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| 1 | DR-3355(氟嗪酸光学异构体)的体外与体内抗菌作用显示文摘DR-3355[S-(-)-ofloxacin]和 DR-3354[R-(+)-ofloxacin]均是氟嗪酸的光学异构体(图1),现已成功地从合成的中间体中分离出。氟嗪酸为 S 和 R 异构体1:1的消旋混合物,其分子带一份水,而每一异构体只带半份水。 | Tanaka M 张永信 | 1992 | 国外医药(抗生素分册)1992，13，1： | 30 |
| 2 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 3 | Cranial base chordoma——long term outcome and review of the literature显示文摘BACKGROUND: The purpose of this study is to clarify the latest long-term therapeutic result for cranial base chordomas.We are seeking an improvement of long term therapeutic outcome through a review of cranial base chordomas treated in | Yoneoka Y Tsumanuma I Fukuda M Tamura T Morii K Tanaka R Fujii Y | 2008 | 中国神经肿瘤杂志2008，6，3： | 9 |
| 4 | 小胶质细胞可能通过选择性吞噬丘脑底核谷氨酸能突触来代偿多巴胺能神经元丢失造成的帕金森模型鼠的功能缺失显示文摘当帕金森患者出现临床症状时,其黑质致密部的绝大部分多巴胺神经元已发生退行性改变。这提示可能存在某些代偿机制,延缓了临床症状的出现。本研究制作6-羟多巴胺诱导的偏侧帕金森大鼠模型,观察位于黑质下网状部和苍白球的激活的小胶质细胞在代偿机制中的作用。研究发现,在偏侧帕金森大鼠中,黑质下网状部聚集的激活的小胶质细胞远多于苍白球中。激活的小胶质细胞胞体增大并表达吞噬物标志物CD68和NG2蛋白多糖。激活的小胶质细胞聚集在黑质下网状部的特定部位,该部位的突触蛋白I和突触后密集蛋白95的表达降低。活化的小胶质细胞吞噬突触前、后膜上的各种蛋白,包括NMDA受体。将红色荧光标记物Di I作为顺行示踪剂注入丘脑底核,可见黑质下网状部和苍白球内的细胞吞噬了Di I。在谷氨酸刺激下,原代培养的小胶质细胞吞噬活动增强,编码吞噬相关因子的m RNA转录水平也增加。人工合成的糖皮质激素地塞米松可以减弱这种改变。给PD大鼠皮下注射地塞米松,可以抑制黑质下网状部小胶质细胞的活化,运动功能障碍进一步加重,谷氨酸能突触转录m RNA增加,GABA能突触转录m RNA水平未增加。这些发现提示,当谷氨酸能神经元活动增强时,黑质下网状部和苍白球的小胶质细胞活化,选择性吞噬丘脑底核的谷氨酸能突触。因此,在基底核区可能存在一个负反馈环路,间接地代偿了由于多巴胺能神经元丢失而导致的功能障碍。小胶质细胞在这个负反馈环路中扮演了重要的角色。 | Aono H Choudhury ME Higaki H Miyanishi K Kigami Y Fujita K Akiyama JI Takahashi H Yano H Kubo M Nishikawa N Nomoto M Tanaka J 唐颖馨 | 2017 | 神经损伤与功能重建2017，12，5： | 7 |
| 5 | Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt显示文摘AIM:To investigate characteristics of hepatitis B virus(HBV)implicated in HBV reactivation in patients with hematological malignancies receiving immunosuppressive therapy.METHODS:Serum samples were collected from 53 patients with hematological malignancies negative for hepatitis B surface antigen(HBsAg)before the start of and throughout the chemotherapy course.HBV reactivation was diagnosed when the HBsAg status changed from negative to positive after the initiation of chemotherapy and/or when HBV DNA was detected by realtime detection polymerase chain reaction(RTD-PCR).For detecting the serological markers of HBV infection,HBsAg as well as antibodies to the core antigen(antiHBc)and to the surface antigen were measured in the sera by CEIA.Nucleic acids were extracted from sera,and HBV DNA sequences spanning the S gene were amplified by RTD-PCR.The extracted DNA was further subjected to PCR to amplify the complete genome as well as the specific genomic sequences bearing the enhancerⅡ/core promoter/pre-core/core regions(nt1628-2364).Amplicons were sequenced directly.RESULTS:Thirty-five(66%)of the 53 HBsAg-negative patients were found to be negative serologically for antiHBc,and the remaining 18(34%)patients were positive for anti-HBc.Five of the 53(9.4%)patients with hematologic malignancies experienced HBV reactivation.Genotype D1 was detected in all five patients.Four types of mutant strains were detected in the S gene product of HBV strains and were isolated from 3 patients with HBV reactivation:T/S120,L143,and I126.HBV DNA was detected in the pretreatment HBsAg-negative samples in one of the