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| 1 | Magnifying endoscopy in upper gastroenterology for assessing lesions before completing endoscopic removal显示文摘Any prognosis of gastrointestinal (GI) cancer is closely related to the stage of the disease at diagnosis.Endoscopic submucosal dissection (ESD) and en bloc endoscopic mucosal resection (EMR) have been performed as curative treatments for many early-stage GI lesions in recent years.The technologies have been widely accepted in many Asian countries because they are minimally invasive and supply thorough histopathologic evaluation of the specimens.However,before engaging in endoscopic therapy,an accurate diagnosis is a precondition to effecting the complete cure of the underlying malignancy or carcinoma in situ.For the past few years,many new types of endoscopic techniques,including magnifying endoscopy with narrow-band imaging (MENBI),have emerged in many countries because these methods provide a strong indication of early lesions and are very useful in determining treatment options before ESD or EMR.However,to date,there is no comparable classification equivalent to 'Kudo's Pit Pattern Classification in the colon',for the upper GI,there is still no clear internationally accepted classification system of magnifying endoscopy.Therefore,in order to help unify some viewpoints,here we will review the defining optical imaging characteristics and the current representative classifications of microvascular and microsurface patterns in the upper GI tract under ME-NBI,describe the accurate relationship between them and the pathological diagnosis,and their clinical applications prior to ESD or en bloc EMR.We will also discuss assessing the differentiation and depth of invasion,defying the lateral spread of involvement and targeting biopsy in real time. | Ning-Li Chai En-Qiang Ling-Hu Yoshinori Morita Daisuke Obata Takashi Toyonaqa Takeshi Azuma Ben-Yan Wu | 2012 | World Journal of Gastroenterology2012，18，12： | 7 |
| 2 | Feasibility and safety of endoscopic submucosal dissection for lower rectal tumors with hemorrhoids显示文摘AIM: To evaluate the feasibility and safety of endoscopic submucosal dissection(ESD) for lower rectal lesions with hemorrhoids.METHODS: The outcome of ESD for 23 lesions with hemorrhoids(hemorrhoid group) was compared with that of 48 lesions without hemorrhoids extending to the dentate line(non-hemorrhoid group) during the same study period. RESULTS: Median operation times(ranges) in the hemorrhoid and non-hemorrhoid groups were 121(51-390) and 130(28-540) min. The en bloc resection rate and the curative resection rate in the hemorrhoid group were 96% and 83%, and they were 100% and 90% in the non-hemorrhoid group, respectively. In terms of adverse events, perforation and postoperative bleeding did not occur in both groups. In terms of the clinical course of hemorrhoids after ESD, the rate of complete recovery of hemorrhoids after ESD in lesions with resection of more than 90% was significantly higher than that in lesions with resection of less than 90%.CONCLUSION: ESD on lower rectal lesions with hemorrhoids could be performed safely, similarly to that on rectal lesions extending to the dentate line without hemorrhoids. In addition, all hemorrhoids after ESD improved to various degrees, depending on the resection range. | Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Namiko Hoshi Tsukasa Ishida Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Eiji Umegaki Takeshi Azuma | 2016 | World Journal of Gastroenterology2016，22，27： | 6 |
