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| 1 | 硅灰对轻骨料混凝土抗海水冻融性能的影响显示文摘对100mm×100mm×100mm硅灰轻骨料混凝土立方体试块分别进行了25,50,75次海水中的冻融循环试验,通过对试件的质量损失计算、表面剥落观察和超声波探测,分析了硅灰提高轻骨料混凝土抗冻性能的效果.对比研究了试验过程中试件两端减摩与否对轻骨料混凝土力学性能的影响.分别对冻融0次(常态)和不同冻融循环次数后的硅灰轻骨料混凝土试块进行了单轴抗压强度和变形性能试验,得出了极限抗压强度、峰值应力点的应变值、弹性模量等随冻融循环次数变化的规律,并分析了应力-应变全曲线随冻融循环次数变化的规律,结果表明,掺加硅灰能显著提高轻骨料混凝土的抗冻性. | 王立成 刘汉勇 HIWADA Kiyoshi | 2005 | 建筑材料学报2005，8，4： | 31 |
| 2 | 不同溶剂提取芦竹化感物质对铜绿微囊藻生长的影响显示文摘研究并比较了3种极性不同的有机溶剂(甲醇、乙酸乙酯、正己烷)提取的芦竹(Arundo donaxLinn.)化感物质对铜绿微囊藻生长的影响.通过跟踪观察藻细胞形态,测定藻细胞密度和细胞大小,发现3种溶剂提取物对铜绿微囊藻均有抑制作用.抑藻作用出现早晚次序:甲醇提取物<乙酸乙酯提取物<正己烷提取物.随作用时间的延长,投加低浓度甲醇提取物藻细胞生长恢复明显,高浓度抑藻效果较乙酸乙酯提取物及正己烷提取物弱.高浓度乙酸乙酯提取物、正己烷提取物在分别作用2 d、4d后,抑藻效果均接近100%.各溶剂提取物的半效应质量浓度(EC50,6 d)分别为甲醇提取物0.17 g.L-1,乙酸乙酯提取物0.05g.L-1,正己烷提取物0.08 g.L-1.研究同时发现,投加甲醇提取物藻细胞空洞化,投加乙酸乙酯提取物藻细胞空洞化、破碎以及部分抱团,投加正己烷提取物藻细胞出现褶皱及聚团现象.各溶剂提取物均引起铜绿微囊藻细胞体积减小,其中乙酸乙酯提取物的效果最强. | 洪喻 胡洪营 黄晶晶 Sakoda kiyoshi Sagehashi Masaki 李锋民 | 2008 | 环境科学2008，29，11： | 33 |
| 3 | Usefulness of biodegradable stents constructed of poly-l-lactic acid monofilaments in patients with benign esophageal stenosis显示文摘AIM: To report 13 patients with benign esophageal stenosis treated with the biodegradable stent. METHODS: We developed a Ultraflex-type stent by knitting poly-l-lactic acid monofilaments. RESULTS: Two cases were esophageal stenosis caused by drinking of caustic liquid, 4 cases were due to surgical resection of esophageal cancers, and 7 cases were patients with esophageal cancer who received the preventive placement of biodegradable stents for post- endoscopic mucosal dissection (ESD) stenosis. The preventive placement was performed within 2 to 3 d after ESD. In 10 of the 13 cases, spontaneous migration of the stents occurred between 10 to 21 d after placement. In these cases, the migrated stents were excreted with the feces, and no obstructive complications were experienced. In 3 cases, the stents remained at the proper location on d 21 after placement. No symptoms of re-stenosis were observed within the follow-up period of 7 mo to 2 years. Further treatment with balloon dilatation or replacement of the biodegradable stent was not required. CONCLUSION: Biodegradable stents were useful for the treatment of benign esophageal stenosis, particularly for the prevention of post-ESD stenosis. | Yasuharu Saito Toyohiko Tanaka Akira Andoh Hideki Minematsu Kazunori Hata Tomoyuki Tsujikawa Norihisa Nitta Kiyoshi Murata Yoshihide Fujiyama | 2007 | World Journal of Gastroenterology2007，13，29： | 30 |
| 4 | 全球气候变化对中国未来地表径流的影响显示文摘本文应用改进的水分平衡模型研究了不同气候变化情景下中国未来地表径流的变化。结果表明 :基于不同的气候变化情景模拟所得的地表径流变化在空间上有差异 ,总体上 ,中国未来的地表径流将增加 ;长江上游地区的地表径流春季下降但在夏季增加 ,而下游地区的则相反 ,夏季径流下降而春季径流剧增 ;气溶胶对地表径流变化方面有影响 ,但在各个气候变化情景下缺乏一致性。 | 游松财 Kiyoshi Takahashi Yuzuru Matsuoka | 2002 | 第四纪研究2002，22，2： | 29 |
| 5 | Process Modeling for Heat Treatment: Current Status and Future Developments显示文摘Heat Treating is a critical manufacturing technology. This is particularly true in countries with large manufacturing industry including:; automotive, construction, transportation, and aerospace sectors. Technical advancement of the heat treating industry will be a critical component of the increasing need to remain competitive in this manufacturing sector on a global scale. ASM International has identified the development of process modeling and numerical simulation as