five patients with HBV reactivation.In this patient,sequences encompassing the HBV full genome obtained from sera before the start of chemotherapy and at the time of de novo HBV hepatitis were detected and it showed 100%homology.Furthermore,in the phylogenetic tree,the sequences were clustered together,thereby indicating that this patient developed reactivation from an occult HBV infection.CONCLUSION:Past infection with HBV is a risk factor for HBV reactivation in Egypt.Mandatory anti-HBc screening prior to chemotherapy in patients with hematological malignancies is recommended. | Abeer Elkady Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Sayuki Iijima Yasuhito Tanaka | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 6 | Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt显示文摘AIM To investigate the prevalence and virological characteristics of occult hepatitis B virus(HBV) infections in patients with hematological malignancies in South Egypt.METHODS Serum samples were collected from 165 patients with hematological malignancies to monitor titers of HBV DNA, hepatitis B surface antigen(HBs Ag), and antibodies to HBV core(anti-HBc) and surface antigens. Serum samples negative for HBs Ag and positive for anti-HBc were subjected to nucleic acid extraction and HBV DNA detection by real-time polymerase chain reaction. DNA sequences spanning the S region were analyzed in cases with occult HBV infection. In vitro comparative study of constructed 1.24-fold wild type and S protein mutant HBV genotype D clones was further performed. RESULTS HBV DNA was detected in 23(42.6%) of 54 patients with hematological malignancies who were HBsA g negative, but anti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome was retrieved from 6 occult HBV patients, and P120 T and S143 L were detected in 3 and 2 cases, respectively. Site directed mutagenesis was done to produce 1.24-fold genotype D clones with amino acid mutations T120 and L143. The in vitro analyses revealed that a lower level of extracellular HBsA g was detected by chemiluminescence enzyme immunoassay(CLEIA) with the clone containing T120 mutation, compared with the wild type or the clone with S143 L mutation despite the similar levels of extracellular and intracellular HBs Ag detected by Western blot. Southern blot experiments showed that the levels of intracellular HBV DNA were not different between these clones. CONCLUSION Occult HBV infection is common in patients with hematological malignancies and associated with P120 T and S143 L mutations. 120 T mutation impairs the detection of HBsA g by CLEIA. | Abeer Elkady Sayuki Iijima Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Masanori Isogawa Yasuhito Tanaka | 2017 | World Journal of Hepatology2017，9，9： | 2 |
| 7 | The programmed cell death of an immature thymocyte cell line transgenic for an alpha beta TCR and the c - myc proto - oncogene 显示文摘 | Murdjeva M Tanaka Y Norton T | 1996 | Dev Immunol1996，4，4： | 2 |
| 8 | Jahn-Teller instability in spinel Li-Mn-O显示文摘 | Yamada A Tanaka M Tanaka K | 1999 | J Power Sources1999，8182，： | 2 |
| 9 | Structure and function analysis of urinary trypsin inhibitor( UTI) identification of binding domains and signaling property of UTI by analysis of truncated proteins显示文摘 | Suzuki M Kobayashi H Tanaka Y | 2001 | Biochim Biophs Acta2001，1547，1： | 2 |
