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| 1 | Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient显示文摘Dear Editor,SARS-CoV-2,a novel coronavirus and causing COVID-19,has given rise to a worldwide pandemic.1,2 So far,tens of thousands of COVID-19 patients have been clinically cured and discharged,but multiple COVID-19 cases showed SARS-CoV-2 positive again in discharged patients,3 which raises an attention for the discharged patients.Also,there is an urgent need to understand the pathogenesis of SARS-CoV-2 infection.Here,we conducted postmortem pathologic study in a ready-fordischarge COVID-19 patient who succumbed to sudden cardiovascular accident.Pathological examination revealed SARSCoV-2-viruses remaining in pneumocytes and virus-caused pathological changes in the lungs.Our study provided new insights into SARS-CoV-2 pathogenesis and might facilitate the improvement of clinical guideline for virus containment and disease management. | Xiao-Hong Yao Zhi-Cheng He Ting-Yuan Li Hua-Rong Zhang Yan Wang Huaming Mou Qiaonan Guo Shi-Cang Yu Yanqing Ding Xindong Liu Yi-Fang Ping Xiu-Wu Bian | 2020 | Cell Research2020，30，6： | 35 |
| 2 | Distribution and characteristic of PAHs in snow of Fildes Peninsula显示文摘Polycyclic aromatic hydrocarbons (PAHs) investigation in different matrices has been reported largely,whereas reports on snow samples were limited.Snow,as the main matrix in the polar region,has an important study meaning.PAHs in snow samples were analyzed to investigate the distribution and contamination status of them in the Antarctic,as well as to provide some references for global migration of PAHs.Snow samples collected in Fildes Peninsula were enriched and separated by solid-phase membrane disks and eluted by methylene dichloride,then quantified by gas chromatography/mass spectrometry.All types of PAHs were detected except for Benzo(a)pyrene.Principal component analysis method was applied to characterize them.Three factors (Naphthalene,Fluorene and Phenanthrene) accounted for 60.57%,21.61% and 9.80%,respectively.The results showed that the major PAHs sources maybe the atmospheric transportation,and the combustion of fuel in Fildes Peninsula.The comparison of concentration and types of PAHs between accumulated snow and fresh snow showed that the main compound concentrations in accumulated snow samples were higher than those in fresh ones.The risk assessment indicated that the amount of PAHs in the snow samples would not lead to ecological risk. | Guangshui Na Chunyang Liu Zhen Wang Linke Ge Xindong Ma Ziwei Yao | 2011 | Journal of Environmental Sciences2011，23，9： | 8 |
| 3 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 4 | Process and challenges of stainless steel based bipolar plates for proton exchange membrane fuel cells显示文摘Proton exchange membrane fuel cell(PEMFC)powered automobiles have been recognized to be the ultimate solution to replace traditional fuel automobiles because of their advantages of PEMFCs such as no pollution,low temperature start-up,high energy density,and low noise.As one of the core components,the bipolar plates(BPs)play an important role in the PEMFC stack.Traditional graphite BPs and composite BPs have been criticized for their shortcomings such as low strength,high brittleness,and high processing cost.In contrast,stainless steel BPs(SSBPs)have recently attracted much attention of domestic and foreign researchers because of their excellent comprehensive performance,low cost,and diverse options for automobile applications.However,the SSBPs are prone to corrosion and passivation in the PEMFC working environment,which lead to reduced output power or premature failure.This review is aimed to summarize the corrosion and passivation mechanisms,characterizations and evaluation,and the surface modification technologies in the current SSBPs research.The non-coating and coating technical routes of SSBPs are demonstrated,such as substrate component regulation,thermal nitriding,electroplating,ion plating,chemical vapor deposition,and physical vapor deposition,etc.Alternative coating materials for SSBPs are metal coatings,metal nitride coatings,conductive polymer coatings,and polymer/carbon coatings,etc.Both the surface modification technologies can solve the corrosion resistance problem of stainless steel without affecting the contact resistance,however still facing restraints such as long-time stability,feasibility of low-cost,and mass production process.This paper is believed to enrich the knowledge of high-performance and long-life BPs applied for PEMFC automobiles. | Gaoyang Liu Faguo Hou Shanlong Peng Xindong Wang Baizeng Fang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，5： | 4 |