a critical technology for the advancement of the heat treating process industry. In this paper, a selective overview of the current accomplishments and future needs of process modeling technologies in heat treatment will be provided. | Tatsuo Inoue, Kiyoshi Funatani and George E. Totters 1.Department of Energy Conversion Science, Kyoto University, Kyoto, Japan 2.Nihan Parkurizing Co., Ltd., Nagoya, Japan 3.Union Carbide Corporation, Tarrytown, NY, USA | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 23 |
| 6 | Novel 3-dimensional virtual hepatectomy simulation combined with real-time deformation显示文摘AIM:To develop a novel 3-dimensional(3D) virtual hepatectomy simulation software,Liversim,to visualize the real-time deformation of the liver.METHODS:We developed a novel real-time virtual hepatectomy simulation software program called Liversim. The software provides 4 basic functions:viewing 3D models from arbitrary directions,changing the colors and opacities of the models,deforming the models based on user interaction,and incising the liver parenchyma and intrahepatic vessels based on user operations. From April 2010 through 2013,99 patients underwent virtual hepatectomies that used the conventional software program SYNAPSE VINCENT preoperatively. Between April 2012 and October 2013,11 patients received virtual hepatectomies using the novel software program Liversim; these hepatectomies were performed both preoperatively and at the same that the actual hepatectomy was performed in an operating room. The perioperative outcomes were analyzed between the patients for whom SYNAPSE VINCENT was used and those for whom Liversim wasused. Furthermore,medical students and surgical residents were asked to complete questionnaires regarding the new software.RESULTS:There were no obvious discrepancies(i.e.,the emergence of branches in the portal vein or hepatic vein or the depth and direction of the resection line) between our simulation and the actual surgery during the resection process. The median operating time was 304 min(range,110 to 846) in the VINCENT group and 397 min(range,232 to 497) in the Liversim group(P = 0.30). The median amount of intraoperative bleeding was 510 m L(range,18 to 5120) in the VINCENT group and 470 m L(range,130 to 1600) in the Liversim group(P = 0.44). The median postoperative stay was 12 d(range,6 to 100) in the VINCENT group and 13 d(range,9 to 21) in the Liversim group(P = 0.36). There were no significant differences in the preoperative outcomes between the two groups. Liversim was not found to be clinically inferior to SYNAPSE VINCENT. Both students and surgical residents reported that the Liversim image was almost the same as the actual hepatectomy.CONCLUSION:Virtual hepatectomy with real-time deformation of the liver using Liversim is useful for the safe performance of hepatectomies and for surgical education. | Yukio Oshiro Hiroaki Yano Jun Mitani Sangtae Kim Jaejeong Kim Kiyoshi Fukunaga Nobuhiro Ohkohchi | 2015 | World Journal of Gastroenterology2015，21，34： | 23 |
| 7 | 紫外线杀菌的原理和最新应用显示文摘 | Kiyoshi Yoshino 姜伟 | 2005 | 中国照明电器2005，，4： | 21 |
| 8 | Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples显示文摘AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP. | Satoshi Mamori Keisuke Nagatsuma Tomokazu Matsuura Kiyoshi Ohkawa Hiroshi Hano Masaharu Fukunaga Masato Matsushima Yoshifumi Masui Nao Fushiya Hiroshi Onoda Yasuyuki Searashi Ichiro Takagi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，21： | 20 |
