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| 1 | Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos显示文摘有类型 II 的最近的进展定期聚类 interspaced 短 palindromic 重复(CRISPR ) 系统诺言染色体编辑的一条改进途径。然而,在模型有机体的这个系统的适用性和效率例如 zebrafish,几乎没被学习。这里,我们报导那指导 RNA 的 Cas9 核酸酶高效地便于染色体以一种简单、柔韧的方式在哺乳动物的房间和 zebrafish 胚胎编辑。当特定的 Cas/gRNA 被用来在 vivo 在 zebrafish 胚胎指向任何一个 etsrp, gata4 或 gata5 时,超过 35% 地点特定的体的变化被发现。Cas9/gRNA 高效地在结果导致了 etsrp 或 gata5 的 biallelic 变换体的房间,在 etsrp 在 fau 异种胚胎或贲门 bifida 显型 > tm236a 异种胚胎。最后,我们成功地完成了 Cas9/gRNA 系统在 zebrafish 胚胎导致的 mloxP 顺序的地点特定的插入。这些结果证明 Cas9/gRNA 系统有为 zebrafish 和另外的模型有机体成为一个简单、柔韧、有效的反向的基因工具的潜力。和另外的染色体工程技术, Cas9 系统为在生物学,农业,环境研究和药的应用是有希望的。 | Nannan Chang Changhong Sun Lu Gao Dan Zhu Xiufei Xu Xiaojun Zhu Jing-Wei Xiong Jianzhong Jeff Xi | 2013 | Cell Research2013，23，4： | 155 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Epidemiology of respiratory distress and the illness severity in late preterm or term infants: a prospective multi-center study显示文摘背景呼吸悲痛的严厉与新生的预后被联系。这研究试图近来探索临床的特征,治疗学的干预和短期的结果要求了的 preterm 或术语婴儿呼吸支持,并且比较不同的病严厉评价 tools.Methods 的用法第三级的医院里的七个新生的特别护理单位被招募。从 2008 年 11 月到 2009 年 10 月,在 34 星期的 gestational 出生的出生不满一月的婴儿变老,在 72 小时年龄承认了,为呼吸支持要求连续积极航线压力(CPAP ) 或机械通风被注册。包括人口统计的变量,内在的疾病,复杂并发症,治疗学的干预和短期的结果的临床的数据是镇定的。所有婴儿被在风险新生儿(橡树子) 的尖锐照顾划分成三个组呼吸分数 5, 5-8,和 8 .Results 在学习时期, 503 新生的迟了的 preterm 或学期婴儿期间要求了呼吸支持。吝啬的 gestational 年龄是(36.8 ? 湥牧獯敳 ? 湩 ? 眠吗? | MA Xi'ao-lu XU Xue-feng CHEN Chao YAN Chao-ying LIU Ya-ming LIU Ling XIONG Hong SUN Hui-qing LAI Jian-pu YI Bin SHI Jing-yun DU Li-zhong | 2010 | Chinese Medical Journal2010，，20： | 31 |
| 4 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 5 | Evaluation of Seven Function-Known Candidate Genes for their Effects on Improving Drought Resistance of Transgenic Rice under Field Conditions显示文摘许多强调应答的基因在在温室条件下面在模型植物改进压力抵抗上与效果被报导了。向为干旱抵抗繁殖的基因的鉴定,七很好记录了基因( CBF3 , SOS2 , NCED2 , NPK1 , LOS5 , ZAT10 ,并且 NHX1 )在应力,抵抗在这研究被选择并且在组成的倡导者 Actin1 和一个米饭 HVA22 相当或相同的事物,和转基因的米饭的压力可诱导的倡导者的控制下面转变了成米饭栽培变种 Zhonghua 11 在领域条件下面为干旱抵抗被测试。1598 独立转基因的 T0 植物的一个总数被产生。transgenes 的单个拷贝和表示的百分比分别地是 36.7% 和 57.6% 。为每基因构造,有 transgene 的表示的 30 个 T1 家庭为在领域里在繁殖阶段测试的干旱抵抗被选择,并且他们中的 10 个在一样的阶段与一个定义压力协议在 PVC 管子中被测试。相对产量和相对小穗状花小穗富饶被用作二个主要标准因为显著地减少的产量在 T1 产生被观察,评估干旱抵抗性能。八构造的转基因的家庭( HVA22P : CBF3 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 , HVA22P : ZAT10 , Actin1 : NHX1 ,并且 HVA22P : NHX1 )比的显示出显著地更高的 RY 野类型( WT )在两个干旱压力下面,地和 PVC 试管调节。9 构造的转基因的家庭(HVA22P : 由两个倡导者的 SOS2 和 CBF3, LOS5, ZAT10,和 NHX1 ) 在这块地或 PVC 管子里比 WT 显示出显著地更高的相对小穗状花小穗富饶。在 T2 测试的地干旱抵抗,家庭们与相对更低的收益减少源于 T1 家庭,七构造的转基因的家庭( HVA22P : CBF3 , Actin1 : NPK1 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 ,并且 HVA22P : ZAT10 )比九构造的 WT ,和家庭每工厂显示出显著地更高的产量( Actin1 : CBF3 , HVA22P : CBF3 , HVA22P : SOS2 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 , HVA22P : ZAT10 ,并且 Actin1 : NHX1 )比 WT 有更高的小穗状花小穗富饶。一般来说, LOS5 和 ZAT10 在在地条件下面改进转基因的大米的干旱抵抗比另外的五基因显示出相对更好的效果。从这研究获得的结果和经验能是为在米饭设计的干旱抵抗的一本有用参考书。 | Ben-Ze Xiao Xi Chen Cheng-Bin Xiang Ning Tang Qi-Fa Zhang Li-Zhong Xiong | 2009 | Molecular Plant2009，2，1： | 24 |
