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| 1 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 2 | Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy显示文摘AIM:To clarify the significance of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 patients who had undergone total gastrectomy with splenectomy,excluding non-curative cases,resection of multiple gastric cancer, and those with remnant stomach cancer.Various clinico-pathological factors were evaluated for any independent contributions to No.10 LN metastasis,usingχ 2 test. Significant factors were extracted for further analysis, carried out using a logistic regression method.Furthermore,lymph node metastasis was evaluated for any independent contribution to No.10 LN metastasis,using the same methods.The cumulative survival rate was calculated using the Kaplan-Meier method.The significance of any difference between the survival curves was determined using the Cox-Mantel test,and any difference was considered significant at the 5%level. RESULTS:From the variables considered to be potentially associated with No.10 LN metastasis,age, depth,invasion of lymph vessel,N factor,the numberof lymph node metastasis,Stage,the number of sites, and location were found to differ significantly between those with metastasis(the Positive Group)and those without(the Negative Group).A logistic regression analysis showed that the localization and Stage were significant parameters for No.10 LN metastasis.There was no case located on the lesser curvature in the Posi-tive Group.The numbers of No.2,No.3,No.4sa,No. 4sb,No.4d,No.7,and No.11 LN metastasis were each found to differ significantly between the Positive Group and the Negative Group.A logistic regression analysis showed that No.4sa,No.4sb,and No.11 LN metastasis were each a significant parameter for No.10 LN metastasis.There was no significant difference in survival curves between the Positive Group and the Negative Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for cases which have No.4sa,No. 4sb or No.11 LN metastasis.However,in cases where the tumor is located on the lesser curvature,splenectomy can be omitted. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Takuya Imaizumi Junya Kizaki Kazuo Shirouzu | 2010 | World Journal of Hepatology2010，2，2： | 26 |
| 3 | 亚甲基四氢叶酸还原酶基因C677T多态性与胃癌易感性的关系显示文摘目的 研究亚甲基四氢叶酸还原酶 (MTHFR)基因C6 77T多态性及其和烟酒嗜好相互作用与胃癌易感性的关系。方法 在上消化道癌高发区江苏省淮安市进行病例对照研究 (胃癌患者10 7例 ,对照人群 2 0 0名 ) ,调查研究对象的生活习惯 ,采用PCR RFLP技术检测研究对象的MTHFR基因型。结果 ①胃癌组中MTHFR变异基因型拥有者的比例为 79.4 % ,显著高于对照组的 6 8.5 %(χ2 =4 .15 ,P =0 .0 4 16 )。MTHFR变异基因型拥有者发生胃癌的危险性显著升高 (OR =1.78,95 %CI :0 .99~ 3.2 2 ;性别和年龄调整OR =1.89,95 %CI:1.0 8~ 3.32 )。②在MTHFR变异基因型拥有者中 ,伴有吸烟习惯者发生胃癌的OR为 7.72 (95 %CI:2 .2 3~ 2 6 .79) ,伴有经常饮酒习惯者发生胃癌的OR为 3.0 8(95 %CI :1.30~ 7.2 3)。与不吸烟、不经常饮酒的野生型纯合子MTHFR基因型拥有者相比 ,伴有吸烟和经常饮酒习惯的MTHFR变异基因型拥有者发生胃癌的OR为 13.96 (95 %CI :2 .76~ 70 .4 6 )。结论 MTHFRC6 77T变异基因型与胃癌的易感性有关 ; | 高长明 吴建中 丁建华 刘燕婷 臧宇 李苏平 苏平 胡旭 徐天亮 Takezaki Toshiro Tajima Kazuo | 2002 | 中华流行病学杂志2002，23，4： | 26 |
