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| 1 | Multi-disciplinary treatment for cholangiocellular carcinoma显示文摘Cholangiocarcinoma(CC)is rare malignant tumors composed of cells that resemble those of the biliary tract.It is notoriously difficult to diagnose,and is associated with a high mortality.Traditionally,CC is divided into intrahepatic and extraheaptic disease according to its location within the biliary tree.Intrahepatic cholangiocellular carcinoma(IH-CCC)or peripheral cholangiocellular carcinoma(CCC)appears within the second bifurcation of hepatic bile duct,and is the second most common primary liver cancer following hepatocellular carcinoma(HCC),IH-CCC or peripheral CCC often presents with advanced clinical features,and the cause for this cancer rise is still unclear.MRI,CT and PET provide useful diagnostic information in those patients.Surgical resection is the only chance for cure,with results depending on selected patients and careful surgical technique.Liver transplantation could offer long-term survival in selected patients when combined with chemotherapy.Chemotherapy,radiation therapy or combination therapies remain as the only treatment for inoperable patients.However,these are uniformly ineffective in patients' survival. | Mitsugi Shimoda Keiichi Kubota | 2007 | World Journal of Gastroenterology2007，13，10： | 17 |
| 2 | Erythropoietin ameliorates early ischemia-reperfusion injury following the Pringle maneuver显示文摘AIM:To investigate the protective effect of erythropoietin (Epo) against ischemia-reperfusion injury (IR/I) following the Pringle maneuver (PM),in comparison with conventional steroid administration in a prospective randomized trial. METHODS:Patients were randomized by age, sex, diagnosis, and surgical method, and assigned to three groups:(1) A steroid group (STRD, n= 9) who received 100 mg of hydrocortisone before PM, and on postoperative days 1, 2 and 3, followed by tapering until postoperative day 7; (2) An EPO1 group (n=10) who received 30 000 U of Epo before the PM and at the end of surgery; and (3) An EPO2 group (n=8) who received 60 000 U of Epo before the PM. Hemoglobin (Hb), hematocrit (Ht), aspartate aminotransferase (AST), alanine transaminase (ALT),lactate dehydrogenase (LDH), lactate, interleukin-6 (IL-6),and tumor necrosis factor(TNF)-α were measured before and just after (Day 0) surgery, and on postoperative days 1, 3, 7 and 14. RESULTS: There were no increases in Hb and Ht in the EPO1 and EPO2 groups. AST was signif icantly lower in EPO1 than in STRD on Day 0 (P=0.041), and lower in EPO1 than in STRD and EPO2 on Day 1 (P=0.018). ALT was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.020) and Day 1 (P=0.004). There were no signif icant inter-group differences in the levels of LDH and lactate. IL-6 was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.0036) and Day 1 (P=0.0451). TNF-α was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.0006) and Day 1 (P<0.0001). Furthermore, hospitalization was signif icantly shorter in EPO1 and EPO2 than in STRD.CONCLUSION:Epo has greater potential than steroids to ameliorate IR/I after the PM. Epo at a dose of 30000 U, administered before PM and just after surgery, yields better results. | Masato Kato Tokihiko Sawada Junji Kita Mitsugi Shimoda Keiichi Kubota | 2010 | World Journal of Gastroenterology2010，16，38： | 11 |
| 3 | Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2:A project of the Kyushu University Liver Disease Study Group显示文摘瞄准:决定一座干扰素高山的功效哈并且为感染遗传型 2 的丙肝病毒(HCV ) 的日本病人的 ribavirin 联合治疗,多中心研究回顾地被分析。方法:总共,有 HCV 遗传型 2 的 173 个病人每天一个星期和 ribavirin 的 600-800 mg 为 24 wk 三次皮下地收到 interferon-alpha。结果:总的来说持续的 virological 反应(SVR ) ,在浆液的定义同样无法发现的 HCV RNA,在治疗的结束以后的 24 wk,在 84.4% 显著地高,(146/173 ) 由 intention-to-treat 分析。在 SVR 的有效差量有或没有 ribavirin (46.9% 对 92.9%) 的中止在病人之间被发现,但是没有差别有或没有 ribavirin 的剂量减小在那些之间被发现。在 SVR 的有效差量也与 16 或更与不到 16 wk 和病人在病人之间被发现 ribavirin 治疗(34.8% 对 92.0%) 的星期。结论:24-wk 干扰素和 ribavirin 治疗为有 HCV 遗传型 2 的日本病人是高度有效的。SVR 的重要预言者是 ribavirin 治疗的继续多达 16 个星期。 | Norihiro Furusyo Masaki Katoh Yuichi Tanabe Eiji Kajiwara Toshihiro Maruyama Junya Shimono Hironori Sakai Makoto Nakamuta Hideyuki Nomura Akihide Masumoto Shinji Shimoda Kazuhiro Takahashi Koichi Azuma Jun Hayashi Kyushu University Liver Disease Study Group | 2006 | World Journal of Gastroenterology2006，12，5： | 8 |
| 4 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 8 |
