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| 1 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 2 | Effects of dietary protein/energy ratio on growth performance,carcass trait,meat quality,and plasma metabolites in pigs of different genotypes显示文摘Background:The protein/energy ratio is important for the production performance and utilization of available feed resources by animals.Increased protein consumption by mammals leads to elevated feed costs and increased nitrogen release into the environment.This study aimed to evaluate the effects of dietary protein/energy ratio on the growth performance,carcass traits,meat quality,and plasma metabolites of pigs of different genotypes.Methods:Bama mini-pigs and Landrace pigs were randomly assigned to two dietary treatment groups(Chinese conventional diet with low protein/energy ratio or National Research Council diet with high protein/energy ratio;n = 24 per treatment) in a 2x2 factorial arrangement.Blood and muscle samples were collected at the end of the nursery,growing,and finishing phases.Results:We observed significant interactions(P< 0.05) between breed and diet for total fat percentage,intramuscular fat(IMF) content,protein content in biceps femoris(BF) muscle,and plasma urea nitrogen(UN) concentration in the nursery phase;for average daily gain(ADG),average daily feed intake(ADFI),dry matter,IMF content in psoas major(PM) muscle,and plasma total protein and albumin concentrations in the growing phase;and for drip loss and plasma UN concentration in the finishing phase.Breed influenced(P < 0.05) growth performance,carcass traits,and meat quality,but not plasma metabolites.Throughout the trial,Landrace pigs showed significantly higher(P < 0.05) ADG,ADFI,dressing percentage,lean mass rate,and loin-eye area than did Bama mini-pigs,but significantly lower(P< 0.05)feed/gain ratio,fat percentage,backfat thickness,and IMF content.Dietary protein/energy ratio influenced the pH value,chemical composition of BF and PM muscles,and plasma activities of glutamic-pyruvic transaminase and gamma-glutamyl transpeptidase,and plasma concentration of UN.Conclusions:Compared with Landrace pigs,Bama mini-pigs showed slower growth and lower carcass performance,but had better meat quality.Moreover,unlike Landrace pigs,the dietary protein/energy ratio did not affect the growth performance of Bama mini-pigs.These results suggest that,in swine production,low dietary protein/energy ratio may be useful for reducing feed costs and minimizing the adverse effects of ammonia release into the environment. | Yingying Liu Xiangfeng Kong Guoli Jiang Bi'e Tan Jinping Deng Xiaojian Yang Fengna Li Xia Xiong Yulong Yin | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 37 |
| 3 | Compensation effects of coated cysteamine on meat quality, amino acid composition, fatty acid composition, mineral content in dorsal muscle and serum biochemical indices in finishing pigs offered reduced trace minerals diet显示文摘Dear Editor.Trace mineral elements(ME)and amino acids have been demonstrated to be essential bioelements in animal nutrition.If there is a deficiency in ME,a number of biological functions in animals may be affected,including physical growth,psychomotor development,and immunity.Supplementation of pig diets with ME is known to improve the animals'growth,reproduction,and their immunity against oxidative stress and cell damage. | Miaomiao Bai Hongnan Liu Kang Xu Xiaofeng Zhang Baichuan Deng Chengquan Tan Jinping Deng Pingping Bing Yulong Yin | 2019 | Science China(Life Sciences)2019，62，11： | 6 |
