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| 1 | Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis显示文摘AIM To reveal better diagnostic markers for differentiating neuroendocrine tumor(NET) from solid-pseudopapillary neoplasm(SPN), focusing primarily on immunohistochemical analysis.METHODS We reviewed 30 pancreatic surgical specimens of NET(24 cases) and SPN(6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,vimentin, α-1-antitrypsin, CD10, and β-catenin.RESULTS E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. The other six markers were not useful because their expression overlapped widely between NETs and SPNs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles. Careful diagnosis is crucial as we actually found two confusing cases showing disagreement between the tumor morphology and immunohistochemical profiles.CONCLUSION E-cadherin, chromogranin A, and β-catenin were the most useful markers which should be employed for differentiating between NET and SPN. | Yusuke Ohara Tatsuya Oda Shinji Hashimoto Yoshimasa Akashi Ryoichi Miyamoto Tsuyoshi Enomoto Kaishi Satomi Yukio Morishita Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，38： | 19 |
| 2 | Three-dimensional imaging identified the accessory bile duct in a patient with cholangiocarcinoma显示文摘The development of diagnostic imaging technology, such as multidetector computed tomography(MDCT) and magnetic resonance cholangiopancreatography(MRCP), has made it possible to obtain detailed images of the bile duct. Recent reports have indicated that a 3-dimensional(3D) reconstructed imaging system would be useful for understanding the liver anatomy before surgery. We have investigated a novel method that fuses MDCT and MRCP images. This novel system easily made it possible to detect the anatomical relationship between the vessels and bile duct in the portal hepatis. In this report, we describe a very rare case of extrahepatic cholangiocarcinoma associated with an accessory bile duct from the caudate lobe connecting with the intrapancreatic bile duct. We were unable to preoperatively detect this accessory bile duct using MDCT and MRCP. However, prior to the second operation, we were able to clearly visualise the injured accessory bile duct using our novel 3D imaging modality. In thisreport, we suggest that this imaging technique can be considered a novel and useful modality for understanding the anatomy of the portal hepatis, including the hilar bile duct. | Ryoichi Miyamoto Yukio Oshiro Shinji Hashimoto Keisuke Kohno Kiyoshi Fukunaga Tatsuya Oda Nobuhiro Ohkohchi | 2014 | World Journal of Gastroenterology2014，20，32： | 6 |
| 3 | Influence of Kupffer cells and platelets on ischemia-reperfusion injury in mild steatotic liver显示文摘AIM: To investigate the effect of mild steatotic liver on ischemia-reperfusion injury by focusing on Kupffer cells (KCs) and platelets. METHODS: Wistar rats were divided into a normal liver group (N group) and a mild steatotic liver group (S group) induced by feeding a choline-deficient diet for 2 wk. Both groups were subjected to 20 min of warm ischemia followed by 120 min of reperfusion. The number of labeled KCs and platelets in sinusoids and the blood perfusion in sinusoids were observed by intravital microscopy (IVM), which was performed at 30, 60 and 120 min after reperfusion. To evaluate serum alanine aminotransferase as a marker of liver deterioration, blood samples were taken at the same time as IVM.RESULTS: In the S group, the number of platelets adhering to KCs decreased significantly compared with the N group (120 after reperfusion; 2.9±1.1 cells/acinus vs 4.8±1.2 cells/acinus, P<0.01). The number of KCs in sinusoids was significantly less in the S group than in the N group throughout the observation periods (before ischemia, 19.6±3.3 cells/acinus vs 28.2±4.1 cells/acinus, P<0.01 and 120 min after reperfusion, 29.0±4.3 cells/acinus vs 40.2±3.3 cells/acinus, P<0.01). The blood perfusion of sinusoids 120 min after reperfusion was maintained in the S group more