| 5 | Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model显示文摘AIM:To investigate the effect of E3-methyl-1-phenyl-2-pyrazolin-5-one (Edr) on hepatic ischemia-reperfusion (I/R) injury and liver regeneration in a porcine hepatectomy model.METHODS:One hour ischemia was induced by occluding the vessels and the bile duct of the right and median lobes.A 40% left hepatectomy was performed after reperfusion.Six animals received Edr (3 mg/kg per hour) intravenously and six control animals received saline just before reperfusion.Remnant liver volume,hemodynamics,aspartate aminotransferase (AST),alanine aminotransferase,lactate dehydrogenase and lactic acid,were compared between the groups.The expression of transforming growth factor (TGF1) and toll-like receptor (TRL) mRNA in hepatic tissues was examined using reverse transcription polymerase chain reaction.Apoptosis was demonstrated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining,respectively.RESULTS:Serum AST (P = 0.029),and toll like receptor 4 level (P = 0.043) were significantly lower after 3 h in animals receiving Edr.In addition,TUNEL staining in Edr-treated pigs showed significantly fewer hepatocytes undergoing apoptosis compared with control pigs.After 1 mo,all factors were non-significantly different between the two groups.CONCLUSION:Edr is considered to reduce hepatic injury in the early stage of I/R injury in a porcine model. | Mitsugi Shimoda Yoshimi Iwasaki Toshie Okada Keiichi Kubota | 2012 | World Journal of Gastroenterology2012，18，27： | 8 |
| 6 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 7 |
| 7 | Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding显示文摘AIM:To investigate the effects of the probiotic Bifidobacterium longum BB536 on the health management of elderly patients receiving enteral feeding.METHODS:Two double-blind,placebo-controlled trials were performed with long-term inpatients receiving enteral tube feeding at Kitakyushu Hospital Group,Fukuoka,Japan.BB536 was administered as BB536-L and BB536-H powders that contained approximately 2.5 × 10 10 and 5 × 10 10 cfu of BB536,respectively.In the first trial,83 patients(age range:67-101 years) were randomized into 2 groups that received placebo(placebo group) or BB536-H(BB536 group) powders.In the second trial,123 patients(age range:65-102years) were randomized into 3 groups,and each group received placebo(placebo group),BB536-L(BB536-L group),or BB536-H(BB536-H group) powders.Each patient received the study medication for 16 wk after 1 wk of pre-observation.Fecal samples were collected from each patient prior to and after the intervention during Trial 2.Clinical observations included body temperature,occurrence of infection,frequency of defecation,and fecal microbiota.RESULTS:No significant changes were observed in the frequency of defecation for either treatment in Trial 1.However,a significant change was noted in the BB536-L group(P = 0.0439) in Trial 2 but not in the placebo or BB536-H groups.Subgroup analyses based on the frequency of defecation for each patient during the pre-observation period for both trials revealed significant increases in bowel movements in patients with a low frequency of defecation and significant decreases in the bowel movements of patients with a high frequency of defecation during the intervention period in the BB536 groups.The combination of Trials 1 and 2 data revealed a modulatory effect of BB536 ingestion on the changes in bowel movements.Significantly increased bowel movements were observed in patients in the low frequency subgroup with significant intergroup differences(P < 0.01).Significantly decreased bowel movements were observed in patients in the high subgroup,but no significant intergroup differences were observed compared with the placebo group.BB536 ingestion increased the prevalence of normally formed stools.BB536 intake also significantly(P < 0.01) increased the cell numbers of bifidobacteria in fecal microbiota,and significant intergroup differences were observed at week 16.No adverse events were reported in any group.CONCLUSION:Our results suggest that BB536 ingestion modulated the intestinal environment and may have improved the health care of elderly patients receiving enteral feeding. | Junko Kondo Jin-Zhong Xiao Akira Shirahata Mieko Baba Akie Abe Koichi Ogawa Taeko Shimoda | 2013 | World Journal of Gastroenterology2013，19，14： | 7 |
| 8 | Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer显示文摘 | Toshiaki Hirasawa Takuji Gotoda Satoshi Miyata You Kato Tadakazu Shimoda Hirokazu Taniguchi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2009 | Gastric Cancer2009，，3： | 5 |