| 5 | Simultaneous Extraction of Carboxylated Celulose Nanocrystals and Nanofibrils via Citric Acid Hydrolysis--A Sustainable Route显示文摘In this study, cellulose nanocrystals(CNC) with surface carboxylic groups were prepared from bleached softwood pulp by hydrolysis with concentrated citric acid at concentrations of 60 wt%~80 wt%. The solid residues from acid hydrolysis were collected for producing cellulose nanofibrils(CNF) via post high-pressure homogenization. Citric acid could be easily recovered after hydrolysis reactions through crystallization due to its low water solubility or through precipitation as a calcium salt followed by acidification. Several important properties of CNC and CNF, such as dimension, crystallinity, surface chemistry, thermal stability, were evaluated. Results showed that the obtained CNC and CNF surfaces contained carboxylic acid groups that facilitated functionalization and dispersion in aqueous processing. The recyclability of citric acid and the carboxylated CNC/CNF give the renewable cellulose nanomaterial huge potential for a wide range of industrial applications. Furthermore, the resultant CNC and CNF were used as reinforcing agents to make sodium carboxymethyl cellulose(CMC) films. Both CNC and CNF showed reinforcing effects in CMC composite films. The tensile strength of CMC films increased by 54.3% and 85.7% with 10 wt% inclusion of CNC and CNF, respectively. This study provides detailed information on carboxylated nanocellulose prepared by critic acid hydrolysis; a sustainable approach for the preparation of CNC/CNF is of significant importance for their various uses. | Chao Liu HaiShun Du Guang Yu YueDong Zhang QingShan Kong Bin Li XinDong Mu | 2017 | Paper And Biomaterials2017，2，4： | 4 |
| 6 | Creation of artificial karyotypes in mice reveals robustness of genome organization显示文摘Dear Editor,Robertsonian(Rb)fusions contribute to the diversity in species karyotypes.However,how it occurs and propels evolution is still unknown,mainly due to the lack of a simple and efficient method for genetically manipulating chromosomes in animals.While the typical mousekaryotype(2n=40)iscompletelytelocentric exceptchromosomeY(ChrY),thewestern European subspeciesM.m.domesticus contains diverse chromosomal races,with a diploid number varying between 38 and 22 due to carrying one or multiple pairs of metacentric chromosomes,which results from the Rb fusions between two telocentricchromosomes. | Xiaoyu Merlin Zhang Meng Yan Zhenhua Yang Hao Xiang Wei Tang Xindong Cai Qigui Wu Xin Liu Gang Pei Jinsong Li | 2022 | Cell Research2022，32，11： | 3 |
| 7 | COVID-19-associated monocytic encephalitis(CAME):histological and proteomic evidence from autopsy显示文摘Severe neurological symptoms are associated with Coronavirus disease 2019(COVID-19).However,the morphologic features,pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection.In this study,neuropathological damages and infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining,ultrastructural examination under electron microscopy,and an image threshold method,in postmortem brains from nine critically ill COVID-19 patients and nine age-matched cadavers of healthy individuals.Differentially expressed proteins were identified by quantitative proteomic assays.Histopathological findings included neurophagocytosis,microglia nodules,satellite phenomena,extensive edema,focal hemorrhage,and infarction,as well as infiltrating mononuclear cells.Immunostaining of COVID-19 brains revealed extensive activation of both microglia and astrocytes,severe damage of the blood-brain barrier(BBB)and various degrees of perivascular infiltration by predominantly CD14+/CD16+/CD141+/CCR7+/CD11c+monocytes and occasionally CD4+/CD8+T lymphocytes.Quantitative proteomic assays combined with bioinformatics analysis identified