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| 1 | Molecular Analysis of Legume Nodule Development and Autoregulation显示文摘Legumes are highly important food, feed and biofuel crops. With few exceptions, they can enter into an intricate symbiotic relationship with specific soil bacteria called rhizobia. This interaction results in the formation of a new root organ called the nodule in which the rhizobia convert atmospheric nitrogen gas into forms of nitrogen that are useable by the plant. The plant tightly controls the number of nodules it forms, via a complex root-to-shoot-to-root signaling loop called autoregulation of nodulation (AON). This regulatory process involves peptide hormones, receptor kinases and small metabolites. Using modern genetic and genomic techniques, many of the components required for nodule formation and AON have now been isolated. This review addresses these recent findings, presents detailed models of the nodulation and AON processes, and identifies gaps in our understanding of these process that have yet to be fully explained. | Brett J. Ferguson Arief Indrasumunar Satomi Hayashi Yu-Hsiang Lin Dugald E. Reid Peter M. Gresshoff | 2010 | Journal of Integrative Plant Biology2010，52，1： | 23 |
| 2 | Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis显示文摘AIM To reveal better diagnostic markers for differentiating neuroendocrine tumor(NET) from solid-pseudopapillary neoplasm(SPN), focusing primarily on immunohistochemical analysis.METHODS We reviewed 30 pancreatic surgical specimens of NET(24 cases) and SPN(6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,vimentin, α-1-antitrypsin, CD10, and β-catenin.RESULTS E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. The other six markers were not useful because their expression overlapped widely between NETs and SPNs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles. Careful diagnosis is crucial as we actually found two confusing cases showing disagreement between the tumor morphology and immunohistochemical profiles.CONCLUSION E-cadherin, chromogranin A, and β-catenin were the most useful markers which should be employed for differentiating between NET and SPN. | Yusuke Ohara Tatsuya Oda Shinji Hashimoto Yoshimasa Akashi Ryoichi Miyamoto Tsuyoshi Enomoto Kaishi Satomi Yukio Morishita Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，38： | 19 |
| 3 | Pharmacological effects of saw palmetto extract in the lower urinary tract显示文摘锯矮棕榈条摘录(SPE ) ,从美国矮子手掌的成熟果浆的一篇摘录,广泛地在欧洲由于良性的 prostatic 增生(BPH ) 为尿机能障碍被用作治疗学的疗法。行动的众多的机制为 SPE 被建议了,包括 5 伪 - reductase 的抑制。今天,伪 1 -adrenoceptor 对手和 muscarinic cholinoceptor 对手通常与对 BPH 第二等的 voiding 症状在人的治疗被使用。在拿 SPE 的病人的 voiding 症状的改进可以在更低的尿道从它的绑定产生到 pharmacologically 相关的受体,例如伪 1 -adrenoceptors, muscarinic cholinoceptors, 1,4-dihyropyridine 受体和 vanilloid 受体。而且, SPE 的口头的管理被显示了在睾丸激素导致的老鼠前列腺稀释伪 1 -adrenoceptors 的起来规定。因此,在临床上相关的剂量的 SPE 可以在更低的尿道在药理学受体上施加直接效果,在有 BPH 和一个 overactive 膀胱的病人的从而改善的尿机能障碍。SPE 没在血与共同管理的药或严肃的不利事件有相互作用生物化学的参数,它的相对安全暗示,甚至与长期的吸入。与 BPH 在人进行的 SPE 的临床的试用(控制安慰剂、活跃控制的试用) 也被考察。这评论应该与 BPH 在病人的治疗贡献 SPE 的药理学效果的理解并且联系更低的尿道症状(LUTS ) 。 | Mayumi SUZUKI Yoshihiko ITO Tomomi FUJINO Masayuki ABE Keizo UMEGAKI Satomi ONOUE Hiroshi NOGUCHI Shizuo YAMADA | 2009 | Acta Pharmacologica Sinica2009，30，3： | 17 |
| 4 | Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?显示文摘In immunoglobulin G4(IgG4)-related disease(RD),organ enlargement or nodular lesions consisting of abundant infiltration of lymphocytes and IgG4-positive plasma cells and fibrosis are seen in various organs.Although infiltration of many IgG4-positive plasma cells is detected in the gastric and colonic mucosa and major duodenal papilla of patients with autoimmune pancreatitis,it cannot be diagnosed as a gastrointestinal lesion involved in IgG4-RD,because none of the following is observed in these lesions:a mass-like formation;dense fibrosis;or obliterative phlebitis.Based on our review of the literature,there appear to be two types of IgG4-related gastrointestinal disease.One is a gastrointestinal lesion showing marked thickening of the wall of the esophagus and stomach,consisting of dense fibrosis with abundant infiltration of IgG4-positive plasma cells,which usually show submucosal spreading.The other is an IgG4-related pseudotumor occurring in gastrointestinal regions such as the stomach,colon,and major duodenal papilla,showing polypoid or mass-like lesions.Most solitary IgG4-related gastrointestinal lesions that are not associated with other IgG4-RD appear to be difficult to diagnose.It is of utmost importance to rule out malignancy.However,these lesions may respond to steroid therapy.To avoid unnecessary resection,IgG4-related gastrointestinal diseases should be considered in the differential diagnosis. | Satomi Koizumi Terumi Kamisawa Sawako Kuruma Taku Tabata Kazuro Chiba Susumu Iwasaki Yuka Endo Go Kuwata Koichi Koizumi Tooru Shimosegawa Kazuichi Okazaki Tsutomu Chiba | 2013 | World Journal of Gastroenterology2013，19，35： | 12 |