| 9 | Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP pancreatitis.METHODS This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December 2013.Serum amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic model.RESULTS A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 cases.Fifty-five of these cases developed PEP.We established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting PEP.Multivariate analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for PEP.Forty-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation times.Only 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation times.CONCLUSION These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP. | Shiro Hayashi Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Takahiro Amano Aya Sugimoto Kei Takahashi Kaori Mukai Tokuhiro Matsubara Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 4 |
| 10 | Size does not determine the grade of malignancy of early invasive colorectal cancer显示文摘AIM:To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers(EI-CRCs),and to determine whether malignancy grade depends on size.METHODS:A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study.Lesions were classified into two groups based on size:small(≤10mm) and large(>10mm).Clinicopathological features,incidence of lymph node metastasis(LNM) and risk factors for LNM,such as depth of invasion,lymphovascular invasion(LVI) and poorly differentiated adenocarcinoma(PDA) were analyzed in all resected specimens.RESULTS:There were 120(21%) small and 463(79%) large lesions.Histopathological analysis of the small lesion group revealed submucosal deep cancer(sm:≥1000 μm) in 90(75%) cases,LVI in 26(22%) cases,and PDA in 12(10%) cases.Similarly,the large lesion group exhibited submucosal deep cancer in 380(82%) cases,LVI in 125(27%) cases,and PDA in 79(17%) cases.The rate of LNM was 11.2% and 12.1% in the small and large lesion groups,respectively.CONCLUSION:Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer. | Takahisa Matsuda Yutaka Saito Takahiro Fujii Toshio Uraoka Takeshi Nakajima Nozomu Kobayashi Fabian Emura Akiko Ono Tadakazu Shimoda Hiroaki Ikematsu Kuang-I Fu Yasushi Sano Takahiro Fujimori | 2009 | World Journal of Gastroenterology2009，15，22： | 4 |
| 11 | Endoscopic characteristics of small intestinal malignant tumors observed by balloon-assisted enteroscopy显示文摘BACKGROUND Capsule endoscopy and balloon-assisted enteroscopy(BAE) enable visualization of rare small bowel conditions such as small intestinal malignant tumors.However,details of the endoscopic characteristics of small intestinal malignant tumors are still unknown.AIM To elucidate the endoscopic characteristics of small intestinal malignant tumors.METHODS From March 2005 to February 2017,1329 BAE procedures were performed at Keio University Hospital. Of these procedures,malignant tumors were classified into three groups,Group 1: epithelial tumors including primary small intestinal cancer,metastatic small intestinal cancer,and direct small intestinal invasion by an adjacent organ cancer; Group 2: small intestinal malignant lymphoma; and Group 3,small intestinal gastrointestinal stromal tumors. We systematically collected clinical and endoscopic data from patients' medical records to determine the endoscopic characteristics for each group.RESULTS The number of patients in each group was 16(Group 1),23(Group 2),and 6(Group 3),and the percentage of solitary tumors was 100%,43.5%,and 100%,respectively(P < 0.001). Patients' clinical background parameters including age,symptoms,and laboratory data were not significantly different between the groups. Seventy-five percent of epithelial tumors(Group 1) were located in the upper small intestine(duodenum and ileum),and approximately 70% of gastrointestinal stromal tumors(Group 3) were located in the jejunum. Solitary protruding or mass-type tumors were not seen in malignant lymphoma(Group2)(P < 0.001). Stenosis was seen more often in Group 1,(68.8%,27.3%,and 0%;Group 1,2,and 3,respectively; P = 0.004). Enlarged white villi inside and/or surrounding the tumor were seen in 12.5%,54.5%,and 0% in Group 1,2,and 3,respectively(P = 0.001).CONCLUSION The differential diagnosis of small intestinal malignant tumors could be tentatively made based on BAE findings. | Tomofumi Horie Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Kenji JL Limpias Kamiya Ryoichi Miyanaga Shinta Mizuno Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Masayuki Shimoda Haruhiko Ogata Takanori Kanai | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 4 |
