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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma显示文摘AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC. | Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 29 |
| 3 | QTLs for Sugar Content of Stalk in Sweet Sorghum(Sorghum bicolor L.Moench)显示文摘High sugar content of sorghum stalk is an important factor in the sorghum silage production. To identify the genomic regions controlling sugar content and to develop molecular markers linked to sugar content in sweet sorghum, we used an F2:3 segregating population consisting of 207 individuals derived from a cross between a high sugar content inbred line, Early Folger, and a normal inbred line, N32B, for genetic linkage mapping and quantitative trait locus (QTL) analysis. We constructed a genetic linkage map spanning 983.5 cM based on a total of 327 markers comprising 31 restriction fragment length polymorphism (RFLP) markers, 254 amplified fragment length polymorphism (AFLP) markers, and 42 simple sequence repeat (SSR) markers. In the 20 linkage groups detected, 98.2% of markers aligned to the 10 linkage groups of sorghum. Variations in sugar content at different growth stages and among internodes suggested that the sugar content of middle internodes is stable and suitable for measuring at early dough stage. The broad sense heritability (hB2) of sugar content was 0.64 and 0.62 estimated from the data of F3 families and each parent in 2003 and 2004. We identified one and two QTLs accounting for 22.2 to 25.0% of phenotypic variance using simple interval mapping method in 2003 and 2004, respectively. These two QTLs showed a negative additive effect, and over-dominance effect. A QTL on LG-D was detected in both two years. Above results will be help us to understand the genetic mechanism of sugar content in sorghum and the QTL detected in this study might be useful in the improvement of sugar content by marker-assisted selection. | BIAN Yun-long Yazaki Seiji Inoue Maiko CAI Hong-wei | 2006 | Agricultural Sciences in China2006，5，10： | 24 |
| 4 | New Technologies and Systems for High Quality Citrus Fruit Production, Labor-saving and Orchard Construction in Mountain Areas of Japan显示文摘Novel technologies have been necessary for improving fruit quality and productivity of citrus, labor-saving and orchard conservation on steep slope lands since aging of growers and decrease in the number of successors is remarkable in mountain areas of southwestern Japan. The purpose of this paper is to introduce new technologies for improving citrus production that have been developed in recent years. A new fruit quality control system using drip irrigation and liquid fertilization technique combined with year-round plastic mulching was developed, and it enables high quality and stable citrus fruit production. Water and/or nutrient solution is automatically supplied through drip tubes that are laid under the mulching sheets to give adequate water stress, so as to improve sugar and acid content of fruit. A new transportation system for steep sloping citrus orchards, which is a combination of the monorail system and contour narrow paths, was suggested. A small walking cultivator was developed to explain the procedure of narrow path excavation. After introducing the narrow path, working hours for fertilizer and chemical herbicide application were reduced. Disaster prevention mapping of citrus orchards on slope lands was developed based on computer-aided seepage estimation and topographic data. The mapping can show zones of both ascending flow and descending flow of underground water during heavy rains in citrus orchards. The mapping is considered to be effective for the management of orchards and prevention of erosion on slope lands. | Kunihisa MORINAGA Osamu SUMIKAWA Osamu KAWAMOTO Hiroyasu YOSHIKAWA Seiji NAKAO Masahiko SHIMAZAKI Shin-no-suke KUSABA Norihiro HOSHI | 2005 | Journal of Mountain Science2005，2，1： | 21 |
