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| 1 | A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle显示文摘Traditional Chinese herbs(TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major challenge to establish a quantitative detection technique that is objective, authentic and sensitive. Based on the two-bottle preference test(TBP), we proposed a novel quantitative strategy using a standardized animal test and a unified quantitative benchmark. To reduce the difference of results, the methodology of TBP was optimized. The relationship between the concentration of quinine and animal preference index(PI) was obtained. Then the PI of TCH was measured through TBP, and bitterness results were converted into a unified numerical system using the relationship of concentration and PI. To verify the authenticity and sensitivity of quantified results,human sensory testing and electronic tongue testing were applied. The quantified results showed a good discrimination ability. For example, the bitterness of Coptidis Rhizoma was equal to 0.0579 mg/mL quinine, and Nelumbinis Folium was equal to 0.0001 mg/mL. The validation results proved that the newassessment method for TCH was objective and reliable. In conclusion, this study provides an option for the quantification of bitterness and the evaluation of taste masking effects. | Xue Han Hong Jiang Li Han Xi Xiong Yanan He Chaomei Fu Runchun Xu Dingkun Zhang Junzhi Lin Ming Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 17 |
| 2 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 3 | Plasma boronizing of Ti6A1V4 using solid precursors by double glow plasma alloying technique 显示文摘 | Qin Lin Qu Junzhi Lin Naiming | 2006 | Transactions of Nonferrous Metals Society of China2006，25，16： | 1 |
| 4 | New State Recovery Attacks on the Grain v1 Stream Cipher显示文摘The Grain v1 stream cipher is one of the seven finalists in the final e STREAM portfolio. Though many attacks have been published,no recovery attack better than exhaustive key search on full Grain v1 in the single key setting has been found yet. In this paper,new state recovery attacks on Grain v1 utilizing the weak normality order of the employed keystream output function in the cipher are proposed. These attacks have remarkable advantages in the offline time,online time and memory complexities,which are all better than exhaustive key search. The success probability of each new attack is 0.632. The proposed attack primarily depends on the order of weak normality of the employed keystream output function. This shows that the weak normality order should be carefully considered when designing the keystream output functions of Grain-like stream ciphers. | Lin Ding Chenhui Jin Jie Guan Shaowu Zhang Junzhi Li Hong Wang Wei Zhao | 2016 | China Communications2016，13，11： | 1 |
| 5 | On-surface synthesis and edge states of NBN-doped zigzag graphene nanoribbons显示文摘Zigzag graphene nanoribbons(ZGNRs)with spin-polarized edge states have potential applications in carbon-based spintronics.The electronic structure of ZGNRs can be effectively tuned by different widths or dopants,which requires delicately designed monomers.Here,we report the successful synthesis of ZGNR with a width of eight carbon zigzag lines and nitrogen-boronnitrogen(NBN)motifs decorated along the zigzag edges(NBN-8-ZGNR)on Au(111)surface,which starts from a specially designed U-shaped monomer with preinstalled NBN units at the zigzag edge.Chemical-bond-resolved non-contact atomic force microscopy(nc-AFM)imaging confirms the zigzag-terminated edges and the existence of NBN dopants.The electronic states distributed along the zigzag edges have been revealed after a silicon-layer intercalation at the interface of NBN-8-ZGNR and Au(111).Our work enriches the ZGNR family with a new dopant and larger width,which provides more candidates for future carbonbased nanoelectronic and spintronic applications. | Xiao Chang Li Huang Yixuan Gao Yubin Fu Ji Ma Huan Yang Junzhi Liu Xiaoshuai Fu Xiao Lin Xinliang Feng Shixuan Du Hong-Jun Gao | 2023 | Nano Research2023，16，7： | 0 |
| 6 | Phyllanthi Fructus:A modal medicinal and food homologous item in quality evaluation显示文摘Phyllanthi Fructus is a highly unique medicine and food homologous item,which exhibits distinctive flavor,notable nutritional value,and abundant pharmacological activity.It has enormous potential in the creation of health products and pharmaceuticals.However,due to the unique laws of quality formation and transfer of Phyllanthi Fructus,its appearance,shape,chemical compositions,nutrients,and sensory flavors are frequently greatly influenced by botanical resources,the processing and storage conditions.As a result,the current quality evaluation model is difficult to meet the needs of Phyllanthi Fructus as a medicine and food homologous item in the development of diversified products.This paper constructs the hierarchical utilization mode of Phyllanthi Fructus based on its unique quality formation and transmission laws,explores the quality evaluation model for food-oriented use and medicinal-oriented use,respectively,and systematically describes the quality evaluation idea under diversified application scenarios.This paper aims to serve as a reference for the construction of a quality evaluation model suitable for the medicine and food homologous item of Phyllanthi Fructus. | Gefei Li Yurou Jiang Dingkun Zhang Li Han Taigang Mo Sanhu Fan Haozhou Huang Junzhi Lin | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 7 | Development of novel-nanobody-based lateral-flow immunochromatographic strip test for rapid detection of recombinant human interferon a2b显示文摘Recombinant human interferon a2b(rhIFNa2b)is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis C.The current identification test for rhIFNa2b is complex.In this study,an anti-rhIFNa2b nanobody was discovered and used for the development of a rapid lateral flow strip for the identification of rhIFNa2b.RhIFNa2b was used to immunize an alpaca,which established a phage nanobody library.After five steps of enrichment,the nanobody I22,which specifically bound rhIFNa2b,was isolated and inserted into the prokaryotic expression vector pET28a.After subsequent purification,the physicochemical properties of the nanobody were determined.A semiquantitative detection and rapid identification assay of rhIFNa2b was developed using this novel nanobody.To develop a rapid test,the nanobody I22 was coupled with a colloidal gold to produce lateral-flow test strips.The developed rhIFNa2b detection assay had a limit of detection of 1 mg/mL.The isolation of I22 and successful construction of a lateral-flow immunochromatographic test strip demonstrated the feasibility of performing ligand-binding assays on a lateral-flow test strip using recombinant protein products.The principle of this novel assay is generally applicable for the rapid testing of other commercial products,with a great potential for routine use in detecting counterfeit recombinant protein products. | Xi Qin Maoqin Duan Dening Pei Jian Lin Lan Wang Peng Zhou Wenrong Yao Ying Guo Xiang Li Lei Tao Youxue Ding Lan Liu Yong Zhou Chuncui Jia Chunming Rao Junzhi Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，2： | 0 |
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