| 4 | Abscisic acid signaling negatively regulates nitrate uptake via phosphorylation of NRT1.1 by SnRK2s in Arabidopsis显示文摘Nitrogen(N)is a limiting nutrient for plant growth and productivity.The phytohormone abscisic acid(ABA)has been suggested to play a vital role in nitrate uptake in fluctuating N environments.However,the molecular mechanisms underlying the involvement of ABA in N deficiency responses are largely unknown.In this study,we demonstrated that ABA signaling components,particularly the three subclass Ⅲ SUCROSE NON-FERMENTING1(SNF1)-RELATED PROTEIN KINASE 2 S(SnRK2)proteins,function in root foraging and uptake of nitrate under N deficiency in Arabidopsis thaliana.The snrk2.2 snrk2.3 snrk2.6 triple mutant grew a longer primary root and had a higher rate of nitrate influx and accumulation compared with wild-type plants under nitrate deficiency.Strikingly,SnRK2.2/2.3/2.6 proteins interacted with and phosphorylated the nitrate transceptor NITRATE TRANSPORTER1.1(NRT1.1)in vitro and in vivo.The phosphorylation of NRT1.1 by SnRK2 s resulted in a significant decrease of nitrate uptake and impairment of root growth.Moreover,we identified NRT1.1Ser585 as a previously unknown functional site:the phosphomimetic NRT1.1S585 D was impaired in both low-and high-affinity transport activities.Taken together,our findings provide new insight into how plants fine-tune growth via ABA signaling under N deficiency. | Hang Su Tian Wang Chuanfeng Ju Jinping Deng Tianqi Zhang Mengjiao Li Hui Tian Cun Wang | 2021 | Journal of Integrative Plant Biology2021，63，3： | 4 |
| 5 | Maternal supply of cysteamine alleviates oxidative stress and enhances angiogenesis in porcine placenta显示文摘Background:Oxidative stress in placenta is associated with the occurrence of adverse pregnancy outcomes in sow,but there are few satisfactory treatment strategies for these conditions.This study investigated the potential of cysteamine(CS)as an antioxidant protectant for regulating the reproductive performance,redox status,and placental angiogenesis of sows.Methods:The placental oxidative stress status and vascular density of piglets with different birth weights:<1.0 kg(low birth weight,LBW)and 1.4–1.6 kg(normal birth weight,NBW)were evaluated,followed by allotting 84 sows to four treatments(n=21)and feeding them with a basal diet supplemented with 0,100,300,or 500 mg/kg of CS from d 85 of gestation to d 21 of lactation,respectively.Placenta,serum,and colostrum samples of sows or piglets were collected,and the characteristics of sows and piglets were recorded.Furthermore,the in vivo results were validated using porcine vascular endothelial cells(PVECs).Results:Compared with the NBW placentae,the LBW placentae showed increased oxidative damage and were vulnerable to angiogenesis impairment.Particularly,H2O2-induced oxidative stress prompted intracellular reactive oxygen species generation and inhibited the tube formation and migration of PVECs as well as the expression of vascular endothelial growth factor-A(VEGF-A)in vitro.However,dietary CS supplementation can alleviate oxidative stress and improve the reproductive performance of sows.Specifically,compared with the control group,dietary 100 mg/kg CS could(1)decrease the stillbirth and invalid rates,and increase both the piglet birth weight in the low yield sows and the placental efficiency;(2)increase glutathione and reduce malondialdehyde in both the serum and the colostrum of sows;(3)increase the levels of total antioxidant capacity and glutathione in LBW placentae;(4)increase the vascular density,the mRNA level of VEGF-A,and the immune-staining intensity of platelet endothelial cell adhesion molecule-1 in the LBW placentae.Furthermore,the in vitro experiment indicated that CS pre-treatment could significantly reverse the NADPH oxidase 2-ROS-mediated inactivation of signal transducer and activator of transcription-3(Stat3)signaling pathway induced by H2O2 inhibition of the proliferation,tube formation,and migration of PVECs.Meanwhile,inhibition of Stat3 significantly decreased the cell viability,tube formation and the VEGF-A protein level in CS pretreated with H_(2)O_(2)-cultured PVECs.Conclusions:The results indicated that oxidative stress and impaired angiogenesis might contribute to the occurrence of LBW piglets during pregnancy,but CS supplementation at 100 mg/kg during late gestation and lactation of sows could alleviate oxidative stress and enhance angiogenesis in placenta,thereby increasing birth weight in low yield sows and reducing stillbirth rate.The in vitro data showed that the underlying mechanism for the positive effects of CS might be related to the activation of Stat3 in PVECs. | Shuangbo Huang Zifang Wu Zihao Huang Xiangyu Hao Longmiao Zhang Chengjun Hu Jianfu Wei Jinping Deng Chengquan Tan | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 4 |
