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| 1 | Classifying genotype F of hepatitis B virus into F1 and F2 subtypes显示文摘AIM: To explore the propriety of providing hepatitis B virus(HBV) genotypes F and H with two distinct genotypes.METHODS: Eleven HBV isolates of genotype F (HBV/F)were recovered from patients living in San Francisco,Japan, Panama, and Venezuela, and their full-length sequences were determined. Phylogenetic analysis was carried out among them along with HBV isolates previously reported.RESULTS: Seven of them clustered with reported HBV/F isolates in the phylogenetic tree constructed on the entire genomic sequence. The remaining four flocked on another branch along with three HBV isolates formerly reported as genotype H. These seven HBV isolates, including the four in this study and the three reported, had a sequence divergence of 7.3-9.5% from the other HBV/F isolates,and differed by > 13.7% from HBV isolates of the other six genotypes (A-E and G). Based on a marked genomic divergence, falling just short of >8% separating the seven genotypes, these seven HBV/F isolates were classified into F2 subtype and the former seven into F1 subtype provisionally. In a pairwise comparison of the S-gene sequences among the 7 HBV/F2 isolates and against 47HBV/F1 isolates as well as 136 representing the other six genotypes (A-E and G), two clusters separated by distinct genetic distances emerged.CONCLUSION: Based on these analyses, classifying HBV/F isolates into two subtypes (F1 and F2) would be more appropriate than providing them with two distinct genotypes (F and H). | Hideaki Kato Kei Fujiwara Robert G. Gish Hiroshi Sakugawa Hiroshi Yoshizawa Fuminaka Sugauchi Etsuro Orito Ryuzo Ueda Yasuhito Tanaka Takanobu Kato Yuzo Miyakawa Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，40： | 6 |
| 2 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 3 | Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii显示文摘AIM: Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of thepresent study was to evaluate the distribution of HBV genotypes and their clinical relevance in Hawaii.METHODS: Genotyping of HBV among 61 multi-ethnicc arriers in Hawaii was performed by genetic methods.Three complete genomes and 61 core promoter/precore regions of HBV were sequenced directly.RESULTS: HBV genotype distribution among the 61 carderswas 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian,Southeast Asian, and various Asian and Micronesian,respectively. All cases of genotype B were composed of recombinant strains with genotype C in the precore plus core region named genotype Ba. HBeAg was detected more frequently in genotype C than in genotype B (68.4% vs 33.3%, P<0.05) and basal core promoter (BCP) mutation (T1762/A1764) was more frequently found in genotype C than in genotype B. Twelve of the 38 genotype C strains possessed C at nucleotide (nt) position 1858 (C-1858).However there was no significant difference in clinical characteristics between C-1858 and T-1858 variants. Based on complete genome sequences, phylogenetic analysis revealed one patient of Micronesian ethnicity as having C1858 clustered with two isolates from Polynesia with T-1858.In addition, two strains from Asian ethnidties were clustered with known isolates in carriers from Southeast Asia.CONCLUSION: Genotypes A, B and C are predominant types among multi-ethnic HBV carriers in Hawaii, and distribution of HBV genotypes is dependent on the ethnic background of the carriers in Hawaii. | Mayumi Sakurai Fuminaka Sugauchi Naoky Tsai Seiji Suzuki Izumi Hasegawa Kei Fujiwara Etsuro Orito Ryuzo Ueda Masashi Mizokami | 2004 | World Journal of Gastroenterology2004，10，15： | 2 |
| 4 | Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma显示文摘 | Shigeru Kusumoto Yasuhito Tanaka Masashi Mizokami Ryuzo Ueda | 2009 | International Journal of Hematology2009，，1： | 2 |