| 4 | Criteria for the diagnosis and severity stratification of acute pancreatitis显示文摘Recent diagnostic and therapeutic progress for severe acute pancreatitis(SAP)remarkably decreased the casemortality rate.To further decrease the mortality rate of SAP,it is important to precisely evaluate the severity at an early stage,and initiate appropriate treatment as early as possible.Research Committee of Intractable Diseases of the Pancreas in Japan developed simpler criteria combining routinely available data with clinical signs.Severity can be evaluated by laboratory examinations or by clinical signs,reducing the defect values of the severity factors.Moreover,the severity criteria considered laboratory/clinical severity scores and contrastenhanced computed tomography(CE-CT)findings as independent risk factors.Thus,CE-CT scans are not necessarily required to evaluate the severity of acute pancreatitis.There was no fatal case in mild AP diagnosed by the CE-CT severity score,whereas case-mortality rate in those with SAP was 14.8%.Case-mortality of SAP that fulfilled both the laboratory/clinical and the CE-CT severity criteria was 30.8%.It is recommended,therefore,to perform CE-CT examination to clarify the prognosis in those patients who were diagnosed as SAP by laboratory/clinical severity criteria.Because the mortality rate of these patients with SAP is high,such patients should be transferred to advanced medical units. | Makoto Otsuki Kazunori Takeda Seiki Matsuno Yasuyuki Kihara Masaru Koizumi Masahiko Hirota Tetsuhide Ito Keisho Kataoka Motoji Kitagawa Kazuo Inui Yoshifumi Takeyama | 2013 | World Journal of Gastroenterology2013，19，35： | 24 |
| 5 | 南极中山站极光形态的统计特征显示文摘利用极光全天空摄象机1995年和1997年在南极中山站观测的极光数据,对中山站上空极光的出现情况进行了统计分析。在南极中山站,午后(磁地方时1400~1800MLT)和子夜前后(2200~0300MLT)出现极光的情况比较多,在傍晚(1800~2200MLT)出现极光的情况要少一些;较强的极光主要也出现在午后和子夜附近。冕状极光主要出现在子夜附近和午后的极向侧和天顶,在傍晚出现很少;带状极光主要出现在午后和赤道侧的傍晚与子夜;极光浪涌主要出现在子夜前后;向日极光弧则主要出现在子夜前后,子夜前比子夜后多,极向和天顶比赤道侧多。除向日极光弧外,其它形态的极光在中山站的出现情况与Kp指数相关。中山站进入极光带的时间通常在午后。 | 胡红桥 刘瑞源 王敬芳 杨惠根 KAZUO MAKITA 王幸 NATSUO SATO | 1999 | 极地研究1999，11，1： | 22 |
| 6 | Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation显示文摘AIM:To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy. METHODS:We conducted a randomized,double-blind, placebo-controlled study with mosapride in addition to polyethylene glycol(PEG)-electrolyte solution.Of 250 patients undergoing colonoscopy,124 were randomized to receive 2 L PEG plus 15 mg of mosapride citrate (mosapride group),and 126 received 2 L PEG plus placebo(placebo group).Patients completed a questionnaire reporting the acceptability and tolerability of the bowel preparation process.The efficacy of bowel preparation was assessed by colonoscopists using a 5-point scale based on Aronchick's criteria.The primary end point was optimal bowel preparation rates(scores of excellent/good/fair vs poor/inadequate). RESULTS:A total of 249 patients were included in the analysis.In the mosapride group,optimal bowel preparation rates were significantly higher in the left colon compared with the placebo group(78.2%vs 65.6%,P<0.05),but not in the right colon(76.5%vs 66.4%,P=0.08).After excluding patients with severe constipation,there