than in the N group. Furthermore, elevation of serum alanine aminotransferase was lower in the S group than in the N group 120 min after reperfusion (99.7±19.8 IU/L vs 166.3±61.1 IU/L, P=0.041), and histological impairment of hepatocyte structure was prevented in the S group. CONCLUSION: Ischemia-reperfusion injury in mild steatotic liver was attenuated compared with normal liver due to the decreased number of KCs and the reduction of the KC-platelet interaction. | Koichi Ogawa Tadashi Kondo Takafumi Tamura Hideki Matsumura Kiyoshi Fukunaga Tatsuya Oda Nobuhiro Ohkohchi | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 4 | Distal pancreatectomy with resection of the celiac axis and reconstruction of the hepatic artery for carcinoma of the body and tail of the pancreas显示文摘 | Masaru Konishi Taira Kinoshita Toshio Nakagori Kazuto Inoue Tatsuya Oda Takahiro Kimata Hiroyuki Kikuchi Munemasa Ryu | 2000 | Journal of Hepato - Biliary - Pancreatic Surgery2000，，2： | 4 |
| 5 | Comparative study on modeccin- and phytohemagglutinin (PHA)-induced secretion of cytokines and nitric oxide (NO) in RAW264.7 cells显示文摘老鼠巨噬细胞房间线 RAW264.7 上的细胞毒素的 lectins, modeccin 和 phytohemagglutinin (公众房产管理局) 的效果被检测煽动性的调停人的正式就职学习。结果证明 modeccin 导致了肿瘤坏死因素的版本 --(TNF-) 从 RAW264.7,有一个钟形状集中依赖者的房间介绍。没在 RAW264.7 房间上显示出重要 cytotoxicity 直到 100,000 ng/ml 的公众房产管理局比 modeccin 导致了 TNF- 的许多高水平。公众房产管理局同时比 TNF- 的与甚至许多高水平从 RAW264.7 房间导致了 granulocyte 殖民地刺激因素(G-CSF ) 的分泌物,而 modeccin 不。而且,公众房产管理局导致了氮的氧化物的分泌物(没有) 在 RAW264.7 房间,当时没有重要水平不在对待 modeccin 的房间被检测。NH4Cl (一个 lysomotoropic 代理人) 和酮环己酰亚胺(一个核糖体禁止者) 强烈禁止了导致 modeccin 的 TNF- 分泌物,但是导致公众房产管理局的 TNF- 分泌物上的这些试剂的重要禁止的效果都没被观察。与导致 modeccin 的 TNF- 分泌物相反,平稍微增加的 TNF- 分泌物面对 10 公里 NH4Cl 在对待公众房产管理局的房间被观察。另外,由各种各样的 kinase 禁止者的导致 modeccin 的 TNF- 分泌物的抑制侧面与公众房产管理局的那些不同。这些结果建议 modeccin 的行动模式包括 TNF- ,刺激导致煽动性的分子的分泌物的 RAW264.7 房间从公众房产管理局的是不同的。在另一方面,显著地增加了使活跃之物 protein-1 (AP-1 ) 的 translocation,涉及煽动性的分子的表示的一个关键抄写因素,在与公众房产管理局和 modeccin 对待的 RAW264.7 房间被观察进原子核。 | Daekyung Kim Yasuhiro Yamasaki Zedong Jiang Yuki Nakayama Tomohiro Yamanishi Kenichi Yamaguchi Tatsuya Oda | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 3 |
| 6 | Novel alternative transplantation therapy for orthotopic liver transplantation in liver failure:A systematic review显示文摘BACKGROUND Orthotopic liver transplantation(OLT)is the only treatment for end-stage liver failure;however,graft shortage impedes its applicability.Therefore,studies investigating alternative therapies are plenty.Nevertheless,no study has comprehensively analyzed these therapies from different perspectives.AIM To summarize the current status of alternative transplantation therapies for OLT and to support future research.METHODS A systematic literature search was performed using PubMed,Cochrane Library and EMBASE for articles published between January 2010 and 2018,using the following MeSH terms:[(liver transplantation)AND cell]OR[(liver transplantation)AND differentiation]OR[(liver transplantation)AND organoid]OR[(liver transplantation)AND xenotransplantation].Various types of studies describing therapies to replace OLT were retrieved for full-text evaluation.Among them,we selected articles including in vivo transplantation.RESULTS A total of 89 studies were selected.There are three principle forms of treatment for liver failure:Xeno-organ transplantation,scaffold-based transplantation,and cell transplantation.Xeno-organ transplantation was covered in 14 articles,scaffold-based transplantation was discussed in 22 articles,and cell transplantation was discussed in 53 articles.Various types of alternative therapies were discussed:Organ liver,25 articles;adult hepatocytes,31 articles;fetal hepatocytes,three articles;mesenchymal stem cells(MSCs),25 articles;embryonic stem cells,one article;and induced pluripotent stem cells,three articles and other sources.Clinical applications were discussed in 12 studies:Cell transplantation using hepatocytes in four studies,five studies using umbilical cord-derived MSCs,three studies using bone marrow-derived MSCs,and two studies using hematopoietic stem cells.CONCLUSION The clinical applications are present only for cell transplantation.Scaffold-based transplantation is a comprehensive treatment combining organ and cell transplantations,which warrants future research to find relevant clinical applications. | Tomoaki Furuta Kinji Furuya Yun-Wen Zheng Tatsuya Oda | 2020 | World Journal of Transplantation2020，10，3： | 3 |
