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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 3 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 4 | SPH modeling of fluid-structure interaction显示文摘This work concerns numerical modeling of fluid-structure interaction(FSI) problems in a uniform smoothed particle hydrodynamics(SPH) framework. It combines a transport-velocity SPH scheme, advancing fluid motions, with a total Lagrangian SPH formulation dealing with the structure deformations. Since both fluid and solid governing equations are solved in SPH framework, while coupling becomes straightforward, the momentum conservation of the FSI system is satisfied strictly. A well-known FSI benchmark test case has been performed to validate the modeling and to demonstrate its potential. | Luhui Han Xiangyu Hu | 2018 | Journal of Hydrodynamics2018，30，1： | 7 |
| 5 | Rapid growth of a long-seed KDP crystal显示文摘To reduce the seed length while maintaining the advantages of the cuboid KDP-type crystal,a long-seed KDP crystal with size 471 mm×480 mm×400 mm is rapidly grown.With almost the same high cutting efficiency to obtain third harmonic generation oriented samples,this long-seed KDP-type crystal can be grown with a shorter seed than that of the cuboid KDP-type crystal.The full width at half maximum of the high-resolution X-ray diffraction of the(200)crystalline face is 28.8 arc seconds,indicating that the long-seed KDP crystal has good crystalline quality.In the wavelength range of 377–1022 nm,the transmittance of the long-seed KDP crystal is higher than 90%.The fluence for the 50%probability of laser-induced damage(LID)is 18.5 J/cm^2(3 ns,355 nm).Several test points survive when the laser fluence exceeds 30 J/cm^2(3 ns,355 nm),indicating the good LID performance of the long-seed KDP crystal.At present,the growth of a long-seed DKDP crystal is under way. | Duanyang Chen Bin Wang Hu Wang Xiangyu Zhu Ziyuan Xu Yuanan Zhao Shenghao Wang Kaizao Ni Lili Zheng Hui Zhang Hongji Qi Jianda Shao | 2020 | High Power Laser Science and Engineering2020，8，1： | 5 |
| 6 | A CAD-compatible body-fitted particle generator for arbitrarily complex geo-metry and its application to wave-structure interaction显示文摘Generating body-fitted particle distribution for arbitrarily complex geometry underpins the applications of particle-based method to engineering and bioengineering and is highly challenging,and thus hinders the potential of particle methods.In this paper,we present a new computer-aided design(CAD)compatible body-fitted particle generator,termed as CAD-BPG,for arbitrarily complex 3-D geometry.By parsing a CAD model,the present method can accurately tackle arbitrarily complex geometry representation and describe the corresponding geometry surface by constructing an implicit zero level-set function on Cartesian background mesh.To achieve a body-fitted and isotropic particle distribution,physics-driven relaxation process with surface bounding governed by the transport-velocity formulation of smoothed particle hydrodynamics(SPH)methodology is conducted to characterize the particle evolution.A set of examples,ranging from propeller,stent structures and anatomical heart models,show simplicity,accuracy and versatility of the present CAD-BPG for generating body-fitted particle distribution of arbitrarily complex 3-D geometry.Last but not least,the present CAD-BPG is applied for modeling wave-structure interaction,where wave interaction with an oscillating wave surge converter is studied,and the results show that the present method not only provides an efficient and easy-to-implement pre-processing tool for particle-based simulation but also improves the numerical accuracy compared with lattice particle distribution.Consequently,the propose CAD-BPG sheds light on simulating real-world applications by particle-based methods for researchers and engineers. | Yujie Zhu Chi Zhang Yongchuan Yu Xiangyu Hu | 2021 | Journal of Hydrodynamics2021，33，2： | 5 |
| 7 | Enhanced Photocatalytic Activity of Nanoparticle-Aggregated Ag–AgX(X=Cl, Br)@TiO_2 Microspheres Under Visible Light显示文摘Ag–AgX(X = Cl, Br)@TiO_2 nanoparticle-aggregated spheres with different mass ratio of R = TiO2/Ag(X) from 35:1 to 5:1 were synthesized by a facile sol–gel technique with post-photoreduction. The photocatalytic activities of both Ag–Ag Cl@TiO_2 and Ag–Ag Br@TiO_2 under visible light are effectively improved by ~3 times relative to TiO_2 NPAS under the simulated sunlight for the decomposition of methyl orange(MO). Ag–AgBr@TiO_2 showed 30% improvement and less stable in photocatalytic activity than that of AgCl@TiO_2. The role of Ag and Ag X nanoparticles on the surface of Ag–Ag X(X = Cl,Br)@TiO_2 was discussed. Ag on these samples not onlycan efficiently harvest visible light especially for Ag Cl, but also efficiently separate excited electrons and holes via the fast electron transfer from Ag X(X = Cl, Br) to metal Ag nanoparticles and then to TiO_2-aggregated spheres on the surface of heterostructure. On the basis of their efficient and stable photocatalytic activities under visible-light irradiation, these photocatalysts could be widely used for degradation of organic pollutants in aqueous solution. | Cuiling Zhang Hao Hua Jianlin Liu Xiangyu Han Qipeng Liu Zidong Wei Chengbin Shao Chenguo Hu | 2017 | Nano-Micro Letters2017，9，4： | 5 |