| 9 | 中国儿童15项常用临床检验指标的生物参考区间研究显示文摘目的建立不同年龄、性别儿童的临床常用检验指标的生物参考区间。方法横断面多中心研究。由全国15个省、市(北京、广东、湖北、江苏、福建、陕西、山东、浙江、湖南、河南、天津、上海、重庆、四川、吉林)20家医学中心合作完成,自2013年6月至2014年12月招募6月龄-17岁的表观正常儿童作为研究对象,通过问卷调查、体格检查和腹部超声等筛选、建立"参考人群";留取研究对象空腹血液标本,送中心实验室进行检测,检测指标包括性激素(雌二醇、睾酮、黄体生成素、卵泡刺激素,化学发光微粒子免疫检测法)、肝功能(丙氨酸转氨酶,加磷酸吡哆醛、不加磷酸吡哆醛试剂速率法两种方法同时检测)、肾功能(肌酐,碱性苦味酸法、酶法两种方法检测;胱抑素C,免疫透射比浊法)、免疫功能(免疫球蛋白A、免疫球蛋白G、免疫球蛋白M、补体C3、补体C4,免疫透射比浊法)、碱性磷酸酶(磷酸对硝基苯法)、尿酸(尿酸酶法)和肌酸激酶(酶法)。将"参考人群"上述15项指标的检测数据按照性别、年龄进行分层统计分析,建立中国儿童参考区间。
结果共招募2 259名儿童完成现场调查,筛选"表观正常儿童"1 648名作为"参考人群";其中男830名、女818名,年龄(7.4±4.9)岁。建立了15项检验指标的生物参考区间,各指标参考区间随性别、年龄变化的趋势如下:(1)性激素:随年龄增长逐渐上升,卵泡刺激素在各年龄组均存在性别差异;(2)肝功能:2岁以下儿童的血丙氨酸转氨酶相对较高,5-9岁相对稳定,之后随年龄增长缓慢上升;(3)肾功能:儿童血肌酐随年龄增长持续上升,血胱抑素C在2岁以下相对高;(4)免疫功能:儿童血免疫球蛋白水平随年龄增长逐渐上升,而补体的参考范围相对恒定(年龄、性别差异不明显);(5)其他:碱性磷酸酶和肌酸激酶在生后早期(2岁以下)处于较高水平,肌酸激酶和尿酸的检测值在5-9岁儿童相对稳定。上述指标中,性激素、肌酐、免疫球蛋白、肌酸激酶、碱性磷酸酶和尿酸的参考区间在进入青春期后迅速升高、伴有性别差异。检测丙氨酸转氨酶时,加磷酸吡哆醛试剂速率法的参考区间高于不加磷酸吡哆醛法;苦味酸法检测出的肌酐参考区间高于酶法(特别是9岁及以下儿童)。结论建立了中国儿童基于年龄、性别分层的生物参考区间,涵盖肝肾功能、免疫功能和性激素等15项临床常用检验指标。 | 钟旭辉 丁洁 周建华 余自华 孙书珍 包瑛 毛建华 于力 李志辉 韩子明 宋红梅 蒋小云 刘玉玲 张碧丽 夏正坤 金春华 朱光华 王墨 冯仕品 沈颖 黄松明 马青山 李海霞 王学晶 Ichihara Kiyoshi 姚晨 董冲亚 | 2018 | 中华儿科杂志2018，56，11： | 19 |
| 10 | Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer显示文摘AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative chemotherapy.METHODS:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of chemotherapy.RESULTS:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR values.CONCLUSION:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy. | Masatsune Shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastroenterology2015，21，34： | 19 |
| 11 | 奥斯特/GPS掩星与地面雷达联合观测电离层电子密度的初步结果显示文摘1999年2月丹麦发射了一颗奥斯特小卫星,它装载了两台GPS接收机,其中一台用于电离层和中性大气掩星测量,另一台用于自主定位。本文给出了1999年10月奥斯特/GPS掩星与日本MU雷达和数字测高仪的联合观测结果。奥斯特掩星反演得到的电子密度剖面与地面雷达观测的进行了比较,结果表明:天基和地基雷达观测的电子密度是一致的。文章还给出利用GPS的单频信号反演电离层电子密度剖面技术和3维射线追踪技术模拟掩星结果。 | 张训械 P.Hoeg G.B.Larsen Stig Syndergaard Martin B.S Jakob G.R S.Fukao Kiyoshi lgarashi Seiji Kawamura | 2000 | 全球定位系统2000，25，3： | 18 |
| 12 | Maintenance for healed erosive esophagitis:PhaseⅢcomparison of vonoprazan with lansoprazole显示文摘AIM To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis(EE).METHODS A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg(n = 201), vonoprazan 10 mg(n = 202), or vonoprazan 20 mg(n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period. The secondary endpoint was the EE recurrence rate at Week 12 during maintenance treatment. Additional efficacy endpoints included the incidence of heartburn and acid reflux, and the EE healing rate 4 wk after the initiation of maintenance treatment. Safety endpoints comprised adverse events(AEs), vital signs, electrocardiogram findings, clinical laboratory results, serum gastrin and pepsinogen Ⅰ/Ⅱ levels, and gastric mucosa histopathology results.RESULTS Rates of EE recurrence during the 24-wk maintenance period were 16.8%, 5.1%, and 2.0% with lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg, respectively. Vonoprazan was shown to be non-inferior to lansoprazole 15 mg(P < 0.0001 for both doses). In a post-hoc analysis, EE recurrence at Week 24 was significantly reduced with vonoprazan at both the 10 mg and the 20 mg