| 7 | Impact of three-dimensional analysis of multidetector row computed tomography cholangioportography in operative planning for hilar cholangiocarcinoma显示文摘 | Ryoko Sasaki Tadashi Kondo Tatsuya Oda Soichiro Murata Go Wakabayashi Nobuhiro Ohkohchi | 2011 | The American Journal of Surgery2011，，4： | 2 |
| 8 | Preoperative 3D volumetric analysis for liver congestion applied in a patient with hilar cholangiocarcinoma显示文摘 | Kazuhiro Takahashi Ryoko Sasaki Tadashi Kondo Tatsuya Oda Soichiro Murata Nobuhiro Ohkohchi | 2010 | Langenbeck’s Archives of Surgery2010，，6： | 2 |
| 9 | Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells显示文摘Chronic infection with hepatitis B virus(HBV)remains a global health concern despite the availability of vaccines.To date,the development of effective treatments has been severely hampered by the lack of reliable,reproducible,and scalable in vitro modeling systems that precisely recapitulate the virus life cycle and represent virus-host interactions.With the progressive understanding of liver organogenesis mechanisms,the development of human induced pluripotent stem cell(iPSC)-derived hepatic sources and stromal cellular compositions provides novel strategies for personalized modeling and treatment of liver disease.Further,advancements in three-dimensional culture of self-organized liver-like organoids considerably promote in vitro modeling of intact human liver tissue,in terms of both hepatic function and other physiological characteristics.Combined with our experiences in the investigation of HBV infections using liver organoids,we have summarized the advances in modeling reported thus far and discussed the limitations and ongoing challenges in the application of liver organoids,particularly those with multi-cellular components derived from human iPSCs.This review provides general guidelines for establishing clinical-grade iPSC-derived multi-cellular organoids in modeling personalized hepatitis virus infection and other liver diseases,as well as drug testing and transplantation therapy. | Di Cao Jian-Yun Ge Yun Wang Tatsuya Oda Yun-Wen Zheng | 2021 | World Journal of Gastroenterology2021，27，29： | 2 |
| 10 | Dualistic role of platelets in living donor liver transplantation: Are they harmful?显示文摘Platelets are anucleate fragments mainly involved in hemostasis and thrombosis,and there is emerging evidence that platelets have other nonhemostatic potentials in inflammation,angiogenesis,regeneration and ischemia/reperfusion injury(I/R injury),which are involved in the physiological and pathological processes during living donor liver transplantation(LDLT).LDLT is sometimes associated with impaired regeneration and severe I/R injury,leading to postoperative complications and decreased patient survival.Recent studies have suggested that perioperative thrombocytopenia is associated with poor graft regeneration and postoperative morbidity in the short and long term after LDLT.Although it is not fully understood whether thrombocytopenia is the cause or result,increasing platelet counts are frequently suggested to improve posttransplant outcomes in clinical studies.Based on rodent experiments,previous studies have identified that platelets stimulate liver regeneration after partial hepatectomy.However,the role of platelets in LDLT is controversial,as platelets are supposed to aggravate I/R injury in the liver.Recently,a rat model of partial liver transplantation(LT)was used to demonstrate that thrombopoietin-induced thrombocytosis prior to surgery accelerated graft regeneration and improved the survival rate after transplantation.It was clarified that platelet-derived liver regeneration outweighed the associated risk of I/R injury after partial LT.Clinical strategies to increase perioperative platelet counts,such as thrombopoietin,thrombopoietin receptor agonist and platelet transfusion,may improve graft regeneration and survival after LDLT. | Chen Liang Kazuhiro Takahashi Kinji Furuya Nobuhiro Ohkohchi Tatsuya Oda | 2022 | World Journal of Gastroenterology2022，28，9： | 2 |