| 5 | Smoking Increases the Treatment Failure for Helicobacter pylori Eradication显示文摘 | Takeshi Suzuki Keitaro Matsuo Hidemi Ito Akira Sawaki Kaoru Hirose Kenji Wakai Shigeki Sato Tsuneya Nakamura Kenji Yamao Ryuzo Ueda Kazuo Tajima | 2006 | The American Journal of Medicine2006，，3： | 2 |
| 6 | Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C显示文摘 | Fuminaka Sugauchi Etsuro Orito Takafumi Ichida Hideaki Kato Hiroshi Sakugawa Shinichi Kakumu Takafumi Ishida Anuchit Chutaputti Ching-Ling Lai Robert G. Gish Ryuzo Ueda Yuzo Miyakawa Masashi Mizokami | 2003 | Gastroenterology2003，，4： | 1 |
| 7 | The first report of successful nasogastric Coca-Cola lavage treatment for bitter persimmon phytobezoars in Japan显示文摘 | Hideaki Kato Makoto Nakamura Etsuro Orito Ryuzo Ueda Masashi Mizokami | 2003 | The American Journal of Gastroenterology2003，，7： | 1 |
| 8 | Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5′-deoxy-5-fluorouridine (5′-DFUR)显示文摘 | Hiromichi Ebi Yasushi Sigeoka Toshiaki Saeki Kenji Kawada Tadahiko Igarashi Noriko Usubuchi Ryuzo Ueda Yasutsuna Sasaki Hironobu Minami | 2005 | Cancer Chemotherapy and Pharmacology2005，，2： | 1 |
| 9 | Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma显示文摘 | Yasuhito Tanaka Motokazu Mukaide Etsuro Orito Man-Fung Yuen Kiyoaki Ito Fuat Kurbanov Fuminaka Sugauchi Yasuhiro Asahina Namiki Izumi Michio Kato Ching-Lung Lai Ryuzo Ueda Masashi Mizokami | 2006 | Journal of Hepatology2006，，5： | 1 |
| 10 | The absence of human equilibrative nucleoside transporter 1 expression predicts nonresponse to gemcitabine-containing chemotherapy in non-small cell lung cancer显示文摘 | Tetsuya Oguri Hiroyuki Achiwa Hideki Muramatsu Hiroaki Ozasa Shigeki Sato Shigeki Shimizu Hideko Yamazaki Tadaaki Eimoto Ryuzo Ueda | 2007 | Cancer Letters2007，，1： | 1 |
| 11 | Efficacy of S-1 monotherapy for non-small cell lung cancer after thefailure of two or more prior chemotherapy regimens显示文摘 | Osamu Takakuwa Tetsuya Oguri Ken Maeno Hiroaki Ozasa Yasuhito Iwashima Mikinori Miyazaki Hideharu Kunii Yuko Takano Toshiyuki Mori Shigeki Sato Ryuzo Ueda | 2010 | Oncology Letters2010，，1： | 1 |
| 12 | Reactivation of hepatitis B virus in a patient with adult T ‐cell leukemia–lymphoma receiving the anti‐ CC chemokine receptor 4 antibody mogamulizumab显示文摘 | Nobuaki Nakano Shigeru Kusumoto Yasuhito Tanaka Takashi Ishida Shogo Takeuchi Yoshifusa Takatsuka Shiro Akinaga Masashi Mizokami Ryuzo Ueda Atae Utsunomiya | 2014 | Hepatol Res2014，，3： | 1 |
| 13 | The role of thymidylate synthase and dihydropyrimidine dehydrogenase in resistance to 5-fluorouracil in human lung cancer cells显示文摘 | Tetsuya Oguri Hiroyuki Achiwa Yuji Bessho Hideki Muramatsu Hiroyoshi Maeda Takashi Niimi Shigeki Sato Ryuzo Ueda | 2005 | Lung Cancer2005，，3： | 1 |
| 14 | Reactivation of hepatitis B virus in HBsAg-negative patients with multiple myeloma: two case reports显示文摘 | Tatsuya Yoshida Shigeru Kusumoto Atsushi Inagaki Fumiko Mori Asahi Ito Masaki Ri Takashi Ishida Hirokazu Komatsu Shinsuke Iida Fuminaka Sugauchi Yasuhito Tanaka Masashi Mizokami Ryuzo Ueda | 2010 | International Journal of Hematology2010，，5： | 1 |
| 15 | Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5′-deoxy-5-fluorouridine (5′-DFUR)显示文摘 | Hiromichi Ebi Yasushi Sigeoka Toshiaki Saeki Kenji Kawada Tadahiko Igarashi Noriko Usubuchi Ryuzo Ueda Yasutsuna Sasaki Hironobu Minami | 2005 | Cancer Chemotherapy and Pharmacology2005，，2： | 1 |
| 16 | Effects of atorvastatin on inflammation and oxidative stress显示文摘 | Masaya Sugiyama Masuo Ohashi Hiroyuki Takase Koichi Sato Ryuzo Ueda Yasuaki Dohi | 2005 | Heart and Vessels2005，，4： | 1 |
| 17 | Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma显示文摘 | Shigeru Kusumoto Yasuhito Tanaka Masashi Mizokami Ryuzo Ueda | 2009 | International Journal of Hematology2009，，1： | 1 |
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