| 6 | Arctic oscillation and the antarcic oscillation modes in the atmospheric stratosphere显示文摘On the basis of the EOF analysis of global geopotential height anomaly (GHA) field at 10 hPa level, the arctic oscillation (AO) and the means antarctic oscillation (AAO) can be detected more obviously at the upper level of atmosphere than the AO or the AAO in surface layer. Unlike the hemisphere pattern of the AO and the AAO in the surface lager given by previous authors, the AO or the AAO in the stratosphere has its global features. The zonal oscillations-the Southern Oscillation (SO) and the north oscillation (NO) in atmospheric surface layer become less clear in the upper air. The first mode (AO mode, abbreviated to AOM hereafter) and the second mode (AAO mode, abbreviated to AAOM hereafter) respectively have 41.47% and 27.04% of the total variance contribution. The cumulative variance contribution of the first two modes reaches 68.51%. These two modes are the main components for the interdecadal or decadal oscillation in the stratosphere. In addition, there still exist two kinds of oscillation patterns with less probability, namely, the symmetric pattern at mid-high latitudes in the Southern Hemisphere and the asymmetric pattern. Spectral analysis shows that the AOM and the AAOM all have a spectral peak for 22 a period, being consistent with the periodic variations of the solar magnetic field, and a peak for 11 a period, being consistent with the period of the numbers of sunspots. Step filter analysis shows that the influencing factor for the upper atmospheric oscillation is the solar activity. The fluctuation of the solar magnetic field is the more influencing factor than the variation of the sunspot number. | QU Weizheng HUANG Fei ZHAO Jinping YANG Liang HE Hui DENG Shenggui CAO Yong | 2005 | Acta Oceanologica Sinica2005，24，6： | 4 |
| 7 | A review of the amino acid metabolism in placental function response to fetal loss and low birth weight in pigs显示文摘The fertility of sows mainly depends on the embryo losses during gestation and the survival rate of the postfarrowing piglets.The selection of highly-prolific sows has been mainly focused on the selection of genotypes with high ovulatory quota.However,in the early-and post-implantation stages,the rate of embryo losses was increased with the increase of zygotes.Among the various factors,placental growth and development is the vital determinant for fetal survival,growth,and development.Despite the potential survival of fetuses with deficient placental development,their life-conditions and growth can be damaged by a process termed intrauterine growth retardation(IUGR).The newborn piglets affected by IUGR are prone to increased morbidity and mortality rates;meanwhile,the growth,health and welfare of the surviving piglets will remain hampered by these conditions,with a tendency to exacerbate with age.Functional amino acids such as glycine,proline,and arginine continue to increase with the development of placenta,which are not only essential to placental growth(including vascular growth)and development,but can also be used as substrates for the production of glutathione,polyamines and nitric oxide to benefit placental function in many ways.However,the exact regulation mechanism of these amino acids in placental function has not yet been clarified.In this review,we provide evidence from literature and our own work for the role and mechanism of dietary functional amino acids during pregnancy in regulating the placental functional response to fetal loss and birth weight of piglets.This review will provide novel insights into the response of nutritionally nonessential amino acids(glycine and proline)to placental development as well as feasible strategies to enhance the fertility of sows. | Chengquan Tan Zihao Huang Wenyu Xiong Hongxuan Ye Jinping Deng Yulong Yin | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 3 |