| 8 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 9 | Silk materials for medical, electronic and optical applications显示文摘Silk derived from the silkworm Bombyx mori is among the most important fibrous protein biomaterials due to large-scale production from natural sources, excellent biocompatibility, unique mechanical properties and controllable degradation. Silk fibroin can be processed into a variety of formats to match different applications, such as tissue engineering, drug delivery or as the passive substrate of a bio-device. Advances in fabrication technologies provide new possibilities for the combination of silk fibroin with other nanomaterials to functionalize silk fibroin for specialized purposes, including sensing, cell visualization,resistance to ultraviolet light and provision of antibacterial properties. As the requirement for wearable and intelligent devices has become increasingly important over recent years, silk fibroin has been utilized as the active element in electronic and optical instruments. This review summarizes these recent advances in the innovative applications of silk fibroin. | FAN SuNa ZHANG Yi HUANG XiangYu GENG LiHong SHAO HuiLi HU XueChao ZHANG YaoPeng | 2019 | Science China(Technological Sciences)2019，62，6： | 4 |
| 10 | Maternal supply of cysteamine alleviates oxidative stress and enhances angiogenesis in porcine placenta显示文摘Background:Oxidative stress in placenta is associated with the occurrence of adverse pregnancy outcomes in sow,but there are few satisfactory treatment strategies for these conditions.This study investigated the potential of cysteamine(CS)as an antioxidant protectant for regulating the reproductive performance,redox status,and placental angiogenesis of sows.Methods:The placental oxidative stress status and vascular density of piglets with different birth weights:<1.0 kg(low birth weight,LBW)and 1.4–1.6 kg(normal birth weight,NBW)were evaluated,followed by allotting 84 sows to four treatments(n=21)and feeding them with a basal diet supplemented with 0,100,300,or 500 mg/kg of CS from d 85 of gestation to d 21 of lactation,respectively.Placenta,serum,and colostrum samples of sows or piglets were collected,and the characteristics of sows and piglets were recorded.Furthermore,the in vivo results were validated using porcine vascular endothelial cells(PVECs).Results:Compared with the NBW placentae,the LBW placentae showed increased oxidative damage and were vulnerable to angiogenesis impairment.Particularly,H2O2-induced oxidative stress prompted intracellular reactive oxygen species generation and inhibited the tube formation and migration of PVECs as well as the expression of vascular endothelial growth factor-A(VEGF-A)in vitro.However,dietary CS supplementation can alleviate oxidative stress and improve the reproductive performance of sows.Specifically,compared with the control group,dietary 100 mg/kg CS could(1)decrease the stillbirth and invalid rates,and increase both the piglet birth weight in the low yield sows and the placental efficiency;(2)increase glutathione and reduce malondialdehyde in both the serum and the colostrum of sows;(3)increase the levels of total antioxidant capacity and glutathione in LBW placentae;(4)increase the vascular density,the mRNA level of VEGF-A,and the immune-staining intensity of platelet endothelial cell adhesion molecule-1 in the LBW placentae.Furthermore,the in vitro experiment indicated that CS pre-treatment could significantly reverse the NADPH oxidase 2-ROS-mediated inactivation of signal transducer and activator of transcription-3(Stat3)signaling pathway induced by H2O2 inhibition of the proliferation,tube formation,and migration of PVECs.Meanwhile,inhibition of Stat3 significantly decreased the cell viability,tube formation and the VEGF-A protein level in CS pretreated with H_(2)O_(2)-cultured PVECs.Conclusions:The results indicated that oxidative stress and impaired angiogenesis might contribute to the occurrence of LBW piglets during pregnancy,but CS supplementation at 100 mg/kg during late gestation and lactation of sows could alleviate oxidative stress and enhance angiogenesis in placenta,thereby increasing birth weight in low yield sows and reducing stillbirth rate.The in vitro data showed that the underlying mechanism for the positive effects of CS might be related to the activation of Stat3 in PVECs. | Shuangbo Huang Zifang Wu Zihao Huang Xiangyu Hao Longmiao Zhang Chengjun Hu Jianfu Wei Jinping Deng Chengquan Tan | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 4 |
