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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | 病理性近视患者视乳头周围脱离的特征显示文摘目的:在一组高度近视患者中,评估新近认识的视乳头周围病变。即病理性近视视乳头周围脱离(PD-PM)的患病率和临床特征。
方法:共纳入324位高度近视患者(632只眼)。在这些患者中观察PDPMD的发病率、病变范围、荧光素和吲哚青绿造影检查结果及OCT结果。并对有PDPM的患者进行视野检查(Goldmann动态视野检查法和Humphrey 30-2程序)。结果:632只高度近视眼中有31只眼(4.9%)存在视乳头周围脱离。PDPM病变部位的OCT扫描显示视神经邻近部位视网膜色素上皮层的局限性脱离。PDPM常位于视盘下方。但一些患者的病变几乎环绕整个视盘。邻近PDPM的下方近视弧形斑有陡峭的凹陷。且颞下视网膜静脉在跨过PDPM和凹陷的近视弧形斑时明显弯曲。PDPM眼常被检出存在青光眼性视野缺损(71.0%)。
结论:本研究表明PDPM在高度近视眼中并非罕见。虽然其发病机制和病理学意义尚需进一步分类。高度近视PDPM的出现提示可能存在视野缺损。 | Noriaki Shimada Kyoko Ohno-Matsui Takeshi Yoshida Kenjiro Yasuzumi Ariko Kojima Kanako Kobayashi Soh Futagami Takashi Tokoro Manabu Mochizuki 刘亮(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 9 |
| 3 | Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA显示文摘Schwannomas are peripheral nerve tumors that are typically solitary and benign.Their diagnosis is largely based on surgically resected specimens.Recently,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using EUS-FNA.Subjects were two males and one female,ages 22,40,and 46 years,respectively,all of whom were symptom-free.Imaging findings showed well-circumscribed round tumors.However,as the tumors could not be diagnosed using these findings alone,EUS-FNA was performed.Hematoxylin-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear palisading.There was no disparity in nuclear sizes.Immunostaining revealed S-100 protein positivity and all cases were diagnosed as schwannomas.Ki-67 indexes were 3%-15%,2%-3%,and 3%,respectively.No case showed any signs of malignancy.As most schwannomas are benign tumors and seldom become malignant,we observed these patients without therapy.All tumors demonstrated no enlargement and no change in characteristics.Schwannomas are almost always benign and can be observed following diagnosis by EUS-FNA. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Nobuyuki Ehira Hiroaki Yamato Kazunori Eto Kanako Kubota Masahiro Asaka | 2011 | World Journal of Gastroenterology2011，17，29： | 8 |
| 4 | Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain显示文摘ObjectiveTo 决定在血浆大脑 natriuretic 之间的协会在有心失败( HF )和物理脆弱以及与心血管的药的 106 个门诊病人变老的物理 frailty.MethodsTwo 的每个领域的病人的肽( BNP )水平60岁以上为 HF 被就医了或被给了一为 HF 的药方药被包括。物理脆弱用下列五个领域被估计:缓慢,软弱,疲劳,低活动,并且缩小,根据心血管的健康学习。病人们根据脆弱分数被划分成 nonfrailty 和脆弱组。血浆 BNP 水平被测量。6-min 散步测试被执行测量 endurance.ResultsPlasma BNP 在二个组之间是显著地不同的(脆弱组:158.0 ±214.7 pg/mL, nonfrailty 组:65.2 ±88.0 pg/mL, P <0.01 ) 。Multivariate 逻辑回归分析表明转变木头的血浆 BNP (木头 BNP ) 显著地与物理脆弱被联系(或:1.68, 95% CI:1.11-2.56 ) ,并且木头 BNP 显著地与缓慢领域被联系(走的速度 <1.0 m/s ) 物理脆弱(或:1.75, 95% CI:1.15-2.67 ) 。另外,木头 BNP 否定地被相关到 6 分钟的散步距离(6MWD )(ρ=− 0.37, P <0.01 ) ,当 6MWD 断然被相关到走速度时(ρ= 0.66, P <0.01 ).ConclusionsPlasma BNP 水平与物理脆弱有关,特别在缓慢领域。耐力可以在在血浆 BNP 水平和走的速度之间的协会干涉。 | Shu Nishiguchi Yuma Nozaki Masayuki Yamaji Kanako Oya Yuki Hikita Tomoki Aoyama Hiroshi Mabuchi | 2016 | Journal of Geriatric Cardiology2016，13，7： | 5 |
| 5 | Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis显示文摘AIM: To investigate the correlation between systemic hemodynamics and splanchnic circulation in recipients with cirrhosis undergoing living-donor liver transplantation (LDLT), and to clarify how systemic hemodynamics impact on local graft circulation after LDLT. METHODS: Systemic hemodynamics, indocyanine green (ICG) elimination rate (KICG) and splanchnic circulation were simultaneously and non-invasively investigated by pulse dye densitometry (PDD) and ultrasound. Accurate estimators of optimal systemic hyperdynamics after LDLT [i.e., balance of cardiac output (CO) to blood volume (BV) and mean transit time (MTT), defined as the timerequired for half the administered ICG to pass through an attached PDD sensor in the first circulation] were