dose vs lansoprazole 15 mg(5.1% vs 16.8%, P = 0.0002, and 2.0% vs 16.8%, P < 0.0001, respectively); by contrast, the EE recurrence rate did not differ significantly between the two doses of vonoprazan(P = 0.1090). The safety profiles of vonoprazan 10 and 20 mg were similar to that of lansoprazole 15 mg in patients with healed EE. Treatment-related AEs were reported in 11.4%, 10.4%, and 10.3% of patients in the lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg arms, respectively.CONCLUSION Our findings confirm the non-inferiority of vonoprazan 10 and 20 mg to lansoprazole 15 mg as maintenance therapy for patients with healed EE. | Kiyoshi Ashida Katsuhiko Iwakiri Naoki Hiramatsu Yuuichi Sakurai Tetsuharu Hori Kentarou Kudou Akira Nishimura Eiji Umegaki | 2018 | World Journal of Gastroenterology2018，24，14： | 18 |
| 13 | Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice显示文摘AIM:To investigate the role of human platelets in liver fibrosis.METHODS:Severe combined immunodeficiency(SCID)mice were administered CCl4and either phosphate-buffered saline(PBS group)or human platelet transfusions(hPLT group).Concentrations of hepatocyte growth factor(HGF),matrix metallopeptidases(MMP)-9,and transforming growth factor-β(TGF-β)in the liver tissue were compared between the PBS and the hPLT groups by enzyme-linked immunosorbent assay(ELISA)and Western blotting.The effects of a human platelet transfusion on liver fibrosis included the fibrotic area,hydroxyproline content,and-smooth muscle actin(α-SMA)expression,which were evaluated by picrosirius red staining,ELISA,and immunohistochemical staining using an anti-mouse-SMA antibody,respectively.Phosphorylations of mesenchymal-epithelial transition factor(Met)and SMAD3,downstream signals of HGF and TGF-β,were compared between the two groups by Western blotting and were quantified using densitometry.Hepatocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling.Furthermore,the accumulation of human platelets in the liver 2 h after platelet transfusion was compared between normal and fibrotic livers by immunohistochemical staining using an anti-human CD41 antibody.RESULTS:The fibrotic area and hydroxyproline content in the liver were both significantly lower in the hPLT group when compared to the PBS group(fibrotic area,1.7%±0.6%vs 2.5%±0.6%,P=0.03;hydroxyproline content,121±26 ng/g liver vs 156±47 ng/g liver,P=0.04).There was less α-smooth muscle actin staining in the hPLT group than in the PBS group(0.5%±0.1%vs 0.8%±0.3%,P=0.02).Hepatic expression levels of mouse HGF and MMP-9were significantly higher in the hPLT group than in the PBS group(HGF,109±13 ng/g liver vs 88±22 ng/g liver,P=0.03;MMP-9,113%±7%/GAPDH vs 92%±11%/GAPDH,P=0.04).In contrast,the concentration of mouse TGF-β in the liver tissue was significantly lower in the hPLT group than in the PBS group(22±5ng/g liver vs 39±6 ng/g liver,P=0.02).Phosphorylation of Met was more prevalent in the hPLT group than in the PBS group(37%±4%/GAPDH vs 20%±8%/GAPDH,P=0.03).Phosphorylation of SMAD3was weaker in the hPLT group than in the PBS group(60%±12%/GAPDH vs 84%±12%/GAPDH,P=0.1),although this difference was not significant.Furthermore,a lower rate of hepatocyte apoptosis was observed in the hPLT group than in the PBS group(5.9%±1.7%vs 2.9%±2.1%,P=0.02).Significant human platelet accumulation was observed in the fibrotic liver tissues,whereas few platelets accumulated in the normal liver.CONCLUSION:Human platelets inhibit liver fibrosis in SCID mice.Increased concentration of HGF in the liver suppresses hepatic stellate cell activation,induces MMPs,and inhibits hepatocyte apoptosis. | Kazuhiro Takahashi Soichiro Murata Kiyoshi Fukunaga Nobuhiro Ohkohchi | 2013 | World Journal of Gastroenterology2013，19，32： | 17 |