| 10 | Increased prevalence of intestinal inflammation in patients with liver cirrhosis显示文摘AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions. | Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S Teranishi T Hirata I Katsu Ki K | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 11 | 利用共轨系统(ECD-U2)复合喷油改善冷起动能力和减少白烟显示文摘在柴油机领域中,日益严格的排放法规和用户的要求迫切需要先进的技术。柴油机的一个重要课题是在冷态条件下的冷起动能力和白烟排放。讨论在冷态条件下的多缸发动机的燃烧机理。首先,经证实,在起动条件下的断续燃烧期间由前面的未着火燃油所产生的冷火焰能促进在随后的循环中良好燃烧。第二,随着发动机的起动,确认存在着为进行燃烧所需的最小喷油量。该最小喷油量取决于燃烧室的温度。在最小喷油量和实际喷油量之间的不平衡就会产生白烟排放。根据这些分析,为了改善在冷态条件下的柴油机性能,使用了称为'ECD-U2'的共轨型喷油系统,采取了'复合喷油'的策略。确认能同时在冷起动能力和白烟排放方面获得很大的改善。 | Osuka I Nishimura M Tanaka Y 翁立克 | 1998 | 国外内燃机1998，30，1： | 2 |
| 12 | Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration显示文摘在生长因素刺激之上,支架蛋白质, Gab1,是酷氨酸 phosphorylated 并且随后适配器蛋白质, Crk,从 Gab1 播送信号。我们以前证明了没有细胞外的刺激, Crk overexpression,在各种各样的人的癌症可检测,导致 Gab1 的酷氨酸 phosphorylation。在现在的学习,内在的机制进一步被调查。CrkII 的 Mutational 分析证明 SH2 领域,然而并非 SH3 (N) 或 CrkII 的规章的 Y221 残余,为 Gab1-Y307 phosphorylation 的正式就职是批评的。CrkII 的 SH2 变化也减少了和 Gab1 的相互作用。在 GST 下拉试金,而 Crk-SH3 (N) 与 Gab1 异种交往了, Crk-SH2 跳了到野类型的 Gab1,它缺乏聚类的酷氨酸区域(残余 242-410 ) 。Gab1 的酷氨酸 phosphorylation 被表明适配器的所有 Crk 家庭蛋白质,然而并非另外的包含 SH2 导致。Src 家庭 kinase 禁止者, PP2,废除 Gab1 的导致 Crk 的酷氨酸 phosphorylations。Y307 phosphorylation 在缺乏 Src,是,和 Fyn 的成纤维细胞是无法发现的,甚至在 Crk 的 overexpression 之上,而缺乏仅仅是和 Fyn 的房间仍然与 phosphorylated Y307 包含了 Gab1。而且, Crk 导致了 Src-Y416 的 phosphorylation;因此,在 Crk 和 Csk 之间的相互作用被增加。Gab1-Y307F 异种没能近甚至在 HGF 之上本地化血浆膜刺激和减少的房间移植。而且, Gab1-Y307F 扰乱了 Crk, FAK,和 paxillin 的本地化,它是焦点的粘附的典型部件。一起拿,这些结果显示 Crk 通过 Src 便于 Gab1-Y307 的酷氨酸 phosphorylation,贡献焦点的粘附和提高的房间移植的组织,可能从而支持人的癌症开发。 | Takuya Watanabe Masumi Tsuda Yoshinori Makino Tassos Konstantinou Hiroshi Nishihara Tokifumi Majima Akio Minami Stephan M Feller Shinya Tanaka | 2009 | Cell Research2009，19，5： | 2 |
| 13 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 14 | Cerebral blood flow and oxygen metabolism in patients with progessive dementia and amyotrophic lateral sclerosis显示文摘 | Tanaka M Ichiba T Konda S | 2003 | Neurol Res2003，25，4： | 2 |
| 15 | 西尼地平L/N型钙拮抗剂可降低2型糖尿病患者的心率和尿蛋白显示文摘 | 张玲玉 叶鹏 Tanaka M | 2010 | 中华高血压杂志2010，18，10： | 2 |
| 16 | Overexpression of vascular endothelial growth factor is responsible for the hematogeneous recurrence of early-staged gastric carcinoma显示文摘 | KONNO H BABA M TANAKA T | 2000 | Eur Surg Res2000，32，3： | 2 |
| 17 | An approach to fuzzy control of nonlinear systems:Stability and design issues 显示文摘 | Wang H O Tanaka K Griffin M F | 1996 | IEEE Trans on Fuzzy Systems1996，4，1： | 1 |
| 18 | Clinical evaluation of 3rd generation assay for thyrotropin receptor antibodies: the M22-biotin- based ELISA initiated by Smith显示文摘 | Kamijo K Ishikawa K Tanaka M | 2005 | Endocr J2005，52，5： | 1 |
| 19 | Increased expression of cyclooxygenase-2 correlates with resistance to radiation in human prostate adenocarcinoma cells显示文摘 | Anai S Tanaka M Shiverick KT | 2007 | J Urol2007，177，5： | 1 |
| 20 | Fast ignition inertial fusion: An inroduction and preview显示文摘 | CAMPBELL E M FEEEMAN R R TANAKA K A | 2006 | Fusion Sci Technol2006，49，3： | 1 |
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