| 6 | A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle显示文摘Traditional Chinese herbs(TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major challenge to establish a quantitative detection technique that is objective, authentic and sensitive. Based on the two-bottle preference test(TBP), we proposed a novel quantitative strategy using a standardized animal test and a unified quantitative benchmark. To reduce the difference of results, the methodology of TBP was optimized. The relationship between the concentration of quinine and animal preference index(PI) was obtained. Then the PI of TCH was measured through TBP, and bitterness results were converted into a unified numerical system using the relationship of concentration and PI. To verify the authenticity and sensitivity of quantified results,human sensory testing and electronic tongue testing were applied. The quantified results showed a good discrimination ability. For example, the bitterness of Coptidis Rhizoma was equal to 0.0579 mg/mL quinine, and Nelumbinis Folium was equal to 0.0001 mg/mL. The validation results proved that the newassessment method for TCH was objective and reliable. In conclusion, this study provides an option for the quantification of bitterness and the evaluation of taste masking effects. | Xue Han Hong Jiang Li Han Xi Xiong Yanan He Chaomei Fu Runchun Xu Dingkun Zhang Junzhi Lin Ming Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 17 |
| 7 | End-stage liver disease score and future liver remnant volume predict post-hepatectomy liver failure in hepatocellular carcinoma显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is the world’s sixth most common malignant tumor and the third cause of cancer death.Although great progress has been made in hepatectomy,it is still associated with a certain degree of risk of posthepatectomy liver failure(PHLF),which extends the length of hospital stay and remains the leading cause of postoperative death.Studies have shown that assessment of hepatic functional reserve before hepatectomy is beneficial for reducing the incidence of PHLF.AIM To assess the value of model for end-stage liver disease(MELD)score combined with standardized future liver remnant(sFLR)volume in predicting PHLF in patients undergoing hepatectomy for HCC.METHODS This study was attended by 238 patients with HCC who underwent hepatectomy between January 2015 and January 2018.Discrimination of sFLR volume,MELD score,and sFLR/MELD ratio to predict PHLF was evaluated according to the area under the receiver operating characteristic curve.RESULTS The patients were divided into two groups according to whether PHLF occurred after hepatectomy.The incidence of PHLF was 8.4%in our research.The incidence of PHLF increased with the decrease in sFLR volume and the increase in MELD score.Both sFLR volume and MELD score were considered independent predictive factors for PHLF.Moreover,the cut-off value of the sFLR/MELD score to predict PHLF was 0.078(P<0.001).This suggests that an sFLR/MELD≥0.078 indicates a higher incidence of PHLF than an sFLR/MELD<0.078.CONCLUSION MELD combined with sFLR is a reliable and effective PHLF predictor,which is superior to MELD score or sFLR volume alone. | Fan-Hua Kong Xiong-Ying Miao Heng Zou Li Xiong Yu Wen Bo Chen Xi Liu Jiang-Jiao Zhou | 2019 | World Journal of Clinical Cases2019，7，22： | 14 |
| 8 | Pf-Rel, a Rel/Nuclear Factor-κB Homolog Identified from the Pearl Oyster, Pinctada fucata显示文摘自从它的发现,转录因子 Rel/nuclear factor-kappa B (NF-kappa B ) 是许多研究的焦点。Rel/NF-kappa B 的不同相当或相同的事物在脊椎动物和无脊椎动物被发现了。编码一个通常认为的 Rel/NF-kappa B 相当或相同的事物(指明的 Pf-Rel ) 的 cDNA 克隆从珍珠牡蛎被孤立, Pinctada fucata。Rel 相同领域, IPT NF-kappa B 领域和 C 终端 transactivation 领域的 Pf-Relconsists 的顺序。Pf-Rel 的顺序分析证明它与另外的 Rel/NF-kappa B 家庭蛋白质分享高类似,特别在保存领域以内。反向的抄写聚合酶链反应分析表明 Pf-Rel mRNA 无所不在地被表示。进一步,在 situ 杂交,分析证明 Pf-Rel mRNA 主要在中间的褶层的外部上皮的房间和外部褶层的内部上皮的房间被表示。珍珠牡蛎 Pf-Rel 的鉴定和描述帮助进一步在牡蛎免疫和另外的生物过程调查 Rel/NF-kappa B 的参与。 | Xi WU Xunhao XIONG Liping XIE Rongqing ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 11 |