also measured. Thirty recipients with cirrhosis were divided into two groups based on clinical outcomes corresponding to postoperative graft function. RESULTS: Cirrhotic systemic hyperdynamics characterized by high CO, expanded BV and low total peripheral resistance (TPR) were observed before LDLT. TPR reflecting cirrhotic vascular alterations was slowly restored after LDLT in both groups. Although no significant temporal differences in TPR were detected between the two groups, CO/BV and MTT differed significantly. Recipients with good outcomes showed persistent cirrhotic systemic hyperdynamics after LDLT, whereas recipients with poor outcomes presented with unstable cirrhotic systemic hyperdynamics and severely decreased KICG. Systemic hyperdynamic disorders after LDLT impacted on portal venous flow but not hepatic arterial flow. CONCLUSION: We conclude that subtle systemic hyperdynamics disorders impact on splanchnic circulation, and that an imbalance between CO and BV decreases portal venous flow, which results in critical outcomes. | Tomohide Hori Shintaro Yagi Taku Iida Kentaro Taniguchi Kentaro Yamagiwa Chiduru Yamamoto Takashi Hasegawa Koichiro Yamakado Takuma Kato Kanako Saito Linan Wang Mie Torii Yukinobu Hori Kan Takeda Kazuo Maruyama Shinji Uemoto | 2007 | World Journal of Gastroenterology2007，13，44： | 5 |
| 6 | Peeling a giant ileal lipoma with endoscopic unroofing and submucosal dissection显示文摘Lipoma is relatively common in the colon but is less often in the small intestine. Most lipomas are incidentally detected at endoscopy and are usually small and asymptomatic. However, some of them can present with obstruction and/or intussusceptions. Surgical resection is commonly recommended to remove such significant lipomas with a limited pedicle and larger than 2 cm in size, as endoscopic resection may result in unfavorable complications such as intestinal perforations. We report a case of 62-year-old man presenting with hematochezia. Colonoscopy showed a submucosal tumor, about 50 mm in size, in the terminal ileum. A clinical diagnosis of lipoma was established based on the findings of colonoscopy and abdominal computed tomography (CT). As the patient complained of hematochezia and mild iron deficiency anemia associated with repeated tumor prolapse, we decided to remove his lipoma. Consequently, the lesion was completely removed en bloc . Although abdominal CT immediately after removal of the lesion showed a small amount of free air, conservative treatment was successfully carried out for the perforation. Histologically, the removed lesion was a lipoma. | Takashi Morimoto Kuang-I Fu Hironori Konuma Yuko Izumi Syujirou Matsuyama Kanako Ogura Akihisa Miyazaki Sumio Watanabe | 2010 | World Journal of Gastroenterology2010，16，13： | 4 |
| 7 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 8 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 9 | Loss-of-Function of a Ubiquitin-Related Modifier Promotes the Mobilization of the Active MITE mPing显示文摘缩小的转换重复的 transposable 元素(螨) 在原核生物、真核细胞的染色体是普遍的,在他们的拷贝数字能达到几的地方千。然而,很少对影响他们的调换的基因因素被知道。这里,我们证明没有任何外长的压力,显著地编码象 ubiquitin 一样蛋白质的基因的那混乱在未经触动的米饭植物提高螨 mPing 的调换活动。我们发现 mPing 的调换活动在在 Rurm1 怀有非功能的等位基因的线更高是远的(瑞斯 ubiquitin 相关的 modifier-1 ) 地点比在野类型的线。尽管 cytosine methylation 模式的改变在外长的压力条件,在整个染色体的 methylation 度, mPing 身体区域,和胁腹 mPing 下面触发 transposable 元素的激活,非功能的 Rurm1 线的区域是未改变的。这研究为在房间以内的基因事故提高的染色体吃惊理论的模型之一提供试验性的证据 transposable 元素的调换活动。 | Takuji Tsukiyama Shota Teramoto KanakoYasuda Akira Horibata Nanako Mori Yutaka Okumoto Masayoshi Teraishi Hiroki Saito Akiko Onishi Kanako Tamura Takatoshi Tanisaka | 2013 | Molecular Plant2013，6，3： | 3 |