| 12 | Efficacy of pegylated interferon alpha-2b and ribavirin treatment on the risk of hepatocellular carcinoma in patients with chronic hepatitis C: A prospective, multicenter study显示文摘 | Eiichi Ogawa Norihiro Furusyo Eiji Kajiwara Kazuhiro Takahashi Hideyuki Nomura Toshihiro Maruyama Yuichi Tanabe Takeaki Satoh Makoto Nakamuta Kazuhiro Kotoh Koichi Azuma Kazufumi Dohmen Shinji Shimoda Jun Hayashi | 2012 | Journal of Hepatology2012，，： | 3 |
| 13 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 14 | Control of T H 17/T reg Balance by Hypoxia-Inducible Factor 1显示文摘 | Eric V. Dang Joseph Barbi Huang-Yu Yang Dilini Jinasena Hong Yu Ying Zheng Zachary Bordman Juan Fu Young Kim Hung-Rong Yen Weibo Luo Karen Zeller Larissa Shimoda Suzanne L. Topalian Gregg L. Semenza Chi V. Dang Drew M. Pardoll Fan Pan | 2011 | Cell2011，，5： | 3 |
| 15 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 16 | Nonpolypoid neoplastic lesions of the colorectal mucosa显示文摘 | Shin ei Kudo René Lambert John I. Allen Hiroaki Fujii Takahiro Fujii Hiroshi Kashida Takahisa Matsuda Masaki Mori Hiroshi Saito Tadakazu Shimoda Shinji Tanaka Hidenobu Watanabe Joseph J. Sung Andrew D. Feld John M. Inadomi Michael J. O’Brien David A. Lieb | 2008 | Gastrointestinal Endoscopy2008，，4： | 3 |
| 17 | Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer显示文摘 | Toshiaki Hirasawa Takuji Gotoda Satoshi Miyata You Kato Tadakazu Shimoda Hirokazu Taniguchi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2009 | Gastric Cancer2009，，3： | 3 |
| 18 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 19 | 自身免疫性肝炎治疗的专家意见介绍显示文摘 | Ishibashi H Komori A Shimoda S 马雄 王绮夏 邱德凯 | 2008 | 肝脏2008，13，2： | 2 |
| 20 | Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy显示文摘BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among pathologists remains unresolved. Moreover, there is no globally accepted consensus regarding the optimal evaluation. A previous study based on a clinical trial suggested that pathological response measured using digitally captured virtual microscopic slides predicted patients’ survival well. However, the pathological concordance rate of this approach and its usefulness in clinical practice were unknown. AIM To investigate the prognostic utility of pathological response measured using digital microscopic slides in clinical practice. METHODS We retrospectively evaluated pathological specimens of gastric cancer patients who underwent NAC followed by surgery and achieved R0 resection between March 2009 and May 2015. Residual tumor area and primary tumor beds were measured in one captured image slide, which contained the largest diameter of the resected specimens. We classified patients with < 10% residual tumor relative to the primary tumorous area as responders, and the rest as non-responders;we then compared overall survival (OS) and relapse-free survival (RFS) between these two groups. Next, we compared the prognostic utility of this method using conventional Japanese criteria. RESULTS Fifty-four patients were evaluated. The concordance rate between two evaluators was 96.2%. Median RFS of 25 responders and 29 non-responders was not reached (NR) vs 18.2 mo [hazard ratio (HR)= 0.35, P = 0.023], and median OS was NR vs 40.7 mo (HR = 0.3, P = 0.016), respectively. This prognostic value was statistically significant even after adjustment for age, eastern cooperative oncology group performance status, macroscopic type, reason for NAC, and T- and Nclassification (HR = 0.23, P = 0.018). This result was also observed even in subgroup analyses for different macroscopic types (Borrmann type 4/non-type 4) and histological types (differentiated/undifferentiated). Moreover, the adjusted HR for OS between responders and non-responders was lower in this method than that in the conventional histological evaluation of Japanese Classification of Gastric Carcinoma criteria (0.23 vs 0.39, respectively). CONCLUSION The measurement of pathological response using digitally captured virtual microscopic slides may be useful in clinical practice. | Sadayuki Kawai Tadakazu Shimoda Takashi Nakajima Masanori Terashima Katsuhiro Omae Nozomu Machida Hirofumi Yasui | 2019 | World Journal of Gastroenterology2019，25，35： | 2 |
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