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| 1 | Risk factors for bleeding after endoscopic submucosal dissection of colorectal neoplasms显示文摘AIM:To investigate the risk factors for delayed bleeding following endoscopic submucosal dissection(ESD)treatment for colorectal neoplasms.METHODS:We retrospectively reviewed the medical records of 317 consecutive patients with 325 lesions who underwent ESD for superficial colorectal neoplasms at our hospital from January 2009 to June2013.Delayed post-ESD bleeding was defined as bleeding that resulted in overt hematochezia 6 h to 30d after ESD and the observation of bleeding spots as confirmed by repeat colonoscopy or a required blood transfusion.We analyzed the relationship between risk factors for delayed bleeding following ESD and the following factors using univariate and multivariate analyses:age,gender,presence of comorbidities,use of antithrombotic drugs,use of intravenous heparin,resected specimen size,lesion size,lesion location,lesion morphology,lesion histology,the device used,procedure time,and the presence of significant bleeding during ESD.RESULTS:Delayed post-ESD bleeding was found in14 lesions from 14 patients(4.3%of all specimens,4.4%patients).Patients with episodes of delayed postESD bleeding had a mean hemoglobin decrease of2.35 g/dL.All episodes were treated successfully using endoscopic hemostatic clips.Emergency surgery was not required in any of the cases.Blood transfusion was needed in 1 patient(0.3%).Univariate analysis revealed that lesions located in the cecum(P=0.012)and the presence of significant bleeding during ESD(P=0.024)were significantly associated with delayed post-ESD bleeding.The risk of delayed bleeding was higher for larger lesion sizes,but this trend was not statistically significant.Multivariate analysis revealed that lesions located in the cecum(OR=7.26,95%CI:1.99-26.55,P=0.003)and the presence of significant bleeding during ESD(OR=16.41,95%CI:2.60-103.68,P=0.003)were independent risk factors for delayed post-ESD bleeding.CONCLUSION:Location in the cecum and significant bleeding during ESD predispose patients to delayed post-procedural bleeding.Therefore,careful and additional management is recommended for these patients. | Sho Suzuki Akiko Chino Teruhito Kishihara Naoyuki Uragami Yoshiro Tamegai Takanori Suganuma Junko Fujisaki Masaaki Matsuura Takao Itoi Takuji Gotoda Masahiro Igarashi Fuminori Moriyasu | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | Prediction of lymph node metastasis and sentinel node navigation surgery for patients with early-stage gastric cancer显示文摘Accurate prediction of lymph node(LN) status is crucially important for appropriate treatment planning in patients with early gastric cancer(EGC). However,consensus on patient and tumor characteristics associated with LN metastasis are yet to be reached. Through systematic search,we identified several independent variables associated with LN metastasis in EGC,which should be included in future research to assess which of these variables remain as significant predictors of LN metastasis. On the other hand,even if we use these promising parameters,we should realize the limitation and the difficulty of predicting LN metastasis accurately. The sentinel LN(SLN) is defined as first possible site to receive cancer cells along the route of lymphatic drainage from the primary tumor. The absence of metastasis in SLN is believed to correlate with the absence of metastasis in downstream LNs. In this review,we have attempted to focus on several independent parameters which have close relationship between tumor and LN metastasis in EGC. In addition,we evaluated the history of sentinel node navigation surgery and the usefulness for EGC. | Atsuo Shida Norio Mitsumori Hiroshi Nimura Yuta Takano Taizou Iwasaki Muneharu Fujisaki Naoto Takahashi Katsuhiko Yanaga | 2016 | World Journal of Gastroenterology2016，22，33： | 13 |
| 3 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 6 |
| 4 | Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer显示文摘 | Toshiaki Hirasawa Takuji Gotoda Satoshi Miyata You Kato Tadakazu Shimoda Hirokazu Taniguchi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2009 | Gastric Cancer2009，，3： | 5 |