| 10 | Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity显示文摘After the first observation of the immunosuppressive effects of ultraviolet(UV) irradiation was reported in 1974, therapeutic modification of immune responses by UV irradiation began to be investigated in the context immunization. UV-induced immunosuppression is via the action of regulatory T cells(Tregs). Antigen-specific Tregs were induced by high-dose UV-B irradiation before antigen immunization in many studies, as it was considered that functional alteration and/or modulation of antigen-presenting cells by UV irradiation was required for the induction of antigen-specific immunosuppression. However, it is also reported that UV irradiation after immunization induces antigen-specific Tregs. UV-induced Tregs are also dominantly transferable, with interleukin-10 being important for UV-induced immunosuppression. Currently, various possible mechanisms involving Treg phenotype and cytokine profile have been suggested. UV irradiation accompanied by alloantigen immunization induces alloantigen-specific transferable Tregs, which have potential therapeutic applications in the transplantation field. Here we review the current status of UV-induced antigen-specific immunosuppression on the 40th anniversary of its discovery. | Tomohide Hori Kagemasa Kuribayashi Kanako Saito Linan Wang Mie Torii Shinji Uemoto Taku Iida Shintaro Yagi Takuma Kato | 2015 | World Journal of Transplantation2015，5，1： | 3 |
| 11 | The relationship between tyrosine kinase inhibitor therapy and overall survival in patients with non-small cell lung cancer carrying EGFR mutations显示文摘For patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer, the relationship between the dose or duration of treatment with tyrosine kinase inhibitor (TKI) and overall survival remains unclear. Here, we analyzed clinical data of 39 patients who were diagnosed with EGFR mutation-positive non-small cell lung cancer and treated with TKI, but subsequently died. Several parameters were measured in this study: overall survival; first, second, and overall TKI therapy durations; first TKI intensity (actual dose/normal dose); and TKI rate (overall TKI therapy duration/overall survival). The response rate to TKI therapy was 50% , and the median survival was 553 days. After TKI therapy failed, 38.5% patients were re-challenged with TKI. We observed a moderate relationship [r = 0.534, 95% confidential interval (CI) = 0.263 to 0.727, P < 0.001] between overall TKI therapy duration and overall survival. However, we found no relationship between overall survival and first TKI intensity (r = 0.073, 95% CI = -0.380 to 0.247, P = 0.657) or TKI rate (r = 0.0345, 95% CI = -0.284 to 0.346, P = 0.835). Nonsmall cell lung cancer patients with mutation-positive tumors remained on TKI therapy for, on average, 33% of the overall survival time. These findings suggest that patients with EGFR mutation-positive tumors should not stick to using TKIs. | Hidekazu Suzuki Tomonori Hirashima Norio Okamoto Tadahiro Yamadori Motohiro Tamiya Naoko Morishita Takayuki Shiroyama Tomoyuki Otsuka Kanako Kitai Ichiro Kawase | 2013 | Chinese Journal of Cancer2013，32，3： | 3 |
| 12 | A pilot randomized control study to evaluate endoscopic resection using a ligation device for rectal carcinoid tumors显示文摘瞄准:比 10 公里小的直肠的良性肿瘤肿瘤能是有用内视镜检查法的本地切除的 resected。以便完全移开直肠的良性肿瘤肿瘤,我们在这飞行员控制与一台结扎设备评估了内视镜的粘膜切除术使随机化的学习。方法:十五个病人从 1993 ~ 2002 在我们的医院里与直肠的良性肿瘤肿瘤(不到 10 公里) 被诊断。有 9 男性和 6 女性,与吝啬的年龄 61.5 年(范围, 34-77 年) 。病人没有良性肿瘤症候群症状的抱怨。十五个病人随机被划分成 2 个组:7 个良性肿瘤肿瘤被常规内视镜的切除术治疗,并且 8 个良性肿瘤肿瘤被内视镜的切除术用一台结扎设备治疗。结果:所有直肠的良性肿瘤肿瘤在中间被定位到远侧的直肠。从 3 公里改变到 10 公里和病人的背景特征的肿瘤的尺寸不在二个组是不同的。用一台结扎设备的良性肿瘤肿瘤的完全的移动的率(100% , 8/8 ) 比常规内视镜的切除术的显著地高(57.1% , 4/7 ) 。三个病人有深边缘,另外的治疗为被执行的肿瘤参与。没有复杂并发症用一台结扎设备发生了在期间或在内视镜的切除术以后。在两个组的所有病人在 3 年的观察时期期间是活着的。结论:用一台结扎设备的内视镜的切除术是为小直肠的良性肿瘤肿瘤的切除术的一个有用、安全的方法。 | Hiroyuki Sakata Ryuichi Iwakiri Akifumi Ootani Seiji Tsunada Shinichi Ogata Hibiki Ootani Ryo Shimoda Kanako Yamaguchi Yasuhisa Sakata Sadahiro Amemori Kotaro Mannen Masanobu Mizuguchi Kazuma Fujimoto | 2006 | World Journal of Gastroenterology2006，12，25： | 2 |