was a significant difference in bowel preparation in both the left and right colon(82.4%vs 66.7%,80.8%vs 67.5%,P<0.05,P<0.01).The incidence of adverse events was similar in both groups. Among the subgroup who had previous colonoscopy experience,a significantly higher number of patients in the mosapride group felt that the current preparation was easier compared with patients in the placebo group(34/72 patients vs 24/74 patients,P<0.05). CONCLUSION:Mosapride citrate may be an effective and safe adjunct to PEG-electrolyte solution that leads to improved quality of bowel preparation,especially in patients without severe constipation. | Masahiro Tajika Yasumasa Niwa Vikram Bhatia Hiroki Kawai Shinya Kondo Akira Sawaki Nobumasa Mizuno Kazuo Hara Susumu Hijioka Kazuya Matsumoto Yuji Kobayashi Akira Saeki Asana Akabane Koji Komori Kenji Yamao | 2012 | World Journal of Gastroenterology2012，18，20： | 21 |
| 7 | Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization显示文摘AIM: To determine the role of interleukin (IL)-17 in gastric ulcerogenesis. METHODS: Thirty-six gastric ulcer (GU) patients and 29 non-ulcer (NU) patients were enrolled in this study. Mucosal biopsy samples were obtained from the gastric antrum and GU site during endoscopy. Samples were used in in situ stimulation for 48 h in the presence of 10 μg/mL phytohemagglutinin-P (PHA), histological examination, and Helicobacter pylori(H pylori) culture. IL-17 and IL-8 protein levels in culture supernatants were assayed by ELISA. IL-17 mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). H pylori cagA and vacA status was assessed by reverse hybridization using a line probe assay (LiPA). IL-8 levels in culture supernatants were assayed after AGS cells were co-cultured with H pylori strain 26 695 or recombinant human (rh) IL-17. RESULTS: All 36 GU patients and 15 of 29 NU patients were found to be H pylori-positive, while 14 NU patients were H pylori-negative. All 51 H pylori strains from both GU and NU patients were cagA- and vacAs1/m1-positive. Antral mucosal tissues from H pylori-positive patients contained significantly (H pylori-positive NU patients: median 467 pg/mg/protein, range 53-2 499; H pylori-negative NU patients: median 104 pg/mg/protein, range 16-312, P<0.0005) higher levels of IL-17 than those from uninfected patients. IL-17 levels at the ulcer site were significantly (ulcer site: median 1356 pg/mg/protein, range 121-1 3730; antrum: median 761 pg/mg/protein, range 24-7 620, P<0.005) higher than those at distant sites in the antrum. Biopsies from H pylori-positive GU and NU patients showed IL-17 mRNA expression in all samples whereas those from the antrum of the H pylori-negative controls showed no detectable expression. A significant correlation was seen between IL-17 and IL-8 levels at each biopsy site (ulcer: r= 0.62, P<0.0001; antrum: r = 0.61, P<0.0001) in GU patients. RhIL-17 and H pylori strain 26 695 each stimulated IL-8 production from AGS cells. CONCLUSION: IL-17 may play an important role in the inflammatory response to H pylori colonization, and may ultimately influence the outcome of H pylori-associated diseases that arise within the context of gastritis. | Tomokazu Mizuno Takafumi Ando Kazuo Nobata Tomoyuki Tsuzuki Osamu Maeda Osamu Watanabe Masaaki Minami Kenji Ina Kazuo Kusugami Richard M. Peek Hidemi Goto | 2005 | World Journal of Gastroenterology2005，11，40： | 18 |