| 11 | Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment显示文摘BACKGROUND To solve the problem of liver transplantation donor insufficiency,an alternative cell transplantation therapy was investigated.We focused on amniotic epithelial cells(AECs)as a cell source because,unlike induced pluripotent stem cells,they are cost-effective and non-tumorigenic.The utilization of AECs in regenerative medicine,however,is in its infancy.A general profile for AECs has not been comprehensively analyzed.Moreover,no hepatic differentiation protocol for AECs has yet been established.To this end,we independently compiled human AEC libraries,purified amniotic stem cells(ASCs),and co-cultured them with mesenchymal stem cells(MSCs)and human umbilical vein endothelial cell(HUVECs)in a 3D system which induces functional hepatic organoids.AIM To characterize AECs and generate functional hepatic organoids from ASCs and other somatic stem cells METHODS AECs,MSCs,and HUVECs were isolated from the placentae and umbilical cords of cesarean section patients.Amnion and primary AEC stemness characteristics and heterogeneity were analyzed by immunocytochemistry,Alkaline phosphatase(AP)staining,and flow cytometry.An adherent AEC subpopulation was selected and evaluated for ASC purification quality by a colony formation assay.AEC transcriptomes were compared with those for other hepatocytes cell sources by bioinformatics.The 2D and 3D culture were compared by relative gene expression using several differentiation protocols.ASCs,MSCs,and HUVECs were combined in a 3D co-culture system to generate hepatic organoids whose structure was compared with a 3D AEC sphere and whose function was elucidated by immunofluorescence imaging,periodic acid Schiff,and an indocyanine green(ICG)test.RESULTS AECs have certain stemness markers such as EPCAM,SSEA4,and E-cadherin.One AEC subpopulation was also either positive for AP staining or expressed the TRA-1-60 and TRA-1-81 stemness markers.Moreover,it could form colonies and its frequency was enhanced ten-fold in the adherent subpopulation after selective primary passage.Bioinformatics analysis of ribose nucleic acid sequencing revealed that the total AEC gene expression was distant from those of pluripotent stem cells and hepatocytes but some gene expression overlapped among these cells.TJP1,associated with epidermal growth factor receptor,and MET,associated with hepatocyte growth factor receptor,were upregulated and may be important for hepatic differentiation.In conventional flat culture,the cells turned unviable and did not readily differentiate into hepatocytes.In 3D culture,however,hepatic gene expression of the AEC sphere was elevated even under a two-step differentiation protocol.Furthermore,the organoids derived from the MSC and HUVEC co-culture showed 3D structure with polarity,hepatic-like glycogen storage,and ICG absorption/elimination.CONCLUSION Human amniotic epithelial cells are heterogeneous and certain subpopulations have high stemness.Under a 3D co-culture system,functional hepatic organoids were generated in a multicellular microenvironment. | Kinji Furuya Yun-Wen Zheng Daisuke Sako Kenichi Iwasaki Dong-Xu Zheng Jian-Yun Ge Li-Ping Liu Tomoaki Furuta Kazunori Akimoto Hiroya Yagi Hiromi Hamada Hiroko Isoda Tatsuya Oda Nobuhiro Ohkohchi | 2019 | World Journal of Stem Cells2019，11，9： | 2 |