| 3 | A High-Precision US-Guided Robot-Assisted HIFU Treatment System for Breast Cancer显示文摘乳腺癌是女性中最常见的癌症。高强度聚焦超声(波)(HIFU)是一种很有前景的非介入式治疗方法。为了提高HIFU治疗的精确度和降低治疗成本,开发了一套基于超声引导(US)的五自由度辅助HIFU系统。搭建了一套功能齐全的样机,它可以轻松地实现三维超声图像重建、目标分割、治疗路径生成和HIFU自动照射等功能。利用线模型实现点定位,并且在异构组织模型上对凝固区域进行评估。在超声引导下,HIFU治疗区域的中心偏离目标治疗区域中心不到2 mm。规划治疗区域周围出现的超调值远低于在临床使用的允许值。对于乳腺癌的治疗,本系统有足够的准确性。 | Tianhan Tang Takashi Azuma Toshihide Iwahashi Hideki Takeuchi Etsuko Kobayashi Ichiro Sakuma | 2018 | Engineering2018，4，5： | 3 |
| 4 | Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection after observation of chronological changes:A case report显示文摘A 66-year-old man was diagnosed with a gastric submucosal tumor. Endoscopic ultrasound(EUS) revealed an iso/hypoechoic mass in the third layer. No malignant cells were detected in a histological examination. Yearly follow-up endoscopy and EUS showed the slow growth of the tumor. Endoscopic submucosal dissection(ESD) was performed and a glistening tumor was resected. The lesion showed a multinodular plexiform growth pattern consisting of spindle cells with an abundant fibromyxoid stroma that was rich in small vessels. The tumor was diagnosed as plexiform fibromyxoma(PF) by immunohistochemistry. Although difficulties are associated with reaching a diagnosis preoperatively, chronological changes on EUS may contribute to the diagnosis of PF. ESD may also be useful in the diagnosis and treatment of PF. | Fumiaki Kawara Shinwa Tanaka Takashi Yamasaki Yoshinori Morita Yoshiko Ohara Yoshihiro Okabe Namiko Hoshi Takashi Toyonaga Eiji Umegaki Hiroshi Yokozaki Takanori Hirose Takeshi Azuma | 2017 | World Journal of Gastrointestinal Oncology2017，9，6： | 3 |
| 5 | A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Hiroshi Ohtani Yutaka Tamamori Kozo Noguchi Takashi Azuma Shunsuke Fujimoto Hiroko Oba Tetsuya Aoki Mieko Minami Kosei Hirakawa | 2010 | Journal of Gastrointestinal Surgery2010，，6： | 3 |
| 6 | Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma(ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy. | Yuichi Sanada Yujo Kawashita Satomi Okada Takashi Azuma Shigetoshi Matsuo | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 3 |
| 7 | Esophageal diverticulum exposed during endoscopic submucosal dissection of superficial cancer显示文摘Endoscopic submucosal dissection(ESD) is now widely accepted as a strategy to treat superficial esophageal neoplasms.The rate of adverse events,such as perforation,has been decreasing with the improvement of devices and techniques.In this paper,we report a case of esophageal cancer that had a diverticulum under cancerous epithelium.The diverticulum was not detected during preoperative examination,and led to perforation during the ESD procedure.Our case shows that,although rare,some diverticula can exist underneath the mucosal surface without obvious depression.If there is any sign of hidden diverticula during ESD,surgeons should proceed with caution or,depending on the case,the procedure should be discontinued to avoid adverse events. | Shinwa Tanaka Takashi Toyonaga Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Tsukasa Ishida Namiko Hoshi Yoshinori Morita Takeshi Azuma | 2015 | World Journal of Gastroenterology2015，21，10： | 2 |
| 8 | Endoscopic submucosal dissection for early gastric cancer in anastomosis site after distal gastrectomy显示文摘 | Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Tsuyoshi Fujita Tetsuya Yoshizaki Fumiaki Kawara Chika Wakahara Daisuke Obata Aya Sakai Tsukasa Ishida Nobunao Ikehara Takeshi Azuma | 2014 | Gastric Cancer2014，，2： | 2 |