| 11 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 12 | Progress on major genes for high fecundity in ewes显示文摘The existence of major genes affecting fecundity in sheep flocks throughout the world has been demonstrated.Three major genes whose mutations can increase ovulation rate have been discovered,and all related to the transforming growth factorβ(TGF-β)superfamily.The mutant FecB of bone morphogenetic protein receptor 1B(BMPR1B)has an additive effect on ovulation rate.Six mutations(Fec^(XI),Fec^(XH),Fec^(XG),Fec^(XB),Fec^(XL),Fec^(XR))of bone morphogenetic protein 15(BMP15)related with fertility have been identified that share the same mechanism.All the mutants can increase ovulation rate in heterozygotes and cause complete sterility in homozygotes.Homozygous ewes with two new mutations(FecX^(Gr),FecX^(O))of BMP15 had increased ovulation rate without causing sterility.There are five mutations in growth differentiation factor 9(GDF9)associated with sheep prolificacy where FecG^(E) and FecG^(F) have additive an effect on ovulation rate and litter size.The newly identifiedβ-1,4-N-acetylgalactosaminyltransferase 2(B4GALNT2)gene of FecL is proposed as a new mechanism of ovulation rate regulation in sheep.Woodlands is an X-linked maternally imprinted gene which increases ovulation rate.In addition,several putative major genes need to be verified.This review is focused on the identification of the mutations and mechanisms whereby the major genes affecting ovulation rate. | Qiuyue LIU Zhangyuan PAN Xiangyu WANG Wenping HU Ran DI Yaxing YAO Mingxing CHU | 2014 | Frontiers of Agricultural Science and Engineering2014，1，4： | 3 |
| 13 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 14 | Stabilization Mechanism of Calcium Lignosulphonate Used in Expansion Sensitive Soil显示文摘A series of tests were performed to investigate the macroscopic properties and the stabilization mechanism of calcium lignosulphonate modified expansive soil.Compared with natural soil,soil modified by 4%calcium lignosulphonate showed 56.5%increased 28 days unconfined compressive strength and 23.8%decreased free expansion rate.The X-ray diffraction analysis results indicate the existence of cation exchange and the reduction of montmorillonite interplanar spacing.The X-computed tomography results demonstrate that calcium lignosulphonate decreased the porosity and optimized the pore distribution.The calcium lignosulphonate also increased the stability of the suspension system according to the Zeta potential results.Moreover,the results of rheological tests show that the moderate amount of calcium lignosulphonate enhanced the yield stress and the plastic viscosity,proving the formation of a strong connection between soil particles. | 吴大江 佘伟 WEI Luansu ZUO Wenqiang HU Xiangyu HONG Jinxiang MIAO Changwen | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，5： | 2 |
| 15 | Size-resolved effective density of submicron particles during summertime in the rural atmosphere of Beijing, China显示文摘Particle density is an important physical property of atmospheric particles.The information on high time-resolution size-resolved particle density is essential for understanding the atmospheric physical and chemical aging processes of aerosols particles.In the present study,a centrifugal particle mass analyzer(CPMA) combined with a differential mobility analyzer(DMA) was deployed to determine the size-resolved effective density of 50 to 350 nm particles at a rural site of Beijing during summer 2016.The measured particle effective densities decreased with increasing particle sizes and ranged from 1.43 to 1.55 g/cm^3,on average.The effective particle density distributions were dominated by a mode peaked at around 1.5 g/cm^3 for 50 to350 nm particles.Extra modes with peaks at 1.0,0.8,and 0.6 g/cm3 for 150,240,and 350 nm particles,which might be freshly emitted soot particles,were observed during intensive primary emissions episodes.The particle effective densities showed a diurnal variation pattern,with higher values during daytime.A case study showed that the effective density of Aitken mode particles during the new particle formation(NPF) event decreased considerably,indicating the significant contribution of organics to new particle growth. | Kai Qiao Zhijun Wu Xiangyu Pei Qianyun Liu Dongjie Shang Jing Zheng Zhuofei Du Wenfei Zhu Yusheng Wu Shengrong Lou Song Guo Chak K.Chan Ravi Kant Pathak Mattias Hallquist Min Hu | 2018 | Journal of Environmental Sciences2018，30，11： | 2 |
