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| 1 | Achieving the best bowel preparation for colonoscopy显示文摘Bowel preparation is a core issue in colonoscopy,as it is closely related to the quality of the procedure.Patients often find that bowel preparation is the most unpleasant part of the examination.It is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic lesions.In spite of its importance and potential implications,until recently,bowel preparation has not been the subject of much study.The most commonly used agents are high-volume polyethylene glycol(PEG)electrolyte solution and sodium phosphate.There has been some confusion,even in published meta-analyses,regarding which of the two agents provides better cleansing.It is clear now that both PEG and sodium phosphate are effectivewhen administered with proper timing.Consequently,the timing of administration is recognized as one of the central factors to the quality of cleansing.The bowel preparation agent should be administered,at least in part,a few hours in advance of the colonoscopy.Several low volume agents are available,and either new or modified schedules with PEG that usually improve tolerance.Certain adjuvants can also be used to reduce the volume of PEG,or to improve the efficacy of other agents.Other factors apart from the choice of agent can improve the quality of bowel cleansing.For instance,the effect of diet before colonoscopy has not been completely clarified,but an exclusively liquid diet is probably not required,and a low-fiber diet may be preferable because it improves patient satisfaction and the quality of the procedure.Some patients,such as diabetics and persons with heart or kidney disease,require modified procedures and certain precautions.Bowel preparation for pediatric patients is also reviewed here.In such cases,PEG remains the most commonly used agent.As detecting neoplasia is not the main objective with these patients,less intensive preparation may suffice.Special considerations must be made for patients with inflammatory bowel disease,including safety and diagnostic issues,so that the most adequate agent is chosen.Identifying neoplasia is one of the main objectives of colonoscopy with these patients,and the target lesions are often almost invisible with white light endoscopy.Therefore excellent quality preparation is required to find these lesions and to apply advanced methods such as chromoendoscopy.Bowel preparation for patients with lower gastrointestinal bleeding represents a challenge,and the strategies available are also reviewed here. | Adolfo Parra-Blanco Alex Ruiz Manuel Alvarez-Lobos Ana Amorós Juan Cristóbal Gana Patricio Ibáez Akiko Ono Takahiro Fujii | 2014 | World Journal of Gastroenterology2014，20，47： | 37 |
| 2 | Prospective controlled study on the effects of polyethylene glycol in capsule endoscopy显示文摘AIM:To prospectively confirm whether a small amount of polyethylene glycol(PEG)ingested after swallowing endoscopy capsule improves image quality and completion rate.METHODS:Forty-four consecutive patients referred to us for capsule endoscopy(CE)were randomized to two groups.All patients were restricted to clear fluids for 12 h before the examination.Patients in group A(22 cases)received no additional preparation,while those in group B(20 cases)ingested 500 mL of PEG within a 2 h period starting 30 min after swallowing the capsule.Clear fluids and meals were allowed 2 h and 4 h after capsule ingestion,respectively.Image quality was assessed as the percentage of visualized bowel surface area as follows:1:<25%;2:25%-49%;3:50%-74%;4:75%-89%;5:>90%.The small bowel record was divided into five segments by time,and the score for each segment was evaluated.All CE examinations were performed with the Pillcam SB capsule endoscopy sys-tem(Given Imaging Co.Ltd.,Yoqnem).RESULTS:This study ended in December 2009,because sample size was considered large enough.A total of 44 patients were enrolled.Two patients in group B were excluded from the analysis because small bowel images could not be obtained from these patients;one had a full stomach,while the other presented with a massive gastric bleed.Thus,22 patients from group A and 20 patients from group B completed the study.There was no significant difference in age(P=0.22),sex(P=0.31),and indication for CE.No significant adverse events occurred in any of the study patients.In group A,image quality deteriorated as the capsule progressed distally.However,in