| 9 | Ex vivo pig training model for esophageal endosopic submucosal dissection (ESD) for endoscopists with experience in gastric ESD显示文摘 | Shinwa Tanaka Yoshinori Morita Tsuyoshi Fujita Chika Wakahara Atsuki Ikeda Takashi Toyonaga Takeshi Azuma | 2012 | Surgical Endoscopy2012，，6： | 1 |
| 10 | Small bowel anisakiosis: A report of two cases显示文摘小肠狭窄是肠的 anisakiosis 的严肃的复杂并发症。这份报告的目的是调查小肠的严重狭窄是否能保存地被管理。我们与 anisakiosis 引起的小肠的严重狭窄对待二个病人。外科的干预最后被执行在上第 23 和第 35 在医院里分别地。 resected 标本的组织病理学说的检查表明肠的墙被 anisakiosis 的炎性反应完全损坏了,并且损坏是不可逆的,从而建议那剖腹术在严重的小肠狭窄的情况下被需要由肠的 anisakiosis 引起了,就算为肠的 anisakiosis 的保守疗法的一个长时期允许病人通过尖锐阶段成功地过去。 | Shigetoshi Matsuo Takashi Azuma Seiya Susumu Satoshi Yamaguchi Shirou Obata Tomayoshi Hayashi | 2006 | World Journal of Gastroenterology2006，12，25： | 1 |
| 11 | Sustained cavity obliteration and apical aneurysm formation in apical hypertrophic cardiomyopathy显示文摘 | Kinya Matsubara Takashi Nakamura Toshiro Kuribayashi Akihiro Azuma Masao Nakagawa | 2003 | Journal of the American College of Cardiology2003，，2： | 1 |
| 12 | 1,635 Endoscopic submucosal dissection cases in the esophagus, stomach, and colorectum: complication rates and long-term outcomes显示文摘 | Takashi Toyonaga Mariko Man-i James E. East Eisei Nishino Wataru Ono Tomoomi Hirooka Chie Ueda Yoshinori Iwata Takeshi Sugiyama Toshio Dozaiku Takashi Hirooka Tsuyoshi Fujita Hideto Inokuchi Takeshi Azuma | 2013 | Surgical Endoscopy2013，，3： | 1 |
| 13 | Beneficial and preventive effect of chitin nanofibrils in a dextran sulfate sodium-induced acute ulcerative colitis model显示文摘 | Kazuo Azuma Tomohiro Osaki Takashi Wakuda | 2012 | Carbohydrate Polymers2012，87，2： | 1 |
| 14 | Mass balance of anti-influenza drugs discharged into the Yodo River system, Japan, under an influenza outbreak显示文摘 | Takashi Azuma Norihide Nakada Naoyuki Yamashita Hiroaki Tanaka | 2013 | Chemosphere2013，，： | 1 |
| 15 | Feasibility and Safety of Endoscopic Submucosal Dissection for Large Colorectal Tumors显示文摘 | Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Namiko Hoshi Tsukasa Ishida Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Takeshi Azuma | 2015 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2015，，3： | 1 |
| 16 | Plasma ghrelin isoforms and gastric ghrelin O -acyltransferase expression are influenced by Helicobacter pylori status显示文摘 | Takashi Ando Shigeto Mizuno Tsukasa Ishida Yasuyuki Kondo Ikuya Miki Masaru Yoshida Takeshi Azuma Takeshi Ishikawa Tomohisa Takagi Nobuaki Yagi Satoshi Kokura Yuji Naito Toshikazu Yoshikawa Akihiro Asakawa Akio Inui | 2012 | Nutrition2012，，10： | 1 |
| 17 | Modification of the Nuss procedure for pectus excavatum to prevent cardiac perforation显示文摘 | Koichi Ohno Tetsuro Nakamura Takashi Azuma | 2009 | J Pediatr Surg2009，44，12： | 1 |
| 18 | Utility of Technetium-99m-Labeled-Galactosyl Human Serum Albumin Scintigraphy for Estimating the Hepatic Functional Reserve显示文摘 | Hikaru Fujioka Yujo Kawashita Yukio Kamohara Akihiko Yamashita Akihiko Mizoe Junzo Yamaguchi Takashi Azuma Junichiro Furui Takashi Kanematsu | 1999 | Journal of Clinical Gastroenterology1999，，4： | 1 |
| 19 | Enhanced IκB kinase activity is responsible for the augmented activity of NF-κB in human head and neck carcinoma cells显示文摘 | Tetsuya Tamatani Masayuki Azuma Keiko Aota Tsuyoshi Yamashita Takashi Bando Mitsunobu Sato | 2001 | Cancer Letters2001，，2： | 1 |
| 20 | Effect of taurine on ischemia–reperfusion injury显示文摘 | Stephen W. Schaffer Chian Ju Jong Takashi Ito Junichi Azuma | 2014 | Amino Acids2014，，1： | 1 |
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