| 8 | Bismuth oxide nanoflake@carbon film: A free-standing battery-type electrode for aqueous sodium ion hybrid supercapacitors显示文摘Aqueous hybrid supercapacitors are promising due to their low cost and high safety. Herein, a freestanding battery-type electrode of Bi_2O_3 nanoflake@C on carbon cloth is designed for aqueous sodium ion hybrid supercapacitors. Due to the integration of nanoarray architecture and the conductive carbon,the Bi_2O_3@C electrode exhibits a high specific capacity of 207 mAh/g at 2 A/g(6C), good rate capability and cycling stability(133 m Ah/g after 1000 cycles). With the activated carbon as the capacitive electrode and neutral sodium salts as the electrolyte, a 1.9 V hybrid supercapacitor is assembled,delivering a high energy density of 18.94 Wh/kg. The device can still maintain 72.3% of initial capacity after 650 cycles. The present work holds great promise for developing next-generation hybrid supercapacitors. | Zhenshuai Zhao Yihua Ye Weihua Zhu Liang Xiao Bohua Deng Jinping Liu | 2018 | Chinese Chemical Letters2018，29，4： | 2 |
| 9 | Gas hydrate formation and its accumulation potential in Mohe permafrost, China显示文摘 | Xingmin Zhao Jian Deng Jinping Li Cheng Lu Jian Song | 2012 | Marine and Petroleum Geology2012，，1： | 1 |
| 10 | Study on the Activation Effect of Fermented Organic Fertilizers on Selenium in the Soil of Southern Dragon Fruit Orchards显示文摘[Objectives]This study was conducted to explore the effects of using fermented organic fertilizers such as cow manure on the activity of selenium in the soil.[Methods]The project team applied the organic fertilizer prepared by fermenting cow manure and other raw materials to activate selenium in the soil at two dragon fruit orchard bases in Shilong Town,Guiping City and Dingdang Town,Long an County,and carried out many years of experiments.[Results]The contents of available selenium in the two experimental orchards in Shilong Town and Dingdang Town increased by 10%and 5%,respectively,and the selenium contents in dragon fruit increased by 228.6%and 200.0%,respectively.[Conclusions]The application of fermented organic fertilizers such as cow manure can increase available selenium content in the soil,thereby increasing the selenium content of dragon fruit. | Boqian CHEN Liping PAN Ying XING Jinping CHEN Kun DENG Yongxian LIU | 2021 | Agricultural Biotechnology2021，10，5： | 1 |
| 11 | Dietary fibers with low hydration properties exacerbate diarrhea and impair intestinal health and nutrient digestibility in weaned piglets显示文摘Background:This study aimed to investigate the hydration properties of different-source fibrous materials by com-paring their water-binding capacity(WBC),water swelling capacity(WSC),viscosity,and in vivo effects of selected samples on growth performance,nutrient digestibility,diarrhea,and intestinal health in weaned piglets.Methods:A total of 13 commercially available fibrous materials were first compared in chemical composition and in vitro hydration property.Subsequently,40 weaned piglets were randomized to five experimental dietary groups(8 piglets per group):control diet(a basal diet without dietary fiber,CON),basal diet supplemented with 5%microcrys-talline cellulose(MCC),5%wheat bran(WB),5%Moringa oleifera leaf powder(MOLP),or 5%sugar beet pulp(SBP),fol-lowed by analyzing their growth performance and diarrhea rate in a 28-d experiment.After the feeding experiment,anaesthetized piglets were killed,and their intestinal and colon content or plasma samples were analyzed in nutrient digestibility,intestinal morphology,intestinal barrier,short-chain fatty acids(SCFAs),and bacterial population.Results:In vitro studies showed low hydration properties for WB and MCC,while medium hydration properties for MOLP and SBP.In vivo studies indicated that compared with medium hydration property groups,low hydration prop-erty groups showed(1)exacerbated diarrhea,impaired intestinal health,and reduced apparent