group B,image quality was maintained to the distal small bowel.In each of the five segments,the visibility score was significantly higher in group B than in group A(segment 1:4.3± 0.7vs 4.7±0.5,P=0.03;segment 2:4.2±0.9vs 4.8 ±0.4,P=0.01;segment 3:4.0±1.0 vs 4.6±0.7,P =0.04;segment 4:3.6±1.1 vs 4.5±0.6,P=0.003;segment 5:2.7±1.0vs 4.4±0.8,P=0.00004).Thus,the use of PEG during CE examination significantly improved image quality in all time segments,and this effect was more pronounced in the distal ileum.The completion rate to the cecum was not significantly different between groups A and B(81.8%vs 85.0%,P =0.89).There was no difference in the gastric transit time between groups(36.2±35.0 min vs 54.0±56.6 min,P=0.23),but the small bowel transit time was significantly longer in group A than in group B(246.0± 107.0 minvs 171.0±104.0 min,P=0.04).CONCLUSION:The ingestion of a small amount of PEG after the swallowing of an endoscopy capsule significantly improved CE image quality,but did not enhance the completion rate to the cecum. | Takafumi Ito Ken Ohata Akiko Ono Hideyuki Chiba Yosuke Tsuji Hajime Sato Nobuyuki Matsuhashi | 2012 | World Journal of Gastroenterology2012，18，15： | 7 |
| 3 | Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case report显示文摘The anti-arrhythmic agent amiodarone (AD) is associated with numerous adverse effects, but serious liver disease is rare. The improved safety of administration of daily low doses of AD has already been established and this regimen is used for long-term medication. Nevertheless,asymptomatic continuous liver injury by AD may increase the risk of step-wise progression of non-alcoholic fatty liver disease. We present an autopsy case of AD-induced liver cirrhosis in a patient who had been treated with a low dose of AD (200 mg/d) daily for 84 mo. The patient was a 85-year-old male with a history of ischemic heart disease.Seven years after initiation of treatment with AD, he was admitted with cardiac congestion. The total dose of AD was 528 g. Mild elevation of serum aminotransferase and hepatomegaly were present. Liver biopsy specimens revealed cirrhosis, and under electron microscopy numerous lysosomes with electron-dense, whorled, lamellar inclusions characteristic of a secondary phospholipidosis were observed. Initially, withdrawal of AD led to a slight improvement of serum aminotransferase levels, but unfortunately his general condition deteriorated and he died from complications of pneumonia and renal failure.Long-term administration of daily low doses of AD carries the risk of progression to irreversible liver injury. Therefore,periodic examination of liver function and/or liver biopsy is required for the management of patients receiving long-term treatment with AD. | Hiroki Oikawa Chihaya Maesawa Ryo Sato Kanta Oikawa Hiroyuki Yamada Seizo Oriso Sadahide Ono Akiko Yashima-Abo Koji Kotani Kazuyuki Suzuki Tomoyuki Masuda | 2005 | World Journal of Gastroenterology2005，11，34： | 4 |
| 4 | Size does not determine the grade of malignancy of early invasive colorectal cancer显示文摘AIM:To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers(EI-CRCs),and to determine whether malignancy grade depends on size.METHODS:A total of 583 consecutive EI-CRCs treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study.Lesions were classified into two groups based on size:small(≤10mm) and large(>10mm).Clinicopathological features,incidence of lymph node metastasis(LNM) and risk factors for LNM,such as depth of invasion,lymphovascular invasion(LVI) and poorly differentiated adenocarcinoma(PDA) were analyzed in all resected specimens.RESULTS:There were 120(21%) small and 463(79%) large lesions.Histopathological analysis of the small lesion group revealed submucosal deep cancer(sm:≥1000 μm) in 90(75%) cases,LVI in 26(22%) cases,and PDA in 12(10%) cases.Similarly,the large lesion group exhibited submucosal deep cancer in 380(82%) cases,LVI in 125(27%) cases,and PDA in 79(17%) cases.The rate of LNM was 11.2% and 12.1% in the small and large lesion groups,respectively.CONCLUSION:Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer. | Takahisa Matsuda Yutaka Saito Takahiro Fujii Toshio Uraoka Takeshi Nakajima Nozomu Kobayashi Fabian Emura Akiko Ono Tadakazu Shimoda Hiroaki Ikematsu Kuang-I Fu Yasushi Sano Takahiro Fujimori | 2009 | World Journal of Gastroenterology2009，15，22： | 4 |