| 8 | Characteristics and prognosis of synchronous multiple early gastric cancer显示文摘AIM:To assess the clinicopathologic characteristics,risk factors,and prognosis for synchronous multiple early gastric cancer(SMGC).METHODS:A total of 146 patients with SMGC and1194 patients with single gastric cancer who had undergone gastrectomy between 1989 and 2008 were retrospectively analyzed to determine their clinicopathologic characteristics and postoperative survival.Tumors were classified into groups on the basis of location and histology.Smoking habits were evaluated using the Brinkman index.Clinical and pathological factors were compared using either Fisher’s exact test or Pearson’sχ2test.Logistic regression analysis was performed to identify independent risk factors.Survival rate was calculated using the Kaplan-Meier method.RESULTS:SMGCs accounted for 10.9%of gastric cancer cases and occurred predominantly in elderly male patients with a family history of gastric cancer who were both smokers and drinkers.These tumors were typically macroscopically elevated and histologically differentiated.There were no significant differences between SMGC and single gastric cancer patients with respect to tumor location,tumor size,lymph node metastasis,the number of metastatic lymph nodes,venous invasion,or tumor stage(P=0.052,P=0.347,P=0.595,P=0.805,P=0.559,and P=0.408,respectively).Further,there was no significant difference in postoperative survival between the patient groups(P=0.200).Of the 146SMGC patients,a single patient had remnant cancer.CONCLUSION:A careful preoperative endoscopy is necessary for patients who are at high risk of SMGC,and minimally invasive treatment may be indicated in some cases. | Taro Isobe Kousuke Hashimoto Junya Kizaki Naotaka Murakami Keishiro Aoyagi Kikuo Koufuji Yoshito Akagi Kazuo Shirouzu | 2013 | World Journal of Gastroenterology2013，19，41： | 17 |
| 9 | Effect of phosphorus fluctuation caused by river water dilution in eutrophic lake on competition between blue-green alga Microcystis aeruginosa and diatom Cyclotella sp.显示文摘Tega-numa (Lake Tega) is one of the eutrophic lakes in Japan. For the improvement of water quality in Lake Tega, the North-chiba Water Conveyance Channel was constructed in 2000, which transfer water from Tone River into the lake. After 2000, the dominant species of diatoms, mainly Cyclotella sp., have been replacing blue-green algae, mainly Microcystis aeruginosa in Lake Tega. This transition of dominant species would be due to the dilution, but the detail mechanism has not been understood yet. This study examined the relationship between phosphorus fluctuation caused by river water dilution to Lake Tega and dominance of algal species, M. aeruginosa or Cyclotella sp. based on the single-species and the mixed-species