upregulated proteins predominantly involved in immune responses,autophagy and cellular metabolism in COVID-19 patient brains compared with control brains.Proteins involved in brain development,neuroprotection,and extracellular matrix proteins of the basement membrane were downregulated,potentially caused by the activation of transforming growth factorβreceptor and vascular endothelial growth factor signaling pathways.Thus,our results define histopathological and molecular profiles of COVID-19-associated monocytic encephalitis(CAME)and suggest potential therapeutic targets. | Pei-Pei Zhang Zhi-Cheng He Xiao-Hong Yao Rui Tang Jie Ma Tao Luo Chuhong Zhu Tian-Ran Li Xindong Liu Dingyu Zhang Shuyang Zhang Yi-Fang Ping Ling Leng Xiu-Wu Bian | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
| 8 | Novel Au nanoparticles-inlaid titanium paper for PEM water electrolysis with enhanced interfacial electrical conductivity显示文摘Proton-exchange membrane water electrolysis(PEM WE)is a particularly promising technology for renewable hydrogen produc-tion.However,the excessive passivation of the gas diffusion layer(GDL)will seriously affect the high surface-contact resistance and result in energy losses.Thus,a mechanism for improving the conductivity and interface stability of the GDL is an urgent issue.In this work,we have prepared a hydrophilic and corrosion resistant conductive composite protective coating.The polydopamine(PDA)film on the Ti surface,which was obtained via the solution oxidation method,ensured that neither micropores nor pinholes existed in the final hybrid coatings.In-situ reduced gold nanoparticles(AuNPs)improved the conductivity to achieve the desired interfacial contact resistance and further enhanced the corrosion resistance.The surface composition of the treated samples was investigated using scanning electron microscopy(SEM),transmis-sion electron microscopy(TEM),X-ray diffraction(XRD),and Fourier transform infrared spectroscopy(FTIR).The results indicated that the optimized reaction conditions included a pH value of 3 of HAuCl_(4) solution with PDA deposition(48 h)on papers and revealed the lowest con-tact resistance(0.5 mΩ·cm^(2))and corrosion resistance(0.001μA·cm^(−2))in a 0.5 M H_(2)SO_(4)+2 ppm F−solution(1.7 V vs.RHE)among all the modified specimens,where RHE represents reversible hydrogen electrode.These findings indicated that the Au-PDA coating is very appropriate for the modification of Ti GDLs in PEM WE systems. | Yue Liu Shaobo Huang Shanlong Peng Heng Zhang Lifan Wang Xindong Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，5： | 2 |
| 9 | Top 10 algorithms in data mining显示文摘 | Xindong Wu Vipin Kumar J. Ross Quinlan Joydeep Ghosh Qiang Yang Hiroshi Motoda Geoffrey J. McLachlan Angus Ng Bing Liu Philip S. Yu Zhi-Hua Zhou Michael Steinbach David J. Hand Dan Steinberg | 2008 | Knowledge and Information Systems2008，，1： | 1 |
| 10 | PVDF HFP based porous polymer electrolyte membranes for lithium-ion batteries显示文摘 | Ruiying Miao Bowen Liu Xindong Wang | 2008 | Journal of Power Sources2008，184，2： | 1 |
| 11 | Research on the threshold effect of population aging on the industrial structure upgrading in China显示文摘This paper constructs coefficients of the integral and the internal structure upgrading in the secondary and tertiary industries, selects per capita real gross domestic product as a threshold variable and build panel threshold model according to inter-provincial panel data of China from 1998 to 2016. Results indicated that population aging has a double threshold effect on the integral industrial structure upgrading, whose influence increases first and then decreases, significantly promoting the upgrading process. As for internal structure, population aging has no significant threshold effect on the upgrading in the secondary industry, but exerts a single negative threshold effect in the tertiary industry. When economic development is under the threshold, its negative impact is greater. Further analysis also suggests that regional differences exist significantly in the threshold effect of population aging on the industrial structure upgrading. | Chengkun Liu Shuyu Li Xindong Zhao | 2019 | Chinese Journal of Population,Resources and Environment2019，17，1： | 1 |