fecal digestibility of dry matter,gross energy,acid detergent fiber,and neutral detergent fiber;(2)decreased SCFAs concentration and rela-tive levels of Lactobacillus and Bifidobacterium,but increased levels of Escherichia coli and Brachyspira hyodysenteriae in colon contents.Additionally,SBP showed optimal performance in reducing diarrhea and increasing SCFAs produc-tion.Correlation analysis revealed a positive correlation of fiber hydration properties with in vitro SCFAs production,and diarrhea index and nutrient digestibility were negatively and positively correlated with SCFAs levels in the colon contents of weaned piglets,respectively.Conclusions:Different-source dietary fibers varied in their hydration properties and impacts on diarrhea,microbial composition and SCFAs production in weaned piglets.WB and MCC could exacerbate diarrhea and impair nutrient digestibility,probably because their low hydration properties were detrimental to gut microbial homeostasis and fermentation.Our findings provide new ideas for rational use of fiber resources in weaned piglets. | Shuangbo Huang Zhijuan Cui Xiangyu Hao Chuanhui Cheng Jianzhao Chen Deyuan Wu Hefeng Luo Jinping Deng Chengquan Tan | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 1 |
| 12 | BAK1 plays contrasting roles in regulating abscisic acid-induced stomatal closure and abscisic acid-inhibited primary root growth in Arabidopsis显示文摘The mechanisms that balance plant growth and stress responses are poorly understood, but they appear to involve abscisic acid(ABA) signaling mediated by protein kinases. Here, to explore these mechanisms, we examined the responses of Arabidopsis thaliana protein kinase mutants to ABA treatment. We found that mutants of BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1(BAK1) were hypersensitive to the effects of ABA on both seed germination and primary root growth. The kinase OPEN STOMATA 1(OST1) was more highly activated by ABA in bak1 mutant than the wild type. BAK1 was not activated by ABA treatment in the dominant negative mutant abi1-1 or the pyr1 pyl4 pyl5 pyl8 quadruple mutant, but it was more highly activated by this treatment in the abi1-2 abi2-2 hab1-1 loss-of-function triple mutant than the wild type. BAK1 phosphorylates OST1 T146 and inhibits its activity. Genetic analyses suggested that BAK1 acts at or upstream of core components in the ABA signaling pathway, including PYLs, PP2 Cs,and Sn RK2 s, during seed germination and primary root growth. Although the upstream brassinosteroid(BR) signaling components BAK1 and BR INSENSITIVE 1(BRI1) positively regulate ABAinduced stomatal closure, mutations affecting downstream components of BR signaling, including BRASSINOSTEROID-SIGNALING KINASEs(BSKs)and BRASSINOSTEROID-INSENSITIVE 2(BIN2), did not affect ABA-mediated stomatal movement. Thus,our study uncovered an important role of BAK1 in negatively regulating ABA signaling during seed germination and primary root growth, but positively modulating ABA-induced stomatal closure, thus optimizing the plant growth under drought stress. | Jinping Deng Lingyao Kong Yinhua Zhu Dan Pei Xuexue Chen Yu Wang Junsheng Qi Chunpeng Song Shuhua Yang Zhizhong Gong | 2022 | Journal of Integrative Plant Biology2022，64，6： | 1 |
| 13 | Flexible quasi-solid-state dual-ion asymmetric supercapacitor based on Ni(OH)2 and Nb2O5 nanosheet arrays显示文摘Increasing the energy density, power density as well as widening the operation voltage are essential to electrochemical capacitors to meet the practical energy demands. Herein, a novel flexible quasi-solid-state dual-ion asymmetric supercapacitor(ASC) with Ni(OH)2 and Nb2O5 nanosheets directly grown on stainless steel mesh is developed. In the dual-ion ASC, Nb2O5 negative and Ni(OH)2 positive electrodes react with Li+ and OH- respectively in alkaline gel electrolyte to store energy, which is quite different from conventional alkali metal ion SCs and alkaline SCs. The as-assembled flexible device has an extended working voltage of 1.7 V and delivers a capacity of 5.37 mAh cm-2, a maximum energy density and power density of 0.52 mWh cm-3 and 170 mW cm-3 , respectively. The device maintains around 60% capacity retention after long cycling up to 1000 cycles. Moreover, our device can light up a LED light efficiently upon fast charging. The proposed quasi-solid-state dual-ion ASC has potential applications in future portable electronics and flexible energy storage devices. | Xiaolan Deng Yuqi Jiang Zengxi Wei Minglei Mao Ramyakrishna Pothu Hongxia Wang Caiyun Wang Jinping Liu Jianmin Ma | 2019 | Green Energy & Environment2019，4，4： | 1 |