| 5 | Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer显示文摘 | Toshiaki Hirasawa Takuji Gotoda Satoshi Miyata You Kato Tadakazu Shimoda Hirokazu Taniguchi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2009 | Gastric Cancer2009，，3： | 3 |
| 6 | A multicenter retrospective study of endoscopic resection for early gastric cancer显示文摘 | Ichiro Oda Daizo Saito Masahiro Tada Hiroyasu Iishi Satoshi Tanabe Tsuneo Oyama Toshihiko Doi Yoshihide Otani Junko Fujisaki Yoichi Ajioka Tsutomu Hamada Haruhiro Inoue Takuji Gotoda Shigeaki Yoshida | 2006 | Gastric Cancer2006，，4： | 3 |
| 7 | Laparoscopic-endoscopic cooperative surgery for duodenal tumors: a unique procedure that helps ensure the safety of endoscopic submucosal dissection显示文摘 | Tomoyuki Irino Souya Nunobe Naoki Hiki Yorimasa Yamamoto Toshiaki Hirasawa Manabu Ohashi Junko Fujisaki Takeshi Sano Toshiharu Yamaguchi | 2014 | Endoscopy2014，，： | 2 |
| 8 | Clinical problems with antithrombotic therapy for endoscopic submucosal dissection for gastric neoplasms显示文摘Endoscopic submucosal dissection(ESD) is minimally invasive and thus has become a widely accepted treatment for gastric neoplasms,particularly for patients with comorbidities.Antithrombotic agents are used to prevent thrombotic events in patients with comorbidities such as cardio-cerebrovascular diseases and atrial fibrillation.With appropriate cessation,antithrombotic therapy does not increase delayed bleeding in low thrombosis-risk patients.However,high thrombosisrisk patients are often treated with combination therapy with antithrombotic agents and occasionally require the continuation of antithrombotic agents or heparin bridge therapy(HBT) in the perioperative period.Dual antiplatelet therapy(DAPT),a representative combination therapy,is frequently used after placement of drug-eluting stents and has a high risk of delayed bleeding.In patients receiving DAPT,gastric ESD may be postponed until DAPT is no longer required.HBT is often required for patients treated with anticoagulants and has an extremely high bleeding risk.The continuous use of warfarin or direct oral anticoagulants may be possible alternatives.Here,we show that some antithrombotic therapies in high thrombosis-risk patients increase delayed bleeding after gastric ESD,whereas most antithrombotic therapies do not.The management of high thrombosis-risk patients is crucial for improved outcomes. | Toshiyuki Yoshio Tsutomu Nishida Yoshito Hayashi Hideki Iijima Masahiko Tsujii Junko Fujisaki Tetsuo Takehara | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 9 | Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration显示文摘 | Dongsu Park Joel A. Spencer Bong Ihn Koh Tatsuya Kobayashi Joji Fujisaki Thomas L. Clemens Charles P. Lin Henry M. Kronenberg David T. Scadden | 2012 | Cell Stem Cell2012，，3： | 2 |
| 10 | Water Striders:The Biomechanics of Water Locomotion and Functional Morphology of the Hydrophobic Surface(Insecta:Hemiptera-Heteroptera)显示文摘Water striders are insects living on the water surface,over which they can move very quickly and rarely get wetted.We measured the force of free walking in water striders,using a hair attached to their backs and a 3D strain gauge.The error was calculated by comparing force and data derived from geometry and was estimated as 13%.Females on average were stronger(1.32 mN) than males(0.87 mN),however,the ratio of force to weight was not significantly different.Compared with other lighter species,Aquarius paludum seems stronger,but the ratio of force to weight is actually lower.A.paludum applies about 0.3 mN·cm-1 to 0.4 mN·cm-1 with its mid-legs,thus avoiding penetrating the surface tension layer while propelling itself rapidly over the water surface.We also investigated the external morphology with SEM.The body is covered by effectively two layers of macro-and micro-hairs,which renders them hydrophobic.The setae are long(40 μm-60 μm) and stiff,being responsible for waterproofing,and the microtrichia are much smaller(<10 μm),slender,and flexible,holding a bubble over the body when submerged. | P. J. Perez Goodwynj Jin-tong Wang Zhou-ji Wang Ai-hong Ji Zhen-dong Dai K. Fujisaki | 2008 | Journal of Bionic Engineering2008，5，2： | 2 |