| 14 | 轴心受压方钢管混凝土短柱的性能研究:Ⅱ分析显示文摘利用三维非线性有限元方法编制的计算机程序,对试验结果进行了分析、比较,并探讨了方钢管混凝土截面受力机理和破坏机制.对截面尺寸和材料强度在较大范围内变化的方钢管混凝土短柱进行了模拟试验,通过参数分析、回归得到方钢管混凝土短柱的承载力计算公式. | 余勇 吕西林 Tanaka Kiyoshi Sasaki Satoshi | 2000 | 建筑结构2000，30，2： | 17 |
| 15 | Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma显示文摘The prevalence of hepatocellular carcinoma(HCC)worldwide parallels that of persistent infection with the hepatitis B virus(HBV)and/or hepatitis C virus(HCV).According to recommendations by the World Health Organization guidelines for HBV/HCV,alpha-fetoprotein(AFP)testing and abdominal ultrasound should be performed in routine surveillance of HCC every 6 mo for high-risk patients.These examinations have also been recommended worldwide by many other HCC guidelines over the past few decades.In recent years,however,the role of AFP in HCC surveillance and diagnosis has diminished due to advances in imaging modalities.AFP was excluded from the surveillance and/or diagnostic criteria in the HCC guidelines published by the American Association for the Study of Liver Diseases in 2010,the European Association for the Study of the Liver in 2012,and the National Comprehensive Cancer Network in 2014.Other biomarkers,including the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),des-γ-carboxyprothrombin,Dickkopf-1,midkine,and micro RNA,are being studied in this regard.Furthermore,increasing attention has focused on the clinical utility of biomarkers as pre-treatment predictors for tumor recurrence and as post-treatment monitors.Serum and tissue-based biomarkers and genomics may aid in the diagnosis of HCC,determination of patient prognosis,and selection of appropriate treatment.However,further studies are needed to better characterize the accuracy and potential role of these approaches in clinical practice. | Pei-Pei Song Ju-Feng Xia Yoshinori Inagaki Kiyoshi Hasegawa Yoshihiro Sakamoto Norihiro Kokudo Wei Tang | 2016 | World Journal of Gastroenterology2016，22，1： | 15 |
| 16 | Conjugate Heat Transfer Analysis of Film Cooling Flows显示文摘这研究的目的是评估各种各样的格子的潜力令人满意地模仿一部冷却电影的发展,用考虑完整的几何学的 a coupled 计算。30 度的单个排的详细计算在一个扁平的盘子上绕行洞为吹 0.764, 1.01 和 1.54 的比率被介绍。模拟结果与试验性的数据被作比较很好。二层的模型给了更精确的结果,但是比标准墙工作的消费了更计算的时间。有有 y + 的适当的值的墙函数的 k- 蔚骚乱模型对实际使用合适。结果为精确地在冷却电影以内描述热转移的影响显示出 conjugate 计算的重要性。关键词拍摄冷却 - 结合热转移 - 刮的比率 CLC 数字 | Xiaochen LU Peixue JIANG Hideaki SUGISHITA Hideyuki UECHI Kiyoshi SUENAGA | 2006 | Journal of Thermal Science2006，15，1： | 12 |
| 17 | Inflammation-based factors and prognosis in patients with colorectal cancer显示文摘Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival. | Kiyoshi Maeda Masatusne Shibutani Hiroshi Otani Hisashi Nagahara Tetsuro Ikeya Yasuhito Iseki Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastrointestinal Oncology2015，7，8： | 12 |