| 5 | Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer显示文摘AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain reaction (PCR). Eighty patients were divided into 3 groups; Group A (n=35):the depth of cancer invasion was less than the muscularis propria; Group B (n=31): the depth of cancer invasion was beyond the muscularis propria. Both group A and B were diagnosed as no cancer cells in peritoneal cytology and histology; Group C (n=14): disseminated nodule was histologically diagnosed or cancer cells were cytologically defi ned in the peritoneal cavity.RESULTS: The positive rates of methylation in CHFR, E-cadherin and BNIP3 were significantly different among the 3 groups and increased in order of group A, B and C (0%,0% and 21% in CHFR, P<0.05; 20%, 45% and 50% in E-cadherin, P<0.05;26%,35% and 71% in BNIP3, P<0.05). In addition, the multigene methylation rate among CHFR, E-cadherin and BNIP3 was correlated with group A, B and C (9%,19% and 57%, P<0.001). Moreover, the prognosis was analyzed in group B, excluding 3 patients who underwent a non-curative resection. Two of the 5 patients with multigene methylation showed peritoneal recurrence after surgery, while those without or with a single gene methylation did not experience recurrence (P<0.05).CONCLUSION: This study suggested that gene methylation in the PF could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis. | Masatsugu Hiraki Yoshihiko Kitajima Seiji Sato Jun Nakamura Kazuyoshi Hashiguchi Hirokazu Noshiro Kohji Miyazaki | 2010 | World Journal of Gastroenterology2010，16，3： | 20 |
| 6 | 奥斯特/GPS掩星与地面雷达联合观测电离层电子密度的初步结果显示文摘1999年2月丹麦发射了一颗奥斯特小卫星,它装载了两台GPS接收机,其中一台用于电离层和中性大气掩星测量,另一台用于自主定位。本文给出了1999年10月奥斯特/GPS掩星与日本MU雷达和数字测高仪的联合观测结果。奥斯特掩星反演得到的电子密度剖面与地面雷达观测的进行了比较,结果表明:天基和地基雷达观测的电子密度是一致的。文章还给出利用GPS的单频信号反演电离层电子密度剖面技术和3维射线追踪技术模拟掩星结果。 | 张训械 P.Hoeg G.B.Larsen Stig Syndergaard Martin B.S Jakob G.R S.Fukao Kiyoshi lgarashi Seiji Kawamura | 2000 | 全球定位系统2000，25，3： | 18 |
| 7 | Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid显示文摘背景:Methylmalonic 酸尿(MMA ) 是在中国的器官的酸尿的最经常的疾病。各种各样的生物化学的策略为 MMA 的出生前的诊断被跟随。然而,后来, MMA 影响的胎儿减少了 methylmalonic 酸的排泄,出生前的生物化学的诊断的困难是明显的。煤气的层析团分光术(GC/MS ) 和双人脚踏车团分光术(ESI/MS/MS ) 允许我们在影响胎儿识别疾病。这研究的目的是在 MMA 的出生前的诊断在羊膜的液体决定有机酸和全部的人半胱氨酸的分析的价值。方法:临床诊断并且有 MMA 的九个职业人员乐队的结果并且出生前在风险基于九个胎儿的生物化学的分析诊断因为 MMA 被调查。从在为 MMA 的风险的怀孕和新陈代谢的联盟者正常怀孕的羊膜的液体样品在 16 点被获得 - 24 星期怀孕期。Methylmalonic 酸和甲基枸橼酸被 GC/MS 测量, propionylcarnitine 被 ESI/MS/MS 分析,并且全部的人半胱氨酸由荧光极化免疫分析是坚定的。结果:在二怀孕, methylmalonic 酸的高水平,甲基枸橼酸, propionylcarnitine,和总数,人半胱氨酸在胎儿显示了联合 MMA 和 homocysteinemia。继续的怀孕和收到的维生素 B12 作为出生前的处理,和其它补充的母亲之一终止了她的怀孕。在一个,怀孕, methylmalonic 酸的显著地提高的层次,甲基枸橼酸,和 propionylcarnitine,和正常全部的人半胱氨酸铺平被发现在胎儿显示孤立的 MMA;流产在这个案例上被执行。在另外的六怀孕,上述提及的代谢物的所有层次是正常的建议胎儿没被 MMA 影响。diagnoses 被严峻的尿有机酸和血浆总数人半胱氨酸在交货以后证实。结论:MMA 的新陈代谢的畸形在怀孕期早发生。在羊膜的液体的全部的人半胱氨酸的水平可以是胎儿的联合 MMA 和 homocysteinemia 的另外的指示物。在羊膜的液体的全部的人半胱氨酸水平的决心可以为疾病的出生前的诊断成为一个方便、可靠的方法。 | ZHANG Yao YANG Yan-ling HASEGAWA Yuki YAMAGUCHI Seiji SHI Chun-yan SONG Jin-qing SAYAMI Sujan LIU Ping YAN Rong DONG Jin-hua QIN Jiong | 2008 | Chinese Medical Journal2008，，3： | 18 |
| 8 | Progress in numerical simulation of cavitating water jets显示文摘This paper reviews recent progress made toward modeling of cavitation and numerical simulation of cavitating water jets. Properties of existing cavitation models are discussed and a compressible mixture flow method for the numerical simulation of highspeed water jets accompanied by intensive cavitation is introduced. Two-phase fluids media of cavitating flow are treated as a homogeneous bubbly mixture and the mean flow is computed by solving Reynolds-Averaged Navier-Stokes (RANS) equations for compressible fluid. The intensity of cavitation is evaluated by the gas volume fraction, which is governed by the compressibility of bubble-liquid mixture corresponding to the status of mean flow field. Numerical results of cavitating water jet issuing from an orifice nozzle are presented and its applicability to intensively cavitating jets is demonstrated. However, the effect of impact pressure caused by collapsing of bubbles is neglected, and effectively coupling of the present compressible mixture flow method with the dynamics of bubbles remains to be a challenge. | PENG Guoyi SHIMIZU Seiji | 2013 | Journal of Hydrodynamics2013，25，4： | 16 |