| 12 | Optimisation method for carbon black distribution of polypropylene-based semi-conductive screen materials and its effect on charge emission behaviour at screen/insulation interface显示文摘The semi-conductive(SC)screen materials used in polypropylene(PP)-based cables are usually multi-component composites.Polypropylene shows poor compatibility with carbon black(CB),and CB particles tend to disperse in the elastomer phase,which results in CB non-uniform dispersion in screen materials.The non-uniform distribution of CB will cause abnormal electric fields at the screen/insulation interface and affect insulation performance.This paper prepared modified PP grafted by molecule maleic anhydride,and four PP-based SC shielding materials were blended in combination with PP,PP-g-MAH,and thermoplastic elastomer(POE)as matrix resin.The CB distribution,electrical conductivity,and basic physical properties of the shielding material were characterised.Different screen materials were served as electrodes to test their effects on the space charge and conductivity characteristics of insulation.The relationship between the macroscopic properties and the distribution characteristics of CB was discussed.Results show that the selective dispersion of CB in screen material was improved by PPg-MAH and the surface electric potential distribution was homogenised.Charge emission at the screen/insulation interface and conductivity can be reduced by homogenising the CB distribution.CB/PP-g-MAH/POE prepared in this paper exhibits relatively uniform CB distribution,which can reduce the charge emission from the screen/insulation interface. | Jiaming Yang Rui Zhang Xu Yang Zhi Sun Xindong Zhao Hong Zhao Xuan Wang Lin Li Heqian Liu | 2023 | High Voltage2023，8，2： | 1 |
| 13 | Cerium Oxide Film Prepared from Molten Salts显示文摘Cerium oxide film formed on the nickel electrode at 453 K in LiNO3-KNO3 molten salts. The molten salt back- ground and the cathode process of Leeds on the nickel electrode were studied by using cyclic voltammetry. The cathodic reaction mechanism of the molten salt background was: O2+e - O2-2;O2+2NO-3→2NO-2+2O02. According to the results of SEM and XPS, cerium oxide film, which is composed of CeO2, can form on the nickel electrode at - 1.850 V vs. Ag/ AgNO3(0.1mol/L) reference electrode. | Xindong Wang, Guangming Liu, Yanfang Liu, Shuzhen Duan Department of Physical Chemistry, University of Science and Technology Beliing, Beliing 100083. China) | 2001 | Rare Metals2001，20，2： | 1 |
| 14 | Top 10 algorithms in data mining显示文摘 | Xindong Wu Vipin Kumar J. Ross Quinlan Joydeep Ghosh Qiang Yang Hiroshi Motoda Geoffrey J. McLachlan Angus Ng Bing Liu Philip S. Yu Zhi-Hua Zhou Michael Steinbach David J. Hand Dan Steinberg | 2009 | Knowledge and Information Systems2009，，1： | 1 |
| 15 | Top 10 algorithms in data mining显示文摘 | Xindong Wu Vipin Kumar J. Ross Quinlan Joydeep Ghosh Qiang Yang Hiroshi Motoda Geoffrey J. McLachlan Angus Ng Bing Liu Philip S. Yu Zhi-Hua Zhou Michael Steinbach David J. Hand Dan Steinberg | 2008 | Knowledge and Information Systems2008，，1： | 1 |
| 16 | Top 10 algorithms in data mining显示文摘 | Wu Xindong Kumar Vipin Ross Quinlan J Ghosh Joydeep Yang Qiang Motoda Hiroshi McLachlan Geoffrey J Ng Angus Liu Bing Yu Philip S Zhou Zhi-Hua Steinbach Michael Hand David J Steinberg Dan | 2008 | Knowledge and Information Systems2008，，1： | 1 |
| 17 | Sustainable preparation and characterization of thermally stable and functional cellulose nanocrystals and nanofibrils via formic acid hydrolysis显示文摘In this work,a sustainable method to prepare functional cellulose nanocrystals(CNCs)and cellulose nanofibrils(CNFs)using formic acid(FA)(a recoverable organic acid)was established.After FA hydrolysis,the obtained CNCs could be well dispersed in DMAC.Thus,the CNC products and fibrous cellulosic solid residue(FCSR)in DMAC could be easily separated by a conventional centrifugal process,and the collected FCSR could be further fibrillated to CNFs with relatively low-intensity mechanical fibrillation process.The isolated CNC products showed high crystallinity index(about 75%)and excellent thermal stability(with onset thermal degradation temperature of 325℃).Both the resultant CNCs and CNFs showed better dispersibility in DMSO,DMF and DMAC respectively because of the introduction of ester groups on the surface of the products.The presence of surface ester groups could increase the interface compatibility of nanocelluloses with polymeric matrices and enable their applications in reinforcing polymeric matrix materials(e.g.the composite films like PHVB+CNFs). | Haishun Du Chao Liu Dong Wang Yuedong Zhang Guang Yu Chuanling Si Bin Li Xindong Mu Hui Peng | 2017 | Journal of Bioresources and Bioproducts2017，2，1： | 1 |