| 14 | Hybrid architecture design enhances the areal capacity and cycling life of low-overpotential nanoarray oxygen electrode for lithium–oxygen batteries显示文摘Transition metal oxide(TMO)nanoarrays are promising architecture designs for self-supporting oxygen electrodes to achieve high catalytic activities in lithium-oxygen(Li-O2)batteries.However,the poor conductive nature of TMOs and the confined growth of nanostructures on the limited surfaces of electrode substrates result in the low areal capacities of TMO nanoarray electrodes,which seriously deteriorates the intrinsically high energy densities of Li-O2 batteries.Herein,we propose a hybrid nanoarray architecture design that integrates the high electronic conductivity of carbon nanoflakes(CNFs)and the high catalytic activity of Co3 O4 nanosheets on carbon cloth(CC).Due to the synergistic effect of two differently featured components,the hybrid nanoarrays(Co3 O4-CNF@CC)achieve a high reversible capacity of3.14 mA h cm-2 that cannot be achieved by only single components.Further,CNFs grown on CC induce the three-dimensionally distributed growth of ultrafine Co3 O4 nanosheets to enable the efficient utilization of catalysts.Thus,with the high catalytic efficiency,hybrid Co3 O4-CNF@CC also achieves a more prolonged cycling life than pristine TMO nanoarrays.The present work provides a new strategy for improving the performance of nanoarray oxygen electrodes via the hybrid architecture design that integrates the intrinsic properties of each component and induces the three-dimensional distribution of catalysts. | Liang Xiao Duo Wang Ming Li Bohua Deng Jinping Liu | 2020 | Journal of Energy Chemistry2020，29，7： | 1 |
| 15 | Structure, mechanical andswelling behaviors of poly (vinyl alcohol )/SiO2 hybrid membranes 显示文摘 | Juan Li Jinping Suo Runzhi Deng | 2010 | J Rein Plast Comp2010，29，4： | 1 |
| 16 | Isogeometric analysis based on geometric reconstruction models显示文摘In isogeometric analysis(IGA),the boundary representation of computer-aided design(CAD)and the tensor-product non-uniform rational B-spline structure make the analysis of three-dimensional(3D)problems with irregular geometries difficult.In this paper,an IGA method for complex models is presented by reconstructing analysis-suitable models.The CAD model is represented by boundary polygons or point cloud and is embedded into a regular background grid,and a model reconstruction method is proposed to obtain the level set function of the approximate model,which can be directly used in IGA.Three 3D examples are used to test the proposed method,and the results demonstrate that the proposed method can deal with complex engineering parts reconstructed by boundary polygons or point clouds. | Yingjun WANG Liang GAO Jinping QU Zhaohui XIA Xiaowei DENG | 2021 | Frontiers of Mechanical Engineering2021，16，4： | 0 |
| 17 | Total synthesis of lespedezavirgatol显示文摘Lespedezavirgatol,a novel 2-phenylbenzofuran compound which was isolated from Lespedeza virgata,was firstly synthesized from pyrogallic acid and 3,4-dimethoxyphenol as starting materials with 8 steps.The key steps for the total synthesis were the selective iodination at 3-position of 1,2-dimethoxy-4-methoxymethoxybenzene and the Sonogashira cross-coupling reaction between 4-iodo-2-methoxybenzene-1,3-diol and 2-ethynyl-3,4-dimethoxy-1-(methoxy-methoxy)-benzene. | QI JinPing 1,DENG HongZhu 2 & CAO DeRong 1 1 School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,China 2 School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China | 2010 | Science China Chemistry2010，53，12： | 0 |