culture experiments. The single-species culture experiment showed that the half-saturation constant and uptake rate of phosphorus were one order lower and seven times higher for M. aeruginosa than those for Cyclotella sp. These findings implied that M. aeruginosa would possess a potential for the growth and survival over Cyclotella sp. in the phosphorus limited condition. The superiority of M. aeruginosa was reflected in the outcome of the mixed-species culture experiment, i.e., dominance of M. aeruginosa, even phosphorus concentration was lowered to 0.01 mg-P/L. Therefore, it could be concluded that the decrease in phosphorus concentration due to the river water dilution to Lake Tega would be interpreted as a minor factor for the transition of dominant species from M. aeruginosa to Cyclotella sp. | Yoshimasa Amano Yusuke Sakai Takumi Sekiya Kimitaka Takeya Kazuo Taki Motoi Machida | 2010 | Journal of Environmental Sciences2010，22，11： | 16 |
| 10 | 胸苷酸合成酶基因多态和生活习惯及亚甲基四氢叶酸还原酶基因协同作用与胃癌的易感性显示文摘目的 研究胸苷酸合成酶 (TS) 3’ UTR基因多态和生活习惯及亚甲基还原酶基因相互作用与胃癌易感性的关系。方法 在上消化道癌高发区淮安市进行病例对照研究 (胃癌患者 1 0 7例 ,人群对照 2 0 0名 ) ,调查研究对象的生活习惯 ,采用聚合酶链反应 限制性片段长度多态性 (PCR RFLP)技术检测研究对象的TS 3’ UTR基因型。结果 (1 )胃癌组中TS +6bp +6bp、+6bp - 6bp、- 6bp - 6bp基因型频度分别为5 .6 %、47.7%和 46 .7% ,与对照组的 9.0 %、54 .0 %和 37.0 %相比 ,差异无显著性 (χ2 =3 .1 90 ,P =0 .2 0 3)。与携带 +6bp等位基因者相比 ,携带TS - 6bp - 6bp基因型者胃癌发生的危险性有所升高 (调整OR =1 .36 ,95 %CI:1 .0 0~ 1 .78,P =0 .0 4 7)。 (2 )TS - 6bp - 6bp基因型对吸烟、饮酒及不饮茶的习惯在胃癌发生中的作用有放大效应。与携带 +6bp等位基因且不吸烟者或不经常饮酒者或饮茶者相比 ,携带 - 6bp - 6bp基因型且有吸烟习惯者或经常饮酒者或不饮茶者发生胃癌的调整OR分别为 2 .79(95 %CI :1 .51~ 5 .1 8)、1 .76(95 %CI:1 .0 7~ 2 .90 )和 2 .34(95 %CI :1 .43~ 3 .82 )。 (3)TS - 6bp - 6bp基因型与亚甲基四氢叶酸还原酶 (MTHFR)C T或T T基因型有协同作用。携带TS - 6bp - | 高长明 吴建中 刘燕婷 丁建华 李苏平 苏平 胡旭 开海涛 Takezaki Toshiro Tajima Kazuo | 2003 | 中华流行病学杂志2003，24，7： | 16 |
| 11 | 谷胱甘肽转硫酶T1、M1基因型和烟酒茶嗜好与食管癌、胃癌显示文摘目的 :研究谷胱甘肽转硫酶T1、M1(GSTT1、GSTM 1)基因多态性和烟酒茶嗜好及其相互作用与食管癌、胃癌易感性的关系。方法 :在上消化道癌高发区淮安市进行了病例 -对照研究 (食管癌 141例 ,胃癌 15 3例 ;人群对照 2 2 3例 ) ,调查研究对象的烟酒茶嗜好习惯 ,以多重PCR方法分析GSTT1、GSTM1基因型。结果 :食管癌组GSTM1-基因型频度 (75 .18% )显著高于对照组 (5 9.6 4 % ,P =0 .0 0 2 4 ;多因素调整OR =2 .33,95 %CI =1.39~ 3.92 )。吸烟或不饮茶与GSTM 1 基因型在增加食管癌发生的风险中有明显的协同作用。在GSTT1+基因型者中 ,吸烟习惯显著增加食管癌、胃癌的危险性 ;在GSTM1+基因型者中 ,经常饮酒显著增加食管癌、胃癌的危险性。结论 :食管癌、胃癌的发生与生活习惯、GSTM1和GSTT1基因型以及它们的相互作用有关。 | 高长明 Takezaki Toshiro 吴建中 李忠佑 丁建华 刘燕婷 李苏平 苏平 胡旭 徐天亮 Tajima Kazuo | 2002 | 肿瘤防治杂志2002，9，2： | 15 |
| 12 | Development of Simulation System for the Disaster Evacuation Based on Multi-Agent Model Using显示文摘This paper presents a simulation system for the disaster evacuation based on multi-agent model considering geographical information. This system consists of three parts, the modeling for the land and buildings using GIS data, the analysis of disaster evacuation using multi-agent model, and the visualization for the numerical results using the virtual reality technique. By introducing the numerical solver of the natural disaster to the present system, it is possible to evaluate not only the damage of structure but also the damage of human being. Furthermore, it is possible to investigate the appropriate evacuation route by the simulation. The Dijkstra algorithm is used to obtain shortest route to the refuge. In addition, the visualization using virtual reality technique is curried out to understand the feeling of refugee. The present system is applied to the evacuation analysis by the flood flow in urban area and is shown to be a useful tool to investigate the damage by natural disasters. | GISKeisuke Uno Kazuo Kashiyama | 2008 | Tsinghua Science and Technology2008，13，S1： | 15 |
