll a concentration in the water of the Bering Sea was 0. 720 μg/dm^3 at 0 m and 0. 765μg/dm^3 at 10 m in 1997 and 0. 723 μg/dm^3 at 0 m and 0. 731 μg/dm^3 at 10 m in 2003,and the concentration was very close to each other,which was affected by El Ni1 o and the negative phase of AO. It was 0. 395 μg/dm^3 at 0 m in 1999 and 0. 399 μg/dm^3 at 0 m and 0. 357 μg/dm^3 at 10 m in 2008,which was influenced by La Ni1 a and the positive phase of AO. The phases and intensity of AO and ENSO had various effects on the quantity and dominant species of phytoplankton and zooplankton in the Chukchi Sea and the Bering Sea. During the period of AO with positive or negative phase and El Ni1o( in 1997 and 2003),their combination was favorable to the growth of phytoplankton and zooplankton,while the combination of negative phase of AO and La Nina( in 2010) had adverse effects on the growth of phytoplankton. The combination of AO with positive phase and strong La Nina( in 1999 and 2008) had small effects on phytoplankton community. | Zhang Haisheng Chen Jianfang Han Zhengbing Ji Zhongqiang Xu Xudan Han Xibing Liu Zilin Peter, H.-U Vetter Walter | 2017 | Meteorological and Environmental Research2017，8，2： | 1 |
| 19 | Effects of vertical mixing on phytoplankton blooms in Xiangxi Bay of Three Gorges Reservoir: Implications for management显示文摘 | Liu Liu Defu Liu David M. Johnson Zhongqiang Yi Yuling Huang | 2012 | Water Research2012，，7： | 1 |
| 20 | Bayesian doubly adaptive randomization in clinical trials显示文摘Bayesian adaptive randomization has attracted increasingly attention in the literature and has been implemented in many phase II clinical trials. Doubly adaptive biased coin design(DBCD) is a superior choice in response-adaptive designs owing to its promising properties. In this paper, we propose a randomized design by combining Bayesian adaptive randomization with doubly adaptive biased coin design. By selecting a fixed tuning parameter, the proposed randomization procedure can target an explicit allocation proportion, and assign more patients to the better treatment simultaneously. Moreover, the proposed randomization is efficient to detect treatment differences. We illustrate the proposed design by its applications to both discrete and continuous responses, and evaluate its operating features through simulation studies. | XIAO YiKe LIU ZhongQiang HU FeiFang | 2017 | Science China Mathematics2017，60，12： | 1 |
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