| 9 | 大功率光纤激光焊熔池形态及焊接稳定性分析显示文摘在大功率光纤激光焊接过程中,熔池热辐射含有丰富的焊接质量信息,熔池形态及其变化特征与焊接稳定性密切相关.研究一种基于红外热像的大功率光纤激光深熔焊熔池形态分析及焊缝质量稳定性评价的方法.以10 kW大功率光纤连续激光焊接304不锈钢为试验对象,应用近红外传感高速摄像机摄取熔池动态热像,通过动态自动阈值和数学形态学方法重点分析熔池和匙孔形态以及对应的焊缝宽度变化,以熔池宽度、匙孔面积和匙孔宽度作为熔池形态参数,焊缝宽度作为衡量焊接过程稳定性的参数,研究熔池形态参数与焊接稳定性的关联.结果表明,通过熔池形态参数能够较准确地反映大功率光纤激光焊接过程的稳定性. | 高向东 张勇 游德勇 Katayama Seiji | 2011 | 焊接学报2011，32，9： | 16 |
| 10 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 11 | 大功率盘形激光焊飞溅特征分析显示文摘焊接过程的在线监控是保证激光焊接质量的关键,为此,首先要找到焊接过程传感特征量变化规律以及与焊缝质量间的关系.飞溅是大功率盘型激光焊接过程中的一个重要现象,其特征与焊接质量、焊接过程稳定性以及能量利用率等有着密切的联系.以大功率盘形激光焊接304不锈钢为试验对象,研究焊接过程中的飞溅特征.在紫外波段和可见光波段应用高速摄像机摄取焊接过程中产生飞溅的瞬态特征,通过计算机图像处理技术分析飞溅的数量、面积、行程和质心高度特征参量.以焊件熔宽作为衡量焊接质量与焊接过程稳定性的因素,对飞溅特征量进行线性和高次拟合,研究飞溅特征参量的波动规律,并与焊件熔宽的变化对比,探索焊接过程的飞溅特征参量变化规律.试验结果表明,根据飞溅特征量变化规律能够对大功率盘形激光焊接304不锈钢板焊接质量做出动态评估,为实现焊接质量的在线监控提供了试验依据. | 高向东 龙观富 汪润林 Katayama Seiji | 2012 | 物理学报2012，61，9： | 15 |
| 12 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 13 | Differential diagnosis of benign and malignant branch duct intraductal papillary mucinous neoplasm using contrastenhanced endoscopic ultrasonography显示文摘AIM: To elucidate the role of contrast-enhanced endoscopic ultrasonography(CE-EUS) in the diagnosis of branch duct intraductal papillary mucinous neoplasm(BD-IPMN).METHODS: A total of 50 patients diagnosed with BDIPMN by computed tomography(CT) and endoscopic ultrasonography(EUS) at our institute were included in this study. CE-EUS was performed when mural lesions were detected by EUS. The diagnostic accuracy for identifying mural nodules(MNs) was evaluated by CT, EUS, and EUS combined with CE-EUS. In the patients who underwent resection, the accuracy of measuring MN height with each imaging modality was compared. The cut-off values to diagnose malignant BD-IPMNs based on MN height for each imaging modality were determined using receiver operating characteristic curve analysis.RESULTS: Fifteen patients were diagnosed with BD-IPMN with MNs and underwent resection. The remaining 35 patients were diagnosed with BD-IPMN without MNs and underwent follow-up monitoring. The pathological findings revealed 14 cases with MNs and one case without. The accuracy for diagnosing MNs was 92% using CT and 72% using EUS; the diagnostic accuracy increased to 98% when EUS and CE-EUS were combined. The accuracy for measuring MN height significantly improved when using CE-EUS compared with using CT or EUS(median measurement error value, CT: 3.3 mm vs CE-EUS: 0.6 mm, P < 0.05; EUS: 2.1 mm vs CE-EUS: 0.6 mm, P < 0.01). A cut-off value of 8.8 mm for MN height as measured by CE-EUS improved the accuracy of diagnosing malignant BDIPMN to 93%. CONCLUSION: Using CE-EUS to measure MN height provides a highly accurate method for differentiating benign from malignant BD-IPMN. | Hirofumi Harima Seiji Kaino Shuhei Shinoda Michitaka Kawano Shigeyuki Suenaga Isao Sakaida | 2015 | World Journal of Gastroenterology2015，21，20： | 12 |
| 14 | Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture显示文摘AIM:To investigate the usefulness of chromoendoscopy,using an acetic acid indigocarmine mixture(AIM),for gastric adenoma diagnosed by forceps biopsy.METHODS:A total of 54 lesions in 45 patients diagnosed as gastric adenoma by forceps biopsy were prospectively enrolled in this study and treated by endoscopic submucosal dissection(ESD)between January 2011 and January 2012.AIM-chromoendoscopy(AIMCE)was performed followed by ESD.AIM solution was sprinkled and images were recorded every 30 s for 3min.Clinical characteristics such as tumor size(<2cm,≥2 cm),surface color in white light endoscopy(WLE)(whitish,normochromic or