| 9 | Stems and leaves of Aconitum carmichaelii Debx.as potential herbal resources for treating rheumatoid arthritis: Chemical analysis,toxicity and activity evaluation显示文摘According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibrous roots, stems, and leaves of Aconitum carmichaelii Debx. were measured by HPLC-MS/MS. And multivariate analysis methods, such as clustering analysis and principal component analysis, were applied to analyze the difference among various parts. In addition, the acute toxicity, analgesia, and anti-inflammatory tests were carried out. The results suggested that the contents of alkaloids in mother roots and fibrous roots were approximate, but those of leaves and stems were different from mother roots and fibrous roots. The results of the acute toxicity testing demonstrated the toxicity of fibrous root was strongest, and mother roots were slightly less toxic than fibrous roots. The stems and leaves were far less toxic than mother and fibrous roots. In addition, the analgesia and inflammatory tests showed the effects of the various tissues had no difference each other. These results provided a basis for developing new complementary and alternative treatments for rheumatoid arthritis patients. Simultaneously, the approach may also turn wastes into treasure and promote the development of circular economy. | HE Ya-Nan OU Shui-Ping XIONG Xi PAN Yuan PEI Jin XU Run-Chun GENG Fu-Neng HAN Li ZHANG Ding-Kun YANG Ming | 2018 | Chinese Journal of Natural Medicines2018，16，9： | 10 |
| 10 | Effect of proteolytic starter culture isolated from Chinese Dong fermented pork(Nanx Wudl)on microbiological,biochemical and organoleptic attributes in dry fermented sausages显示文摘The effect of a proteolytic starter culture isolated from Nanx Wudl,on microbiological,biochemical and organoleptic attributes of dry fermented sausages was investigated during processing.Based on preliminary screening,the combination of Staphylococcus xylosus SX16 and Lactobacillus plantarum CMRC6,showing excellent proteolytic activity in vitro,was selected as the multi-strain starter(starter LS).For comparison,the single-strain starter culture of L.plantarum CMRC6(starter LB)and non-inoculated control were also tested.During fermentation,lactic acid bacteria and staphylococci dominated the microbiota and suppressed the Enterobacteriaceae growth in LS-inoculated sausages.The addition of LS starter accelerated acidification and proteolysis during ripening,improving the contents of total free amino acids and several essential free amino acids(Phe,Ile and Leu).Volatile compounds analysis revealed that LS-fermented sausage showed the highest abundance of 3-methyl-1-butanol,probably due to the inoculated S.xylosus.The inoculation of LS starter improved the sensory properties of sausages,especially the flavor attribute.Therefore,S.xylosus SX16 and L.plantarum CMRC6 are promising candidates for inclusion as multi-strain starters in the manufacture of gourmet fermented dry sausage. | Xi Chen Ruifang Mi Biao Qi Suyue Xiong Jiapeng Li Chao Qu Xiaoling Qiao Wenhua Chen Shouwei Wang | 2021 | Food Science and Human Wellness2021，10，1： | 9 |