| 18 | Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C显示文摘AIM: To elucidate risk factors contributing to the development of hepatocellular carcinoma (HCC) among patients with sustained viral response (SVR) after interferon (IFN) treatment and to examine whether HCV-RNA still remained in the liver of SVR patients who developed HCC. METHODS: Two-hundred and sixty-six patients, who achieved SVR, were enrolled in this study. We retrospectively reviewed clinical, viral and histological features of the patients, and examined whether the development of HCC depends on several clinical variables using Kaplan-Meier Method. RT-PCR was used to seek HCV-RNA in 3 out of 7 patients in whom liver tissue was available for molecular analysis. RESULTS: Among the enrolled 266 patients with SVR, HCC developed in 7 patients (7/266; 2.6%). We failed to detect HCV-RNA both in cancer and non-cancerous liver tissue in all three patients. The cumulative incidence for HCC was significantly different depending on hepatic fibrosis (F3-4) (P = 0.0028), hepatic steatosis (Grade 2-3) (P = 0.0002) and age (≥ 55) (P = 0.021) at the pre-interferon treatment. CONCLUSION: The current study demonstrated that age, hepatic fibrosis, and hepatic steatosis at pre- interferon treatment might be risk factors for developing HCC after SVR. | Atsushi Tanaka Satoko Uegaki Hiroko Kurihara Kiyoshi Aida Masaki Mikami Ikuo Nagashima Junji Shiga Hajime Takikawa | 2007 | World Journal of Gastroenterology2007，13，39： | 12 |
| 19 | Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy显示文摘An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed. | Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki Takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara | 2012 | World Journal of Gastroenterology2012，18，1： | 11 |
| 20 | Prospective randomized controlled trial investigating the type of sutures used during hepatectomy显示文摘AIM: To determine whether absorbable sutures or non-absorbable sutures are better in preventing surgical site infection (SSI), in this paper we discuss the results of a randomized clinical trial which examined the type of sutures used during hepatectomy. METHODS: All hepatic resections performed from January 2007 to November 2008 at the Department of Surgery at Iizuka Hospital in Japan were included in this study. There were 125 patients randomly assigned to an absorbable sutures (Vicryl) group or non-absorbable sutures (Silk) group. RESULTS: SSI was observed in 13.6% (17/125) patients participating in this study, 11.3% in the Vicryl group and 15.8% in the Silk group. Incisional SSI including superficial and deep SSI, was observed in 8% of the Vicryl group and 9.5% of the Silk group. Organ/ space SSI was observed in 3.2% of the Vicryl group and 6.0% of the Silk group. There were no significant differences, but among the patients with SSI, the period for recovery was significantly shorter for the Vicryl group compared to the Silk group.CONCLUSION: The incidence of SSI in patients receiving absorbable sutures and silk sutures is not significantly different in this randomized controlled study; however, the period for recovery in patients with SSI was significantly shorter for absorbable sutures. | Norifumi Harimoto Ken Shirabe Tomoyuki Abe Takafumi Yukaya Eiji Tsujita Tomonobu Gion Kiyoshi Kajiyama Takashi Nagaie | 2011 | World Journal of Gastroenterology2011，17，18： | 11 |
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