reddish),macroscopic appearance(flat or elevated,depressed),and reddish change in AIM-CE were selected as valuables.RESULTS:En bloc resection was achieved in all 54 cases,with curative resection of fifty two lesions(96.3%).Twenty three lesions(42.6%)were diagnosed as welldifferentiated adenocarcinoma and the remaining 31lesions(57.4%)were gastric adenoma.All adenocarcinoma lesions were well-differentiated tubular adenocarcinomas and were restricted within the mucosal layer.The sensitivity of reddish color change in AIM-CE is significantly higher than that in WLE(vs tumor size≥2 cm,P=0.016,vs normochromic or reddish surface color,P=0.046,vs depressed macroscopic type,P=0.0030).On the other hand,no significant differences were found in the specificity and accuracy.In univariate analysis,normochromic or reddish surface color in WLE(OR=3.7,95%CI:1.2-12,P=0.022)and reddish change in AIM-CE(OR=14,95%CI:3.8-70,P<0.001)were significantly related to diagnosis of early gastric cancer(EGC).In multivariate analysis,only reddish change in AIM-CE(OR=11,95%CI:2.3-66,P=0.0022)was a significant factor associated with diagnosis of EGC.CONCLUSION:AIM-CE may have potential for screening EGC in patients initially diagnosed as gastric adenoma by forceps biopsy. | Yoshiyasu Kono Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Seiji Kawano Yasushi Yamasaki Koji Takemoto Takayoshi Miyake Shigeatsu Fujiki Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，17： | 12 |
| 15 | Immunotherapy for colorectal cancer显示文摘The incidence of colorectal cancer(CRC)is on the rise,and the prognosis for patients with recurrent or metastatic disease is extremely poor.Although chemotherapy and radiation therapy can improve survival rates,it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for patients with advanced CRC.In this review,we will discuss the effect of immunotherapy for inducing cytotoxic T lymphocytes and the major immunotherapeutic approaches for CRC that are currently in clinical trials,including peptide vaccines,dendritic cell-based cancer vaccines,whole tumor cell vaccines,viral vector-based cancer vaccines,adoptive cell transfer therapy,antibody-based cancer immunotherapy,and cytokine therapy.The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms. | Shigeo Koido Toshifumi Ohkusa Sadamu Homma Yoshihisa Namiki Kazuki Takakura Keisuke Saito Zensho Ito Hiroko Kobayashi Mikio Kajihara Kan Uchiyama Seiji Arihiro Hiroshi Arakawa Masato Okamoto Jianlin Gong Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 16 | Pathologic complete response confirmed by surgical resection for liver metastases of gastrointestinal stromal tumor after treatment with imatinib mesylate显示文摘A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor(GIST) . Computed tomography(CT) and magnetic resonance imaging(MRI) 107 mo after the operation,revealed a cystic mass(14 cm in diameter) and a solid mass(9 cm in diameter) in the right and left lobes of the liver,respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate(IM) treatment,400 mg/day orally. Following the IM treatment for a period of 35 mo,the patient underwent partial hepatectomy(S4 + S5) . The effect of IM on the metastatic lesions was interpreted as pathologic complete response(CR) . Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported. | Seiji Suzuki Koji Sasajima Masayuki Miyamoto Hidehiro Watanabe Tadashi Yokoyama Hiroshi Maruyama Takeshi Matsutani Aimin Liu Masaru Hosone Shotaro Maeda Takashi Tajiri | 2008 | World Journal of Gastroenterology2008，14，23： | 11 |
| 17 | 大功率光纤激光焊焊缝跟踪偏差测量新方法显示文摘针对大功率光纤激光焊,分析一种基于近红外图像识别的焊缝跟踪偏差测量新方法.通过高速摄像机获取动态熔池近红外图像序列,分析熔池近红外图像的灰度分布特性,利用图像灰度梯度提取熔池温度分布参数.该参数能够体现激光束偏离焊缝时熔池表面温度的变化特性.以熔池温度分布参数作为特征测量值,利用最小二乘法建立焊缝路径与激光束偏离的近红外视觉模型.结果表明,该模型能够准确地反映熔池温度分布参数与焊缝跟踪偏差之间的数学关系. | 高向东 游德勇 Katayama Seiji | 2011 | 焊接学报2011，32，5： | 11 |