| 11 | CHARACTERISTICS OF ELECTROMECHANICAL COUPLING SELF-SYNCHRONIZATION OF A MULTI-MOTOR VIBRATION TRANSMISSION SYSTEM显示文摘Multi-motor vibratory transmission systems have been wide used in large vibratory machines, and four-motor linear vibratory machine is one typical equipment of them. Under non-forcible synchronization condition zero-phase synchronization of the machine is non-stationary and it-phase synchronization is stable. Under half-forcible synchronization condition in which only one motor is controlled being synchronous to another, only lag synchronization near zero-phase synchronization can be realized. Both of the characteristics have never been revealed with classical theory quantitatively. The problem is solved by means of establishing an electromechanical coupling mathematical model of the system and numerical analysis of the starting processes. | Xiong Wanli,Duan Zhishan (School of Mechanical and Electrical Engineering, Xi’ an University of Architecture and Technology) Wen Bangchun (Northeastern University) | 2001 | Chinese Journal of Mechanical Engineering2001，14，3： | 8 |
| 12 | High-throughput Binary Vectors for Plant Gene Function Analysis显示文摘一系列高产量的二进制克隆向量被构造在高等植物便于基因函数分析。这个向量系列为蛋白质本地化为工厂表示,倡导者分析,基因 silencing 和绿荧光灯的蛋白质熔化由 plasmidsdesigned 组成了。这些向量为 lambda 噬菌体 integrase/excisionase 提供了高产量、有效的克隆的利用地点。另外,我们在多重克隆再并入的唯一的限制地点地点和启用的倡导者代替。全部向量系列与完全的顺序信息是可得到的并且详细说明注解并且自由地为非商业性的使用被散布到科学界…… | Zhi-Yong Lei Ping Zhao Min-Jie Cao Rong Cui Xi Chen Li-Zhong Xiong Qi-Fa Zhang David J. Oliver Cheng-Bin Xiang | 2007 | Journal of Integrative Plant Biology2007，49，4： | 8 |
| 13 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 14 | P-doped BN nanosheets decorated graphene as the functional interlayer for Li–S batteries显示文摘Lithium–sulfur(Li–S)batteries have attracted much attention due to their ultrahigh theoretical specific capacity.However,serious capacity attenuation caused by shuttle effect still inhibits the performance improvement.Herein,a modified separator consists of the few-layer graphene as a highly conductive network and stable scaffold to support P-doped boron nitride(denoted as BN-P@GO)as the functional interlayer of Li–S batteries.The cell with the interlayer provides an initial discharge capacity as high as1045.3 mAh g^-1,and retains a high reversible capacity of 728.7 mAh g^-1 at 1 C after 500 cycles with a capacity decay of 0.061%per cycle.Moreover,the rate capability is also superior to cells with BN@GO or BN-P interlayers,i.e.reversible capcity of 457.9 mAh g^-1 even at 3 C.The excellent electrochemical performance is ascribed to the synergistic effect of physical barrier and chemical adsorption for dissolved polysulfides provided by the modified layer.Furhtermore,it also mitigates the polarization and promotes kinetic reactions of the cells.This work provides a concise and effective method for commercialization of lithium–sulfur batteries. | Jing Zhang Wenzhe Ma Zhenyu Feng Fangfang Wu Denghu Wei Baojuan Xi Shenglin Xiong | 2019 | Journal of Energy Chemistry2019，28，12： | 7 |
| 15 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 16 | Bonding VSe2 ultrafine nanocrystals on graphene toward advanced lithium-sulfur batterie显示文摘Lithium–sulfur batteries have been attracting considerable research attention due to their high energy densities and low costs. However, one of their main challenges is the undesired shuttling of polysulfides, causing rapid capacity degradation. Herein, we report the first example of sulfiphilic VSe2 ultrafine nanocrystals immobilized on nitrogen-doped graphene to modify the battery separator for alleviating the shuttling problem. VSe2 nanocrystals provide numerous active sites for chemisorption of polysulfides