| 13 | 区域地下水位插值的整体-局部组合方法显示文摘利用趋势面分析法进行空间插值时估值趋势面光滑,对局部数据起伏较大的区域插值精度不理想。针对这一问题,该文基于非平稳地下水位数据,在用趋势面分析法进行空间插值的基础上,运用Yamamoto提出的修正的普通克里金法对区域残差进行了空间插值。将趋势面分析法的估计值与残差估计值相加,得到区域地下水位的空间分布规律。结果表明,采用这种整体与局部结合的组合插值方法,地下水位插值的结果比趋势面分析结果更接近实际情况,在保证全局最优的同时较好地解决了估值趋势面光滑、局部插值精度低的问题,更能真实地反映区域地下水位空间分布特征。 | 王春颖 尚松浩 毛晓敏 Jorge Kazuo Yamamoto | 2011 | 农业工程学报2011，27，8： | 13 |
| 14 | 亚甲基四氢叶酸还原酶基因1298A→C多态与食管癌易感性关系的病例对照研究显示文摘目的研究亚甲基四氢叶酸还原酶(MTHFR)基因1298A→C多态及其和生活习惯相互作用与食管癌易感性的关系.方法在食管癌高发区的淮安市楚州区开展了一项病例对照研究(食管癌患者141例,人群对照228名), 调查研究对象的生活习惯,采用聚合酶链反应-限制性片段长度多态性技术检测研究对象的MTHFR 1298A→C基因型.结果①食管癌组中MTHFR 1298 AA、AC和CC基因型携带者的比例分别为 63.8%、 34.0%和 2.1%, 与对照组的 71.9%、 28.1%和 0.0%相比,差异有统计学意义( χ2MH= 6.69, P= 0.035).②在MTHFR 1298C等位基因携带者中,伴有吸烟习惯者发生食管癌的调整OR为 3.48(95%CI: 1.57~ 7.71),伴有经常饮酒的习惯者发生食管癌的调整OR为 2.91(95%CI: 1.20~ 7.08),无饮茶习惯者发生食管癌的调整OR为 3.52(95%CI: 1.64~ 7.54).MTHFR 1298AC和CC基因型与吸烟、饮酒和不饮茶在食管癌发生中的相互作用系数r分别为 3.05、 3.69和 6.30.结论 MTHFR 1298AC和CC基因型对吸烟、饮酒和不饮茶增加食管癌发生风险的作用有明显的放大效应. | 高长明 Takezaki Toshiro 吴建中 曹海霞 刘燕婷 丁建华 李苏平 苏平 胡旭 开海涛 Tajima Kazuo | 2004 | 中华流行病学杂志2004，25，4： | 13 |
| 15 | 亚甲基四氢叶酸还原酶基因多态性与结直肠癌易感性的关系显示文摘目的:研究亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因C677T、A1298C多态性与结直肠癌易感性的关系.方法:在江苏省进行了一个病例-对照研究(结直肠癌患者315例,人群对照371例),调查研究对象的生活习惯,抽取静脉血,提取白细胞DNA,采用PCR-RFLP检测研究对象的MTHFR C677T、A1298C基因型.结果:1)男女合计的结直肠癌组、结肠癌组和直肠癌组与对照组之间的MTHFR C677T、A1298C基因型分布频度和等位基因频度差异无统计学意义,MTHFR C677T、A1298C基因多态与结直肠癌、结肠癌和直肠癌的易感性无显著相关.2)在男性中,结肠癌组MTHFR C677T T/T基因型的频度为24.6%,明显高于对照组的14.8%,但差异无统计学意义,X2=3.42,P=0.064.与C677T C等位基因携带者相比,T/T基因型者发生结肠癌的危险性显著升高,其性别、年龄、居住地区及吸烟、饮酒和饮茶习惯调整后的OR为2.15(95%CI:1.07~4.33).与同时携带MTHFR C677T C等位基因和A1298C A/A基因型者相比,男性的MTHFR C677T T/T和A1298C A/A基因型携带者发生结肠癌的危险性显著升高,其调整OR为2.64(95%CI:1.20~5.81),而他们发生直肠癌的危险性则明显降低,(调整OR=0.47,95%CI:0.22~1.03).结论:MTHFR C677T基因多态可以影响男性结、直肠癌的易感性,MTHFR A1298C多态与C677T多态在对男性结、直肠癌易感性的影响中有协同作用. | 高长明 Takezaki Toshiro 吴建中 丁建华 周建农 刘燕婷 李苏平 苏平 曹佳 Hamajima Nobuyuki Tajima Kazuo | 2005 | 肿瘤防治杂志2005，12，16： | 12 |
| 16 | CYP2E1、GSTT1、GSTM1基因型与食管癌关系显示文摘[目的]研究CYP2E1RsaⅠ、GSTT1、GSTM1基因多态性和烟酒茶嗜好及其相互作用与食管癌易感性的关系。[方法]在食管癌高发区淮安市进行了一个病例对照研究(食管癌144例 ,人群对照233例) ,调查研究对象的烟酒茶嗜好习惯 ,以PCR扩增、RsaⅠ内切酶消化 ,分析CYP2E1的基因型 ,以多重PCR方法分析GSTT1、GSTM1基因型。[结果](1)对照组GSTM1基因型频度及饮茶状况分布与食管癌组之间存在显著差异 ,携带GSTM1正常基因型或有饮茶习惯者发生食管癌的危险性显著降低。(2)在不同烟酒茶嗜好者中 ,CYP2E1、GSTT1和GSTM1基因型对食管癌发生的影响有所不同。[结论](1)携带GSTM1正常基因型或饮茶能降低食管癌发生的危险性。(2) | 高长明 Takezaki Toshiro Sugimura Haruhiko 吴建中 丁建华 刘燕婷 李苏平 苏平 李忠佑 王建东 胡旭 徐天亮 Tajima Kazuo | 2001 | 中国肿瘤2001，10，6： | 12 |