| 12 | Automatic registration of MLS point clouds and SfM meshes of urban area显示文摘Recent advances in 3D scanning technologies allow us to acquire accurate and dense 3D scan data of large-scale environments efficiently.Currently,there are various methods for acquiring largescale 3D scan data,such as Mobile Laser Scanning(MLS),Airborne Laser Scanning,Terrestrial Laser Scanning,photogrammetry and Structure from Motion(SfM).Especially,MLS is useful to acquire dense point clouds of road and road-side objects,and SfM is a powerful technique to reconstruct meshes with textures from a set of digital images.In this research,a registration method of point clouds from vehicle-based MLS(MLS point cloud),and textured meshes from the SfM of aerial photographs(SfM mesh),is proposed for creating high-quality surface models of urban areas by combining them.In general,SfM mesh has non-scale information;therefore,scale,position,and orientation of the SfM mesh are adjusted in the registration process.In our method,first,2D feature points are extracted from both SfM mesh and MLS point cloud.This process consists of ground-and building-plane extraction by region growing,random sample consensus and least square method,vertical edge extraction by detecting intersections between the planes,and feature point extraction by intersection tests between the ground plane and the edges.Then,the corresponding feature points between the MLS point cloud and the SfM mesh are searched efficiently,using similarity invariant features and hashing.Next,the coordinate transformation is applied to the SfM mesh so that the ground planes and corresponding feature points are adjusted.Finally,scaling Iterative Closest Point algorithm is applied for accurate registration.Experimental results for three data-sets show that our method is effective for the registration of SfM mesh and MLS point cloud of urban areas including buildings. | Reiji Yoshimura Hiroaki Date Satoshi Kanai Ryohei Honma Kazuo Oda Tatsuya Ikeda | 2016 | Geo-Spatial Information Science2016，19，3： | 1 |
| 13 | Application of periodontal ligament cell sheet for periodontal regeneration:a pilot study in beagle dogs显示文摘 | Tatsuya Akizuki Shigeru Oda Motohiro Komaki | 2005 | J Periodont Res2005，40，： | 1 |
| 14 | Role of p38 MAP kinase pathway in a toxin-induced model of hemolytic uremic syndrome显示文摘 | Xue Jun Fu Kazumoto Iijima Kandai Nozu Kiyoshi Hamahira Ryojiro Tanaka Tatsuya Oda Norishige Yoshikawa Masafumi Matsuo | 2004 | Pediatric Nephrology2004，，8： | 1 |
| 15 | Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation显示文摘 | Takuya Kawasaki Soichiro Murata Kazuhiro Takahashi Reiji Nozaki Yukio Ohshiro Naoya Ikeda Sugiru Pak Andriy Myronovych Katsuji Hisakura Kiyoshi Fukunaga Tatsuya Oda Ryoko Sasaki Nobuhiro Ohkohchi | 2010 | Journal of Hepatology2010，，4： | 1 |
| 16 | Stimulation of multiple cytokine production in mice by alginate oligosaccharides following intraperitoneal administration显示文摘 | Yoshiko Yamamoto Maki Kurachi Kenichi Yamaguchi Tatsuya Oda | 2007 | Carbohydrate Research2007，，8： | 1 |
| 17 | Effect of fat volume on postoperative complications and survival rate after D2 dissection for gastric cancer显示文摘 | Satoshi Inagawa Shinya Adachi Tatsuya Oda Toru Kawamoto Naoto Koike Katashi Fukao | 2000 | Gastric Cancer2000，，3： | 1 |
| 18 | Effect of fat volume on postoperative complications and survival rate after D2 dissection for gastric cancer显示文摘 | Satoshi Inagawa Shinya Adachi Tatsuya Oda Toru Kawamoto Naoto Koike Katashi Fukao | 2000 | Gastric Cancer2000，，3： | 1 |
| 19 | Needle Tract Implantation of Hepatocellular Carcinoma and Pancreatic Carcinoma after Ultrasound-guided Percutaneous Puncture: Clinical and Pathologic Characteristics and the Treatment of Needle Tract Implantation显示文摘 | Chihiro Kosugi M.D. Junji Furuse M.D. Hiroshi Ishii M.D. Yasushi Maru M.D. Masahiro Yoshino M.D. Taira Kinoshita M.D. Masaru Konishi M.D. Toshio Nakagohri M.D. Kazuto Inoue M.D. Tatsuya Oda M.D | 2004 | World Journal of Surgery2004，，1： | 1 |
| 20 | Application of periodontal ligament cell sheet for periodontal regeneration:A pilot study in beagle dogs显示文摘 | Tatsuya Akizuki Shigeru Oda Motohiro Komaki | 2005 | J Periodont Res2005，40，： | 1 |
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