| 11 | Indirect inguinal hernia containing portosystemic shunt vessel: A case report显示文摘BACKGROUND Inguinal hernia repair is one of the most common general surgical operations worldwide.We present a case of indirect inguinal hernia containing an expanded portosystemic shunt vessel.CASE SUMMARY We report a 72-year-old man who had a 4 cm×4 cm swelling in the right inguinal region,which disappeared with light manual pressure.Abdominal-pelvic computed tomography(CT)revealed a right inguinal hernia containing an expanded portosystemic shunt vessel,which had been noted for 7 years due to liver cirrhosis.We performed Lichtenstein’s herniorrhaphy and identified the hernia sac as being indirect and the shunt vessel existing in the extraperitoneal cavity through the internal inguinal ring.Then,we found two short branches between the expanded shunt vessel and testicular vein in the middle part of the inguinal canal and cut these branches to allow the shunt vessel to return to the extraperitoneal cavity of the abdomen.The hernia sac was returned as well.We encountered no intraoperative complications.After discharge,groin seroma requiring puncture at the outpatient clinic was observed.CONCLUSION If an inguinal hernia patient has portal hypertension,ultrasound should be used to determine the contents of the hernia.When atypical vessels are visualized,they may be shunt vessels and additional CT is recommended to ensure the selection of an adequate approach for safe hernia repair. | Masahiro Yura Kikuo Yo Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki AkiraHirata Kiminori Takano Kumiko Hongo Kimiyasu Yoneyama Motohito Nakagawa | 2021 | World Journal of Clinical Cases2021，9，2： | 2 |
| 12 | Relationship between jejunal interdigestive migrating motor complex and quality of life after total gastrectomy with Roux-en-Y reconstruction for early gastric cancer 显示文摘 | Tomita R Fujisaki S Tanjoh K | 2003 | WorldJ Surg2003，10，： | 2 |
| 13 | Clinical characterization of gastric lesions initially diagnosed as low‐grade adenomas on forceps biopsy显示文摘 | Akiyoshi Kasuga Yorimasa Yamamoto Junko Fujisaki Kazuhisa Okada Masami Omae Akiyoshi Ishiyama Toshiaki Hirasawa Akiko Chino Tomohiro Tsuchida Masahiro Igarashi Etsuo Hoshino Noriko Yamamoto Minoru Kawaguchi Rikiya Fujita | 2012 | Digestive Endoscopy2012，，5： | 2 |
| 14 | Long-term outcomes of endoscopic submucosal dissection for undifferentiated-type early gastric cancer显示文摘 | K. Okada J. Fujisaki T. Yoshida H. Ishikawa T. Suganuma A. Kasuga M. Omae M. Kubota A. Ishiyama T. Hirasawa A. Chino M. Inamori Y. Yamamoto N. Yamamoto T. Tsuchida Y. Tamegai A. Nakajima E. Hoshino M. Igarashi | 2012 | Endoscopy2012，，02： | 2 |
| 15 | Therapeutic outcomes of endoscopic resection for superficial non‐ampullary duodenal tumor显示文摘 | Yorimasa Yamamoto Natsuko Yoshizawa Hideomi Tomida Junko Fujisaki Masahiro Igarashi | 2014 | Digestive Endoscopy2014，，： | 2 |
| 16 | Operative technique on nearly today gastrectomy reconstructed by interposition of a jejunal J pouch with preservation of vagal nerve, lower esophageal sphincter, and pyloric sphincter for early gastric cancer 显示文摘 | Tomita R Fujisaki S Tanjoh K | 2001 | World J Surg2001，25，12： | 1 |
| 17 | Responsiveness of Free Surface Flow to MEMS Exciting Frequency 显示文摘 | Sato S Fujisaki K | 2005 | IEEE Transactions on Magnetics2005，41，10： | 1 |
| 18 | Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain- CoA acytransferase that functions in taxol biosynthesis 显示文摘 | Walker K Fujisaki S Long R M | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 19 | Diagnosis of undifferentiated type early gastric cancers by magni- fication endoscopy with narrow-hand imaging 显示文摘 | OKADA K FUJISAKI J KASUGA A | 2011 | J Gastroenterol Hepatol2011，26，： | 1 |
| 20 | Dimerization of the Polycomb-group protein Mel-18 is regulated by PKC phosphorylation 显示文摘 | Fujisaki S Ninomiya Y Ishihara H | 2003 | Biochem Biophys Res Commun2003，300，1： | 1 |
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