| 17 | Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer显示文摘AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line MKN-45 compared with the high potential peritoneal dissemination gastric cancer cell line MKN-45 P. METHODS: The supernatant of culture medium of MKN-45 cells or MKN-45 P cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for MKN-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2013 | World Journal of Critical Care Medicine2013，2，4： | 12 |
| 18 | Bipolar hemiarthroplasty for femoral neck fracture using the direct anterior approach显示文摘AIM: To evaluate whether walking ability recovers early after bipolar hemiarthroplasty(BHA) using a direct anterior approach.METHODS: Between 2008 and 2010, 81 patients with femoral neck fracture underwent BHA using the direct anterior approach(DAA) or the posterior approach(PA). The mean observation period was 36 mo. The age, sex, body mass index(BMI), time from admission to surgery, length of hospitalization, outcome after discharge, walking ability, duration of surgery, blood loss and complications were compared. RESULTS: There was no significant difference in the age, sex, BMI, time from admission to surgery, length of hospitalization, outcome after discharge, duration of surgery and blood loss between the two groups. Two weeks after the operation, assistance was not necessary for walking in the hospital in 65.0% of the patients in the DAA group and in 33.3% in the PA group(P < 0.05). As for complications, fracture of the femoral greater trochanter developed in 1 patient in the DAA group and calcar crack and dislocation in 1 patient each in the PA group.CONCLUSION: DAA is an approach more useful for BHA for femoral neck fracture in elderly patients than total hip arthroplasty in terms of the early acquisition of walking ability. | Tomonori Baba Katsuo Shitoto Kazuo Kaneko | 2013 | World Journal of Orthopedics2013，4，2： | 11 |
| 19 | 亚甲基四氢叶酸还原酶基因多态性与胃癌化疗的敏感性关系的研究显示文摘目的 研究亚甲基四氢叶酸还原酶(MTHFR) 因C677T、A1298C多态与胃癌患者对5-FU为基础的化疗敏感性和毒性的关系。方法 收集经病理学确诊的晚期胃癌患者75例,病例化疗前均抽静脉血,提取白细胞DNA,用聚合酶链反应-限定性片段长度多态性技术检测MTHFR基因型。所有患者经5-FU为基础的化疗方案治疗。结果 (1)在75例晚期胃癌患者中,MTHFR C677TC/C、C/T、T/T基因型者分别为24例(32.0%)、33例(44.0%)和18例(24.0%);MTHFR A1298CA/A、A/C、C/C基因型者分别为52例(69.3%)、22例(29.3%)和1例(1.3%);经化疗后22例患者有效,总有效率29.3%。(2)MTHFR C677T T/T基因型者化疗的有效率为83.3%,显著高于T/C基因型者(15.2%,x2=22.27,P=0.000)和C/C基因型者(8 3%,x2=23.44,P=0.000)。C677T T/T基因型患者化疗敏感性是携带C677T C等位基因者的7.64倍(调整了性别、年龄、以往辅助化疗史及化疗方案,95%CI:3.14-18.62)。MTHFR A1298C A/A基因型者的有效率(36.5%),显著高于携带A1298C C(13.0%)等位基因者(x2=4 19,P=0.041;调整OR=3 75,95%CI:0.94-14.87)。同时携带MTHFR C677T T/T基因型和A1298C A/A基因型者化疗的有效率(86.7%)显著高于其他基因型者(15.0%,Fisher's exact:P=0.000,调整OR=6.57. | 高长明 陆建伟 Takezaki Toshiro 吴建中 曹海霞 陈环球 冯继锋 Tajima Kazuo | 2004 | 中华流行病学杂志2004，25，12： | 11 |
| 20 | 8-羟基鸟嘌呤糖苷酶基因型、生活习惯与食管癌和胃癌显示文摘[目的]研究8 羟基鸟嘌呤糖苷酶基因 (hOGG1)型、生活习惯及其相互作用与食管癌、胃癌易感性的关系。[方法]在上消化道癌高发区淮安市进行了一个病例—对照研究(食管癌93例,胃癌107例 ,人群对照200例),调查研究对象的生活习惯 ,以PCR SSCP方法分析hOGG1基因型。[结果]对照组与食管癌组、胃癌组之间的hOGG1基因型频度分布差异无显著意义。在携带hOGG1Ser326Cys或Cys326Cys基因型者中 ,吸烟显著增加食管癌、胃癌发生的危险性。饮茶习惯能降低食管癌、胃癌发生的危险性 ,这种作用在hOGG1Ser326Ser基因型携带者中更明显。[结论]在不同hOGG1基因型携带者中 ,生活习惯与食管癌、胃癌发生的关系有所不同。这些结果表明 ,食管癌、胃癌的发生与生活习惯、hOGG1基因型以及它们的相互作用有关。 | 高长明 Sugimura Haruhiko Takezaki Toshiro 吴建中 李忠佑 丁建华 刘燕婷 李苏平 苏平 胡旭 徐天亮 Tajima Kazuo | 2001 | 中国肿瘤2001，10，9： | 11 |
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