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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Improvement of Regeneration of Jycopersicon Pennelli Protoplasts by Decreasing Ethylene Production显示文摘 | Jansen C E Snel E A M | 1991 | Plant Cell Report1991，9，： | 1 |
| 5 | Innovative ceramic materials for porous medium burners I显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Miiller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，5： | 1 |
| 6 | CT-angiography beibasilaris throm bosie:ersteerfahrungen显示文摘 | Brant T Jansen O | 1996 | Radiology1996，36，： | 1 |
| 7 | Innovative ceramic materials for porous medium burners Ⅱ显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Muller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，6： | 1 |
| 8 | Potential of CT angiography in acute ischemic stroke显示文摘 | Knauth M Von Kummer R Jansen O | 1997 | AJNR1997，18，： | 1 |
| 9 | Survival from colorectal cancer in Germany in the early 21st century 显示文摘 | Majek O Gondos A Jansen L | 2012 | The British journal of cancer2012，06，11： | 1 |
| 10 | Differences in complication rates among the centres in the SPACE study显示文摘 | Fiehler J Jansen O Berger J | 2008 | Neuroradiology2008，50，12： | 1 |
| 11 | More reliable noninvasive visualization of the cerebral veins and dural sinuses: comparison of three MR angiographic techniques 显示文摘 | Kirchhof K Welzel T Jansen O | 2002 | Radiology2002，224，3： | 1 |
| 12 | Damage control resuscitation for patients with major trauma显示文摘 | Jansen J O Thomas R Loudon M A | 2009 | BMJ2009，338，： | 1 |
| 13 | Immunoglobulin coating of faecal bacteria in inflammatory bowel disease显示文摘 | Laurens A van der Waaij Frans GM Kroese Annie Visser Gerardus F Nelis Bram D Westerveld Peter LM Jansen John O Hunter | 2004 | European Journal of Gastroenterology & Hepatology2004，，7： | 1 |
| 14 | Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients显示文摘 | Boutros NN Korzyukov O Jansen B | 2004 | Psychiatry Research2004，126，3： | 1 |
| 15 | MC-LMAC:a multi-channel MAC protocol for wireIess sensor networks显示文摘 | Incel O D Hoesel L V Jansen P | 2011 | Ad Hoe Networks2011，9，1： | 1 |
| 16 | Early recanalization in acute ischemic stroke saves tissue at risk defined by MRI显示文摘 | Jansen O Schellinger PD Fiebach JB | 1999 | Lancet1999，353，10： | 1 |
| 17 | and clini- cal chara - cterization of the basal - like subtype of invasive breast carcinoma 显示文摘 | Nielsen T O Hsu F D Jansen K | 2004 | Clin Cancer Res2004，10，16： | 1 |
| 18 | Early recanalization in acute ischemic stroke saves tissue at risk denned by MRI 显示文摘 | Jansen O Schellinger PD Fiebach JB | 1999 | Lancet1999，353，10： | 1 |
| 19 | Protection or nonprotection in carotid stent angioplasty: the influence of inteentional techniques on outcome data from the SPACE Trial显示文摘 | Jansen O Fiehler J Hartmann M | 2009 | Stroke2009，40，3： | 1 |
| 20 | Cerebral blood vessel by lesioninng of the trigeminal nerve possible involvement of CGRP显示文摘 | Edvinsson L Jansen O Lsen L | 1995 | Cepgalagia1995，15，5： | 1 |
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