| 5 | Molecular mechanism of noradrenaline during the stress-induced major depressive disorder显示文摘Chronic stress-induced depression is a common hallmark of many psychiatric disorders with high morbidity rate.Stress-induced dysregulation of noradrenergic system has been implicated in the pathogenesis of depression.Lack of monoamine in the brain has been believed to be the main causative factor behind pathophysiology of major depressive disorder(MDD) and several antidepressants functions by increasing the monoamine level at the synapses in the brain.However,it is undetermined whether the noradrenergic receptor stimulation is critical for the therapeutic effect of antidepressant.Contrary to noradrenergic receptor stimulation,it has been suggested that the desensitization of β-adrenoceptor is involved in the therapeutic effect of antidepressant.In addition,enhanced noradrenaline(NA) release is central response to stress and thought to be a risk factor for the development of MDD.Moreover,fast acting antidepressant suppresses the hyperactivation of noradrenergic neurons in locus coeruleus(LC).However,it is unclear how they alter the firing activity of LC neurons.These inconsistent reports about antidepressant effect of NA-reuptake inhibitors(NRIs) and enhanced release of NA as a stress response complicate our understanding about the pathophysiology of MDD.In this review,we will discuss the role of NA in pathophysiology of stress and the mechanism of therapeutic effect of NA in MDD.We will also discuss the possible contributions of each subtype of noradrenergic receptors on LC neurons,hypothalamic-pituitary-adrenal axis(HPA-axis) and brain derived neurotrophic factor-induced hippocampal neurogenesis during stress and therapeutic effect of NRIs in MDD. | Kenjiro Seki Satomi Yoshida Manoj Kumar Jaiswal | 2018 | Neural Regeneration Research2018，13，7： | 10 |
| 6 | Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs显示文摘AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs.METHODS: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated.RESULTS: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P<0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval shunt.CONCLUSION: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury. | Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi | 2005 | World Journal of Gastroenterology2005，11，44： | 8 |
| 7 | Mechanistic action of gibberellins in legume nodulation显示文摘Legume plants are capable of entering into a symbiotic relationship with rhizobia bacteria.This results in the formation of novel organs on their roots,called nodules,in which the bacteria capture atmospheric nitrogen and provide it as ammonium to the host plant.Complex molecular and physiological changes are involved in the formation and establishment of such nodules.Several phytohormones are known to play key roles in this process.Gibberellins(gibberellic acids;GAs),a class of phytohormones known to be involved in a wide range of biological processes(i.e.,cell elongation,germination)are reported to be involved in the formation and maturation of legume nodules,highlighted by recent transcriptional analyses of early soybean symbiotic steps.Here,we summarize what is currently known about GAs in legume nodulation and propose a model of GA action during nodule development.Results from a wide range of studies,including GA application,mutant phenotyping,and gene expression studies,indicate that GAs are required at different stages,with an optimum,tightly regulated level being key to achieve successful nodulation.Gibberellic acids appear to be required at two distinct stages of nodulation:(i)early stages of rhizobia infection and nodule primordium establishment;and(ii)later stages of nodule maturation. | Satomi Hayashi Peter M.Gresshoff Brett J.Ferguson | 2014 | Journal of Integrative Plant Biology2014，56，10： | 3 |
| 8 | Hypothyroidism in patients with autoimmune pancreatitis显示文摘AIM To examine thyroid function and clinical features of hypothyroidism in autoimmune pancreatitis(AIP) patients.METHODS We examined thyroid function in 77 patients with type 1 AIP(50 males, 27 females; median age 68 years, range 33-85) diagnosed according to the Japanese diagnostic criteria for AIP 2011. We compared clinical and serological findings between patients with and without various categories of hypothyroidism. The change in hypothyroidism after steroid therapy was also examined. RESULTS Eight patients(10%) had hypothyroidism of 6 patients had subclinical hypothyroidism with a normal serum free thyroxine(FT4) and high thyroid stimulating hormone(TSH) level, and 2 patients had central hypothyroidism with low serum free triiodothyronine(FT3), FT4 and TSH levels. A significant goiter of the thyroid was not observed in