| 18 | Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar显示文摘AIM: To survey the detailed analyses for Helicobacter pylori(H. pylori) infection and gastric mucosal status in Myanmar.METHODS: A total of 252 volunteers with dyspeptic symptoms(155 female and 97 male; mean age of 43.6 ± 14.2 years) was participated in Yangon and Mandalay. The status of H. pylori infection was determined based on 5 different tests including rapid urease test, culture, histology, immunohistochemistry and serology. Histological scores were evaluated according to the update Sydney system and the Operative Link for Gastritis Assessment system. Pepsinogen(PG)Ⅰand PG Ⅱ were measured using enzyme-linked immunosorbent assays.RESULTS: The overall prevalence of H. pylori infectionwas 48.0%. There was no relationship between age and infection rate. Even in young group(less than 29 years old), the H. pylori infection rate was relatively high(41.9%). The prevalence of H. pylori infection was significantly higher in Yangon than that of Mandalay. H. pylori infection was significantly associated with the presence of gastric mucosal atrophy. All 7 subjects with peptic ulcer were infected with H. pylori. Although H. pylori-positive subjects showed stronger gastritis than H. pylori-negative subjects, most cases had mild gastritis.CONCLUSION: We revealed the prevalence of H. pylori infection in patients with dyspeptic symptoms in Myanmar. The H. pylori infection was a risk factor for peptic ulcer and stronger gastritis. | Thein Myint Seiji Shiota Ratha-korn Vilaichone New Ni Than Than Aye Miyuki Matsuda Trang Thi Huyen Tran Tomohisa Uchida Varocha Mahachai Yoshio Yamaoka | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 19 | Numerical analysis of cavitation cloud shedding in a submerged water jet显示文摘Focused on the unsteady behavior of high-speed water jets with intensive cavitation a numerical analysis is performed by applying a practical compressible mixture flow bubble cavitation model with a simplified estimation of bubble radius. The mean flow of two-phase mixture is calculated by unsteady Reynolds averaged Navier-Stokes(URANS) for compressible flow and the intensity of cavitation in a local field is evaluated by the volume fraction of gas bubbles whose radius is estimated with a simplified RayleighPlesset equation according to pressure variation of the mean flow field. High-speed submerged water jet issuing from a sheathed sharp-edge orifice nozzle is treated. The periodically shedding of cavitation clouds is captured in a certain reliability compared to experiment data of visualization observation and the capability to capture the unsteadily shedding of cavitation clouds is demonstrated. The results demonstrate that cavitation takes place near the entrance of nozzle throat and cavitation cloud expands consequentially while flowing downstream. Developed bubble clouds break up near the nozzle exit and shed downstream periodically along the shear layer. Under the effect of cavitation bubbles the decay of core velocity is delayed compared to the case of no-cavitation jet. | Guoyi PENG 杨从新 Yasuyuki OGUMA Seiji SHIMIZU | 2016 | Journal of Hydrodynamics2016，28，6： | 10 |
| 20 | Low-grade myofibroblastic sarcoma of the palate显示文摘Low-grade myofibroblastic sarcoma(LGMS) is a rare,malignant tumor with myofibroblastic differentiation.Despite it being classified as a distinct entity by the World Health Organization,a few cases were reported in the oral and maxillofacial region.Here,a LGMS developed on the palate of a 73-year-old man who presented with a 1-cm tumor on the posterior border of the palate.Based on the histological and immunohistochemical features,a diagnosis of LGMS was established.The tumor was resected,and no recurrence was observed over 2 years.Although the tongue is the most preferred site for LGMS,it may occur in any region of the oral cavity. | Tomohiro Yamada Tomohide Yoshimura Naoya Kitamura Eri Sasabe Seiji Ohno Tetsuya Yamamoto | 2012 | International Journal of Oral Science2012，4，3： | 9 |
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