| 18 | Chiral Macrocyclic AIEgens from BINOL and Tetraphenylethene via Tailoring Chirality of Luminescent Molecular Propellers显示文摘Herein,a pair of chiral macrocyclic luminogens derived from chiral 1,1-bi(2-naphthol)(BINOL)and tetraphenylethenes(TPEs)have been prepared with high yield via intramolecular McMurry coupling,in which the preferential helicity of propeller-shaped TPE units can be tuned via choosing proper chiral BINOL tethers.The preferential chiral geometry of the macrocyclic luminogen was unambiguously confirmed by X-ray crystal crystallography and theoretical calculation,whereas the variable-temperature NMR spectra and chiral HPLC analysis further verified the intramolecular motions.These two chiral macrocyclic luminogens both exhibit obvious aggregation-induced emission behavior and mechanochromic luminescence properties.Furthermore,aggregation attenuated CD signals and circularly polarized luminescence were observed for these two chiral macrocylic luminogens in THF-water mixture and PMMA matrix.These results had paved a new approach toward constructing chiral aggregation-induced emission luminogens(AIEgens)and their structural engineering. | Yitong Wang Xiaoqing Liu Hongkun Li Xindong Liu Lei Wang Yi Liu | 2022 | Chinese Journal of Chemistry2022，40，20： | 1 |
| 19 | A regulatory perspective on recombinant collagen-based medical devices显示文摘As a class of novel biomaterials manufactured by synthetic biology technologies,recombinant collagens are candidates for a variety of medical applications.In this article,a regulatory scientific perspective on recombinant collagens and their medical devices is presented with a focus on the definition,translation,classification and technical review.Recombinant collagens are categorized as recombinant human collagen,recombinant humanized collagen and recombinant collagen-like protein,as differentiated by specific compositions and structures.Based on their intended uses and associated risks,recombinant collagen-based medical devices are generally classified as Class Ⅱ or Ⅲ in China.The regulatory review of recombinant collagen-based medical devices aims to assess their safety and efficacy demonstrated by scientific evidences generated from preclinical and clinical evaluations.Taken together,opportunities as well as challenges for their future clinical translation of recombinant collagen-based medical devices abound,which highlights the essential role of regulatory science to provide new tools,standards,guidelines and methods to evaluate the safety and efficacy of medical products. | Wenbo Liu Hai Lin Peng Zhao Lina Xing Jie Li Zehua Wang Shan Ju XinLi Shi Yinghui Liu Gang Deng Guobiao Gao Lei Sun Xindong Zhang | 2022 | Bioactive Materials2022，7，6： | 1 |
| 20 | Editorial for special issue on advanced energy storage and materials for the 70th Anniversary of USTB显示文摘1. Foreword Energy storage plays a key role in the transition towards a carbon-neutral economy. By balancing power grids and saving surplus energy, it represents a concrete means of improving energy efficiency and integrating more renewable energy sources into electricity systems. A variety of technologies to store energy are developing at a fast pace and increasingly becomingmoremarketcompetitive,includingtraditional electric energy storage, thermal energy storage, and newly developed hydrogen energy storage, etc. The demand for energy storage system with high power and efficiency boosts the development in the advanced techniques and materials,such as batteries, super-capacitors, molten salts, and catalysts for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). | Xindong Wang Ranbo Yu Chun Zhan Wei Wang Xuan Liu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，5： | 1 |
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