any patient. There were no significant differences in age; male to female ratio; serum concentrations of IgG and IgG 4-related disease(IgG4-RD); presence of antithyroglobulin antibody, antinuclear antigen or rheumatoid factor; or presence of extrapancreatic lesions between the 6 patients with subclinical hypothyroidism and patients with euthyroidism. After steroid therapy, both subclinical and central hypothyroidism improved with improvement of the AIP.CONCLUSION Hypothyroidism was observed in 8(10%) of 77 AIP patients and was subclinical in 6 patients and central in 2 patients. Further studies are necessary to clarify whether this subclinical hypothyroidism is another manifestation of IgG4-RD. | Ryoko Shimizuguchi Terumi Kamisawa Yuka Endo Masataka Kikuyama Sawako Kuruma Kazuro Chiba Taku Tabata Satomi Koizumi | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，2： | 3 |
| 9 | Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma(ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy. | Yuichi Sanada Yujo Kawashita Satomi Okada Takashi Azuma Shigetoshi Matsuo | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 3 |
| 10 | Operative Results and Postoperative Progression of Ossification Among Patients With Ossification of Cervical Posterior Longitudinal Ligament显示文摘 | KIYOSHI HIRABAYASHI JUN MIYAKAWA KAZUHIKO SATOMI TETSUO MARUYAMA KOICHI WAKANO | 1981 | Spine1981，，4： | 2 |
| 11 | Telomerase and mTOR in the brain:the mitochondria connection显示文摘Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA component.Additionally,the protein part TERT(Telomerase Reverse Transcriptase) has various non-canonical functions.For example,it can localize to mitochondria under increased stress and protect cells in vitro from oxidative stress,DNA damage and apoptosis.Recently it has been demonstrated that TERT protein persists in adult neurons in the brain and data emerge suggesting that it might have a protective function in these post-mitotic cells as well.We have recently published that TERT protein accumulated in mitochondria from brain tissue of mice that have undergone short-term dietary restriction(DR) and rapamycin treatment.This localization correlated to lower levels of oxidative stress in these brain mitochondria.Since rapamycin treatment decreases mTOR signaling which is also thought to play an important role for the beneficial effects of DR,we conclude that the mTOR pathway might be involved in the TERT localization and its effects in brain mitochondria in vivo.These data are in line with previous findings from our group about increased mitochondrial localization of TERT in Alzheimer's disease(AD) brains and a protective function of TERT protein in neurons in vitro against pathological tau. | Satomi Miwa Gabriele Saretzki | 2017 | Neural Regeneration Research2017，12，3： | 2 |
| 12 | Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems显示文摘 | Yuko Kakuda Kenichi Harada Seiko Sawada-Kitamura Hiroko Ikeda Yasunori Sato Motoko Sasaki Hirofumi Okafuji Eishiro Mizukoshi Shuichi Terasaki Hajime Ohta Satomi Kasashima Atsuhiro Kawashima Yasuharu Kaizaki Shuichi Kaneko Yasuni Nakanuma | 2013 | Human Pathology2013，，6： | 2 |
| 13 | Effect of Portocaval Shunt on Residual Extreme Small Liver after Extended Hepatectomy in Porcine显示文摘 | HongSheng Wang MD PhD Nobuhiro Ohkohchi MD PhD Yoshitaka Enomoto MD Masahiro Usuda MD Shigehito Miyagi MD Hiroo Masuoka MD Satoshi Sekiguchi MD Naoki Kawagishi MD Keisei Fujimori MD Akira Sato MD Susumu Satomi MD PhD | 2006 | World Journal of Surgery2006，，11： | 2 |
| 14 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 15 | Combination of fluvastatin with pegylated interferon/ribavirin therapy reduces viral relapse in chronic hepatitis C infected with HCV genotype 1b显示文摘 | Masanori Atsukawa Akihito Tsubota Chisa Kondo Norio Itokawa Yoshiyuki Narahara Katsuhisa Nakatsuka Satomi Hashimoto Takeshi Fukuda Yoko Matsushita Hideko Kidokoro Tamaki Kobayashi Hidenori Kanazawa Choitsu Sakamoto | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 16 | Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein显示文摘 | Kazuhiro K Sho Y Satomi T | 2007 | Mol Cancer Ther2007，6，7： | 1 |
| 17 | Occurrence of Vibrio vulnificus in fish and shellfish available from markets in China 显示文摘 | YANO Y YOKOYAMA M SATOMI M | 2004 | J Food Prot2004，67，8： | 1 |
| 18 | Short-term complications and long-term results of expansive open-door laminoplasty for cervical stenotie myelopathy 显示文摘 | Satomi K Ogawa J Ishii Y | 2001 | Spine J2001，1，1： | 1 |
| 19 | Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion 显示文摘 | Takada R Satomi Y Kurata T | 2006 | Dev Cell2006，11，6： | 1 |
| 20 | Short-term complications and long-term results of expansive open-door laminoplasty for cervical stenotic myelopathy 显示文摘 | Satomi K Ogawa J Ishii Y | 2001 | Spine J2001，1，1： | 1 |
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