| 16 | Calibration of Mars Energetic Particle Analyzer (MEPA)显示文摘The first Mars exploration mission of China(Tianwen-1)is scheduled to be launched in 2020;a charged particle telescope,the Mars Energetic Particle Analyzer(MEPA),is carried as one of the payloads on the orbiter.The MEPA is designed to measure solar energetic particles(SEPs)and galactic cosmic rays(GCRs)in the near-Mars space and in the transfer orbit from Earth to Mars.Before the launch,the MEPA was calibrated in ground experiments with radioactive sources,electronic pulses,and accelerator beams.The calibration parameters,such as energy conversion constants,threshold values for the triggers,and particle identification criteria,were determined and have been stored for onboard use.The validity of the calibration parameters has been verified with radioactive sources and beams.The calibration results indicate that the MEPA can measure charged particles reliably,as designed,and that it can satisfy the requirements of the Tianwen-1 mission. | ShuWen Tang Yi Wang HongYun Zhao Fang Fang Yi Qian YongJie Zhang HaiBo Yang CunHui Li Qiang Fu Jie Kong XiangYu Hu Hong Su ZhiYu Sun YuHong Yu BaoMing Zhang Yu Sun ZhiPeng Sun | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 17 | Corrigendum to “The Tianwen-1 Guidance, Navigation, and Control for Mars Entry, Descent, and Landing”显示文摘In the article titled“The Tianwen-1 Guidance,Navigation,and Control for Mars Entry,Descent,and Landing”[1],there was an error in Figure 9(b).On the y-axis,the data read q1,q2,and q1.It should have read q1,q2,and q3.This is updated as shown in Figure 1 below. | Xiangyu Huang Maodeng Li Xiaolei Wang Jinchang Hu Yu Zhao Minwen Guo Chao Xu Wangwang Liu Yunpeng Wang Ce Hao Lijia Xu | 2021 | Space(Science & Technology)2021，，1： | 2 |
| 18 | The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity显示文摘The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well characterized.In particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is elusive.Here,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 levels.Alternatively,these patients mounted potent virus-specific TH1 and CD8+T cell responses.In sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these patients.These results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines. | Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang Jianfang Tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 19 | A humidity resistant and high performance triboelectric nanogenerator enabled by vortex-induced vibration for scavenging wind energy显示文摘Wind energy is a promising renewable energy source for a low-carbon society.This study is to develop a fully packaged vortexinduced vibration triboelectric nanogenerator(VIV-TENG)for scavenging wind energy.The VIV-TENG consists of a wind vane,internal power generation unit,an external frame,four springs,a square cylinder and a circular turntable.The internal power generation unit consists of polytetrafluoroethylene(PTFE)balls,a honeycomb frame and two copper electrodes.Different from most of the previous wind energy harvesting TENGs,the bouncing PTFE balls are fully packaged in the square cylinder.The distinct design separates the process of contact electrification from the external environment,and at the same time avoids the frictional wear of the ordinary wind energy harvesting TENGs.The corresponding VIV parameters are investigated to evaluate their influence on the vibration behaviors and the energy output.Resonant state of the VIV-TENG corresponds to the high output performance from the VIV-TENG.The distinct,robust structure ensures the full-packaged VIV-TENG can harvest wind energy from arbitrary directions and even in undesirable weather conditions.The study proposes a novel TENG configuration for harvesting wind energy and the VIV-TENG proves promising powering micro-electro-mechanical appliances. | Yan Wang Tianyu Chen Shuowen Sun Xiangyu Liu Zhiyuan Hu Zhenhui Lian Long Liu Qiongfeng Shi Hao Wang Jianchun Mi Tongming Zhou Chengkuo Lee Minyi Xu | 2022 | Nano Research2022，15，4： | 2 |
| 20 | Association between gene polymorphisms of vitamin D receptor and pulmonary tuberculosis susceptibility:a meta-analysis显示文摘Background:The vitamin D receptor(VDR) gene is a primary candidate gene for tuberculosis susceptibility,but results of previous studies are somewhat contradictory and underpowered.Thus,it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis(PTB).Methods:A systematic review and meta-analysis about the association between FokI,TaqI,ApaI and BsmI polymorphisms and PTB susceptibility was conducted.Statistical Package for Social Science(Version 13.0) and Review Manager(Version 4.2,The Cochrane Collaboration) were used to analyze the data reported in studies.Results:A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism,and the results showed FokI polymorphism was associated with PTB susceptibility(allele f vs F:OR=1.12,95% CI=[1.02,1.23];the additive effect model ff vs FF:OR=1.40,95%CI=[1.10,1.77];the recessive genetic model ff vs Ff+FF:OR=1.39,95%CI=[1.12,1.71]).No significant associations were observed between TaqI(15 studies with 3 031 cases and 3 132 controls),ApaI(7 studies with 1 495 cases and 1 922 controls),BsmI(6 studies with 919 cases and 1 250 controls) variants and PTB susceptibility.Conclusion:We found variant FokI polymorphism of VDR gene may play a risky role in PTB development,and the genetic model was presumed to be recessive. | Su Qian Ma Xiangyu Lin Hui Li Ying Hu Daiyu Xiong Hongyan Xu Rufu Li Yafei | 2011 | Journal of Medical Colleges of PLA(China)2011，26，2： | 2 |
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