| 13 | Enhancement of the radiation effects by d -allose in head and neck cancer cells显示文摘 | Hiroshi Hoshikawa Kanako Indo Terushige Mori Nozomu Mori | 2011 | Cancer Letters2011，，1： | 2 |
| 14 | Acceleration of Cell Growth by Xyloglucan Oligosaccharides in Suspension-Cultured Tobacco Cells显示文摘进暂停有教养的烟草房间的墙的 xyloglucan oligosaccharide (XXXG ) 的加入加速了房间分割跟随的房间扩大,改变的房间形状从对球形的、减少的房间尺寸,和引起的房间聚集圆柱。荧光灯在强壮的加入发生在表面上的地方,加到文化媒介的 XXXG 被发现被合并到全部墙的表面不仅,而且在在房间之间的接口墙中在房间分割期间。房间扩大比在纵的方向在横向的方向总是是更大的然后立即,扩大面对 XXXG 导致了房间分割;这个过程可能导致在有教养的烟草房间看见的房间聚集的高水平。我们断定进墙的这 oligosaccharide 的集成能在有教养的房间加速不仅房间扩大,而且房间分割。 | Rumi Kaid Satoko Sugawara Kanako Negoro Hisae Maki Takahisa Hayashi Takako S. Kaneko | 2010 | Molecular Plant2010，3，3： | 2 |
| 15 | Possible contribution of(pro)renin receptor to development of gestational diabetes mellitus显示文摘(Pro)renin receptor [(P)RR], a receptor for renin and prorenin, was first cloned in 2002. Since then, the pathophysiological roles of(P)RR have been growing concerns.(P)RR binds renin and prorenin, with two important consequences, nonproteolytic activation of prorenin, leading to the tissue renin-angiotensin system activation and the intracellular signalings. It is now also known to play an important role as vacuolar H+-ATPase associated protein, involving in Wnt signaling, main component of embryonic development. Extracellular domain of full-length(P)RR is cleaved in golgi-complex forming soluble(P)RR [s(P)RR]. The s(P)RR is now possible to be measured in human blood and urine. It is now measured in different pathophysiological states, and recent study showed that elevated plasma s(P)RR levels in the early stage of pregnancies are associated with higher incidence of gestational diabetes mellitus later in the pregnancies. Plasma s(P)RR levels of neonates are known to be higher than that of adults. It was also shown that, increased s(P)RR concentrations in cord blood, associated with a lower small for gestational age birth likelihood. These data suggests the involvement of(P)RR in embryo's growth. In thisreview article, we attempt to figure out the possible pathophysiological roles of the(P)RR in maternal glucose intolerance and embryo's growth, through reviewing previous studies. | Kanako Bokuda Atsuhiro Ichihara | 2014 | World Journal of Diabetes2014，5，6： | 2 |
| 16 | Clonal identification and characterization of self-renewing pluripotent stem cells in the development liver 显示文摘 | Suzuki A Zheng YW Kanako S | 2002 | J Cell Biol2002，156，1： | 1 |
| 17 | Mycophenolate Mofetil Is Effective and Well Tolerated in the Treatment of Refractory Acute and Chronic Graft-versus-Host Disease显示文摘 | Akiyoshi Takami Kanako Mochizuki Hirokazu Okumura Hirohito Yamazaki Masahide Yamazaki Yukio Kondo Hidesaku Asakura Shinji Nakao Satsuki Ito Yukio Suga | 2006 | International Journal of Hematology2006，，1： | 1 |
| 18 | NMR study of the solution structures of the inclusion comple- xes of β - Cyelodextrin with ( + ) - Cateehin and ( - ) - Epieateehin 显示文摘 | Takashi Ishizu Kanako Kintsu Hideji Yamamoto | 1999 | J Phys Chem B1999，103，： | 1 |
| 19 | Effects of the maturity of wood waste compost on the structural featuresof humic acids显示文摘 | MASAMI FUKUSHIMA KANAKO YAMAMOTO KEISHI OOTSUKA etal | 2009 | Bioresource Technology2009，100，： | 1 |
| 20 | Resolution of hydroearb-ons by inlusion eomplexation with a chiral host compound 显示文摘 | Hisakazu Miyamoto Muneyoshi Sakamoto Kanako Yoshioka etal | 2000 | Tetrahedron: Asymmetry2000，，11： | 1 |
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