| 5 | Colorectal endoscopic submucosal dissection: T echnical advantages compared to endoscopic mucosal resection and minimally invasive surgery显示文摘 | Yutaka Saito Masayoshi Yamada Eriko So Seiichiro Abe Taku Sakamoto Takeshi Nakajima Yosuke Otake Akiko Ono Takahisa Matsuda | 2014 | Digestive Endoscopy2014，，： | 2 |
| 6 | Endoscopic submucosal resection of rectal carcinoid tumors with a ligation device显示文摘 | Akiko Ono Takahiro Fujii Yutaka Saito Takahisa Matsuda Daniel T.Y. Lee Takuji Gotoda Daizo Saito | 2003 | Gastrointestinal Endoscopy2003，，4： | 2 |
| 7 | Vaccination with multiple antigen peptide as rejection antigen peptide in murine leukemia显示文摘 | Akira Manki Toshiro Ono Akiko Uenaka | 1998 | Cancer Res1998，58，： | 1 |
| 8 | Dominant human papillomavirus 16 infection in cervical neoplasia in young Japanese women; study of 881 outpatients显示文摘 | Nobuo Masumoto Takuma Fujii Mitsuya Ishikawa Makio Mukai Akiko Ono Takashi Iwata Kaneyuki Kubushiro Shiro Nozawa | 2004 | Gynecologic Oncology2004，，2： | 1 |
| 9 | Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA显示文摘 | Daiju Iwata Mizuki Kitamura Nobuyoshi Kitaichi Yoshinari Saito Shigeyuki Kon Kenichi Namba Junko Morimoto Akiko Ebihara Hirokuni Kitamei Kazuhiko Yoshida Susumu Ishida Shigeaki Ohno Toshimitsu Uede Kazunori Onoé Kazuya Iwabuchi | 2009 | Experimental Eye Research2009，，1： | 1 |
| 10 | Drug interaction between voriconazole and tacrolimus and its association with the bioavailability of oral voriconazole in recipients of allogeneic hematopoietic stem cell transplantation显示文摘 | Takehiko Mori Jun Kato Akiko Yamane Masatoshi Sakurai Sumiko Kohashi Taku Kikuchi Yukako Ono Shinichiro Okamoto | 2012 | International Journal of Hematology2012，，5： | 1 |
| 11 | Factors affecting the long-term stability of orthodontic mini-implants显示文摘 | Mitsuru Motoyoshi Miwa Uemura Akiko Ono Kumiko Okazaki Toru Shigeeda Noriyoshi Shimizu | 2010 | American Journal of Orthodontics & Dentofacial Orthopedics2010，，5： | 1 |
| 12 | A novel endoscopic suturing technique using a specially designed so-called “8-ring” in combination with resolution clips (with videos) 显示文摘 | Takahiro Fujii Akiko Ono Kuang-I Fu | 2007 | Gastrointestinal Endoscopy2007，，6： | 1 |
| 13 | Promotion of metal accumulation in nodule of Astragalus sinicus by the expression of the Iron-regulated Transporter Gene in Mesorhizobium huakuii subsp, rengei B3显示文摘 | AKIKO IKE RUTCHADAPORN SPIPRANG HISAYO ONO | 2008 | Journal of bioscience and bioengineering The Society for Biotechnology Japan2008，105，6： | 1 |
| 14 | A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers显示文摘 | Yoshihiro Kamada Masafumi Ono Hideyuki Hyogo Hideki Fujii Yoshio Sumida Kojiroh Mori Saiyu Tanaka Makoto Yamada Maaya Akita Kayo Mizutani Hironobu Fujii Akiko Yamamoto Shinji Takamatsu Yuichi Yoshida Yoshito Itoh Norifumi Kawada Kazuaki Chayama Toshiji Sa | 2015 | Hepatology2015，，5： | 1 |
| 15 | Endoscopic submucosal resection of rectal carcinoid tumors with a ligation device显示文摘 | Akiko Ono Takahiro Fujii Yutaka Saito Takahisa Matsuda Daniel T.Y. Lee Takuji Gotoda Daizo Saito | 2003 | Gastrointestinal Endoscopy2003，，4： | 1 |
| 16 | The clinical characteristics and outcome of intraabdominal abscess in Crohn’s disease显示文摘 | Akiko Yamaguchi Toshiyuki Matsui Toshihiro Sakurai Toshiharu Ueki Shoichi Nakabayashi Tsuneyoshi Yao Kitaro Futami Sumitaka Arima Hiroyuki Ono | 2004 | Journal of Gastroenterology2004，，5： | 1 |
| 17 | Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients显示文摘 | Masako Ohno Akiko Yamamoto Ayumu Ono Genta Miura Masanobu Funamoto Yasuhiko Takemoto Kinya Otsu Yasushi Kouno Tomoko Tanabe Yuiko Masunaga Shinpei Nonen Yasushi Fujio Junichi Azuma | 2009 | European Journal of Clinical Pharmacology2009，，11： | 1 |
| 18 | Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients显示文摘 | Masako Ohno Akiko Yamamoto Ayumu Ono Genta Miura Masanobu Funamoto Yasuhiko Takemoto Kinya Otsu Yasushi Kouno Tomoko Tanabe Yuiko Masunaga Shinpei Nonen Yasushi Fujio Junichi Azuma | 2009 | European Journal of Clinical Pharmacology2009，，11： | 1 |
| 19 | Betaine and homocysteine concentrations in infant formulae and breast milk显示文摘 | AKIKO SAKAMOTO HIROAKI ONO NOBUYKI MIZOGUCHI | 2001 | Pediatrics International2001，43，： | 1 |
| 20 | The C677T mutation in the methylenetetrahydrofolate reductase gene contributes to hyperhomocysteinemia in patients taking anticonvulsants显示文摘 | Hiroaki Ono Akiko Sakamoto Nobuyuki Mizoguchi Nobuo Sakura | 2002 | Brain and Development2002，，4： | 1 |
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