| 18 | Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study显示文摘Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group. | Ruoyang Shao Yu Zhang Jinping He Fen Huang Zhiping Fan Kaibo Yang Yajing Xu Na Xu Yi Luo Lan Deng Xi Zhang Jia Chen Mingzhe Han Xudong Li Sijian Yu Hui Liu Xinquan Liang Xiaodan Luo Pengcheng Shi Zhixiang Wang Ling Jiang Xuan Zhou Ren Lin Yan Chen Sanfang Tu Jing Sun Yu Wang Qifa Liu Li Xuan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 19 | Surface carboxyl groups enhance the capacities of carbonaceous oxygen electrodes for aprotic lithiumoxygen batteries: A direct observation on binder-free electrodes显示文摘In order to achieve the high capacities of carbonaceous oxygen diffusion electrodes for aprotic lithiumoxygen batteries(Li-O2 batteries),most efforts currently focus on the design of rational porous architectures.Only few works study the surface chemistry effect that might be a critical factor influencing the capacities of carbonaceous electrodes.In addition,the surface chemistry effect is very difficult to be studied in composite electrodes due to the influences of binders and additives.Herein,we propose chemically activated carbon cloth(CACC) as an ideal model to investigate the effect of surface functional groups on the discharge capacities of carbonaceous oxygen electrodes for Li-O2 batteries.The intrinsic surface chemistry effect on the performance of carbonaceous cathode is directly observed for the first time without the influences of binders and additives.Results indicate that the surface carboxyl groups introduced by the chemical treatment not only function as the appropriate nucleation sites for Li2 O2 but also induce the formation of toroid-like Li2 O2.Thus,the surface carboxyl modification enhances the discharge capacities from 0.48 mAh/cm^2 of pristine carbon cloth to 1.23 mAh/cm^2 of CACC.This work presents an effective way to further optimize the carbonaceous oxygen electrodes via surface functional group engineering. | Ming Li Liang Xiao Duo Wang Haoyang Dong Bohua Deng Jinping Liu | 2019 | Chinese Chemical Letters2019，30，12： | 0 |
| 20 | Ca^(2+)-dependent successive phosphorylation of vacuolar transporter MTP8 by CBL2/3-CIPK3/9/26 and CPK5 is critical for manganese homeostasis in Arabidopsis显示文摘Manganese(Mn)is an essential micronutrient for all living organisms.However,excess Mn supply that can occur in acid or waterlogged soils has toxic effects on plant physiology and development.Although a variety of Mn transporter families have been characterized,we have only a rudimentary understanding of how these transporters are regulated to uphold and adjust Mn homeostasis in plants.Here,we demonstrate that two calcineurin-B-like proteins,CBL2/3,and their interacting kinases,CIPK3/9/26,are key regulators of plant Mn homeostasis.Arabidopsis mutants lacking CBL2 and 3 or their interacting protein kinases CIPK3/9/26 exhibit remarkably high Mn tolerance.Intriguingly,CIPK3/9/26 interact with and phosphorylate the tonoplast-localized Mn and iron(Fe)transporter MTP8 primarily at Ser35,which is conserved among MTP8 proteins from various species.Mn transport complementation assays in yeast combined with multiple physiological assays indicate that CBL-CIPK-mediated phosphorylation of MTP8 negatively regulates its transport activity from the cytoplasm to the vacuole.Moreover,we show that sequential phosphorylation of MTP8,initially at Ser31/32 by the calcium-dependent protein kinase CPK5 and subsequently at Ser35 by CIPK26,provides an activation/deactivation fine-tuning mechanism for differential regulation of Mn transport.Collectively,our findings define a two-tiered calcium-controlled mechanism for dynamic regulation of Mn homeostasis under conditions of fluctuating Mn supply. | Chuanfeng Ju Zhenqian Zhang Jinping Deng Cuicui Miao Zhangqing Wang Lukas Wallrad Laiba Javed Dali Fu Ting Zhang Jörg Kudla Zhizhong Gong Cun Wang | 2022 | Molecular Plant2022，15，3： | 0 |
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