as well as benefit the nucleation and growth of Li2S. Furthermore, the kinetic reactions are accelerated which is confirmed by higher exchange current density and higher lithium ion diffusion coefficient. And the first-principles calculations further show that the exposed sulfiphilic planes of VSe2 boost the redox of Li2S. When used as separators within the lithium sulfur batteries, the cell indicates greatly enhanced electrochemical performances with excellent long cycling stability and exceptional rate capability up to 8 C. Moreover, it delivers a higher areal capacity of 4.04 mAh·cm^−2 as well as superior cycling stability with sulfur areal loading up to 6.1 mg·cm^−2. The present strategy can encourage us in engineering novel multifunctional separators for energy-storage devices. | Wenzhi Tian Baojuan Xi Yu Gu Qiang Fu Zhenyu Feng Jinkui Feng Shenglin Xiong | 2020 | Nano Research2020，13，10： | 6 |
| 17 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 18 | Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang Wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang | 2016 | Protein & Cell2016，7，12： | 5 |
| 19 | Immobilizing VN ultrafine nanocrystals on N-doped carbon nanosheets enable multiple effects for high-rate lithium-sulfur batteries显示文摘The exploitation of new sulfiphilic and catalytic materials is considered as the promising strategy to overcome severe shuttle effect and sluggish kinetics conversion of lithium polysulfides within lithium-sulfur batteries.Herein,we design and fabricate monodisperse VN ultrafine nanocrystals immobilized on nitrogen-doped carbon hybrid nanosheets(VN@NCSs)via an one-step in-situ selftemplate and self-reduction strategy,which simultaneously promotes the interaction with polysulfides and the kinetics of the sulfur conversion reactions demonstrated by experimental and theoretical results.By virtue of the multifunctional structural features of VN@NCSs,the cell with ultrathin VN@NCSs(only 5 pm thickness)modified separator indicates improved electrochemical performances with long cycling stability over 1,000 cycles at 2 C with only 0.041%capacity decay per cycle and excellent rate capability(787.6 mAh g^(-1) at 10 C).Importantly,it delivers an areal reversible capacity of 3.71 mAh cm^(-2) accompanied by robust cycling life. | Ning Song Baojuan Xi Peng Wang Xiaojian Ma Weihua Chen Jinkui Feng Shenglin Xiong | 2022 | Nano Research2022，15，2： | 4 |
| 20 | Development of silicon photonic devices for optical interconnects显示文摘Silicon photonic devices based on complementary-metal-oxide-semiconductor(CMOS) compatible technologies have shown attractive performances on very-large-scale monolithic optoelectronic integration,high speed modulation and switching,and efficient off-chip optical coupling.This paper presents the recent progress on fast silicon optical modulation,wavelength-insensitive optical switching and efficient optical coupling techniques in our group.Several CMOS-compatible silicon optical couplers with different structures have been developed,showing the highest coupling efficiency of 65%.Broadband silicon-based optical switches with sub-nanosecond switching on-off time are experimentally realized.Silicon modulators with novel PN junctions are demonstrated with the speed up to 50 Gb s-1. | XIAO Xi LI ZhiYong CHU Tao XU Hao LI XianYao NEMKOVA Anastasia KANG Xiong YU YuDe YU JinZhong | 2013 | Chinese Science Bulletin2013，58，7： | 4 |
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